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WO2020042095A1 - 无醇抑菌花露水及其制备方法 - Google Patents

无醇抑菌花露水及其制备方法 Download PDF

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Publication number
WO2020042095A1
WO2020042095A1 PCT/CN2018/103303 CN2018103303W WO2020042095A1 WO 2020042095 A1 WO2020042095 A1 WO 2020042095A1 CN 2018103303 W CN2018103303 W CN 2018103303W WO 2020042095 A1 WO2020042095 A1 WO 2020042095A1
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WIPO (PCT)
Prior art keywords
parts
weight
extract
propolis
rehmannia glutinosa
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PCT/CN2018/103303
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English (en)
French (fr)
Inventor
吴克
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江苏奇力康皮肤药业有限公司
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Priority to PCT/CN2018/103303 priority Critical patent/WO2020042095A1/zh
Publication of WO2020042095A1 publication Critical patent/WO2020042095A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants

Definitions

  • the invention belongs to the field of daily chemicals, and particularly relates to an alcohol-free bacteriostatic toilet water and a preparation method thereof.
  • toilet water has the characteristics of being easy to use, not limited by time and conditions of use, and being portable, so it is widely loved by people.
  • Toilet water is a perfume product made with toilet oil as the main fragrance and ethanol, and its main effects are refreshing, anti-itching, itching, decontamination and sterilization.
  • toilet water formulations are based on 1 to 3% of essence, 65 to 75% of ethanol, 5% DEET, and 15 to 20% of deionized water.
  • the main problems are:
  • DEET is a broad-spectrum repellent and has a good mosquito repellent effect, but improper use of DEET can cause toxicity problems, especially in high-dose conditions, test animals show dyskinesia, tremor, and convulsions.
  • the commercially available toilet water contains a large amount of ethanol, which can easily irritate the skin when used, cause allergic reactions, and aggravate dermatitis and other symptoms, especially for infants and young children with soft skin.
  • ethanol is a flammable product. Fire is easy to happen. For this reason, most toilet waters are marked with warning words. For example: children should dilute 5 times before use, keep away from fire sources and store, do not expose to the sun, try not to let children use and play with toilet water alone.
  • the function of commercially available toilet water is mainly divided into two types: mosquito repellent and antipruritic.
  • the functions are relatively single, and the skin inflammation caused by mosquito bites cannot be effectively inhibited.
  • the technical problem to be solved by the present invention is to address the deficiencies in the prior art mentioned above, and provide a non-toxic, non-irritating human body, and has a bacteriostatic and anti-inflammatory effect, and a method for preparing the same.
  • the technical solutions adopted by the present invention are:
  • the invention provides an alcohol-free bacteriostatic toilet water, which includes the following raw materials by weight:
  • Sophora flavescens extract 5-10 parts of Sophora flavescens extract, 8-10 parts of Rehmannia glutinosa extract, 8-12 parts of Propolis extract, 8-12 parts of Sophora flavescens-Rehmannia glutinosa-Propolis-Dangjing soaking solution mixture, 80-90 parts of water;
  • the sophora flavescens-rehmannia glutinosa-propolis-huangjing soaking solution mixture is a concentrated solution obtained by soaking flavescens, rehmannia glutinosa, propolis, and huangjing in ethanol and removing the ethanol.
  • the sophora flavescens-rehmannia glutinosa-propolis-huangjing soaking solution mixture comprises 2.5-5 parts by weight of Sophora flavescens, 4-5 parts by weight Rehmannia glutinosa, 4-6 parts by weight propolis, and 2.5-6 parts by weight Polygonatum A concentrated solution is obtained after soaking and removing the ethanol in 60 to 80 parts by weight of ethanol, and the volume concentration of the ethanol is 75 to 85%.
  • the soaking time is 24 to 36 hours, and the soaking temperature is 45 to 50 ° C.
  • the humectant is selected from at least one of glycerin and propylene glycol
  • the solubilizer is selected from at least one of Tween-20 and PEG-40 hydrogenated castor oil.
  • the invention also provides a method for preparing the alcohol-free bacteriostatic toilet water, which includes the following steps:
  • the particle diameter of the Sophora flavescens, the Rehmannia glutinosa, the propolis and the Polygonatum sibiricum is 20-25 mesh.
  • the cooking temperature is 30-35 ° C, and the cooking time is 50-60 minutes.
  • the mass fraction of the sodium chloride solution is 15-20%, and the soaking time is 20-25 minutes.
  • the filtering conditions are: the pressure at the liquid inlet is 0.1 to 0.2 MPa, the pressure at the liquid outlet is 0.05 to 0.15 MPa, and the liquid flow rate is 1.0 to 1.5 m / s.
  • the alcohol-free bacteriostatic toilet water provided by the present invention comprises a Sophora flavescens extract, Rehmannia glutinosa extract, propolis extract, and a concentrated solution obtained by soaking and removing ethanol from Sophora flavescens, Rehmannia glutinosa, Propolis and Polygonatum in ethanol.
  • Sophora flavescens has the effects of clearing heat and dampness, antibacterial and analgesic effect, Dihuang has the effect of clearing heat and swelling, propolis has the effect of antipruritic, anti-ulcer and anti-allergy, and Huangjing has the effect of enhancing immunity.
  • sophora flavescens, rehmannia glutinosa, and propolis the effective components of each can be better integrated into ethanol, especially the addition of Huangjing, which greatly improves the dissolution rate of the effective ingredients of Sophora flavescens, Rehmannia glutinosa, and propolis, thereby improving the detoxification and detoxification of toilet water.
