WO2023045590A1 - Blow-fill-seal device - Google Patents

Abstract

Disclosed in the present invention is a blow-fill-seal device, comprising: an extruder for plasticizing plastic particles and conveying a colloid in a molten state; and a form-fill-seal system, which is arranged linearly, is used for forming a rubber sleeve into an ampoule and for liquid medicine filling and sealing of the ampoule, and comprises a filling and sealing machine, an extrusion head, and a forming mold, wherein the filling and sealing machine is used to fill the formed ampoule with a liquid medicine; the extrusion head is used for preliminarily forming the colloid into the rubber sleeve and conveying the rubber sleeve; and the forming mold is used to re-process the rubber sleeve to form the ampoule, and seal the ampoule filled with the liquid medicine. In this way, an integrated mechanical operation is achieved, so that the production time of the ampoule is greatly shortened, the production efficiency of the ampoule is improved, and the effect of large-scale mass production is achieved.

Description

A blow-fill-seal equipment technical field

The invention relates to the technical field of liquid medicine filling equipment, in particular, to a blow-fill-seal equipment.

Background technique

The traditional ampoule (ampulla) bottle is a kind of fused-sealed thin-walled hard glass container, which is often used to store a small amount of injection drugs, vaccines, serum, etc., and is convenient to store in a sterile state. Moreover, the ampoule bottle can be broken just by scratching the neck of the bottle with a grinding wheel, which is convenient for use.

At present, the application fields of ampoules are becoming more and more extensive. For example, cosmetics/skin care products, health care products and other industries have also begun to use ampoules. The high cost and harsh sealing methods of glass ampoules are no longer suitable for new fields.

A plastic ampoule is increasingly used to hold the contents including liquid and/or solid powder. Plastic ampoules are usually made of PE (polyethylene, polyethylene) plastic or PP (polypropylene, polypropylene) material

However, the traditional production mode of plastic ampoules requires separate operations in three workshops, which takes a long time. Moreover, considering that plastic ampoules are not resistant to high temperatures, especially PE ampoules, they cannot be sterilized, so the long-term production process will easily lead to the introduction of pollution and cause safety problems.

In the prior art, ampoules are produced through multiple workshops, which greatly reduces the production efficiency of ampoules.

Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a blow-fill-seal equipment.

Contents of the invention

The invention provides a blow-fill-seal equipment to solve the technical problem in the prior art that the ampoule bottle production efficiency is greatly reduced through multiple workshops.

According to one aspect of the present invention, a blow-fill-seal equipment is provided, comprising:

an extruder for conveying the molten colloid;

Forming and sealing system, the forming and sealing system is arranged in a straight line, and the forming and sealing system is used for forming rubber cartridges to form ampoules, and is used for filling and sealing the liquid medicine of ampoules.

By adopting the above technical scheme, when producing ampoules, the plastic raw materials are put into the extruder and heated to a molten state, and the molten colloid is transferred to the forming and sealing system through the extruder to form the ampoule , filling and sealing to make ampoules, by extruding the colloid in a forming and filling system to form ampoules, there is no need for multiple workshops to form, fill and seal ampoules, shortening the life of ampoules The processing time improves the production capacity of ampoules, and has mechanical integration operation, which greatly shortens the production time of ampoules, improves the production efficiency of ampoules, and realizes the effect of mass production.

Further, the molding potting system includes a potting machine, an extrusion head and a molding die;

The filling and sealing machine is used for filling the formed ampoules with medicinal liquid;

The extrusion head is used to preliminarily form the rubber cartridge of the colloid and carry out the transmission of the rubber cartridge;

The forming mold is used for reprocessing the rubber cartridge to form an ampoule bottle and sealing the ampoule bottle filled with the medicinal solution.

By adopting the above technical scheme, when producing ampoules, the rubber cylinder is transferred to the forming mold through the extrusion head, the ampoule is filled with liquid medicine through the filling and sealing machine, and the filled ampoule is lowered with the forming mold. Move and open the mold, connect the ampoule bottle through the synchronous clamping mechanism and drive the ampoule bottle to move down synchronously with the rubber cylinder in the extrusion head, and complete the bottle body of the ampoule bottle by opening the mold and moving it up to the rubber cylinder and closing the mold , and then the new ampoules are filled with liquid medicine through the filling and sealing machine, and the filling and sealing of the ampoules is carried out in a cyclic operation, and the filling and sealing machine, the extrusion head and the forming mold move linearly to process and shape the rows of ampoules And it is formed continuously in a straight line, which improves the working efficiency.

Further, the extrusion head includes a die base, a feeding base, an upper pressing plate and a lower pressing plate, the die base is connected to the feeding base, the upper pressing plate is arranged on the die base, and the lower pressing plate Set under the upper platen, it also includes:

A core assembly, the core assembly is arranged on the mold base, the core assembly is located between the upper platen and the lower platen, and the core assembly is used for rubber cylinder molding;

A fastening assembly, the fastening assembly is arranged on the mold base, and the fastening assembly is used to connect the mold core assembly and the mold base.

By adopting the above technical scheme, the colloid in the extruder is transported to the extrusion head along the feeding seat, and the colloid is divided into two through the annular flow channel on the feeding seat, and then divided into four for transmission. The core plate is fixed on the mold base and connected to the core plate through the upper platen and the lower platen, and forms a mold cavity with the core plate, and the colloid is transferred to the mold cavity through the annular flow channel, and the guide flow channel at the discharge end of the cavity For transmission, there are temperature control joints evenly distributed on the mold base, through which the colloid in the mold cavity is heated and the temperature of the colloid is controlled, so as to avoid the colloid being adsorbed on the inner wall of the mold cavity due to excessive temperature of the colloid, so that the outlet of the mold cavity The colloid flow rate is too small, so that the wall thickness of the rubber tube does not meet the production requirements. Continuous operation and output of products in a straight line, preferably continuous operation and output of products in the vertical direction, is more conducive to the miniaturization of equipment design without affecting production efficiency, and continuous operation and output of products in the vertical direction, Better efficiency; due to the vertical forming and continuous output, the waste material area on the product can be designed to be less, which can reduce the amount of materials used, improve the effective utilization of materials and reduce costs.

Further, the extrusion head is also provided with a feeding shunt pipe, and the feeding shunting pipe includes:

Main flow pipe, the main flow pipe is arranged at the outlet end of the extruder, and the main flow pipe connects the extruder and the extrusion head;

A splitter assembly, the splitter assembly is arranged at the end of the main pipe, and the splitter assembly is used to carry out staged transmission of the colloid transported by the main pipe, and is used to control the uniform transmission of the colloid to the extrusion head.

By adopting the above technical scheme, when the colloid is transported to the extrusion head, the hot-melt plastic colloid in the extruder is transmitted to the U-shaped tube through the main pipe, and the colloid is transmitted to the shunt pipe through the two ends of the U-shaped tube, so as to realize the colloid. One split into two and one split into four for shunt transmission, which ensures the molding of the rubber tube in the extrusion head. , the end of the shunt pipe is connected to the extrusion head through a flow valve. When the colloid is transported in the extrusion head, the flow valve is used to control the amount of glue that enters the extrusion head. By extruding the colloid along the Both sides of the head evenly enter the extrusion head to ensure the uniform transmission of the colloid flow in the extrusion head, thereby ensuring the molding pass rate of the rubber tube.

Further, the extrusion head is also provided with an oxygen concentration detection mechanism; the oxygen concentration detection mechanism includes an oxygen concentration detection component, and the oxygen concentration detection component is arranged in the extrusion head and used to detect the oxygen concentration in the extrusion head. The oxygen concentration of the rubber cartridge is monitored.

