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WO2022203634A1 - Tête de pompe à sang centrifuge qui constitue la force de propulsion d'un dispositif d'aspiration - Google Patents

Tête de pompe à sang centrifuge qui constitue la force de propulsion d'un dispositif d'aspiration Download PDF

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Publication number
WO2022203634A1
WO2022203634A1 PCT/TR2022/050257 TR2022050257W WO2022203634A1 WO 2022203634 A1 WO2022203634 A1 WO 2022203634A1 TR 2022050257 W TR2022050257 W TR 2022050257W WO 2022203634 A1 WO2022203634 A1 WO 2022203634A1
Authority
WO
WIPO (PCT)
Prior art keywords
pump head
impeller body
blood pump
impeller
head according
Prior art date
Application number
PCT/TR2022/050257
Other languages
English (en)
Inventor
Erdem Erinç SİLİSTRELİ
Merve SERİN
Ahmet Salih ER
Original Assignee
Dokuz Eylul Universitesi Rektorlugu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dokuz Eylul Universitesi Rektorlugu filed Critical Dokuz Eylul Universitesi Rektorlugu
Priority to EP22776261.4A priority Critical patent/EP4277690A4/fr
Publication of WO2022203634A1 publication Critical patent/WO2022203634A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/804—Impellers
    • A61M60/806—Vanes or blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/117—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body for assisting the heart, e.g. transcutaneous or external ventricular assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A61M60/232—Centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/419—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being permanent magnetic, e.g. from a rotating magnetic coupling between driving and driven magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/804—Impellers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/81—Pump housings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/81—Pump housings
    • A61M60/814—Volutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D13/00—Pumping installations or systems
    • F04D13/02—Units comprising pumps and their driving means
    • F04D13/021—Units comprising pumps and their driving means containing a coupling
    • F04D13/024—Units comprising pumps and their driving means containing a coupling a magnetic coupling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D29/00—Details, component parts, or accessories
    • F04D29/18—Rotors
    • F04D29/22—Rotors specially for centrifugal pumps
    • F04D29/2205—Conventional flow pattern
    • F04D29/2216—Shape, geometry
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D29/00—Details, component parts, or accessories
    • F04D29/40—Casings; Connections of working fluid
    • F04D29/42—Casings; Connections of working fluid for radial or helico-centrifugal pumps
    • F04D29/426—Casings; Connections of working fluid for radial or helico-centrifugal pumps especially adapted for liquid pumps
    • F04D29/4293—Details of fluid inlet or outlet
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D29/00—Details, component parts, or accessories
    • F04D29/60—Mounting; Assembling; Disassembling
    • F04D29/62—Mounting; Assembling; Disassembling of radial or helico-centrifugal pumps
    • F04D29/628—Mounting; Assembling; Disassembling of radial or helico-centrifugal pumps especially adapted for liquid pumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D7/00—Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts
    • F04D7/02—Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts of centrifugal type
    • F04D7/04—Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts of centrifugal type the fluids being viscous or non-homogenous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/11—Laminar flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the invention relates to a portable, usable in surgical field, waterproof blood pump or centrifugal blood pump head that is compatible with an aspiration device and constitutes the propelling force of the aspiration device.
  • ECMO Extra membrane oxygenation
  • the invention relates to a blood pump with a rotor.
  • the invention relates to a blood pump having a rotor housed on a bearing housing within a pump body.
  • the body has a metal rod that moves from the outer wall to the inner side of the body in line with the invention. This rod can conduct heat and has a balancing effect.
  • JP2006280573 Another application included in the state of the art is the patent application numbered JP2006280573. Said patent application relates to a blood pump device having a calculation function in which the axial float amount of the propeller can be easily and reliably calculated without using a position sensor.
  • the invention relates to a portable, usable in surgical field, waterproof blood pump or centrifugal blood pump head that is compatible with an aspiration device and constitutes the propelling force of the aspiration device.
  • the pump head is produced by polycarbonate printing with mold injection method, which receives motion support with the aspiration device, which is a portable device, by magnetic matching method and converts blood, for ECMO (extracorporeal membrane oxygenation) purposes, for use in circulatory support systems and sudden lung failures requiring oxygenation.
  • centrifugal pump head were appropriately modelled considering the computational fluids mechanics tests and the impeller (turbine) structure was designed so that the propelling force would advance the blood in the laminar flow tendency without changing the rheology of the blood.
  • the designed blood pump was designed according to 5000 rpm, 3.3 L/min & 300 mmHg. It was observed in the studies that 6-flap pumps create ideal working conditions in such applications when the previous studies are examined. Flap thickness was selected as 1 mm considering the plastic injection method and material strength. Flap designs were also made using the single-arc method. This method is based on the production of flaps by using a single arc curve in the flap design, as can be understood from the name thereof. An important parameter with the highest uncertainty is the flap exit angle, due to the small size of the pump and therefore the Reynolds number. It is known that such simple flap curves give good results without affecting the performance very much in designs with a small Reynolds number and therefore viscous flow is effective.
  • the centrifugal pump head completes a deficiency in terms of being a portable, usable in surgical field, waterproof, remotely controllable blood pump that can only be intervened by people with a safety module and being compatible with “An Aspiration Device” (TR 2017/20265) and constituting the propelling force of this device.