  • Sophora flavescens-Dihuang-Propolis-Polygonatum infusion mixture and the water extract of Sophora flavescens, Dihuang, propolis synergistically can not only enhance the skin's self-defense ability, but also Enhance the skin's adaptability to various active ingredients, help to improve the adsorption of functional ingredients on the skin surface, and the effect is longer lasting.
  • sophora flavescens-rehmannia glutinosa-propolis-huangjing soaking solution mixture is a concentrated solution obtained by soaking flavescens, rehmannia glutinosa, propolis, and huangjing in ethanol and removing ethanol, so that the toilet water provided by the present invention does not contain ethanol and is an alcohol-free product. It is safer to use, especially suitable for children, pregnant women and those who are allergic to ethanol, expanding the application of toilet water.
  • the alcohol-free antibacterial toilet water provided by the present invention also includes honeysuckle extract, wild chrysanthemum extract, mint extract, wormwood extract, terpineol, linalool, and chlorohexyl gluconate.
  • honeysuckle extract wild chrysanthemum extract
  • mint extract wormwood extract
  • terpineol wormwood extract
  • linalool chlorohexyl gluconate
  • the preparation method of the alcohol-free bacteriostatic toilet water provided by the present invention, firstly soaking a part of Sophora flavescens, Dihuang and propolis with Polygonatum in ethanol, so that the active ingredients of Sophora flavescens, Rehmannia glutinosa and Propolis are incorporated into ethanol, and then with another part of Sophora flavescens , Rehmannia glutinosa, and propolis are mixed with extracts obtained by water extraction, which ultimately improves the effectiveness of toilet water in clearing heat and detoxifying, reducing swelling and pain, sterilizing and sterilizing, mosquito and insect repellent, and enhancing skin immunity.
  • the organic combination of immersion and water extraction technology greatly improves the dissolution rate of each active ingredient and maximizes its effectiveness.
  • the ethanol of Sophora flavescens, Rehmannia glutinosa, Propolis and Polygonatum is removed by concentration, which improves the safety of subsequent production and use. Meet environmental requirements.
  • the invention provides an alcohol-free bacteriostatic toilet water, which includes the following raw materials by weight:
  • Sophora flavescens extract 9 parts of Rehmannia glutinosa extract, 10 parts of Propolis extract, 10 parts of Sophora flavescens-Rehmannia glutinosa-Propolis-Dangjing soaking solution mixture, 12.5 parts of honeysuckle extract, 12.5 parts of wild chrysanthemum extract, 10 mint extract 20 parts, Artemisia oleifera extract, 4.5 parts terpineol, 4.5 parts linalool, 2 parts chlorhexidine gluconate, 12.5 parts humectant, 35 parts solubilizer, and 85 parts water.
  • sophora flavescens-rehmannia glutinosa-propolis-huangjing soaking solution mixture is soaked in 70 parts by weight of ethanol by 3.75 parts by weight of Sophora flavescens, 4.5 parts by weight of Rehmannia glutinosa, 5 parts by weight of propolis and 4 parts by weight of huangjing A concentrated solution was obtained afterwards.
  • the volume concentration of ethanol was 80%, the soaking time was 30 hours, and the soaking temperature was 48 ° C.
  • the humectant is glycerin and the solubilizer is Tween-20.
  • the invention provides a method for preparing alcohol-free bacteriostatic toilet water prepared by using the above raw materials, including the following steps:
  • the particle sizes of Sophora flavescens, Dihuang, Propolis and Polygonatum are all 20 mesh.
  • honeysuckle extract After crushing honeysuckle, wild chrysanthemum, mint, and wormwood leaves, add them to a 17.5% sodium chloride solution and soak them for 22 minutes. Distill and collect the distillate to obtain honeysuckle extract, wild chrysanthemum extract, Mint extract and Artemisia sylvestris extract, then take 12.5 parts by weight of honeysuckle extract, 12.5 parts by weight of wild chrysanthemum extract, 10 parts by weight of mint extract, 20 parts by weight of wormwood extract, and add 4.5 parts by weight of pine oil Alcohol, 4.5 parts by weight of linalool, 2 parts by weight of chlorhexidine gluconate, 12.5 parts by weight of glycerin, and 35 parts by weight of Tween-20 to obtain a second medicinal solution mixture;
  • the first chemical liquid mixture prepared in step (2) and the second chemical liquid mixture prepared in step (3) are mixed and filtered, the liquid inlet pressure is 0.15 MPa, the liquid outlet pressure is 0.10 MPa, and the liquid flow rate is 1.2 m / s to obtain alcohol-free antibacterial toilet water.
  • the invention provides an alcohol-free bacteriostatic toilet water, which includes the following raw materials by weight:
  • sophora flavescens-rehmannia glutinosa-propolis-huangjing soaking solution mixture is immersed in 2.5 parts by weight of Sophora flavescens, 5 parts by weight of Rehmannia glutinosa, 6 parts by weight of propolis and 6 parts by weight of Polygonatum in ethanol and removing ethanol A concentrated solution was obtained afterwards.
  • the volume concentration of ethanol was 75%, the soaking time was 36 hours, and the soaking temperature was 45 ° C.
  • the humectant is propylene glycol and the solubilizing agent is PEG-40 hydrogenated castor oil.