By adopting the above technical scheme, when filling the ampoule bottle in the forming mold with liquid medicine, the oxygen concentration around the filling needle in the extrusion head is detected by the online oxygen concentration detector, and the oxygen concentration detection residual oxygen is less than 3%, the filling and sealing machine is turned on to fill the liquid medicine. When the online oxygen concentration detector detects that the oxygen concentration at the filling needle is too high, the nitrogen gas is delivered through the gas delivery device, so that the ampoule can be filled. Oxygen concentration is adjusted, and it can monitor the oxygen concentration and feed back the signal during the ampoule filling in real time, so that the filling of the ampoule liquid medicine can meet the production demand and improve the production qualification rate of the ampoule bottle.

Further, the extrusion head is also provided with a temperature detection mechanism for the inner wall of the ampoule, and the detection mechanism for the inner wall of the ampoule includes a temperature detection component, which is used for temperature detection of the inner wall of the formed ampoule, and for Determine whether the formed ampoules meet the filling conditions.

By adopting the above technical scheme, when the temperature of the ampoule in the bottle body mold is detected, the filling needle is inserted into the ampoule, and the temperature of the inner wall of the ampoule is detected by a micro temperature sensor, and the temperature value is transmitted to the wireless Observation on the temperature acquisition instrument, by judging whether the inner wall temperature of the ampoule satisfies the condition of less than 60°C and then filling the liquid medicine, has the effect of real-time monitoring on whether the filling temperature of the medicine liquid in the ampoule bottle meets the filling temperature.

Further, the extrusion head is also provided with a rubber tube thickness adjustment mechanism, and the rubber tube thickness adjustment mechanism includes:

An adjustment assembly, the adjustment assembly is arranged on the lower platen and the core plate, the adjustment assembly moves along the bottom of the lower platen and is used to adjust the size of the outlet of the mold cavity;

a driving assembly, the driving assembly is connected to the adjusting assembly and is used to drive the adjusting assembly to move along the bottom of the lower platen.

By adopting the above technical scheme, when the colloid in the extruder is transported, the colloid is transmitted through the extrusion head and the colloid wall is controlled to form multiple groups of rubber tubes to flow into the forming mold, and the colloid is passed along the core plate and the upper part of the mold. The mold cavity between the pressing plate and the lower pressing plate is flowed, the wall thickness of the rubber tube is controlled by the guide block of the adjusting plate, and the wall thickness of the rubber tube is controlled within the range that meets the production requirements, and then the adjusting plate is fixed to ensure the gap between the adjusting plate and the guide block. The gap meets the wall thickness of the rubber tube, thereby realizing the adjustment of the wall thickness of the rubber tube.

Further, the forming mold includes a head mold and a bottle body mold, the head mold is connected to the bottle body mold, and a balanced mold clamping mechanism is also arranged on the head mold and the bottle body mold, The balanced mold clamping mechanism is used to stably drive the mold clamping of the head mold and the bottle body mold.

By adopting the above technical scheme, the bottle body of the ampoule bottle is extruded through the bottle body mold, the bottle head of the ampoule bottle is extruded through the head mold, and the primary bottle body of the head mold is squeezed through the balanced mold clamping mechanism. The molds are molded separately. First, the bottle body mold is molded to complete the body of the ampoule bottle. The ampoule bottle is filled with liquid medicine through the filling machine, and then the head mold is molded by a balanced mold clamping mechanism. The packaging of ampoules has the effect of realizing the integrated operation of filling and sealing.

Further, the balanced mold clamping mechanism includes:

a push assembly, the push is used to push the head mold and the bottle body mold to close;

A balance assembly, the balance assembly is used to connect the push assembly so that the push assembly pushes the head mold and the bottle body mold to close in a straight line.

By adopting the above-mentioned technical scheme, when the rubber tube in the extrusion head flows into the forming mold, the bottle body of the ampoule bottle is completed through the promotion of the bottle body template on the first mold clamping cylinder, and the filling needle is extended. Fill the ampoule bottle with the liquid medicine, and complete the bottle head molding of the ampoule bottle through the second clamping oil cylinder to take the head template and close the mold, thereby completing the medicine liquid filling and sealing of the ampoule bottle, and ensuring the stability of the forming mold Clamping, the mold clamping stroke is short, which improves the precision of mold clamping, improves the speed of ampoule forming, and reduces the stepping distance of the second clamping cylinder to reduce energy consumption.

Further, the bottom of the forming mold is provided with a synchronous clamping mechanism, which is used for stable molding of ampoules, and the synchronous clamping mechanism includes:

A clamping assembly, the clamping assembly is arranged below the bottle body mold, and the clamping assembly is used to clamp the ampoule formed in the bottle body mold;

a stretching assembly connected to the clamping assembly and used to open the clamping assembly so as to form a cooled ampoule;

An elevating assembly, which is connected to the clamping assembly and is used to drive the clamping assembly up and down to repeatedly clamp the ampoule formed by the bottle body mold.

By adopting the above technical scheme, when clamping and moving the ampoule in the forming mold, the stepper motor drives the two-way threaded rod to rotate to drive the clamping plate to move towards each other to clamp the bottom end of the ampoule and open the forming mold. The filled ampoule and the clamping plate move down under the action of the lifting cylinder, and the downward movement speed of the clamping plate is consistent with the extrusion speed of the rubber tube in the extrusion head, avoiding the effect of gravity on the formed ampoule Next, the rubber tube is pulled down and deformed.

The present invention has the following beneficial effects:

When the blowing, filling and sealing equipment of the present invention is filling the ampoule bottle, the plastic original is heated to a molten state through the extruder, and the molten colloid is transferred to the forming and filling system through the extruder. The head is used for preliminary molding of the colloid, and the flow of the colloid is controlled through the cavity in the extrusion, and it flows naturally at the outlet of the extrusion head to form a rubber tube. According to the production requirements, the wall thickness of the rubber tube is controlled by adjusting the components. Transfer the rubber cartridge to the forming mold, push the mobile template to move towards each other through the first clamping cylinder, close the bottle body mold to complete the bottle body of the ampoule bottle, and fill the ampoule bottle with liquid medicine through the filling on the filling and sealing machine to complete the ampoule bottle filling, the head template is driven by the second mold clamping cylinder to close the mold to complete the bottle head of the ampoule bottle, thereby completing the filling and sealing of the ampoule bottle, and the ampoule bottle is clamped by the synchronous clamping mechanism Hold the movement, the positions of the filling and sealing machine and the extrusion head remain unchanged and the filling needle on the filling and sealing machine passes through the extrusion head and abuts against the rubber tube, and the forming mold is driven to clamp the rubber tube by the private servo push rod and The rubber tube is extruded and filled with the liquid medicine through the filling needle, and the filling needle is moved out of the forming mold by moving down the forming mold to close the mold, and the formed ampoule is clamped and transported by the synchronous clamping mechanism, and is extruded The rubber tubes in the machine move synchronously and wait for the rubber tubes to move. The electric push rod drives the forming mold to move upwards to clamp the rubber tubes and continue to extrude the molding. In this way, the extrusion and filling of ampoules is carried out in a cycle, so as to realize the integrated production of machinery. , improving production efficiency.

In addition to the objects, features and advantages described above, the present invention has other objects, features and advantages. Hereinafter, the present invention will be described in further detail with reference to the drawings.

