WO2019235598A1

WO2019235598A1 - Needleless syringe

Info

Publication number: WO2019235598A1
Application number: PCT/JP2019/022645
Authority: WO
Inventors: 崇将鈴木; 山本　裕三; 洋宮崎
Original assignee: 株式会社ダイセル
Priority date: 2018-06-06
Filing date: 2019-06-06
Publication date: 2019-12-12
Also published as: JPWO2019235598A1; JP2024040513A; JP7441166B2

Abstract

The present disclosure provides a needleless syringe for injecting an injection target substance into a region for injection by ejecting the injection target substance without using an injection needle and in a state in which the region for injection is pressed. The needleless syringe is provided with a nozzle part and a pressing part, with a predetermined gap formed between the nozzle part and the pressing part. The pressing part is formed such that the width of a tip-end part thereof is thinner than the width of a tip-end part of the nozzle part, and, as the region for injection is pressed by the pressing part, the predetermined gap accommodates a part of the region for injection. The configuration makes it possible to form and maintain a desired contact state between the region for injection and the nozzle part in a preferable manner.

Description

Needleless syringe

The present invention relates to a needleless syringe that injects an injection target substance into an injection target region without using an injection needle.

A needleless syringe that ejects an injection solution without going through an injection needle and injects the object is widely known. For example, in the needleless syringe described in Patent Document 1, a cylindrical skirt is formed on the distal end side, and an injection tube is disposed in a compartment defined by the skirt. In the needleless syringe, the air in the compartment is sucked by the suction pump with the open end of the skirt pressed against the patient's skin. Then, it is disclosed that the patient's skin is sucked into the compartment and the skin near the tip of the injection tube is kept in a stable state.

US Pat. No. 6,406,456

A needleless syringe is provided with a nozzle part formed with an injection port for injecting an injection target substance. In such a needleless syringe, in order to accurately deliver the injection target substance ejected from the ejection port to the target site of the injection target area, an appropriate contact state is formed between the injection target area and the nozzle portion, This state must be maintained during injection of the injection target substance into the target site. In addition, the contact state between the injection target region and the nozzle part that enables accurate delivery of the injection target substance to the target site of the injection target region in this way may be hereinafter referred to as “desired contact state”. is there.

However, the contact state between the injection target region and the nozzle portion can change due to a difference in user's technique or the like. Therefore, if the user simply presses the nozzle portion against the surface of the injection target region, it may be difficult to form a desired contact state. Moreover, even if a desired contact state is formed when the nozzle portion is first brought into contact with the surface of the injection target region, for example, if a skid or the like occurs during the injection operation, The contact state between the target region and the nozzle portion changes. That is, if the user simply presses the nozzle portion against the surface of the injection target region, it may be difficult to maintain a desired contact state.

Here, according to the needleless syringe described in Patent Document 1, the skin of the patient is sucked into the compartment by decompressing the compartment. Therefore, according to this technology, it seems that a desired contact state can be formed and maintained relatively easily. However, without a configuration for decompressing the compartment, a desired contact state cannot be formed and maintained between the injection target region and the nozzle portion.

In view of the above-described problems, an object of the present invention is to provide a needleless syringe that can suitably form and maintain a desired contact state between an injection target region and a nozzle portion.

The needleless syringe of the present invention includes a nozzle portion and a pressing portion, and a predetermined gap is formed between the nozzle portion and the pressing portion. And in order to solve the said subject, a press part is formed so that the width | variety of the front-end | tip part may become narrower than the width | variety of the front-end | tip part of a nozzle part, and when an injection object area | region is pressed by a press part, predetermined | prescribed part The gap accommodates a part of the injection target area. With such a configuration, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion.

Specifically, the needleless syringe of the present invention is a method for injecting an injection target substance into the injection target area by injecting the injection target substance in a state where the injection target area is pressed without using an injection needle. A needle injector, which is provided in a housing of the needle-free injector, for accommodating the injection target substance, and for injecting the injection target substance provided in the housing and received in the storage part A drive unit that generates injection energy, and a nozzle unit that protrudes from a predetermined end that is a predetermined end on the housing unit side of the housing, and is provided with the injection energy generated by the drive unit An injection port for injecting the injected injection target material toward the injection target region is formed, and when the injection target material is injected from the injection port, the tip is in contact with the injection target region. A pressing portion provided so as to protrude from the predetermined end portion so as to form a predetermined gap between the nozzle portion configured to and the nozzle portion and surrounding the nozzle portion, A pressing portion configured such that a tip portion comes into contact with the injection target region when the injection target substance is injected from an injection port. And in the needleless syringe of this invention, the width | variety of the part which contacts the said injection object area | region in the front-end | tip part of the said press part becomes narrower than the width | variety of the part which contacts the said injection | pouring object area | region in the front-end | tip part of the said nozzle part. When the injection target area is pressed by the pressing portion, the predetermined gap accommodates a part of the injection target area.

