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WO2020154827A1 - Wound oxygen supply dressing composed of multiple films using polymer material as carrier - Google Patents

Wound oxygen supply dressing composed of multiple films using polymer material as carrier Download PDF

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Publication number
WO2020154827A1
WO2020154827A1 PCT/CN2019/000226 CN2019000226W WO2020154827A1 WO 2020154827 A1 WO2020154827 A1 WO 2020154827A1 CN 2019000226 W CN2019000226 W CN 2019000226W WO 2020154827 A1 WO2020154827 A1 WO 2020154827A1
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Prior art keywords
oxygen
wound
dressing
carrier
water
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PCT/CN2019/000226
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French (fr)
Chinese (zh)
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郑岩
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郑岩
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments

Definitions

  • the present invention relates to a medical article, and more specifically, to a dressing which is composed of multiple membranes based on a polymer material as a carrier and generates oxygen to supply oxygen to a wound and a production process thereof.
  • Inert dressing It has the advantages of protecting the wound surface, being absorbent, simple to make and cheap; 2. Double-acting dressing: This type of dressing can use its causes The local environment promotes wound healing and has a strong absorption function.
  • an absorbent film made of polyurethane materials, or a three-dimensional network water-absorbing polymer composed of gelatin, polysaccharides, multi-dielectric complexes and methacrylic resins, or composed of polyurethane and poly Composed of oxyethylene glycol porous foam.
  • Biologically active dressing a combined dressing made of high-tech methods using polymer materials and biological materials. It has a double-layer structure. The outer layer uses polymer materials to provide a barrier function equivalent to the epidermis; the inner layer is selected The main materials are collagen, chitosan and calcium alginate, which have biocompatibility, good water absorption, air permeability, adhesion, antibacterial and hemostatic effects.
  • the purpose of the present invention is to overcome the above-mentioned defects in the prior art and provide an oxygen supply dressing, which provides an oxygen-rich environment for the wound through the dressing.
  • the dressing is divided into two components, the first part is mainly composed of an air leakage protective film, a polymer gel containing water, a protective film and a protective layer from top to bottom.
  • the second part is composed of a protective layer, a calcium peroxide film, a gas-permeable and water-impermeable film, and a perfluoronaphthalene gel preparation structure (perfluorocarbon emulsion gel preparation or a product with similar functions).
  • the water-containing polymer gel The body water can also be replaced by other such as hydrogen peroxide or eutrophic compounds, and the calcium peroxide film can also be replaced by manganese dioxide film as a catalyst (other catalysts can be used).
  • the wound oxygen supply dressing of the present invention can provide an oxygen-rich environment for the wound, accelerate wound healing, and kill anaerobic bacteria.
  • the second part of the peroxide is a calcium peroxide film (controlled release structure).
  • the air-permeable and water-impermeable material is EPTEF material.
  • the structure (8) uses a perfluoronaneane gel preparation structure (perfluorocarbon emulsion gel preparation or a product with similar functions). You can also use absorbent pads coated with soft silicone or coated with sodium alginate.
  • a material with a certain surface tension can be selected for the anti-leakage protective film, which can hold more oxygen, and at the same time form a certain high-pressure oxygen environment on the wound surface, or carry out a certain structural design.
  • the preparation of a wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes is carried out in a closed environment.
  • the air-leakage protective film of the dressing is well sealed with the patient's skin.
  • the water in the polymer gel chemically reacts with calcium peroxide to generate oxygen, which can provide oxygen to the wound, which is beneficial to accelerate the wound healing process and reduce the pain of the patient.
  • the outermost layer of the dressing is an air leakage protective film, which has the effects of dustproof, waterproof, air leakage and pollution prevention.
  • the oxygen generated can contact the wound through the air-permeable and water-impermeable membrane to accelerate wound healing and at the same time kill anaerobic bacteria.
  • perfluoronaneane gel preparations can act as oxygen molecular carriers to increase the concentration of oxygen molecules.
  • absorbent pads can absorb wound exudate, keep the wound surface clean, and can also store oxygen, maintain the oxygen concentration of the wound, and promote cell growth.
  • the surface of the absorbent pad can be covered with sodium alginate, or it can be coated with soft silicone and other similar materials to directly contact the skin.