  • the invention provides a method for preparing alcohol-free bacteriostatic toilet water prepared by using the above raw materials, including the following steps:
  • the invention provides an alcohol-free bacteriostatic toilet water, which includes the following raw materials by weight:
  • Sophora flavescens extract 5 parts of Sophora flavescens extract, 10 parts of Rehmannia glutinosa extract, 8 parts of Propolis extract, 8 parts of Sophora flavescens-Rehmannia glutinosa-Propolis-Dangjing soaking solution mixture, 10 parts of honeysuckle extract, 15 parts of wild chrysanthemum extract, 8 parts of mint extract Parts, 15 parts of wormwood extract, 6 parts of terpineol, 6 parts of linalool, 1 part of chlorhexidine gluconate, 15 parts of humectant, 40 parts of solubilizer, and 90 parts of water.
  • sophora flavescens-rehmannia glutinosa-propolis-huangjing soaking solution mixture is soaked in 80 parts by weight of ethanol by 5 parts by weight of Sophora flavescens, 4 parts by weight of Rehmannia glutinosa, 4 parts by weight of propolis, and 2.5 parts by weight of Polygonatum glutinosa.
  • a concentrated solution was obtained afterwards.
  • the volume concentration of ethanol is 85%, the soaking time is 24 hours, and the soaking temperature is 50 ° C.
  • the invention provides a method for preparing alcohol-free bacteriostatic toilet water prepared by using the above raw materials, including the following steps:
  • the particle sizes of Sophora flavescens, Dihuang, Propolis and Polygonatum are all 20 mesh.
  • the first chemical liquid mixture prepared in step (2) and the second chemical liquid mixture prepared in step (3) are mixed and filtered, the liquid inlet pressure is 0.2 MPa, the liquid outlet pressure is 0.15 MPa, and the liquid flow rate is 1.5 m / s to obtain alcohol-free antibacterial toilet water.
  • the invention provides an alcohol-free bacteriostatic toilet water, which includes the following raw materials by weight:
  • the humectant is glycerin and the solubilizer is Tween-20.
  • the invention provides a method for preparing alcohol-free bacteriostatic toilet water prepared by using the above raw materials, including the following steps:
  • honeysuckle extract After crushing honeysuckle, wild chrysanthemum, mint, and wormwood leaves, add them to a 17.5% sodium chloride solution and soak them for 22 minutes. Distill and collect the distillate to obtain honeysuckle extract, wild chrysanthemum extract, Mint extract and Artemisia sylvestris extract, then take 12.5 parts by weight of honeysuckle extract, 12.5 parts by weight of wild chrysanthemum extract, 10 parts by weight of mint extract, 20 parts by weight of wormwood extract, and add 4.5 parts by weight of pine oil Alcohol, 4.5 parts by weight of linalool, 2 parts by weight of chlorhexidine gluconate, 12.5 parts by weight of glycerin, and 35 parts by weight of Tween-20 to obtain a second medicinal solution mixture;
  • the first chemical liquid mixture prepared in step (2) and the second chemical liquid mixture prepared in step (3) are mixed and filtered, the liquid inlet pressure is 0.15 MPa, the liquid outlet pressure is 0.10 MPa, and the liquid flow rate is 1.2 m / s to obtain alcohol-free antibacterial toilet water.
  • Sophora flavescens extract 9 parts of Rehmannia glutinosa extract, 10 parts of propolis extract, 12.5 parts of honeysuckle extract, 12.5 parts of wild chrysanthemum extract, 10 parts of mint extract, 20 parts of wormwood extract, 4.5 parts of terpineol, 4.5 parts of linalool, 2 parts of chlorhexidine gluconate, 12.5 parts of humectant, 35 parts of solubilizer, 85 parts of water.
  • the first chemical liquid mixture prepared in step (1) and the second chemical liquid mixture prepared in step (2) are mixed and filtered, the liquid inlet pressure is 0.15 MPa, the liquid outlet pressure is 0.10 MPa, and the liquid flow rate is 1.2 m / s to obtain alcohol-free antibacterial toilet water.
  • Example 1-3 Compare the alcohol-free bacteriostatic toilet water prepared in Example 1-3 with the toilet water prepared in Comparative Example 1-2. Put 300 female mosquitoes in a 30cm ⁇ 30cm ⁇ 40cm mosquito cage. A total of 100 healthy volunteers were selected. Before the age of 15 to 60 years, men and women were divided into half. Apply 0.12ml / cm 2 of toilet water on the back of the subject's hand, and then put the hand into a mosquito cage. Expose it for 5 minutes every hour. 6h, and record the number of mosquito bites and calculate the effective protection rate. The test temperature is 27 to 32 ° C, the humidity is 40 to 55%, and the light is dim. The average number of untreated hand bites was 27.
  • Effective protection rate the number of effective attractants within that time / the total number of applied attractants ⁇ 100% (the number of effective attractants refers to the number of attractants that have not been bitten by a mosquito, and the attractant is invalidated by the first mosquito bite), which The results are shown in Table 2.