  • Figure 1 Classification of the Geometries of the Pumps where They are Most Efficient According to Specific Speed.
  • Figure 4 A graph showing the ratio of the total head to the flow rate
  • Figure 5 A graph showing the ratio of efficiency to flow rate
  • FIG. 6 A graph showing the blood elements in the pump Figure 7: Lower view of the impeller body
  • Figure 12 Perspective view of the cover added to the impeller body
  • Figure 15 Perspective view of the impeller body
  • Figure 16 Upper view of pump head lower cover
  • FIG. 18 Perspective view of the pump head lower cover
  • FIG 19 Lower view of pump head upper cover Figure 20: Side view of the pump head upper cover Figure 21: Perspective view of the pump head upper cover Figure 22: Lower view of the pump head upper cover
  • FIG. 23 Side view of the pump head upper cover
  • Figure 24 Perspective view of the pump head upper cover
  • the invention relates to a portable, usable in surgical field, waterproof blood pump or centrifugal blood pump head that is compatible with an aspiration device and constitutes the propelling force of the aspiration device.
  • the centrifugal blood pump head is designed in such a way that the impeller geometry is subjected to at least shear stress of the blood and the rheology (fluid structure) thereof is laminar current.
  • computer modeling was performed for the impeller body (3) placed in the centrifugal pump head.
  • ANSIS software was primarily used for computer modeling, using CFD (Computational Fluid Dynamics) methods.
  • design and modeling were developed in light of minimum shear stress and energy conservation calculations in accordance with fluid mechanics.
  • the impeller body (3) and flaps (3.1) that will rotate by magnetic matching method in a closed system were designed according to the basic energy conservation principles and minimum shear stress.
  • At least 3 geometries were determined with theoretical fluid mechanics and Computational Fluids Mechanics (CFD). Three-dimensional, production-friendly models of these geometries were created.
  • CFD Computational Fluids Mechanics
  • the candidate pump impellers were subjected to a hydrodynamic tests with a fluidic material representing the average blood flow. a) H-Q (Total head-Flow rate) and total efficiency graphs of the pumps were obtained, as a result of these tests. Each candidate impeller was characterized by measuring the pressure fluctuations created by each candidate pump. b) The cavitation limits of the pumps were found by hydrodynamic tests.
  • the pump head was first was prototyped, then produced by polycarbonate printing with the injection method from the mold. It was prepared in a working condition that could give laminar current to the blood.
  • the impeller body, upper cover and lower cover were produced by polycarbonate printing by injection method from the mold.
  • the distance between the cylindrical part (magnet slots) that forms the pump base and holds the magnets that provide magnetic levitation and the wall of the spiral is considered to be 2 mm at this stage.
  • the distance between the upper part of the flaps and the wall of the spiral is taken as 2 mm.
  • the distance between the magnet slots (3.2) and the wall of the spiral may be in the range of 0.2-4.0 mm.
  • the distance between the upper part of the flaps (3.1) and the wall of the spiral may also be in the range of 0.2-4.0 mm.
  • This system can be used in patients with advanced circulation failure, advanced lung failure, patients who cannot live through open heart surgeries, poisonings, suffocation and trauma, and sudden lung failure caused by pandemics such as SARS, MERS, and COVID-19. There is also a use area for children.
  • Perfusate blood from open-heart surgery was used fresh (at room temperature) in hemolysis tests with SLA resin-printed pump head container and polycarbonate impeller. The results are shown in Figure 6.
  • the environment in which the blood rotates for 6 hours is different from the environment in the living body, in this study. In other words, it is not in the range of 34-37°C, which we call normothermic; there is no oxygenation and the excess potassium cannot be eliminated. Ideal conditions can only be done in animal or human studies. However, current hemolysis values can be seen as positive considering these conditions. The results of the decomposition in the blood in the graph have progressed in a line close to the level for 6 hours.
  • the movement from the magnetic disk in an Aspiration Device to the impeller body (3) in the pump head is transferred by magnetic mapping method. Since the device has 6 neodymium magnets, 6 neodymium magnets are positioned near the base of the impeller and in the opposite poles, and they are covered with a cover (4) added to the thin impeller body to prevent contact with blood. Flaps (3.1) that allow blood to be centrifugally directed towards the edge of the pump head: The numbers of these flaps (3.1) vary between 6 and 8 and are in the form of springs and direct blood to the edges and then to the outlet pipe (1.2) by rotation.
  • the exact intermediate part (3.4) of the upper surface of the body of the impeller can be in 3 ways according to its intended use: Flat in the center, convex or concave. One of these 3 shapes is used to reduce the traumatization of the blood that comes quickly from the inlet pipe
  • the inlet pipe (1.3) of the pump is where it is most exposed to pressure by impact during blood flow.
  • the central part of the impeller geometry is designed to reduce the velocity vector where the blood hits and direct the blood to the flaps and to the outlet pipe (1.2) from the spiral section of the pump head.
  • An outwardly parabolic hill or inwardly valley reduces this impact effect.
  • the upper and lower components of the head into which the impeller enters are produced by interlocking together without leaking the blood.
  • one of the methods of bonding with strong adhesives, screwing or ultrasonic bonding is used.
  • the centrifugal blood pump head comprises the following in its most basic form:
  • An upper cover (1) which protects the impeller body (3) from external influences and after the impeller body (2) is placed to the the lower cover, is placed on it.
  • the upper cover (1) located on the centrifugal blood pump head comprises the following:
  • the lower cover (2) located on the centrifugal blood pump head comprises the following:
  • the impeller body (3) located on the centrifugal blood pump head comprises the following:

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)

Abstract

L'invention concerne une tête de pompe à sang étanche à l'eau ou de pompe à sang centrifuge portable, utilisable dans le domaine chirurgical, qui est compatible avec un dispositif d'aspiration et constitue la force de propulsion du dispositif d'aspiration.
PCT/TR2022/050257 2021-03-25 2022-03-22 Tête de pompe à sang centrifuge qui constitue la force de propulsion d'un dispositif d'aspiration WO2022203634A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22776261.4A EP4277690A4 (fr) 2021-03-25 2022-03-22 Tête de pompe à sang centrifuge qui constitue la force de propulsion d'un dispositif d'aspiration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR202105405 2021-03-25
TR2021/005405 2021-03-25

Publications (1)

Publication Number Publication Date
WO2022203634A1 true WO2022203634A1 (fr) 2022-09-29

Family

ID=83396000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2022/050257 WO2022203634A1 (fr) 2021-03-25 2022-03-22 Tête de pompe à sang centrifuge qui constitue la force de propulsion d'un dispositif d'aspiration

Country Status (2)

Country Link
EP (1) EP4277690A4 (fr)
WO (1) WO2022203634A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002306591A (ja) * 2001-04-11 2002-10-22 Terumo Corp 医療器具およびその製造方法ならびに遠心式液体ポンプ
EP1602386A1 (fr) * 1999-04-23 2005-12-07 Ventrassist Pty Ltd Pompe cardiaque rotative et son système de contrôle
CN105268040A (zh) * 2014-07-22 2016-01-27 王辉山 一种磁耦合驱动的离心式血泵
US20190307943A1 (en) * 2012-08-17 2019-10-10 Flow Forward Medical, Inc. Blood pump systems and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5947703A (en) * 1996-01-31 1999-09-07 Ntn Corporation Centrifugal blood pump assembly
JPH09313600A (ja) * 1996-05-28 1997-12-09 Terumo Corp 遠心式液体ポンプ装置
US10428828B2 (en) * 2016-06-20 2019-10-01 Terumo Cardiovascular Systems Corporation Centrifugal pumps for medical uses
CN110947040A (zh) * 2019-12-18 2020-04-03 山东大学 一种体外循环血泵及方法
CN111249551B (zh) * 2020-01-21 2020-11-24 深圳汉诺医疗创新技术有限公司 一种用于人工心脏的蜗式泵头、人工心脏泵和ecmo设备

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1602386A1 (fr) * 1999-04-23 2005-12-07 Ventrassist Pty Ltd Pompe cardiaque rotative et son système de contrôle
JP2002306591A (ja) * 2001-04-11 2002-10-22 Terumo Corp 医療器具およびその製造方法ならびに遠心式液体ポンプ
US20190307943A1 (en) * 2012-08-17 2019-10-10 Flow Forward Medical, Inc. Blood pump systems and methods
CN105268040A (zh) * 2014-07-22 2016-01-27 王辉山 一种磁耦合驱动的离心式血泵

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP4277690A4 *

Also Published As

Publication number Publication date
EP4277690A1 (fr) 2023-11-22
EP4277690A4 (fr) 2024-07-03

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