  • soft silicone also called silicone gel
  • the function of soft silicone is to prevent the dressing from sticking to the skin, and to relieve the patient's pain when it is uncovered. Therefore, the present invention has outstanding features.
  • Figure 1 is a schematic diagram of a wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes provided by the present invention
  • the first part is composed of a protective film (1), a polymer gel containing water (2), a protective film (3), and a protective layer (4) from top to bottom.
  • the second part is the protective layer (5), the calcium peroxide controlled release structure (6), the air-permeable and water-impermeable membrane (7), and the structure of the perfluoronaphthane gel preparation (perfluorocarbon emulsion gel preparation or products with similar functions) ) Or absorbent pads or others such as sodium alginate (8).
  • a high-molecular material as a carrier and multiple membranes constitute a dressing for supplying oxygen to the wound. It is characterized in that the dressing is divided into two components.
  • the first part is mainly composed of air leakage prevention from top to bottom.
  • the protective film (1), the polymer gel containing water (2), the protective film (3), and the protective layer (4) are composed.
  • the second part is the protective layer (5), the calcium peroxide controlled release structure (6), the air-permeable and water-impermeable membrane (7), and the structure of the perfluoronaphthane gel preparation (perfluorocarbon emulsion gel preparation or products with similar functions) ) Or absorbent pads or other structures such as sodium alginate (8).
  • the anti-leakage protective film (1) is partially coated with a medical adhesive glue, which is used to stick to the second part to realize the function of fixing the first part, and has the function of preventing the seepage of liquid and oxygen, and has the function of preventing dust, Waterproof, anti-leakage and anti-pollution effects.
  • the second part of the air-permeable and water-permeable membrane is partially coated with a medical adhesive glue for bonding to the skin and fixing the entire dressing.
  • the wound provides high-concentration oxygen, which is beneficial to speed up the wound healing; reduce the pain of the patient.
  • the structure of the perfluoronaphthane gel preparation (perfluorocarbon emulsion gel preparation or a product with similar functions) (8) as an oxygen molecule carrier to increase the concentration of oxygen molecules it has the ability to absorb wound exudate when an absorbent pad is used At the same time, the water molecules contained in it can also store part of oxygen and maintain high oxygen concentration in the wound.
  • the surface of the absorbent pad (8) is coated with soft silicone, which is in direct contact with the skin.
  • Soft silicone also known as silicone gel
  • silicone gel can prevent the dressing from sticking to the skin, and can reduce or eliminate the pain of the patient when it is opened.
  • the air-leakage protective film 1 of the first part of the dressing and the second part are firmly pasted by an adhesive to ensure that oxygen does not leak out in the wound area and at the same time form a certain pressure.
  • the air-permeable and water-impermeable membrane of the second part of the dressing is sealed on the skin by medical glue to ensure the passage of oxygen to the wound site, and at the same time prevent the liquid after chemical reaction from leaking out and contacting the wound.
  • the preparation method is carried out in a closed and dry environment.
  • the present invention can also be applied in other medical fields, such as making a vaginal oxygen generator to kill anaerobic bacteria such as molds.
  • the protection scope of the present invention is not limited to this. Any person skilled in the art within the technical scope disclosed by the present invention, based on the technical solution of the present invention and its inventive concept, shall be covered by the present invention. Within the scope of protection.
  • the present invention can also use the first part and the second part upside down, replacing the water-containing polymer gel (2) and the protective film (3) with the calcium peroxide controlled release structure (6), and the second part of the calcium peroxide controlling The release structure (6) is replaced by a water-containing polymer gel (2) and a protective film (3).

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a wound oxygen supply dressing composed of multiple films using a polymer material as a carrier, wherein the dressing is divided into two parts, wherein the first part mainly consists of an anti-leakage protective film (1), a water-containing polymer gel (2), a protective film (3) and a protective layer (4) from top to bottom in sequence; the second part consists of a protective layer (5), calcium peroxide (an other peroxide releasing oxygen molecules) (6), a breathable water-impermeable film (7) and a perfluorodecalin gel preparation structure (perfluorocarbon emulsion gel preparations or products with the similar function) (8). The wound dressing can provide an oxygen-rich environment for wound, accelerate wound healing, and kill anaerobic bacteria.