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Abstract

本发明属于日用化学品领域，具体涉及一种无醇抑菌花露水及其制备方法。该无醇抑菌花露水包括苦参提取物、地黄提取物、蜂胶提取物以及由苦参、地黄、蜂胶、黄精在乙醇中浸泡并除去乙醇后得到的浓缩液，黄精的加入提高了苦参、地黄、蜂胶有效成分在乙醇中的溶出率，提高了花露水清热解毒、消肿止痛、除菌杀菌的功效；同时，将苦参-地黄-蜂胶-黄精浸泡液混合物与苦参、地黄、蜂胶的水提取物协同配合，增强了皮肤的自防御能力以及对各种有效成分的适应性，有助于改善功能成分在皮肤表面的吸附性，药效更持久；同时，该花露水不含乙醇，使用更安全。本发明通过浸泡和水提工艺进行有机结合，使得各有效成分溶出率大大提高，功效发挥极致。

Description

无醇抑菌花露水及其制备方法 技术领域
本发明属于日用化学品领域，具体涉及一种无醇抑菌花露水及其制备方法。
背景技术
随着炎炎夏日到来，蚊虫叮咬困扰着人们的生活，蚊虫体内携带多种致病微生物，被蚊虫叮咬后，不仅造成皮肤红肿、瘙痒，还可能被传播多种疾病，如登革热、疟疾、流行性乙型脑炎等，严重危害人类健康。作为驱蚊产品，花露水具有使用方便、不受时间和使用条件的限制、便于携带等特点，因此广泛受到人们的热爱。花露水是用花露油作为主体香料，配以乙醇制成的一种香水类产品，其主要功效在于清凉提神、防痱止痒、去污杀菌。
一般市售花露水配方以1～3％的香精、65～75％的乙醇、5％的避蚊胺(DEET)、15～20％的去离子水为主，其存在的主要问题为：
1.避蚊胺是广谱驱避剂，驱蚊效果良好，但避蚊胺使用不当会出现毒性问题，尤其在高剂量条件下，试验动物出现运动失调、震颤、惊厥等。
2.市售花露水含有大量乙醇，使用时容易刺激皮肤，出现过敏反应，加重皮炎等症状，特别是对肌肤柔嫩的婴幼儿刺激更为突出；同时，乙醇属于易燃品，在生产和使用时容易发生火灾，为此，大多花露水都标有警示用语，例如：儿童应稀释5倍后使用，远离火源使用和储存，切勿暴晒，尽量不要让儿童单独使用和玩耍花露水等等。
3.市售花露水功能主要分为驱蚊和止痒两种，功能较为单一，对于蚊虫叮咬后给皮肤带来的皮肤炎症无法给予有效地抑制。
因此，提供一种无毒、对人体无刺激且具有抑菌消炎功效的花露水是目前日用化学品领域亟需解决的问题。
发明内容
本发明所要解决的技术问题在于针对上述现有技术中的不足，提供一种无毒、对人体无刺激并具有抑菌消炎功效的花露水以及该花露水的制备方法。
为解决上述技术问题，本发明采用的技术方案是：
本发明提供一种无醇抑菌花露水，包括以下重量份的原料：
苦参提取物5～10份，地黄提取物8～10份，蜂胶提取物8～12份，苦参-地黄-蜂胶-黄精浸泡液混合物8～12份，水80～90份；
其中，所述苦参-地黄-蜂胶-黄精浸泡液混合物是由苦参、地黄、蜂胶、黄精在乙醇中浸泡并除去所述乙醇后得到的浓缩液。
优选地，所述苦参-地黄-蜂胶-黄精浸泡液混合物是由2.5～5重量份的苦参、4～5重量份的地黄、4～6重量份的蜂胶以及2.5～6重量份的黄精在60～80重量份的乙醇中浸泡并除去所述乙醇后得到浓缩液，所述乙醇的体积浓度为75～85％。
优选地，所述浸泡的时间为24～36小时，所述浸泡的温度为45～50℃。
进一步优选地，还包括以下重量份的原料：
金银花提取物10～15份，野菊花提取物10～15份，薄荷提取物8～12份，艾叶提取物15～25份，松油醇3～6份，芳樟醇3～6份，葡萄糖酸氯己定1～3份，保湿剂10～15份，增溶剂30～40份。
进一步优选地，所述保湿剂选自甘油、丙二醇中的至少一种，所 述增溶剂选自吐温-20、PEG-40氢化蓖麻油中的至少一种。
本发明还提供上述无醇抑菌花露水的制备方法，包括以下步骤：
(1)将2.5～5重量份的苦参、4～5重量份的地黄、4～6重量份的蜂胶以及2.5～6重量份的黄精在60～80重量份的乙醇中浸泡，浓缩除去所述乙醇，得到苦参-地黄-蜂胶-黄精浸泡液混合物，备用；
(2)将苦参、地黄以及蜂胶分别在40～45重量份的水中煎煮，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取5～10重量份的苦参提取物、8～10重量份的地黄提取物以及8～12重量份的蜂胶提取物混合，加入80～90重量份的水；然后加入步骤(1)中制备的所述苦参-地黄-蜂胶-黄精浸泡液混合物，搅拌，静置，得到第一药液混合物；
(3)将金银花、野菊花、薄荷、艾叶粉碎后加至氯化钠溶液中浸泡，蒸馏，收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，取10～15重量份的金银花提取物、10～15重量份的野菊花提取物、8～12重量份的薄荷提取物、15～25重量份的艾叶提取物，加入3～6重量份的松油醇、3～6重量份的芳樟醇、1～3重量份的葡萄糖酸氯己定、10～15重量份的保湿剂、30～40重量份的增溶剂，即得第二药液混合物；
(4)将步骤(2)制备的所述第一药液混合物和步骤(3)制备的所述第二药液混合物混合，过滤，即得所述无醇抑菌花露水。
优选地，步骤(1)中，所述苦参、所述地黄、所述蜂胶、所述黄精的粒径为20～25目。
优选地，步骤(2)中，所述煎煮温度为30～35℃，所述煎煮时间为50～60分钟。