Description of drawings

The accompanying drawings constituting a part of this application are used to provide further understanding of the present invention, and the schematic embodiments and descriptions of the present invention are used to explain the present invention, and do not constitute an improper limitation of the present invention. In the attached picture:

Fig. 1 is the overall structure schematic diagram of the preferred embodiment of the present invention;

Fig. 2 is an axial sectional view along the width direction of the extrusion head of Fig. 1;

Fig. 3 is a structural diagram of the extrusion head in Fig. 1;

Fig. 4 is the structural diagram of the molding die among Fig. 1;

Fig. 5 is a structural diagram of the forming filling system in Fig. 1;

The schematic structural representation of the feeding shunt pipe in Fig. 6 Fig. 2;

Fig. 7 is a schematic structural diagram of the temperature detection assembly in Fig. 2;

Fig. 8 is a schematic structural diagram of the oxygen concentration detection component in Fig. 2;

Fig. 9 is a schematic structural view of the gas delivery device in Fig. 11;

Fig. 10 is a schematic structural view of the synchronous clamping mechanism in Fig. 1;

Fig. 11 is a structural schematic diagram as a deformation of the synchronous clamping mechanism in Fig. 10;

FIG. 12 is a schematic side view of the synchronous clamping mechanism in FIG. 11 .

illustration:

1. Extruder; 2. Extrusion head; 21. Die base; 211. Upper platen; 212. Lower platen; 213. Space plate; 214. Fastening component; 2141. Fastening screw; 215. Feeding seat; 22. Main flow pipe; 23. Diverter assembly; 231. Primary diversion part; 2311. U-shaped pipe; 232. Secondary diversion part; 2321. Diverter pipe; 24. Core component; 241. Core plate; 242. Buffer 245, the first protrusion; 246, the second protrusion; 243, the mold cavity; 25, the temperature detection component; 251, the micro temperature sensor; 26, the adjustment component; 261, the first adjustment part; 2611, the adjustment plate; 2612, guide plate; 2613, guide block; 2614, accommodation groove; 2615, chute; 262, second adjustment part; 2621, adjustment block; 27, drive assembly; 271, first drive part; 2711, first drive screw ; 2712, adjusting screw; 272, second driving part; 2721, second driving screw; 28, oxygen concentration detection component; 281, online oxygen detector; 282, gas delivery device; 2821, nitrogen cylinder; 2822, filter; 2823. Air pipe; 2824. Branch pipe; 29. Temperature control component; 291. Temperature control joint; 3. Filling and sealing machine; 31. Filling needle; 4. Forming mold; 41. Head mold; 411. Head template; 42. Bottle body mold; 423. Bottle body template; 43. Push assembly; 431. First push part; 4311. First mold clamping cylinder; 432. Second push part; 4321. Second mold clamping cylinder; 44. Balance Component; 441, pull rod; 45, fixed template; 46, mobile template; 5, synchronous clamping mechanism; 51, clamping component; 511, clamping plate; 512, baffle; ; ; 55, stretching part; 551, stretching cylinder; 552, the first stretching rack; ; 562, drive wheel; 563, conveyor belt; 564, slide plate; 565, slide rail; 566, driving motor.

Detailed ways

The embodiments of the present invention will be described in detail below with reference to the accompanying drawings, but the present invention can be implemented in various ways defined and covered below.

Example 1

As shown in Figure 1 and Figure 2, this embodiment discloses a blow-fill-seal equipment, including an extruder 1 and a forming and filling system. The filling system forms, fills and seals ampoules. The forming and filling system includes a filling and sealing machine 3, an extrusion head 2, and a forming mold 4. Through the extrusion head 2, the colloid forming rubber cylinder is transported to the forming mold 4 for forming ampoules, and the filling and sealing machine 3 pairs the formed The ampoules are filled with liquid medicine, which realizes the integrated production of machinery and improves the production capacity of filling ampoules.

Referring to Fig. 1, Fig. 2, Fig. 3, the extrusion head 2 includes the mold base 21 and the feed base 215, the upper platen 211 and the lower platen 212, the core assembly 24 and the fastening assembly 214, the mold base 21 and the feed base 215 connection, the feed seat 215 is connected to the discharge end of the extruder 1, and the colloid is transported to the extrusion head 2 through the feed seat 215 for pre-forming treatment. An upper pressing plate 211 and a lower pressing plate 212 are arranged on the mold base 21, and the mold core assembly 24 is arranged between the upper pressing plate 211 and the lower pressing plate 212, and the mold core assembly 24 is installed through the upper pressing plate 211 and the lower pressing plate 212. The fastening assembly 214 on the mold core assembly 21 is fixedly installed on the mold core assembly 21.

With reference to Fig. 1, Fig. 2, Fig. 3, in order to control the transmission flow rate of the colloid in the extruder 1 in the feed seat 215, the feed assembly is set in the feed seat 215, and the colloid is controlled under the action of the feed assembly in the feed. Transport flow in seat 215. The feeding assembly includes an annular flow path, and the annular flow path includes a main flow pipe 22 and a flow distribution assembly 23. When blow molding and filling plastic ampoules, the plastic is heated through the extruder 1, and the hot-melt shape is conveyed through the extruder 1. Colloid, the colloid is delivered to the main pipe 22, and the colloid and the retrograde shunt treatment of the colloid delivered by the main pipe 22 through the shunt assembly 23, and the colloid is transported to both sides of the extrusion head 2 for glue feeding, and the colloid is passed along the extrusion head. The glue is fed evenly on both sides of the extrusion head 2, which ensures the uniform glue output in the extrusion head 2, so that the thickness of the rubber tube is consistent, and the molding of the plastic ampoule is realized.

Referring to Fig. 1, Fig. 2, Fig. 6, the splitter assembly 23 includes a primary splitter 231 and a secondary splitter 232, the primary splitter 231 is arranged at the end of the main flow pipe 22, and the primary splitter 231 includes a U-shaped pipe 2311 Connect the bent end of the U-shaped tube 2311 to the main flow pipe 22, and the two ends of the U-shaped pipe 2311 are provided with openings, so as to divide the colloid transported by the main flow tube 22 into two to control the transmission of the colloid. The secondary splitter 232 is arranged at both ends of the U-shaped pipe 2311. The secondary splitter 232 includes two splitter pipes 2321. The middle position of the branch pipe 2824 communicates with the end of the U-shaped pipe 2311. The splitter pipe 2321 connects the U-shaped pipe 2311 The transmitted colloid is divided into four for transmission. The two sides of the shunt tube 2321 are set on both sides of the rubber inlet of the extrusion head 2, and the glue is evenly fed along the two sides of the rubber inlet of the extrusion head 2, so that the shape of the rubber cylinder in the extrusion head 2 is regular and meets the production requirements. . The shunt pipe 2321 is arranged symmetrically along the axis of the width direction of the extrusion head 2, so that the colloid transported in the shunt pipe 2321 is evenly fed on both sides of the extrusion head 2, ensuring the stability of the amount of glue fed into the extrusion head 2, thereby The stable molding of the rubber cartridge can meet the production demand.

Referring to Fig. 1, Fig. 2, Fig. 3, the core assembly 24 includes a core plate 241, the core plate 241 is arranged between the upper platen 211 and the lower platen 212, and passes between the core plate 241 and the upper platen 211 and the lower platen 212. A mold cavity 243 is formed between them, and the glue is molded and flowed out in the mold cavity 243 to form a rubber cartridge. Adjusting assembly 26 is set at the exit of mold cavity 243, and the wall thickness of the outflow rubber cylinder is controlled by adjusting assembly 26. Adjusting assembly 26 includes adjusting block 2621. The width of the cavity outlet can adjust the wall thickness of the rubber tube. The lower end of the core plate is also provided with a guide block, which is used to connect the filling needle that passes through the core plate and guide the filling needle so that the filling The needle stably penetrates into the rubber tube, and when the drug solution is filled into the rubber tube, sterile air or sterile inert gas is passed into the rubber tube in the extrusion head.