Description

一种高分子材料为载体多种膜构成的伤口供氧敷料Wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes 技术领域Technical field
本发明涉及一种医疗用品，更具体地，涉及一种基于高分子材料为载体多种膜构成的产生氧气为伤口供氧的敷料及其生产工艺。The present invention relates to a medical article, and more specifically, to a dressing which is composed of multiple membranes based on a polymer material as a carrier and generates oxygen to supply oxygen to a wound and a production process thereof.
背景技术Background technique
人们受伤后，会利用伤口敷料进行伤口护理。众所周知，氧在伤口的愈合过程中起着重要作用，能控制细菌的生长与扩散，同时由于伤口周边毛细血管的破坏造成细胞缺氧不利于细胞再生，而外部给氧有利于细胞的再生从而加快伤口的愈合。目前传统的伤口敷料均无法达到这个效果。按其所用材料和功能可分为以下三种：1、惰性敷料：具有保护创面、有吸收性、制作简单和价格便宜的优点；2、双作用性敷料：这类敷料可利用它所造成的局部环境促进伤口愈合，具有较强的吸收功能。例如由多氨基甲酸乙酯材料制成的吸收膜，或由明胶、多糖、多电介质复合物和甲基丙烯酸树脂组成的三维立体网状吸水性多聚体，或由聚氨基甲酸乙酯和聚氧乙烯乙二醇多孔泡沫组成。3、生物活性敷料：采用高分子材料与生物性材料经高新技术方法加工制成的组合性敷料，具有双层结构，外层应用高分子材料，提供了相当于表皮的屏障功能；内层选用的主要材料为胶原、壳聚糖和海藻酸钙，具有生物相容性、较好的吸水性、透气性、黏附性和抗菌、止血作用。After people are injured, they use wound dressings for wound care. As we all know, oxygen plays an important role in the healing process of wounds. It can control the growth and spread of bacteria. At the same time, hypoxia caused by the destruction of capillaries around the wound is not conducive to cell regeneration, while external oxygen is conducive to cell regeneration and accelerates Wound healing. Current traditional wound dressings cannot achieve this effect. According to the materials and functions used, it can be divided into the following three types: 1. Inert dressing: It has the advantages of protecting the wound surface, being absorbent, simple to make and cheap; 2. Double-acting dressing: This type of dressing can use its causes The local environment promotes wound healing and has a strong absorption function. For example, an absorbent film made of polyurethane materials, or a three-dimensional network water-absorbing polymer composed of gelatin, polysaccharides, multi-dielectric complexes and methacrylic resins, or composed of polyurethane and poly Composed of oxyethylene glycol porous foam. 3. Biologically active dressing: a combined dressing made of high-tech methods using polymer materials and biological materials. It has a double-layer structure. The outer layer uses polymer materials to provide a barrier function equivalent to the epidermis; the inner layer is selected The main materials are collagen, chitosan and calcium alginate, which have biocompatibility, good water absorption, air permeability, adhesion, antibacterial and hemostatic effects.
虽然传统敷料能保护伤口，在不同程度促进伤口愈合，但由于伤口在愈合过程中处于缺氧状态，愈合效果往往不好。Although traditional dressings can protect the wound and promote wound healing to varying degrees, the healing effect is often not good because the wound is in a state of hypoxia during the healing process.
因此，目前急需一种能够自主供氧的敷料，为伤口提供富氧环境，减少因毛细血管被破坏后细胞因缺氧而愈合缓慢，减轻患者疼痛感。Therefore, there is an urgent need for a dressing that can autonomously supply oxygen to provide an oxygen-rich environment for the wound, reduce the slow healing of cells due to hypoxia due to capillary damage, and reduce the pain of patients.
发明内容Summary of the invention
本发明的目的在于克服现有技术存在的上述缺陷，提供一种供氧敷料，通过敷料为伤口提供富氧环境。The purpose of the present invention is to overcome the above-mentioned defects in the prior art and provide an oxygen supply dressing, which provides an oxygen-rich environment for the wound through the dressing.