优选地，步骤(3)中，所述氯化钠溶液的质量分数为15～20％， 所述浸泡的时间为20～25分钟。
优选地，步骤(4)中，所述过滤条件为：进液口压力为0.1～0.2MPa，出液口压力为0.05～0.15MPa，液体流速为1.0～1.5米/秒。
本发明技术方案，具有如下优点：
1.本发明提供的无醇抑菌花露水，包括苦参提取物、地黄提取物、蜂胶提取物以及由苦参、地黄、蜂胶、黄精在乙醇中浸泡并除去乙醇后得到的浓缩液。
苦参具有清热燥湿、抗菌、止痛的功效，地黄有清热、消肿的功效，蜂胶具有止痒、抗溃疡、抗过敏的功效，黄精有增强免疫的功效。苦参、地黄、蜂胶经过在乙醇中长时间浸泡，各自有效成分能够更好融入乙醇，尤其黄精的加入，使得苦参、地黄、蜂胶的有效成分的溶出率大大提高，从而提高了花露水清热解毒、消肿止痛、除菌杀菌的功效；同时，将苦参-地黄-蜂胶-黄精浸泡液混合物与苦参、地黄、蜂胶的水提取物协同配合，既能增强皮肤的自防御能力，又能增强皮肤对各种有效成分的适应性，有助于改善功能成分在皮肤表面的吸附性，药效更持久。
而且，苦参-地黄-蜂胶-黄精浸泡液混合物是由苦参、地黄、蜂胶、黄精在乙醇中浸泡并除去乙醇后得到的浓缩液，使得本发明提供的花露水不含乙醇，为无醇产品，使用更安全，尤其适合儿童、孕妇以及对乙醇过敏者，扩大了花露水的应用范围。
2.本发明提供的无醇抑菌花露水，还包括金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物、松油醇、芳樟醇、葡萄糖酸氯己，在具备水清热解毒、消肿止痛、除菌杀菌以及增强皮肤免疫力的基础上，还具有持久的驱蚊虫效果，缓解蚊虫叮咬后给皮肤带来的皮肤炎症。
3.本发明提供的无醇抑菌花露水的制备方法，先将一部分苦参、地黄、蜂胶配合黄精在乙醇中浸泡，使得苦参、地黄、蜂胶的有效成分融入乙醇，然后与另一部分苦参、地黄、蜂胶通过水提得到提取物混合，最终提高了花露水清热解毒、消肿止痛、除菌杀菌、驱蚊灭虫以及增强皮肤免疫力的功效。通过浸泡和水提工艺进行有机结合，使得各有效成分溶出率大大提高，功效发挥极致；而且，浸泡苦参、地黄、蜂胶、黄精的乙醇通过浓缩除去，提高了后续生产和使用的安全性，满足环保要求。
具体实施方式
为了便于理解本发明的目的、技术方案和要点，下面将对本发明的实施方式作进一步详细描述。本发明可以多种不同的形式实施，而不应该被理解为仅限于在此阐述的实施例。相反，提供此实施例，使得本发明将是彻底的和完整的，并且将把本发明的构思充分传达给本领域技术人员，本发明将仅由权利要求来限定。
实施例1
本发明提供一种无醇抑菌花露水，包括以下重量份的原料：
苦参提取物7.5份，地黄提取物9份，蜂胶提取物10份，苦参-地黄-蜂胶-黄精浸泡液混合物10份，金银花提取物12.5份，野菊花提取物12.5份，薄荷提取物10份，艾叶提取物20份，松油醇4.5份，芳樟醇4.5份，葡萄糖酸氯己定2份，保湿剂12.5份，增溶剂35份，水85份。
其中，苦参-地黄-蜂胶-黄精浸泡液混合物是由3.75重量份的苦参、4.5重量份的地黄、5重量份的蜂胶以及4重量份的黄精在70重量份的乙醇中浸泡并除去乙醇后得到浓缩液。乙醇的体积浓度为80％，浸泡的时间为30小时，浸泡的温度为48℃。
上述保湿剂为甘油，增溶剂为吐温-20。
本发明提供一种采用上述原料制备得到的无醇抑菌花露水的制备方法，包括以下步骤：
(1)将3.75重量份的苦参、4.5重量份的地黄、5重量份的蜂胶以及4重量份的黄精在70重量份的80％乙醇中浸泡，浸泡的时间为30小时，浸泡的温度为48℃，然后减压浓缩蒸去乙醇，得到苦参-地黄-蜂胶-黄精浸泡液混合物，备用；
其中，苦参、地黄、蜂胶和黄精的粒径均为20目。
(2)将苦参、地黄以及蜂胶分别在42.5重量份的水中煎煮，煎煮温度为32.5℃，煎煮时间为55分钟，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取7.5重量份的苦参提取物、9重量份的地黄提取物以及10重量份的蜂胶提取物，加入85重量份的水；然后加入步骤(1)中制备的苦参-地黄-蜂胶-黄精浸泡液混合物，搅拌，静置，得到第一药液混合物；
(3)将金银花、野菊花、薄荷、艾叶粉碎后分别加至质量分数为17.5％的氯化钠溶液中浸泡22分钟，分别蒸馏，分别收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，然后取12.5重量份的金银花提取物、12.5重量份的野菊花提取物、10重量份的薄荷提取物、20重量份的艾叶提取物，加入4.5重量份的松油醇、4.5重量份的芳樟醇、2重量份的葡萄糖酸氯己定、12.5重量份的甘油、35重量份的吐温-20，即得第二药液混合物；
(4)将步骤(2)制备的第一药液混合物和步骤(3)制备的第二药液混合物混合，过滤，进液口压力为0.15MPa，出液口压力为0.10MPa，液体流速为1.2米/秒，得无醇抑菌花露水。
实施例2
本发明提供一种无醇抑菌花露水，包括以下重量份的原料：
苦参提取物10份，地黄提取物8份，蜂胶提取物8份，苦参-地黄-蜂胶-黄精浸泡液混合物12份，金银花提取物15份，野菊花提取物10份，薄荷提取物12份，艾叶提取物15份，松油醇3份，芳樟醇3份，葡萄糖酸氯己定3份，保湿剂10份，增溶剂30份，水80份。