Referring to Fig. 1, Fig. 2 and Fig. 3, a temperature control assembly 29 is also arranged on the extrusion head 2, and the temperature control assembly 29 includes a temperature control joint 291, which is arranged on the mold base 21, and through the temperature control joint 291 The temperature in the extruder 1 is monitored and adjusted so that the temperature of the colloid in the mold cavity 243 meets the production requirements, and the temperature-controlled joints 291 are evenly distributed on the mold base 21 .

Referring to Fig. 1, Fig. 2 and Fig. 3, the fastening assembly 214 includes a fastening screw 2141, which is arranged on the mold base 21, and the fastening screw 2141 threads pass through the mold base 21 and is threadedly connected with the mold core plate 241 The mold core plate 241 is fixed on the mold base 21 by fastening screws 2141 and installed between the upper platen 211 and the lower platen 212 .

Referring to Fig. 1, Fig. 2 and Fig. 3, in order to make the colloid flow out smoothly along the cavity 243 and compensate for the extrusion pressure loss of the colloid, the pressure values of the colloid along the feed end of the cavity 243 to the discharge end of the cavity 243 are consistent, Make the extrusion pressure of the colloid consistent. The buffer part 242 includes a first protrusion 245 and a second protrusion 246, and by arranging the first protrusion 245 and the second protrusion 246 at intervals, the colloid is transported to the second protrusion 246 along the first protrusion 245, Through the first protrusion 245 and the second protrusion 246 , the glue flows along the cavity 243 to compensate for the pressure loss and reduce the gas generated by the glue in the cavity 243 , so that the rubber barrel formed in the extrusion head 2 meets the production requirements.

Referring to Fig. 1 , Fig. 2 and Fig. 6 , the extrusion head 2 is provided with a discharge shunt pipe 2321 . The feed distribution pipe 2321 includes the main flow pipe 22 and the distribution assembly 23. During the blow molding and filling of plastic ampoules, the plastic is heated through the extruder 1, and the hot-melt colloid is conveyed through the extruder 1 to transfer the colloid. To the main pipe 22, the colloid delivered by the main pipe 22 is diverted through the diversion assembly 23, and the colloid is transported to both sides of the extrusion head 2 for glue feeding, and the colloid is evenly fed along the two sides of the extrusion head 2. The glue ensures the uniform amount of glue output in the extrusion head 2, so that the thickness of the glue tube is consistent, and the molding of the plastic ampoule is realized.

Referring to Fig. 1, Fig. 8, Fig. 9, an oxygen concentration detection mechanism is also arranged on the extrusion head 2, and the oxygen concentration detection mechanism includes an oxygen concentration detection assembly 28, and the oxygen concentration detection assembly 28 includes an online oxygen detector 281, which will detect the oxygen concentration online. The probe of the instrument 281 is set in the extrusion head 2 and along the adjacent filling needle 31, and the oxygen concentration near the rubber cylinder is monitored in real time by the online oxygen detector 281, and the oxygen concentration monitoring result is fed back to the controller to control The sensor is connected to the alarm device and performs a feedback alarm when the oxygen concentration is greater than 3%. The alarm device includes an alarm bell, which reminds the filling workers that the oxygen concentration is too high to fill the liquid medicine at this time.

Referring to Fig. 1, Fig. 8 and Fig. 9, in order to prevent the oxygen concentration at the filling needle 31 from being too high when filling the liquid medicine, a gas delivery device 282 is provided on the extrusion head 2, and the gas delivery device 282 is used to control the extrusion head. The inert gas nitrogen is transported inside 2, the filling needle 31 is isolated from oxygen, and the rubber tube to be filled extruded by the extrusion head 2 is isolated from oxygen through the gas delivery device 282, so as to avoid the excessive oxygen content in the rubber tube from causing the liquid Filled ampoules failed monitoring, making them unusable.

Referring to Fig. 1, Fig. 8 and Fig. 9, the gas delivery device 282 includes a nitrogen bottle 2821, a filter 2822 and a gas delivery pipe 2823, and the filter 2822 connects the nitrogen bottle 2821 and the gas delivery pipe 2823 to transmit nitrogen along the gas delivery pipe 2823 to the extrusion head 2, the end of the air pipe 2823 is provided with a branch pipe 2824, which is arranged along the gap of the filling needle 31 and abuts against the rubber tube, and the oxygen in the extrusion head 2 is discharged by filling the extrusion head 2 with nitrogen , the oxygen concentration is detected by the online oxygen detector 281, the rubber cartridge transferred from the extrusion head 2 to the molding die 4 is filled by the filling needle 31, and the rubber cartridge is die-cast into an ampoule.

With reference to Fig. 1, Fig. 2, Fig. 7, extruder 1 is also provided with temperature detection mechanism, and temperature detection mechanism comprises temperature detection assembly 25, and temperature detection assembly 25 comprises miniature temperature sensor 251, and miniature temperature sensor 251 is arranged on filling. The outer wall of the needle 31 extends into the ampoule along with the filling needle 31, and the temperature on the inner wall of the ampoule is detected by the miniature temperature sensor 251 on the outer wall of the filling needle 31, and the temperature information is fed back to the wireless temperature acquisition instrument for observation . The position of the miniature temperature sensor 251 is set close to the mouth of the ampoule bottle.

With reference to Fig. 1, Fig. 2, Fig. 7, when miniature temperature sensor 251 is set to 1 group, miniature temperature sensor 251 is arranged on the position near the ampoule bottle mouth, when miniature temperature sensor 251 is set to at least 2 groups, miniature temperature sensor The sensor 251 is arranged on the filling needle 31 and arranged along the outer wall of the filling needle 31 and is located in the ampoule to detect the temperature of the inner wall of the ampoule. The temperature of the inner wall of the ampoule is detected by the miniature temperature sensor 251 installed on the filling needle 31. When the temperature in the ampoule is lower than 60°C, the filling requirements of the medicinal liquid are met, and the medicinal liquid filling of the ampoule can be carried out at this time. .

Referring to Fig. 1, Fig. 2 and Fig. 3, the extrusion head 2 is also provided with a rubber tube thickness adjustment mechanism, which includes a mold base 21, an upper platen 211, a lower platen 212, a core plate 241, and an upper platen 211 It is connected with the lower pressing plate 212 and fixed on the mold base 21, and the mold cavity 243 is formed by setting the mold core plate 241 on the mold base 21 and between the upper pressing plate 211 and the lower pressing plate 212, and by moving the colloid along the mold cavity 243 Control the wall thickness of the cartridge and shape the cartridge.

Referring to Fig. 1, Fig. 2 and Fig. 3, the lower platen 212 and the mold core plate 241 are provided with an adjustment assembly 26, through the adjustment assembly 26, the flow rate of the colloid at the outlet of the mold cavity 243 is controlled, thereby controlling the wall thickness of the rubber cylinder, and according to After forming, the wall thickness of the rubber tube is adjusted so that the wall thickness of the formed rubber tube meets the production requirements. The adjustment assembly 26 is connected with a drive assembly 27, and the operation of the drive assembly 27 drives the operation of the adjustment assembly 26 to control the wall thickness of the rubber cartridge.