为实现上述目的，本发明的技术方案如下：In order to achieve the above objective, the technical solution of the present invention is as follows:
该敷料分为两个组成部分，第一部分由上到下依次主要由防漏气保护膜、含有水的高分子凝胶体、保护膜和保护层。第二部分为保护层、过氧化钙膜、透气不透水膜及全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能 的产品)组成，所述含水的高分子凝胶体中水也可用其他如双氧水或富养化合物代替，过氧化钙膜也可由二氧化锰膜作为催化剂(可用其他催化剂)代替。本发明涉及的伤口供氧敷料，能为伤口提供富氧环境，加速伤口愈合，杀灭厌氧菌。The dressing is divided into two components, the first part is mainly composed of an air leakage protective film, a polymer gel containing water, a protective film and a protective layer from top to bottom. The second part is composed of a protective layer, a calcium peroxide film, a gas-permeable and water-impermeable film, and a perfluoronaphthalene gel preparation structure (perfluorocarbon emulsion gel preparation or a product with similar functions). The water-containing polymer gel The body water can also be replaced by other such as hydrogen peroxide or eutrophic compounds, and the calcium peroxide film can also be replaced by manganese dioxide film as a catalyst (other catalysts can be used). The wound oxygen supply dressing of the present invention can provide an oxygen-rich environment for the wound, accelerate wound healing, and kill anaerobic bacteria.
优选地，高分子凝胶内只含水时，第二部分的过氧化物为过氧化钙膜(控释结构)。Preferably, when only water is contained in the polymer gel, the second part of the peroxide is a calcium peroxide film (controlled release structure).
优选地，透气不透水材料选用EPTEF材料。Preferably, the air-permeable and water-impermeable material is EPTEF material.
优选地，结构(8)使用全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)。也可使用表面涂有软聚硅酮的吸水垫或表面覆海藻酸钠。Preferably, the structure (8) uses a perfluoronaneane gel preparation structure (perfluorocarbon emulsion gel preparation or a product with similar functions). You can also use absorbent pads coated with soft silicone or coated with sodium alginate.
优选地，防漏气保护膜可选用有一定的表面张力的材料，可容纳更多的氧气，同时在伤口表面形成一定的高压氧环境，或进行一定的结构设计。Preferably, a material with a certain surface tension can be selected for the anti-leakage protective film, which can hold more oxygen, and at the same time form a certain high-pressure oxygen environment on the wound surface, or carry out a certain structural design.
一种高分子材料为载体多种膜构成的伤口供氧敷料的制备，在密闭的环境中进行。The preparation of a wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes is carried out in a closed environment.
敷料的防漏气保护膜与患者皮肤之间密封良好。The air-leakage protective film of the dressing is well sealed with the patient's skin.
从上述技术方案可以看出，本发明具有有益效果：It can be seen from the above technical solutions that the present invention has beneficial effects:
(1)高分子凝胶内的水遇过氧化钙后发生化学反应生成氧气，能够为伤口提供氧气，有利于加速伤口愈合过程，减轻患者疼痛感。(1) The water in the polymer gel chemically reacts with calcium peroxide to generate oxygen, which can provide oxygen to the wound, which is beneficial to accelerate the wound healing process and reduce the pain of the patient.
(2)敷料最外层为防漏气保护膜，起到防尘、防水、防漏气、防污染的效果。(2) The outermost layer of the dressing is an air leakage protective film, which has the effects of dustproof, waterproof, air leakage and pollution prevention.
(3)产生的氧透过透气不透水膜与伤口接触加速伤口愈合，同时杀灭厌氧菌。(3) The oxygen generated can contact the wound through the air-permeable and water-impermeable membrane to accelerate wound healing and at the same time kill anaerobic bacteria.
(4)全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)能够作为氧分子载体增加氧分子浓度。使用吸水垫替代时，吸水垫能够吸收伤口渗出液，保持伤口表面干净，也可储存氧气，保持伤口氧气浓度，促进细胞生长。(4) The structure of perfluoronaneane gel preparations (perfluorocarbon emulsion gel preparations or products with similar functions) can act as oxygen molecular carriers to increase the concentration of oxygen molecules. When using absorbent pads instead, the absorbent pads can absorb wound exudate, keep the wound surface clean, and can also store oxygen, maintain the oxygen concentration of the wound, and promote cell growth.
