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WO2023018355A3 - Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов - Google Patents

Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов Download PDF

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Publication number
WO2023018355A3
WO2023018355A3 PCT/RU2022/050059 RU2022050059W WO2023018355A3 WO 2023018355 A3 WO2023018355 A3 WO 2023018355A3 RU 2022050059 W RU2022050059 W RU 2022050059W WO 2023018355 A3 WO2023018355 A3 WO 2023018355A3
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WIPO (PCT)
Prior art keywords
fermenter
microorganisms
blocks
fermentation system
continuous cultivation
Prior art date
Application number
PCT/RU2022/050059
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English (en)
French (fr)
Other versions
WO2023018355A2 (ru
Inventor
Яков Владимирович БРЕЕВ
Станислав Николаевич НОВИКОВ
Сергей Александрович ПОРТНОВ
Анастасия Сергеевна ЧЕРВИНСКАЯ
Евгений Александрович ШМАКОВ
Александр Сергеевич АРБУЗОВ
Павел Юрьевич БОНДАРЕНКО
Всеволод Николаевич ЖДАНОВ
Виталий Дмитриевич ПЛОТНИКОВ
Original Assignee
Общество с ограниченной ответственностью "Биопрактика" (ООО "Биопрактика")
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2021123706A external-priority patent/RU2777059C1/ru
Application filed by Общество с ограниченной ответственностью "Биопрактика" (ООО "Биопрактика") filed Critical Общество с ограниченной ответственностью "Биопрактика" (ООО "Биопрактика")
Publication of WO2023018355A2 publication Critical patent/WO2023018355A2/ru
Publication of WO2023018355A3 publication Critical patent/WO2023018355A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0042—Degasification of liquids modifying the liquid flow
    • B01D19/0052—Degasification of liquids modifying the liquid flow in rotating vessels, vessels containing movable parts or in which centrifugal movement is caused
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0042—Degasification of liquids modifying the liquid flow
    • B01D19/0052—Degasification of liquids modifying the liquid flow in rotating vessels, vessels containing movable parts or in which centrifugal movement is caused
    • B01D19/0057—Degasification of liquids modifying the liquid flow in rotating vessels, vessels containing movable parts or in which centrifugal movement is caused the centrifugal movement being caused by a vortex, e.g. using a cyclone, or by a tangential inlet
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/24—Recirculation of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Computer Hardware Design (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение относится к биотехнологии, а именно, к способам и устройствам для культивирования микроорганизмов, в том числе метилотрофных и метанотрофных бактерий, а также их спутников. Технический результат, достигаемый при использовании заявляемого изобретения, заключается в повышении скорости и эффективности газообмена в процессе циркулирования культуральной жидкости по контуру ферментера при обеспечении возможности масштабирования ферментера и ферментационной установки в целом до промышленных объемов. Ферментёр включает - по меньшей мере, четыре блока, соединенных между собой с образованием замкнутого контура для движения потока культуральной жидкости (КЖ) с микроорганизмами, при этом первый и третий блоки выполнены преимущественно вертикально ориентированными, второй и четвертый блоки выполнены преимущественно горизонтально ориентированными.
PCT/RU2022/050059 2021-08-10 2022-02-28 Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов WO2023018355A2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2021123706 2021-08-10
RU2021123706A RU2777059C1 (ru) 2021-08-10 Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов

Publications (2)

Publication Number Publication Date
WO2023018355A2 WO2023018355A2 (ru) 2023-02-16
WO2023018355A3 true WO2023018355A3 (ru) 2023-06-15

Family

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Family Applications (1)

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PCT/RU2022/050059 WO2023018355A2 (ru) 2021-08-10 2022-02-28 Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов

Country Status (1)

Country Link
WO (1) WO2023018355A2 (ru)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3007543A (en) * 1960-04-20 1961-11-07 Nat Tank Co Process and apparatus for recovering hydrocarbons from gas streams
FR2209837A1 (en) * 1972-12-13 1974-07-05 Baranovsky Vladimir Tubular appts. for microorganism growing - medium being moved by propel-lers through froth dampers and heat exchangers
US4704363A (en) * 1985-10-28 1987-11-03 Sulzer Brothers Limited Fermentation system
US5342781A (en) * 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
WO2020251408A1 (ru) * 2019-06-11 2020-12-17 Общество с ограниченной ответственностью "Биопрактика" (ООО "Биопрактика") Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3007543A (en) * 1960-04-20 1961-11-07 Nat Tank Co Process and apparatus for recovering hydrocarbons from gas streams
FR2209837A1 (en) * 1972-12-13 1974-07-05 Baranovsky Vladimir Tubular appts. for microorganism growing - medium being moved by propel-lers through froth dampers and heat exchangers
US4704363A (en) * 1985-10-28 1987-11-03 Sulzer Brothers Limited Fermentation system
US5342781A (en) * 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
WO2020251408A1 (ru) * 2019-06-11 2020-12-17 Общество с ограниченной ответственностью "Биопрактика" (ООО "Биопрактика") Ферментер и ферментационная установка для непрерывного культивирования микроорганизмов

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