其中，苦参-地黄-蜂胶-黄精浸泡液混合物是由2.5重量份的苦参、5重量份的地黄、6重量份的蜂胶以及6重量份的黄精在60重量份的乙醇中浸泡并除去乙醇后得到浓缩液。乙醇的体积浓度为75％，浸泡的时间为36小时，浸泡的温度为45℃。
上述保湿剂为丙二醇，增溶剂为PEG-40氢化蓖麻油。
本发明提供一种采用上述原料制备得到的无醇抑菌花露水的制备方法，包括以下步骤：
(1)将2.5重量份的苦参、5重量份的地黄、6重量份的蜂胶以及6重量份的黄精在60重量份的75％乙醇中浸泡，浸泡的时间为36小时，浸泡的温度为45℃，然后减压浓缩蒸去乙醇，得到苦参-地黄-蜂胶-黄精浸泡液混合物，备用；
其中，苦参、地黄、蜂胶和黄精的粒径均为25目。
(2)将苦参、地黄以及蜂胶分别在40重量份的水中煎煮，煎煮温度为35℃，煎煮时间为50分钟，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取10重量份的苦参提取物、8重量份的地黄提取物以及8重量份的蜂胶提取物，加入80重量份的水；然后加入步骤(1)中制备的苦参-地黄-蜂胶-黄精浸泡液混合物，搅拌，静置，得到第一药液混合物；
(3)将金银花、野菊花、薄荷、艾叶粉碎后分别加至质量分数 为15％的氯化钠溶液中浸泡25分钟，分别蒸馏，分别收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，然后取15重量份的金银花提取物、10重量份的野菊花提取物、12重量份的薄荷提取物、25重量份的艾叶提取物，加入3重量份的松油醇、3重量份的芳樟醇、3重量份的葡萄糖酸氯己定、10重量份的丙二醇、30重量份的PEG-40氢化蓖麻油，即得第二药液混合物；
(4)将步骤(2)制备的第一药液混合物和步骤(3)制备的第二药液混合物混合，过滤，进液口压力为0.1MPa，出液口压力为0.05MPa，液体流速为1.0米/秒，得无醇抑菌花露水。
实施例3
本发明提供一种无醇抑菌花露水，包括以下重量份的原料：
苦参提取物5份，地黄提取物10份，蜂胶提取物8份，苦参-地黄-蜂胶-黄精浸泡液混合物8份，金银花提取物10份，野菊花提取物15份，薄荷提取物8份，艾叶提取物15份，松油醇6份，芳樟醇6份，葡萄糖酸氯己定1份，保湿剂15份，增溶剂40份，水90份。
其中，苦参-地黄-蜂胶-黄精浸泡液混合物是由5重量份的苦参、4重量份的地黄、4重量份的蜂胶以及2.5重量份的黄精在80重量份的乙醇中浸泡并除去乙醇后得到浓缩液。乙醇的体积浓度为85％，浸泡的时间为24小时，浸泡的温度为50℃。
上述保湿剂为甘油和丙二醇，质量比为1:1；增溶剂为吐温-20和PEG-40氢化蓖麻油，质量比为1:1。
本发明提供一种采用上述原料制备得到的无醇抑菌花露水的制备方法，包括以下步骤：
(1)将5重量份的苦参、4重量份的地黄、4重量份的蜂胶以及 2.5重量份的黄精在80重量份的85％乙醇中浸泡，浸泡的时间为24小时，浸泡的温度为50℃，然后减压浓缩蒸去乙醇，得到苦参-地黄-蜂胶-黄精浸泡液混合物，备用；
其中，苦参、地黄、蜂胶和黄精的粒径均为20目。
(2)将苦参、地黄以及蜂胶分别在45重量份的水中煎煮，煎煮温度为30℃，煎煮时间为60分钟，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取5重量份的苦参提取物、10重量份的地黄提取物以及8重量份的蜂胶提取物，加入90重量份的水；然后加入步骤(1)中制备的苦参-地黄-蜂胶-黄精浸泡液混合物，搅拌，静置，得到第一药液混合物；
(3)将金银花、野菊花、薄荷、艾叶粉碎后分别加至质量分数为20％的氯化钠溶液中浸泡20分钟，分别蒸馏，分别收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，然后取10重量份的金银花提取物、15重量份的野菊花提取物、8重量份的薄荷提取物、15重量份的艾叶提取物，加入6重量份的松油醇、6重量份的芳樟醇、1重量份的葡萄糖酸氯己定、7.5重量份的甘油、.5重量份的丙二醇、20重量份的吐温-20、20重量份的PEG-40氢化蓖麻油，即得第二药液混合物；
(4)将步骤(2)制备的第一药液混合物和步骤(3)制备的第二药液混合物混合，过滤，进液口压力为0.2MPa，出液口压力为0.15MPa，液体流速为1.5米/秒，得无醇抑菌花露水。
对比例1
本发明提供一种无醇抑菌花露水，包括以下重量份的原料：
苦参提取物7.5份，地黄提取物9份，蜂胶提取物10份，苦参-地黄-蜂胶浸泡液混合物12.5份，金银花提取物12.5份，野菊花提取 物12.5份，薄荷提取物10份，艾叶提取物20份，松油醇4.5份，芳樟醇4.5份，葡萄糖酸氯己定2份，保湿剂12.5份，增溶剂35份，水85份。
其中，苦参-地黄-蜂胶浸泡液混合物是由3.75重量份的苦参、4.5重量份的地黄、5重量份的蜂胶在70重量份的乙醇中浸泡并除去乙醇后得到浓缩液。乙醇的体积浓度为80％，浸泡的时间为30小时，浸泡的温度为48℃。
上述保湿剂为甘油，增溶剂为吐温-20。
本发明提供一种采用上述原料制备得到的无醇抑菌花露水的制备方法，包括以下步骤：