Referring to Fig. 1, Fig. 2, Fig. 3, the adjustment assembly 26 includes a first adjustment part 261 and a second adjustment part 262, the first adjustment part 261 adjusts the gap size of the discharge end of the mold cavity 243 along the length direction of the mold base 21, and the second adjustment part 261 The adjustment part 262 adjusts the gap size of the mold cavity 243 along the width direction of the mold base 21 . The first adjustment part 261 comprises a space plate 213, an adjustment plate 2611 and a guide plate 2612, the space plate 213 is arranged between the upper platen 211 and the lower platen 212, and the mold cavity 243 is formed between the space plate 213 and the mold core plate 241 The space plate 213 is provided with a receiving groove 2614 communicating with the mold cavity 243, the guide block is slid along the receiving groove 2614, the lower pressing plate 212 is provided with a sliding groove 2615 along the length direction, and the adjusting plate 2611 is arranged along the sliding groove 2615 Move and adjust the gap between the adjustment plate 2611 and the core plate 241. A guide block 2613 is provided at the lower end of the core plate 241, and the filling needle is connected and guided through the guide block 2613 so that the filling needle can stably pass through. Inject into the rubber tube, and control the gap between the adjusting plate 2611 and the core plate 241 through the first adjusting part 261 to control the wall thickness of the outflowing rubber tube. The second adjustment part 262 includes an adjustment block 2621, the adjustment block 2621 is arranged on the lower platen 212, and moves along the lower platen 212, the adjustment block 2621 is arranged along the two sides of the width direction of the mold core plate 241, by controlling the adjustment block 2621 and the mold core The distance between the plates 241 controls the wall thickness of the cartridge. The adjustment plate 2611 is fixedly connected with the guide plate 2612 to move together, and the end of the guide plate 2612 facing the mold core plate 241 is arranged continuously with the end surface of the adjustment plate 2611 .

Referring to Fig. 1, Fig. 2, Fig. 3, the driving assembly 27 includes a first driving part 271 and a second driving part 272, and the first driving part 271 connects the driving plate and the guide plate 2612 for driving the driving plate and the guide plate 2612 to move so as to facilitate To drive the wall thickness of the rubber cartridge, the second driving part 272 is disposed on the lower pressing plate 212, and the second driving part 272 is connected to the driving block and is used to drive the driving block to move so as to control the wall thickness of the rubber cartridge. The first driving part 271 includes a first driving screw 2711 and an adjusting screw 2712. The adjusting screw 2712 is threaded through the space plate 213 and is threadedly connected with the guide plate 2612. The first driving screw 2711 is threaded through the lower pressing plate 212 and the adjusting plate 2611 to rotate. connect. The second driving part 272 includes a second driving screw 2721 , and the second driving screw 2721 is screwed through the lower pressing plate 212 and is rotatably connected with the adjusting block 2621 .

Referring to Fig. 1, Fig. 4 and Fig. 5, the forming mold 4 includes a head mold 41 and a bottle body mold 42, and a balanced mold clamping mechanism is also provided in the forming mold 4, and the balanced mold clamping mechanism includes a push assembly 43 and a balance assembly 44 , when the rubber cartridge is transferred to the forming mold 4, the bottle body mold 42 is driven by the push assembly 43 to close the mold of the bottle body of the ampoule bottle, and the head mold is driven by the push assembly 43 after the ampoule bottle is filled with medicinal liquid 41 Mold closing The bottle head of the ampoule bottle is molded, thereby completing the filling and sealing of the ampoule bottle.

Referring to Fig. 1, Fig. 4, Fig. 5, the push assembly 43 includes a first push part 431 and a second push part, the first push part 431 drives the bottle body mold 42 to close the mold, and the second drive part 272 takes the head mold 41 to close mold. A balance component 44 is arranged on the bottle body mold 42 and the head mold 41 , and the head mold 41 and the bottle body mold 42 are stably clamped by the balance component 44 .

Referring to Fig. 1, Fig. 4 and Fig. 5, the balance assembly 44 includes pull rods 441, four pull rods 441 are provided, the pull rods 441 pass through the head mold 41 and the bottle body mold 42, and four pull rods 441 are provided, through which the pull rods 441 penetrate The head mold 41 and the bottle body mold 42 are guided on the head mold 41 and the bottle body mold 42, so that the head mold 41 and the bottle body mold 42 are stably molded. Bottle body mold 42 comprises fixed formwork 45 and movable formwork 46 and bottle body formwork 423, pull bar 441 is fixedly connected on the fixed mold, and pull bar 441 passes through moveable formwork 46, and bottle body formwork 423 is fixed on the moveable formwork 46, through the first A pusher 431 drives the movable template 46 to move along the pull rod 441 to close the bottle body mold 42, and under the action of the second pusher, the head mold 41 is driven to close the mold to complete the molding and packaging of the ampoule bottle.

Referring to Fig. 1, Fig. 4, Fig. 5, the first pusher 431 includes a first mold clamping cylinder 4311, the first mold clamping cylinder 4311 is arranged on the fixed template 45, and the output end of the first mold clamping cylinder 4311 is connected to the movable template 46 Above, the first mold clamping cylinder 4311 pushes the movable template 46 to close the bottle body template 423 to complete the bottle body mold clamping of the ampoule bottle. The second pushing part includes a second mold clamping cylinder 4321, through which the head mold 41 is driven to close the mold of the head of the ampoule bottle. The head mold 41 includes a head template 411, the head template 411 is arranged on the movable template 46 and is connected to the movable template 46 through the second clamping cylinder 4321, the output end of the second clamping cylinder 4321 is connected to the head template 411 and Drive the head template 411 to close the mold to complete the mold closing of the bottle head of the ampoule bottle, thereby completing the filling and sealing of the ampoule bottle. And the first clamping cylinder 4311 is symmetrically distributed along the fixed template 45, and the second clamping cylinder 4321 is symmetrically distributed along the movable template 46, so as to ensure uniform mold clamping between the bottle body template 423 and the head template 411, and avoid uneven molding of ampoules , so that the production demand cannot be met.

Referring to Fig. 1, Fig. 4, and Fig. 10, the bottom end of the forming mold 4 is also provided with a synchronous clamping mechanism 5. The synchronous clamping mechanism 5 includes a clamping assembly 51, a stretching assembly 52 and a lifting assembly 53, which are used for ampoule molding. When the molded ampoule bottle is clamped by the clamping assembly 51, when the ampoule bottle is continuously formed at the previous station, the molded ampoule bottle is clamped by the clamping assembly 51, and the molding is continued in the forming mold 4 The ampoule bottle is naturally flowed and formed at the discharge end of the extrusion head 2, and the lifting assembly 53 drives the clamping assembly 51 to move down and flow with the speed of the rubber tube, so as to prevent the formed ampoule from exerting a gravity on the rubber tube and causing the glue The ampoule formed by the natural flow of the barrel is deformed, which does not meet the production requirements.

Referring to Fig. 1, Fig. 4, Fig. 10, the clamping assembly 51 includes a clamping plate 511, and the clamping plate 511 clamps the adjacent ampoules formed in the forming mold 4 to prevent the ampoule formed in the forming mold 4 from The rubber cartridge flowing naturally in the extrusion head 2 is pulled down, so that the wall thickness of the ampoule bottle does not meet the production requirements. Under the action of the clamping plate 511, the joints between adjacent ampoules are clamped, and the ampoule molded in the forming mold 4 is clamped by the clamping plate 511, and the speed at which the rubber tube falls naturally Consistent, to prevent the ampoule held by the clamping plate 511 from pulling down the rubber tube due to gravity, resulting in a change in the wall thickness of the rubber tube and thus not meeting the production requirements. Both sides of the clamping plate 511 are provided with baffles 512 to avoid damage caused by the collision of the ampoule when the ampoule is clamped and move, and to protect the falling ampoule.

