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WO2021207517A3 - Modified hr2 peptide inhibitors of coronavirus fusion - Google Patents

Modified hr2 peptide inhibitors of coronavirus fusion Download PDF

Info

Publication number
WO2021207517A3
WO2021207517A3 PCT/US2021/026416 US2021026416W WO2021207517A3 WO 2021207517 A3 WO2021207517 A3 WO 2021207517A3 US 2021026416 W US2021026416 W US 2021026416W WO 2021207517 A3 WO2021207517 A3 WO 2021207517A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified
fusion
peptide inhibitors
peptides
coronavirus
Prior art date
Application number
PCT/US2021/026416
Other languages
French (fr)
Other versions
WO2021207517A2 (en
Inventor
Gene Merutka
Original Assignee
Sapience Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapience Therapeutics, Inc. filed Critical Sapience Therapeutics, Inc.
Publication of WO2021207517A2 publication Critical patent/WO2021207517A2/en
Publication of WO2021207517A3 publication Critical patent/WO2021207517A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided are modified HR2 peptides that are capable of competing with the native HR2 region of a viral spike (S) protein for binding to the HR1 region, thereby inhibiting formation of the 6-HB fusion complex and fusion with a target host cell, compositions comprising the modified HR2 peptides, and methods of inhibiting viral fusion using the HR2 peptides.
PCT/US2021/026416 2020-04-10 2021-04-08 Modified hr2 peptide inhibitors of coronavirus fusion WO2021207517A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063008469P 2020-04-10 2020-04-10
US63/008,469 2020-04-10

Publications (2)

Publication Number Publication Date
WO2021207517A2 WO2021207517A2 (en) 2021-10-14
WO2021207517A3 true WO2021207517A3 (en) 2022-01-06

Family

ID=78023205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/026416 WO2021207517A2 (en) 2020-04-10 2021-04-08 Modified hr2 peptide inhibitors of coronavirus fusion

Country Status (1)

Country Link
WO (1) WO2021207517A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4281096A4 (en) 2021-01-22 2025-06-11 Decoy Therapeutics Inc. Methods and compositions for treating infections
WO2023150375A2 (en) * 2022-02-07 2023-08-10 Decoy Therapeutics Inc. Methods and compositions for treating covid infections
WO2023159113A1 (en) * 2022-02-16 2023-08-24 Greene Warner C Peptide fusion inhibitors exhibiting pan-coronavirus inhibitory activity
CN115746148B (en) * 2022-10-14 2023-09-12 中国医学科学院病原生物学研究所 Proteins with coronavirus RBD and membrane fusion inhibitory polypeptides and their use as coronavirus inhibitors
WO2024213127A1 (en) * 2023-04-12 2024-10-17 Westlake University Fusion lipopeptide for inhibiting coronavirus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053728A2 (en) * 2000-12-29 2002-07-11 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
US20160237123A1 (en) * 2008-01-23 2016-08-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of viral infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053728A2 (en) * 2000-12-29 2002-07-11 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
US20160237123A1 (en) * 2008-01-23 2016-08-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of viral infections

Also Published As

Publication number Publication date
WO2021207517A2 (en) 2021-10-14

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