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WO2021071372A8 - Process of vitamin k2 derivatives preparation - Google Patents

Process of vitamin k2 derivatives preparation Download PDF

Info

Publication number
WO2021071372A8
WO2021071372A8 PCT/PL2019/000086 PL2019000086W WO2021071372A8 WO 2021071372 A8 WO2021071372 A8 WO 2021071372A8 PL 2019000086 W PL2019000086 W PL 2019000086W WO 2021071372 A8 WO2021071372 A8 WO 2021071372A8
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
derivatives preparation
derivatives
preparation
menadione
Prior art date
Application number
PCT/PL2019/000086
Other languages
French (fr)
Other versions
WO2021071372A1 (en
Inventor
Katarzyna Sidoryk
Kamil JATCZAK
Agnieszka Burzyńska-Prajzner
Marcin Cybulski
Marek NAPIÓRKOWSKI
Dorota PIETRZKOWSKA
Łukasz JEDYNAK
Marek Kubiszewski
Original Assignee
Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny filed Critical Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny
Priority to PCT/PL2019/000086 priority Critical patent/WO2021071372A1/en
Publication of WO2021071372A1 publication Critical patent/WO2021071372A1/en
Publication of WO2021071372A8 publication Critical patent/WO2021071372A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to an improved process of vitamin K2 derivatives preparation via the alkylation of the menadione-cyclopentadiene adduct.
PCT/PL2019/000086 2019-10-07 2019-10-07 Process of vitamin k2 derivatives preparation WO2021071372A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/PL2019/000086 WO2021071372A1 (en) 2019-10-07 2019-10-07 Process of vitamin k2 derivatives preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/PL2019/000086 WO2021071372A1 (en) 2019-10-07 2019-10-07 Process of vitamin k2 derivatives preparation

Publications (2)

Publication Number Publication Date
WO2021071372A1 WO2021071372A1 (en) 2021-04-15
WO2021071372A8 true WO2021071372A8 (en) 2021-06-24

Family

ID=68542716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2019/000086 WO2021071372A1 (en) 2019-10-07 2019-10-07 Process of vitamin k2 derivatives preparation

Country Status (1)

Country Link
WO (1) WO2021071372A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202103137D0 (en) * 2021-03-05 2021-04-21 Kappa Bioscience As Process for the preparation of vitamin K2 and novel intermediates
WO2023031841A1 (en) * 2021-09-03 2023-03-09 Synergia Life Sciences Pvt. Ltd. A process for the stereospecific synthesis of vitamin k2 and its intermediates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1091680A (en) 1976-10-19 1980-12-16 Shinji Terao Method for production of quinones
DK172072B1 (en) 1983-07-28 1997-10-13 Hoffmann La Roche Process for the preparation of vitamin K derivatives and ubiquinones and compounds useful for use in this process
US4854156A (en) 1989-01-03 1989-08-08 Systems Research Laboratories, Inc. Pneumatic surface-following control system
CN1218918C (en) 2003-08-22 2005-09-14 浙江大学 The synthetic method of geranyl geraniol
CN101029003A (en) * 2007-04-13 2007-09-05 北京化工大学 Method for synthesizing vitamin k solanine
DE202008008134U1 (en) 2008-06-17 2009-06-25 Bischof + Klein Gmbh & Co. Kg Satchel bags
GB201004876D0 (en) 2010-03-23 2010-05-05 Syntavit As Process for the preparation of vitamin K2
PL401195A1 (en) 2012-10-12 2014-04-14 Instytut Farmaceutyczny Process for the preparation of vitamin K2 in the form of MK-7

Also Published As

Publication number Publication date
WO2021071372A1 (en) 2021-04-15

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