Referring to Fig. 1, Fig. 4, Fig. 10, the expansion assembly 52 is connected to the clamping plate 511 for opening the clamping plate 511, the expansion assembly 52 includes a lifting plate 521, a two-way threaded rod 522, and the lifting plate 521 is slidably arranged along the frame , the two-way threaded rod 522 is rotatably connected between the connecting plates, the connecting plate is fixed on the lifting plate 521, the end of the two-way threaded rod 522 is provided with a driving part, and the driving part drives the two-way threaded rod 522 to rotate to drive the clamping plate 511 along the The two-way threaded rods 522 move toward or depart from each other. The driving part includes a stepping motor 523 , which is arranged on the lifting plate 521 , and the output shaft of the stepping motor 523 is fixed to the end of the bidirectional threaded rod 522 . When clamping the bottom end of the ampoule bottle in the forming mold 4, give the stepper motor 523 a signal of forward rotation to drive the stepper motor 523 to rotate and drive the clamping plate 511 to move toward each other on the two-way threaded rod 522 to move the ampoule bottle Clamping, when the molding of the ampoule bottle is completed in the forming mold 4, the ampoule bottle in the forming mold 4 is driven to move together by the clamping plate 511 and is consistent with the falling speed of the rubber tube in the extrusion head 2. When the rubber tube touches After being in the molding die 4, the two-way threaded rod 522 is driven to rotate reversely by giving the stepper motor 523 a signal of reverse rotation so as to drive the clamping plate 511 to deviate from the two-way threaded rod 522, and the clamping plate 511 is moved to the forming mold The lower part of 4 works sequentially on the ampoules that are about to be formed and the retrograde clamping.

Referring to Fig. 1, Fig. 4, Fig. 10, lifting assembly 53 comprises lifting frame 531 and lifting oil cylinder 532, and lifting frame 531 is arranged on the frame, and lifting oil cylinder 532 is arranged on lifting frame 531, and lifting oil cylinder 532 is arranged on lifting plate 521 In the molding mold 4, the clamping plate 511 is opened by the stepper motor 523 after the molding and filling of the ampoule bottle is completed, and the lifting plate 521 is driven to move along the lifting frame 531 by the lifting cylinder 532, and the clamping plate 511 is moved to the molding The bottom of the mold 4 clamps and supports the flat bottom of the ampoule bottle to be molded. The lifting frame 531 is provided with a chute 2615 , and the lifting plate 521 moves along the chute 2615 , and the lifting plate 521 is limited and guided by the chute 2615 to ensure the stability of the movement of the lifting plate 521 . One end of the lifting plate 521 facing the chute 2615 is arranged in an arc shape to reduce the abutting friction force between the lifting plate 521 and the bottom of the chute 2615, so that the movement of the lifting plate 521 is more stable. The lifting frame 531 is provided with a level sensor 533, through which the levelness of the clamping plate 511 is detected, and when the clamping plate 511 is tilted, a signal is sent and feedback reminds the worker to adjust the angle of the clamping plate 511.

Referring to Fig. 1, Fig. 11 and Fig. 12, as another modification of this embodiment, the synchronous clamping mechanism 5 includes a clamping part 54, a stretching part 55 and a lifting part 56, and the ampoule bottle in the forming mold 4 is When clamping, the tail end of the ampoule bottle is clamped by the clamping part 54, and the clamping part 54 is clamped and opened under the action of the stretching part 55, and the clamping part 54 is driven to move up and down in a straight line by the lifting part 56. The formed ampoules are conveyed out of the forming die 4 . The clamping part 54 includes a first clamping plate 541 and a second clamping plate 542, the first clamping plate 541 and the second clamping plate 542 are moved relatively to clamp the tail end of the ampoule, and the first clamping plate 541 and the second clamping plate are controlled by the stretching part 55 542 clamping and opening and closing. Stretching part 55 comprises strutting cylinder 551, the first strutting rack 552, the second strutting rack 553 and synchronous gear 554 and the frame, by setting strutting cylinder 551 on support frame 555, stretching The cylinder 551 is connected to the first spreading rack 552, and the first spreading rack 552 and the second spreading rack 553 are meshed through the synchronous gear 554, and the first spreading rack 552 is fixed to the first splint 541, and the second spreading rack 552 is fixed to the first splint 541. The rack 553 is fixed to the second splint 542, and the first splint rack 552 is driven to slide to drive the synchronous gear 554 to drive the second splint rack 553 to slide through the stretching cylinder 551 to achieve the first splint 541 and the second splint 542. Clamp and open. Under the action of the lifting part 56, the clamping part 54 is driven to move linearly up and down along the frame. Lifting part 56 comprises lifting rod 561, transmission wheel 562, conveyer belt 563, slide plate 564 and slide rail 565 and drive motor 566, and lifting rod 561 is fixed on the frame, and driving wheel 562 is arranged along the rotation on lifting rod 561, and on the same The two drive wheels 562 outer walls on the lifting rod 561 are sleeved with a tensioned conveyor belt 563. By setting the slide rail 565 on the lifting rod 561, the sliding plate 564 is slid along the slide rail 565, and the drive motor 566 is connected to the drive wheel 562. The rotating shaft end of the sliding plate 564 is connected to the support frame 555 and the sliding plate 564 is fixedly connected to the conveyor belt 563. The driving motor 566 runs to drive the transmission wheel 562 to rotate, and the conveyor belt 563 is driven to rotate to move the sliding plate 564 along the slide rail 565. Thereby driving the support frame 555 to move up and down, when the support frame 555 is moved to the discharge position, a signal of the stretch cylinder 551 is contracted at the output end of the stretch cylinder 551, and drives the first stretch rack 552 to move through the synchronous gear 554 Moving the first spreading rack 552 drives the first spreading rack 552 and the second spreading rack 553 to move in opposite directions to open the first clamping plate 541 and the second clamping plate 542 to discharge the molded ampoule.