(5)吸水垫表面即可覆海藻酸钠，也可涂有软聚硅酮等类似材料，与皮肤接直接触。软聚硅酮(也称硅凝胶)的作用是使敷料不粘连皮肤，揭开时使患者没有或减轻疼痛感。因此，本发明具有的显著特点。(5) The surface of the absorbent pad can be covered with sodium alginate, or it can be coated with soft silicone and other similar materials to directly contact the skin. The function of soft silicone (also called silicone gel) is to prevent the dressing from sticking to the skin, and to relieve the patient's pain when it is uncovered. Therefore, the present invention has outstanding features.
附图说明Description of the drawings
为了更清楚的说明本发明，下面将对实施例所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to explain the present invention more clearly, the following will briefly introduce the accompanying drawings used in the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention, which are for those of ordinary skill in the art. Under the premise of no creative work, other drawings can be obtained based on these drawings.
图1是本发明提供的一种高分子材料为载体多种膜构成的伤口供氧敷料的结构示意图Figure 1 is a schematic diagram of a wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes provided by the present invention
图中1.第一部分由上到下依次主要由防漏气保护膜(1)、含有水的高分子凝胶体(2)、保护膜(3)、保护层(4)组成。第二部分为保护层(5)、过氧化钙控释结构(6)、透气不透水膜(7)及全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)或吸水垫或其他如海藻酸钠等(8)。In the figure 1. The first part is composed of a protective film (1), a polymer gel containing water (2), a protective film (3), and a protective layer (4) from top to bottom. The second part is the protective layer (5), the calcium peroxide controlled release structure (6), the air-permeable and water-impermeable membrane (7), and the structure of the perfluoronaphthane gel preparation (perfluorocarbon emulsion gel preparation or products with similar functions) ) Or absorbent pads or others such as sodium alginate (8).
具体实施方式detailed description
下面结合附图，对本发明的具体实施方式作进一步的详细说明。需要说明的是，在下述的具体实施方式中，在详述本发明的实施方式时，为了清楚地表示本发明的结构以便于说明，特对附图中的结构不依照一般比例绘图，并进行了局部放大、变形及简化处理，因此，应避免以此作为对本发明的限定来加以理解。The specific embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings. It should be noted that, in the following specific embodiments, when the embodiments of the present invention are described in detail, in order to clearly show the structure of the present invention for ease of description, the structure in the drawings is not drawn according to the general scale. Partial enlargement, deformation, and simplification of processing have been implemented. Therefore, this should be avoided as a limitation of the present invention.
实施例1Example 1
如图1所示，一种高分子材料为载体多种膜构成的为伤口供氧的敷料，其特征在于，该敷料分为两个组成部分，第一部分由上到下依次主要由防漏气保护膜(1)、含有水的高分子凝胶体(2)、保护膜(3)、保护层(4)组成。第二部分为保护层(5)、过氧化钙控释结构(6)、透气不透水膜(7)及全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)或吸水垫或其他如海藻酸钠制成的结构(8)。As shown in Figure 1, a high-molecular material as a carrier and multiple membranes constitute a dressing for supplying oxygen to the wound. It is characterized in that the dressing is divided into two components. The first part is mainly composed of air leakage prevention from top to bottom. The protective film (1), the polymer gel containing water (2), the protective film (3), and the protective layer (4) are composed. The second part is the protective layer (5), the calcium peroxide controlled release structure (6), the air-permeable and water-impermeable membrane (7), and the structure of the perfluoronaphthane gel preparation (perfluorocarbon emulsion gel preparation or products with similar functions) ) Or absorbent pads or other structures such as sodium alginate (8).
所述防漏气保护膜(1)上部分涂有医用粘结剂胶，用于粘在第二部分上实现固定第一部分的作用，具有防止液体和氧气渗出的作用，同时具有防尘、防水、防漏气、防污染的效果。The anti-leakage protective film (1) is partially coated with a medical adhesive glue, which is used to stick to the second part to realize the function of fixing the first part, and has the function of preventing the seepage of liquid and oxygen, and has the function of preventing dust, Waterproof, anti-leakage and anti-pollution effects.
所述第二部分透气不透水膜上部分涂有医用粘结剂胶，用于粘接在皮肤上，固定整个敷料。The second part of the air-permeable and water-permeable membrane is partially coated with a medical adhesive glue for bonding to the skin and fixing the entire dressing.