In the needleless syringe of the present invention, when the injection target area is pressed by the pressing part, the part of the injection target area surrounded by the pressing part tends to rise toward the syringe. However, in the above needleless syringe, the nozzle portion is provided so as to protrude from a predetermined end portion of the housing and be surrounded by a pressing portion that presses the injection target region. Therefore, a part of the region surrounded by the pressing portion in the injection target region is pressed by the tip portion of the nozzle portion. Further, another part of the region enters the predetermined gap so as to rise toward the syringe as described above. When the injection target area and the nozzle portion are brought into contact with each other in this way, a desired contact state is easily formed and maintained between the injection target area and the nozzle portion.

However, when the injection target area is pressed by the pressing part, the injection target area may not be sufficiently pressed unless the tip of the pressing part and the surface of the injection target area are in good contact with each other. As a result, when the injection target substance is injected into the injection target area, if the desired contact state is not formed and maintained between the injection target area and the nozzle part, the injection target substance is accurately injected. There is a possibility that it cannot be delivered to the target part of the target region.

Therefore, in the needleless syringe according to the present invention, the width of the portion in contact with the injection target region in the tip portion of the pressing portion is smaller than the width of the portion in contact with the injection target region in the tip portion of the nozzle portion, A pressing part is formed. In addition, the said width | variety in a press part and a nozzle part is a width | variety when each syringe is seen in the longitudinal cross-section of a housing, and is a width | variety in each front-end | tip part which touches an injection object area | region. Then, compared with the case where a press part is formed so that the said width | variety of a press part may become thicker than the said width | variety of a nozzle part, the adhesiveness of the front-end | tip part of a press part and the surface of an injection object area | region improves. . As a result, the injection target area can be sufficiently pressed by the pressing portion, and thus a desired contact state can be formed between the injection target area and the nozzle portion. That is, by narrowing the width of the tip portion of the pressing portion, it is possible to concentrate the load applied to the injection target region and increase the accommodation amount (intrusion amount) of the injection target region into the predetermined gap. Accordingly, the injection target region can be positioned around the pressing portion and the tip portion of the nozzle portion, so that the pressing portion and the nozzle portion are easily held. Further, when the amount of the injection target area (intrusion amount) into the predetermined gap is increased, the portion surrounded by the pressing portion in the injection target area is likely to rise higher toward the syringe. It becomes easy to adhere to the nozzle part. Furthermore, when the adhesion between the tip of the pressing part and the surface of the injection target area is improved, the pressing state by the pressing part with respect to the injection target area is easily maintained, so that the injection target deformed as described above by being pressed The region can be well fixed in the form after the deformation. As a result, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion. Therefore, as long as such an effect is obtained, the shape and specification of the pressing portion are not limited, and the pressing portion may be, for example, an annular aspect that continuously covers the periphery of the nozzle portion, or a plurality of pressing portions. The aspect which the part arrange | positioned in the circumferential direction at intervals may be sufficient.

According to the needleless syringe described above, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion, and the injection target substance can be administered to the target site in the injection target region. Therefore, it is possible to carry out accurately, stably and with good reproducibility.

Here, the pressing portion is formed in a cylindrical shape, and the interval between the inner peripheral surface and the outer peripheral surface may have a tapered shape that gradually decreases toward the distal end side along the axial direction. Good. Thereby, the adhesiveness of the front-end | tip part of a press part and the surface of an injection object area | region can be improved.

Further, the pressing portion may be formed such that the area of the end surface of the tip portion is larger than the area of the end surface of the tip portion of the nozzle portion. In addition, the said end surface in a press part and a nozzle part is the front end surface of these press parts and a nozzle part extended so that the axial direction of a housing may be followed. Thus, when the area of the tip surface of the pressing part is larger than the area of the tip surface of the nozzle part, when the injection target area is pressed by the pressing part, the end surface of the injection target area and the tip part of the pressing part The contact area becomes large, and the pressed state is easily maintained stably. According to this, for example, it is possible to suppress as much as possible a situation in which a side slip or a tilt of the syringe occurs in the course of the injection operation. Therefore, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion.