Referring to Figure 1, Figure 11, and Figure 12, the filling machine is equipped with a filling needle 31, through which the filling needle 31 passes through the extrusion head 2 and extends into the rubber tube. Drive the forming mold 4 to move up and hold it on both sides of the rubber tube, drive the bottle body mold 42 to close the mold through the first mold clamping oil cylinder 4311 to complete the bottle body of the row of ampoule bottles, and the filling needle 31 on the filling machine is paired with the ampoule The body of the bottle is filled with liquid medicine. After the filling of the liquid medicine is completed, the head mold 41 is driven by the second clamping cylinder 4321 on the mobile template 46 to close the mold to complete the filling and sealing of the ampoule bottle. The first clamping plate 541 and the second clamping plate 542 clamp the tail end of the ampoule bottle, and drive the driving motor 566 to move the conveyor belt 563 downward and drive the forming mold 4 to move downward under the action of the servo push rod. One mold clamping cylinder 4311 opens the bottle body mold 42 and the second mold clamping cylinder 4321 opens the bottle head mold to transport the formed ampoule bottle out of the molding mold 4, and controls the transmission speed of the conveyor belt 563 and the extrusion of the inner rubber cylinder of the extrusion head 2 The speed is consistent to ensure that the wall thickness of the rubber tube remains consistent after extrusion along the extrusion head 2 and will not be stretched by external force. After the rubber tube is extruded along the extrusion head 2, the forming mold 4 is pulled up by the servo push rod and clamped in Both sides of the rubber tube are molded together to make a new ampoule. When the ampoule produced by the previous station is transported to the designated position, the first splint 541 and the second splint 542 are opened by the stretching cylinder 551, and are driven Under the action of the motor 566, the sliding plate 564 is driven upward so that the first clamping plate 541 and the second clamping plate 542 are clamped and supported on the tail end of the new ampoule at the lower end of the forming mold 4, and then the mass production of the ampoule is carried out in a cyclic operation. The working principle of a blow-fill-seal equipment in this embodiment: when filling the ampoule bottle with liquid medicine, the plastic original is heated to a molten state through the extruder 1, and the molten colloid is transferred to the molding machine through the extruder 1 In the filling system, the colloid is preliminarily formed through the extrusion head 2, and the flow of the colloid is controlled by the cavity 243 in the extrusion, and only the rubber tube flows naturally at the outlet of the extrusion head 2. The adjustment assembly 26 controls the wall thickness of the rubber tube, transfers the rubber tube to the forming mold 4, pushes the moving template 46 to move towards each other through the first clamping cylinder 4311, and closes the bottle body mold 42 to complete the bottle body of the ampoule bottle. The filling needle 31 on the sealing machine 3 fills the ampoule bottle with medicinal liquid to complete the filling of the ampoule bottle, and drives the head template 411 to close the mold through the second mold clamping cylinder 4321 to complete the bottle head of the ampoule bottle, thereby completing the filling of the ampoule bottle. Filling and sealing, after the filling and sealing of the ampoule bottle is completed, the ampoule bottle is clamped and moved by the synchronous clamping mechanism 5, and the position of the filling and sealing machine 3 and the extrusion head 2 remains unchanged and the filling needle 31 on the filling and sealing machine 3 Pass through the extrusion head 2 and abut against the inside of the rubber tube, drive the molding die 4 to clamp the rubber tube through the servo push rod and extrude the rubber tube, and fill the liquid medicine through the filling needle 31, and pass through the forming mold 4Move down and close the mold to move the filling needle 31 out of the forming mold 4, and transport the formed ampoule via the synchronous clamping mechanism 5, and move synchronously with the rubber tube in the extruder 1. After the rubber tube moves, the electric push rod Drive the molding die 4 to move up to clamp the rubber tube and continue to extrude the ampoule bottle, thereby realizing the mechanical integrated production and improving the production efficiency.

The working principle of the blow-fill-seal equipment in this embodiment: when filling the ampoule with liquid medicine, the plastic original is heated to a molten state through the extruder 1, and the melt distribution mechanism at the end of the extruder 1, In the molten colloid transfer molding filling system, the colloid is preliminarily formed through the extrusion head 2, and the flow of the colloid is controlled by the cavity 243 in the extrusion, and extruded at the outlet of the extrusion head 2 to form a rubber tube According to the production requirements, the wall thickness of the rubber cylinder is controlled by the adjustment component 26, and the rubber cylinder is transferred to the forming mold 4, and the moving template 46 is pushed to move towards each other by the first mold clamping cylinder 4311, and the bottle body mold 42 is molded to complete the ampoule bottle bottle body, the ampoule bottle is filled with liquid medicine through the filling needle 31 on the filling and sealing machine 3 to complete the filling of the ampoule bottle, and the head template 411 is driven by the second mold clamping cylinder 4321 to close the mold to complete the bottle head of the ampoule bottle , so as to complete the filling and sealing of the ampoule bottle. After the filling and sealing of the ampoule bottle is completed, the ampoule bottle is clamped and moved by the synchronous clamping mechanism 5, and the positions of the filling and sealing machine 3 and the extrusion head 2 remain unchanged and the filling and sealing machine 3 The filling needle 31 on the top passes through the extrusion head 2 and abuts against the inside of the rubber tube, drives the molding die 4 to grip the rubber tube through the servo push rod and extrudes the rubber tube, and fills it through the filling needle 31 The liquid medicine moves down through the forming mold 4 and closes the mold to move the filling needle 31 out of the forming mold 4, and the molded ampoule is clamped and transported by the synchronous clamping mechanism 5, and moves synchronously with the rubber cylinder in the extruder 1 to wait for the rubber cylinder Move, drive the forming mold 4 to move up through the servo push rod to clamp the rubber tube and continue to extrude and form the ampoule bottle in this cycle, so that multiple stations can work at the same time and improve the efficiency of ampoule bottle filling efficiency.

Example 2

The difference between this embodiment and Embodiment 1 is that the temperature detection assembly 25 includes a conventional temperature sensor, the conventional temperature sensor is arranged on the bottle body mold 42, the conventional temperature sensor is used to detect the body temperature of the ampoule bottle, and the conventional temperature sensor is arranged on The bottle body mold 42 is arranged on both sides of the ampoule bottle, and the bottle body mold 42 is provided with a cooling block, which is used for cooling the formed ampoule bottle.

Example 3

The difference between this embodiment and Embodiment 1 is that the end of the gas delivery pipe 2823 is provided with a rotary nozzle, and the rotary nozzle is set in the extrusion head 2, and the nitrogen in the nitrogen tank is delivered to the rotary nozzle through the filter 2822 through the gas delivery pipe 2823 , transfer nitrogen to various positions in the extrusion head 2 through the rotating nozzle to squeeze out the oxygen in the extrusion head 2, thereby ensuring that the oxygen concentration in the extrusion head 2 is lower than 3%, and then through the filling needle 31 to The liquid medicine is filled in the rubber cartridge, and the oxygen concentration in the glue cartridge meets the standard for filling the liquid medicine.

Example 4

The difference between this embodiment and Embodiment 1 is that the temperature control assembly includes a heating plate. The heating plate is arranged on the upper platen 211 and the lower platen 212 and along the mold cavity 243. When the glue flows along the mold cavity 243, the Under the action of the heating plate, the colloid is continuously heated to prevent the colloid from contacting the upper platen 211 and the lower platen 212 for heat conduction, so that the colloid cools and adsorbs on the inner wall of the mold cavity 243, resulting in the obstruction of the colloid transmission.

Example 5

The difference between this embodiment and Embodiment 1 is that the adjustment assembly 26 includes an adjustment bucket, and the adjustment bucket is plugged into the outlet of the mold cavity 243, and the glue flows out along the inner wall of the adjustment bucket to form a rubber tube to meet production requirements. , Adjust the size of the adjusting bucket according to the production specifications to obtain rubber cartridges of different sizes for the production of ampoules of different sizes.

Example 6

The difference between this embodiment and Embodiment 1 is that a flow regulating part is provided on the shunt pipe 2321. In order to control the flow of the colloid entering the extrusion head 2, a flow regulating part is set at the output end of the shunt pipe 2321. The flow regulating part includes The adjusting screw 2712, the thread of the adjusting screw 2712 passes through the outer wall of the shunt tube 2321 and abuts against the inside of the shunt tube 2321, and the flow of the colloid is controlled by controlling the cross-sectional area of the shunt tube 2321.

Example 7

The difference between this embodiment and Embodiment 1 is that the adjustment component 26 includes an adjustment bucket, and the adjustment bucket is inserted into the discharge port of the mold cavity 243, and the glue flows out along the inner wall of the adjustment bucket to form a rubber tube to meet production requirements. Adjusting the size of the adjusting bucket according to the production specifications can obtain different sizes of rubber cartridges for the production of different sizes of ampoules.