在使用时先将第二部分固定住伤口上，撕去第一部分保护膜、保护层和第二部分的保护层，将其密合在一起，形成供氧结构，通过化学反应生成氧气，能为伤口提供高浓度氧气，有利于加速伤口愈合；减轻患者疼痛感。所述全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)(8)作为氧分子载体增加氧分子浓度，当使用吸水垫时其具有吸收伤口渗出液的作用，同时其含有的水分子也可以储存部分氧，维持伤口高氧浓度。吸水垫(8)表面涂有软聚硅酮，与皮肤直接接触。When using, fix the second part on the wound first, tear off the first part of the protective film, the protective layer and the second part of the protective layer, and close them together to form an oxygen supply structure, which can generate oxygen through chemical reactions The wound provides high-concentration oxygen, which is beneficial to speed up the wound healing; reduce the pain of the patient. The structure of the perfluoronaphthane gel preparation (perfluorocarbon emulsion gel preparation or a product with similar functions) (8) as an oxygen molecule carrier to increase the concentration of oxygen molecules, it has the ability to absorb wound exudate when an absorbent pad is used At the same time, the water molecules contained in it can also store part of oxygen and maintain high oxygen concentration in the wound. The surface of the absorbent pad (8) is coated with soft silicone, which is in direct contact with the skin.
软聚硅酮(也称硅凝胶)可以使敷料不粘连皮肤，揭开时能够减轻或消除患者疼痛感。Soft silicone (also known as silicone gel) can prevent the dressing from sticking to the skin, and can reduce or eliminate the pain of the patient when it is opened.
所述该敷料第一部分的防漏气保护膜1与第二部分通过胶黏剂粘贴牢固，保证氧气在伤口范围内不外泄，同时形成一定的压强。The air-leakage protective film 1 of the first part of the dressing and the second part are firmly pasted by an adhesive to ensure that oxygen does not leak out in the wound area and at the same time form a certain pressure.
所述该敷料第二部分的透气不透水膜通过医用胶密封在皮肤上，保证氧气的通过到达伤口部位，同时阻止化学反应后的液体不会渗出与伤口接触。The air-permeable and water-impermeable membrane of the second part of the dressing is sealed on the skin by medical glue to ensure the passage of oxygen to the wound site, and at the same time prevent the liquid after chemical reaction from leaking out and contacting the wound.
所述的制备方法在密闭的干燥环境中进行。The preparation method is carried out in a closed and dry environment.
以上所述，仅为本发明在伤口敷料领域的较佳具体实施方式，本发明亦可在医学其他领域应用，如制成阴道氧气发生装置杀灭霉菌等厌氧菌。本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭示的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。本发明也可将第一部分和第二部分颠倒使用，将含水高分子凝胶(2)和保护膜(3)换成过氧化钙控释结构(6)，而第二部分的过氧化钙控释结构(6)换成含水高分子凝胶(2)和保护膜(3)。The above are only preferred embodiments of the present invention in the field of wound dressings. The present invention can also be applied in other medical fields, such as making a vaginal oxygen generator to kill anaerobic bacteria such as molds. The protection scope of the present invention is not limited to this. Any person skilled in the art within the technical scope disclosed by the present invention, based on the technical solution of the present invention and its inventive concept, shall be covered by the present invention. Within the scope of protection. The present invention can also use the first part and the second part upside down, replacing the water-containing polymer gel (2) and the protective film (3) with the calcium peroxide controlled release structure (6), and the second part of the calcium peroxide controlling The release structure (6) is replaced by a water-containing polymer gel (2) and a protective film (3).

Claims (9)

  1. 一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于，该敷料分为两个组成部分，第一部分由上到下依次主要由防漏气保护膜(1)、含有水的高分子凝胶体(2)、保护膜(3)、保护层(4)组成。第二部分为保护层(5)、过氧化钙(其他释放氧分子的过氧化物)(6)、透气不透水膜(7)及全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)(8)组成。A wound oxygen-supply dressing composed of a polymer material as a carrier and multiple membranes is characterized in that the dressing is divided into two components, the first part from top to bottom is mainly composed of a leak-proof protective film (1), containing water The polymer gel (2), the protective film (3) and the protective layer (4) are composed. The second part is the protective layer (5), calcium peroxide (other peroxides that release oxygen molecules) (6), air-permeable and water-impermeable membrane (7), and the structure of perfluoronaphthane gel formulation (perfluorocarbon emulsion gel) Formulations or products with similar functions) (8) composition.