(1)将3.75重量份的苦参、4.5重量份的地黄以及5重量份的蜂胶在70重量份的80％乙醇中浸泡，浸泡的时间为30小时，浸泡的温度为48℃，然后减压浓缩蒸去乙醇，得到苦参-地黄-蜂胶浸泡液混合物，备用；
其中，苦参、地黄和蜂胶的粒径均为20目。
(2)将苦参、地黄以及蜂胶分别在42.5重量份的水中煎煮，煎煮温度为32.5℃，煎煮时间为55分钟，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取7.5重量份的苦参提取物、9重量份的地黄提取物以及10重量份的蜂胶提取物，加入85重量份的水；然后加入步骤(1)中制备的苦参-地黄-蜂胶浸泡液混合物，搅拌，静置，得到第一药液混合物；
(3)将金银花、野菊花、薄荷、艾叶粉碎后分别加至质量分数为17.5％的氯化钠溶液中浸泡22分钟，分别蒸馏，分别收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，然后取12.5重量份的金银花提取物、12.5重量份的野菊花提取物、10重 量份的薄荷提取物、20重量份的艾叶提取物，加入4.5重量份的松油醇、4.5重量份的芳樟醇、2重量份的葡萄糖酸氯己定、12.5重量份的甘油、35重量份的吐温-20，即得第二药液混合物；
(4)将步骤(2)制备的第一药液混合物和步骤(3)制备的第二药液混合物混合，过滤，进液口压力为0.15MPa，出液口压力为0.10MPa，液体流速为1.2米/秒，得无醇抑菌花露水。
对比例2
本发明提供一种无醇抑菌花露水，包括以下重量份的原料：
苦参提取物7.5份，地黄提取物9份，蜂胶提取物10份，金银花提取物12.5份，野菊花提取物12.5份，薄荷提取物10份，艾叶提取物20份，松油醇4.5份，芳樟醇4.5份，葡萄糖酸氯己定2份，保湿剂12.5份，增溶剂35份，水85份。
本发明提供一种采用上述原料制备得到的无醇抑菌花露水的制备方法，包括以下步骤：
(1)将苦参、地黄以及蜂胶分别在42.5重量份的水中煎煮，煎煮温度为32.5℃，煎煮时间为55分钟，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取7.5重量份的苦参提取物、9重量份的地黄提取物以及10重量份的蜂胶提取物，加入85重量份的水，得到第一药液混合物；
(2)将金银花、野菊花、薄荷、艾叶粉碎后分别加至质量分数为17.5％的氯化钠溶液中浸泡22分钟，分别蒸馏，分别收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，然后取12.5重量份的金银花提取物、12.5重量份的野菊花提取物、10重量份的薄荷提取物、20重量份的艾叶提取物，加入4.5重量份的松油醇、4.5重量份的芳樟醇、2重量份的葡萄糖酸氯己定、12.5重量份 的甘油、35重量份的吐温-20，即得第二药液混合物；
(3)将步骤(1)制备的第一药液混合物和步骤(2)制备的第二药液混合物混合，过滤，进液口压力为0.15MPa，出液口压力为0.10MPa，液体流速为1.2米/秒，得无醇抑菌花露水。
测试例1
1.原料成分溶出率
通过高效液相色谱法，检测了本发明实施例1-3、对比例1-2制备的无醇抑菌花露水中所含主要原料苦参、地黄、蜂胶有效成分在乙醇中的溶出率，如表1所示。
表1 原料成分溶出率
  苦参 地黄 蜂胶
实施例1 38.6％ 29.8％ 37.1％
实施例2 35.9％ 26.9％ 34.9％
实施例3 38.0％ 25.1％ 35.0％
对比例1 26.3％ 19.5％ 29.9％
对比例2 19.8％ 10.4％ 22.4％
结果显示，苦参、地黄、蜂胶经过在乙醇中长时间浸泡，使得各自的有效成分更好地融入乙醇，尤其黄精的加入，使得苦参、地黄、蜂胶的有效成分的溶出率大大提高。本发明通过浸泡和水提工艺进行有机结合，使得各有效成分溶出率大大提高，功效发挥极致。
2.气味检查
实施例1-3制备的无醇抑菌花露水无刺激气味，气味清新。
3.驱避试验
将实施例1-3制备的无醇抑菌花露水与对比例1-2制备的花露水对比。在30cm×30cm×40cm的蚊笼内放入300只雌蚊。选取100名身体健康的志愿者，年龄15～60岁之前，男女各半，在受试者手背涂抹约0.12ml/cm 2的花露水，然后将手伸入蚊笼内，每小时暴露5min，观察6h，并记录蚊虫叮咬次数并计算有有效保护率。试验温 度27～32℃，湿度为40～55％，光线暗淡。未处理的人手叮咬平均次数为27次。
有效保护率＝该时间内有效诱体数/施药诱体总数×100％(有效诱体数是指没有被蚊虫叮咬的诱体数量，诱体受第一只蚊叮咬即为失效)，其结果如表2所示。
表2 驱避试验结果
  有效保护率(％)
实施例1 99
实施例2 98
实施例3 98
对比例1 88
对比例2 72
结果显示，本发明提供的无醇抑菌花露水在具有较好的驱蚊效果。
4.抑菌性能测试
以大肠杆菌、金黄色葡萄球菌剂为菌种，采用震荡烧瓶法对实施例1-3、对比例1-2制备的花露水进行抗菌性能测试，检测结果见表3。
表3 抑菌性能测试
Figure PCTCN2018103303-appb-000001
结果显示，本发明提供的无醇抑菌花露水在具有较好的抑菌效果。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用。它完全可以被适用于各种适合本发明的领域。对于熟悉本领域的人员而言，可容易地实现另外的修改。因此在不背 离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (10)