Example 8

The difference between this embodiment and Embodiment 1 is that the first driving part 271 includes a screw, and the screw thread passes through the lower pressing plate 212 and is rotationally connected with the adjusting plate 2611. The end of the screw is provided with a turntable. There are several groups of pin holes on the outer wall of the pressure plate 212. By turning the turntable, the screw rotates to drive the adjustment plate 2611 and the guide plate 2612 to move together. After adjusting the gap between the adjustment plate 2611 and the core plate 241, the pins penetrate The screw rod is fixed to prevent the screw rod from turning over by inserting the turntable into the pin hole.

Example 9

The difference between this embodiment and Embodiment 1 is that the first driving part 271 includes a screw rod, through which the screw rod passes through the fixed template 45, and the end of the screw rod is connected to the end of the movable template 46 in rotation, The end of the rod is connected with a stepper motor 523, and the screw rod is driven to rotate by the stepper motor 523, and the circumferential rotation of the movable template 46 is limited under the limit of the pull rod 441 so that the movable template 46 moves axially along the screw rod, thereby Drive the bottle body formwork 423 closing moulds.

Example 10

The difference between this embodiment and Embodiment 1 is that the first pushing part 431 adopts the first mold clamping electric push rod, and the second pushing part adopts the second mold closing electric push rod. The mold electric push rod respectively drives the bottle body mold 42 and the head mold 41 to close the mold, which is easier to operate and lower in cost.

Example 11

The difference between this embodiment and Embodiment 1 is that the stretching assembly 52 includes a stretching oil cylinder, which is a two-way oil cylinder. The output end of the oil cylinder opens the clamping plate 511 to realize the clamping replacement of the clamping plate 511, and performs cyclic work. When clamping the ampoule bottle in the forming mold, the two output ends of the stretching oil cylinder shrink, and the clamping plate 511 will be clamped. The plate 511 is contracted and clamped, so that the bottom end of the ampoule bottle to be formed in the forming mold 4 is clamped by the clamping plate 511 .

Example 12

The difference between this embodiment and Embodiment 1 is that the lifting assembly 53 includes a screw rod, which is arranged on the lifting frame 531, and is connected to the lifting plate 521 through the screw rod, and the screw rod is driven to rotate under the action of an external force, thereby driving the lifting plate 521 along Moving along the lifting frame 531, the clamping block is driven to move along the lifting frame 531 and clamp the formed ampoule bottle, and the cycle work is carried out successively. The end of the screw rod is provided with a motor, and the external power of the motor is used to drive the screw rod to rotate so as to drive the lifting plate 521 to drive the clamping plate 511 to move integrally.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (10)

A blow-fill-seal equipment, characterized in that: comprising: an extruder (1) for plasticizing plastic particles and transporting molten colloids; Forming and sealing system, the forming and sealing system is used to form rubber cartridges to make ampoules, and is used for filling and sealing of liquid medicine in ampoules, and it operates continuously and outputs products in a straight line. A blow-fill-seal device according to claim 1, characterized in that: the forming and sealing system comprises a filling and sealing machine (3), an extrusion head (2) and a forming die (4); The filling and sealing machine (3) is used for filling the formed ampoule with medicinal liquid; The extruding head (2) is used to initially shape the rubber cartridge of the colloid and carry out the transmission of the rubber cartridge; The molding die (4) is used for reprocessing the rubber cartridge to form an ampoule bottle and sealing the ampoule bottle filled with the medicinal solution. A blow-fill-seal device according to claim 2, characterized in that: the extrusion head (2) includes a mold base (21), a feed base (215), an upper pressing plate (211) and a lower pressing plate (212 ), the die base (21) is connected to the feed base (215), the upper pressing plate (211) is set on the die base (21), and the lower pressing plate (212) is set on the upper Below the pressure plate (211), The extrusion head (2) also includes: A mold core assembly (24), the mold core assembly (24) is arranged on the mold base (21), and the mold core assembly (24) is located on the upper pressing plate (211) and the lower pressing plate (212) Between, described mold core assembly (24) is used for rubber cylinder molding; A fastening assembly (214), the fastening assembly (214) is arranged on the mold base (21), and the fastening assembly (214) is used to connect the mold core assembly (24) and the mold base (twenty one). A blow-fill-seal device according to claim 3, characterized in that: the extrusion head (2) is further provided with a discharge diverter pipe (2321), and the discharge diverter pipe (2321) includes: A main flow pipe (22), the main flow pipe (22) is arranged at the outlet end of the extruder (1), and the main flow pipe (22) is connected to the extruder (1) and the extrusion head (2); A splitter assembly (23), the splitter assembly (23) is arranged at the end of the main flow pipe (22), and the splitter assembly (23) is used to carry out graded transmission of the colloid transported by the main flow pipe (22), And it is used to control the uniform transmission of the colloid to the extrusion head (2). A blow-fill-seal device according to claim 3, characterized in that: the extrusion head (2) is also provided with an oxygen concentration detection mechanism; the oxygen concentration detection mechanism includes an oxygen concentration detection component (28), the The oxygen concentration detection component (28) is arranged in the extrusion head (2) and is used for monitoring the residual oxygen concentration of the rubber cartridge in the extrusion head (2). A blow-fill-seal device according to claim 3, characterized in that: the extrusion head (2) is also provided with a temperature detection mechanism for the inner wall of the ampoule bottle, and the detection mechanism for the inner wall of the ampoule bottle includes a temperature detection component (25), The temperature detection component (25) is used to detect the temperature of the inner wall of the formed ampoule bottle and determine whether the formed ampoule bottle meets the filling conditions. A blow-fill-seal device according to claim 3, characterized in that: the extrusion head (2) is also provided with a rubber tube thickness adjustment mechanism, and the rubber tube thickness adjustment mechanism includes: An adjustment assembly (26), the adjustment assembly (26) is arranged on the lower pressing plate (212) and the mold core plate (241), the adjustment assembly (26) moves along the bottom of the lower pressing plate (212) and is used for Adjust the size of the discharge opening of the mold cavity (243); A driving assembly (27), the driving assembly (27) is connected with the adjustment assembly (26) and is used to drive the adjustment assembly (26) to move along the bottom of the lower pressing plate (212). A blow-fill-seal device according to claim 2, characterized in that: the forming mold (4) comprises a head mold (41) and a bottle body mold (42), and the head mold (41) and the bottle body mold (42) The bottle body mold (42) is connected, the head mold (41) and the bottle body mold (42) are also provided with a balanced mold clamping mechanism, and the balanced mold clamping mechanism is used to stably drive the head The part mold (41) and the bottle body mold (42) are mold-closed or mold-opened. The blow-fill-seal equipment according to claim 8, wherein the balanced mold clamping mechanism comprises: A push assembly (43), the push assembly (43) is used to push the head mold (41) and the bottle body mold (42) to close or open the mold; A balance assembly (44), the balance assembly (44) is used to connect the push assembly (43) so that the push assembly (43) pushes the head mold (41) and the bottle body mold (42) straightly ) mold closing or mold opening. A blow-fill-seal device according to claim 8, characterized in that: the bottom of the forming mold (4) is provided with a synchronous clamping mechanism (5), and the synchronous clamping mechanism (5) is used for For stable molding, the synchronous clamping mechanism (5) includes: Clamping assembly (51), described clamping assembly (51) is arranged on the below of bottle body mold (42), and described clamping assembly (51) is used for clamping the ampoule bottle molded in bottle body mold (42) tight; a stretching assembly (52), which is connected to the clamping assembly (51) and used to open the clamping assembly (51) so as to form a cooled ampoule; An elevating assembly (53), the elevating assembly (53) is connected to the clamping assembly (51) and is used to drive the clamping assembly (51) to lift and repeatedly clamp the ampoule formed by the bottle body mold (42).

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