  2. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于，所述敷料由两部分组成以保证安全可靠。The wound oxygen-supply dressing composed of a polymer material as a carrier and multiple membranes according to claim 1, wherein the dressing is composed of two parts to ensure safety and reliability.
  3. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于，所述第一部分含水高分子凝胶(2)。第二部分过氧化钙制成的控释膜或薄片(6)，为避免在不使用时相互发生化学反应作用采取分开包装隔离保护或其他方式隔离保护。The wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that the first part contains a water-containing polymer gel (2). The second part of the controlled release film or sheet (6) made of calcium peroxide is to adopt separate packaging isolation protection or other means of isolation protection in order to avoid mutual chemical reactions when not in use.
  4. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于所述不透气不透水材料(1)能够将产生的氧固定在伤口范围内并维持一定的压力。The wound oxygen dressing composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that the gas and water impermeable material (1) can fix the oxygen generated in the wound and maintain a certain pressure.
  5. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于保护膜(3)将含水高分子凝胶固定在要求的范围内使其在使用前不会渗出，从而避免破坏不透气不透水材料(1)上的粘结剂的黏度。同时设置保护层(4)与不透气不透水材料(1)粘合，在使用时才去除，保证不使用时无液体渗出。The oxygen-supply dressing for wounds composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that the protective film (3) fixes the water-containing polymer gel within the required range to prevent it from being used before use. It will ooze out, so as to avoid damaging the viscosity of the adhesive on the air and water impermeable material (1). At the same time, the protective layer (4) is bonded with the air- and water-impermeable material (1), and is only removed when in use to ensure that no liquid seeps out when not in use.
  6. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于，所述透气不透水膜(7)能够阻挡一切液体通过，但产生的氧(其他气体)能自由通过，从而保证伤口处于高浓度氧气的状态。The oxygen-supply dressing for wounds composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that the gas-permeable and water-impermeable membrane (7) can block all liquids from passing through, but generates oxygen (other gas) ) Can pass freely, so as to ensure that the wound is in a state of high concentration of oxygen.
  7. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于全氟奈烷凝胶制剂结构(全氟碳乳剂凝胶制剂或具有类似功能的产品)(8)能够增加液体氧分子浓度，形成高浓度氧液体，加速伤口的愈合。The oxygen-supply dressing for wounds composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that the structure of a perfluoronaphthalene gel preparation (perfluorocarbon emulsion gel preparation or a product with similar functions) (8) It can increase the concentration of liquid oxygen molecules to form a high-concentration oxygen liquid and accelerate wound healing.
  8. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于，所述第一部分中(2)为含水高分子凝胶。第二部分(6)用由过氧化钙制作的可控反应速度的缓释膜(薄片)或其他工艺制作的结构(如微胶囊控释)构成，过氧化钙与水反应生成氢氧化钙和氧分子，此方法不限于达到相似结果、类似作用的物理或化学方法。The wound oxygen supply dressing composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that (2) in the first part is an aqueous polymer gel. The second part (6) is composed of a slow-release film (sheet) made of calcium peroxide with a controllable reaction rate or a structure made by other processes (such as microcapsule controlled release). The calcium peroxide reacts with water to form calcium hydroxide and Molecular oxygen, this method is not limited to physical or chemical methods that achieve similar results and similar effects.
  9. 根据权利要求1所述的一种高分子材料为载体多种膜构成的伤口供氧敷料，其特征在于敷料制备完成后第一部分和第二部分独立由不透水不透气包装封闭保存，同时在放置于同一不透水不透气包装封闭保存。The wound oxygen dressing composed of a polymer material as a carrier and multiple membranes according to claim 1, characterized in that after the dressing is prepared, the first part and the second part are independently sealed and stored in an impermeable and air-tight package, and at the same time Stored in the same impermeable and airtight packaging closed.
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