  1. 一种无醇抑菌花露水，其特征在于，包括以下重量份的原料：
    苦参提取物5～10份，地黄提取物8～10份，蜂胶提取物8～12份，苦参-地黄-蜂胶-黄精浸泡液混合物8～12份，水80～90份；
    其中，所述苦参-地黄-蜂胶-黄精浸泡液混合物是由苦参、地黄、蜂胶、黄精在乙醇中浸泡并除去所述乙醇后得到的浓缩液。
  2. 根据权利要求1所述的无醇抑菌花露水，其特征在于，所述苦参-地黄-蜂胶-黄精浸泡液混合物是由2.5～5重量份的苦参、4～5重量份的地黄、4～6重量份的蜂胶以及2.5～6重量份的黄精在60～80重量份的乙醇中浸泡并除去所述乙醇后得到浓缩液，所述乙醇的体积浓度为75～85％。
  3. 根据权利要求1或2所述的无醇抑菌花露水，其特征在于，所述浸泡的时间为24～36小时，所述浸泡的温度为45～50℃。
  4. 根据权利要求3所述的无醇抑菌花露水，其特征在于，还包括以下重量份的原料：
    金银花提取物10～15份，野菊花提取物10～15份，薄荷提取物8～12份，艾叶提取物15～25份，松油醇3～6份，芳樟醇3～6份，葡萄糖酸氯己定1～3份，保湿剂10～15份，增溶剂30～40份。
  5. 根据权利要求4所述的无醇抑菌花露水，其特征在于，所述保湿剂选自甘油、丙二醇中的至少一种，所述增溶剂选自吐温-20、PEG-40氢化蓖麻油中的至少一种。
  6. 一种如权利要求4所述的无醇抑菌花露水的制备方法，其特征在于，包括以下步骤：
    (1)将2.5～5重量份的苦参、4～5重量份的地黄、4～6重量份的蜂胶以及2.5～6重量份的黄精在60～80重量份的乙醇中浸泡， 浓缩除去所述乙醇，得到苦参-地黄-蜂胶-黄精浸泡液混合物，备用；
    (2)将苦参、地黄以及蜂胶分别在40～45重量份的水中煎煮，过滤得滤液，浓缩除水，分别得到苦参提取物、地黄提取物、蜂胶提取物，取5～10重量份的苦参提取物、8～10重量份的地黄提取物以及8～12重量份的蜂胶提取物混合，加入80～90重量份的水；然后加入步骤(1)中制备的所述苦参-地黄-蜂胶-黄精浸泡液混合物，搅拌，静置，得到第一药液混合物；
    (3)将金银花、野菊花、薄荷、艾叶粉碎后加至氯化钠溶液中浸泡，蒸馏，收集蒸馏液，得到金银花提取物、野菊花提取物、薄荷提取物、艾叶提取物，取10～15重量份的金银花提取物、10～15重量份的野菊花提取物、8～12重量份的薄荷提取物、15～25重量份的艾叶提取物，加入3～6重量份的松油醇、3～6重量份的芳樟醇、1～3重量份的葡萄糖酸氯己定、10～15重量份的保湿剂、30～40重量份的增溶剂，即得第二药液混合物；
    (4)将步骤(2)制备的所述第一药液混合物和步骤(3)制备的所述第二药液混合物混合，过滤，即得所述无醇抑菌花露水。
  7. 根据权利要求6所述的制备方法，其特征在于，步骤(1)中，所述苦参、所述地黄、所述蜂胶、所述黄精的粒径为20～25目。
  8. 根据权利要求6或7所述的制备方法，其特征在于，步骤(2)中，所述煎煮温度为30～35℃，所述煎煮时间为50～60分钟。
  9. 根据权利要求6或7所述的制备方法，其特征在于，步骤(3)中，所述氯化钠溶液的质量分数为15～20％，所述浸泡的时间为20～25分钟。
  10. 根据权利要求6或7所述的制备方法，其特征在于，步骤(4)中，所述过滤条件为：进液口压力为0.1～0.2MPa，出液口压力为 0.05～0.15MPa，液体流速为1.0～1.5米/秒。
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Publication number Priority date Publication date Assignee Title
CN101461771A (zh) * 2009-01-06 2009-06-24 天津郁美净集团有限公司 无醇中药花露水及其生产方法
CN103432051A (zh) * 2013-06-29 2013-12-11 安徽榄菊日用制品有限公司 一种驱蚊止痒花露水及其制备方法
CN103690449A (zh) * 2013-12-17 2014-04-02 天津商业大学 无醇驱蚊花露水及其制备方法
CN104721078A (zh) * 2013-12-22 2015-06-24 王新 一种美白花露水

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461771A (zh) * 2009-01-06 2009-06-24 天津郁美净集团有限公司 无醇中药花露水及其生产方法
CN103432051A (zh) * 2013-06-29 2013-12-11 安徽榄菊日用制品有限公司 一种驱蚊止痒花露水及其制备方法
CN103690449A (zh) * 2013-12-17 2014-04-02 天津商业大学 无醇驱蚊花露水及其制备方法
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