Alternatively, when the pressing portion has the above-described tapered shape, the pressing portion may be formed such that the area of the end surface of the tip portion is smaller than the area of the end surface of the tip portion of the nozzle portion. According to such a structure, the front-end | tip part of this press part can be made as thin as possible, ensuring the mechanical strength of a press part. Thus, even when the tip of the pressing portion is made as thin as possible, when the injection target region is pressed by the pressing portion, the pressing state is easily maintained stably. According to this, even if the syringe is tilted in the course of the injection operation, for example, the surface of the injection target area is pressed relatively strongly by the distal end surface of the pressing portion, and thus pressed. Thus, the injection target region deformed as described above can be satisfactorily fixed in the form after the deformation. Further, it is possible to suppress as much as possible a situation in which a side slip or the like of the syringe occurs in the process of performing the injection operation. Therefore, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion.

In the needleless syringe described above, the nozzle portion may be formed so that its width gradually decreases toward the distal end side. In addition, the said width | variety is a width | variety of a nozzle part when seeing a syringe in the longitudinal cross-section of a housing. According to such a configuration, when the injection target area is pressed by the pressing portion and the injection target area is deformed as described above, the deformed injection target area and the tip of the nozzle part are more likely to be in close contact with each other. Then, the injection target region surrounds the tip portion of the nozzle portion and comes into close contact with the tip portion, and the nozzle portion is easily fixed by the injection target region. As a result, a desired contact state is easily maintained between the injection target region and the nozzle portion.

According to the present invention, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion.

It is a 1st figure which shows schematic structure of the syringe which concerns on Example 1 of this invention. It is a figure for demonstrating the contact state of this injection target area | region and the front-end | tip part of a nozzle part when injection solution is injected into the injection target area | region of a target object. It is a figure showing the contact state between the skin of the living body and the tip of the nozzle part when the skin of the living body is pressed by the rim, and the case where the desired contact state is not formed between the skin and the nozzle part. FIG. It is a figure showing the contact state between the living body skin and the tip of the nozzle part when the living body skin is pressed by the rim, and a desired contact state is formed between the skin and the nozzle part FIG. It is a 2nd figure which shows schematic structure of the syringe which concerns on Example 1 of this invention. It is a figure which shows schematic structure of the syringe which concerns on the modification 1 of Example 1 of this invention. It is a figure showing the contact state of the living body skin and the front-end | tip part of a nozzle part in the modification 1 of Example 1 when the living body skin is pressed by the rim | limb. It is a figure which shows schematic structure of the syringe which concerns on the modification 2 of Example 1 of this invention. It is a figure showing the contact state of the living body skin and the front-end | tip part of a nozzle part when the living body skin is pressed by the rim | limb in the modification 2 of Example 1. FIG.

Hereinafter, a needleless syringe 1 having no needle (hereinafter simply referred to as “syringe 1”) will be described as an example of a syringe according to an embodiment of the present invention with reference to the drawings. In addition, the structure of the following embodiment is an illustration and this invention is not limited to the structure of these embodiment.

<Example 1>
FIG. 1A is a cross-sectional view of the syringe 1, and FIGS. 1B and 1C are views of the syringe 1 as viewed from the distal end side. In the following description of the present application, injection target substances that are injected into the injection target area of the target by the syringe 1 are collectively referred to as “injection solution”. However, this is not intended to limit the content or form of the injected substance. Injectable substances may or may not dissolve components to be delivered to the skin structure, and the injectable substance can be injected from the injection port to the skin structure by applying pressure. If it exists, the specific form is not ask | required and various forms, such as a liquid, a gel form, and a powder form, are employable.

Here, the syringe 1 has a housing 2 including a distal end side housing 3, a proximal end side housing 4, and a syringe portion 5, and the syringe portion 5 is interposed between the distal end side housing 3 and the proximal end side housing 4. Is arranged. And these are fixed with a screw and united, and housing 2 is constituted. However, the front end side housing 3, the base end side housing 4, and the syringe part 5 can be connected also by well-known methods other than a screw | thread. Here, a hole 40, which is an internal space extending in the axial direction, is formed in the base end side housing 4.

The syringe part 5 has an accommodation chamber (accommodation part) 50 for accommodating the injection solution ML. The syringe part 5 is screwed and attached to the base end side housing 4, and in the attached state, the hole 40 in the base end side housing 4 and the accommodation chamber 50 in the syringe part 5 are continuous spaces. It becomes. In the attached state, the injection liquid ML is liquid-tightly stored in the storage chamber 50 by the plunger 7 and the plunger 7 is exposed to the hole 40 side. Here, the plunger 7 is slidably disposed in the storage chamber 50, and further pressurizes the injection liquid ML by sliding to inject the injection liquid from the injection port. Moreover, the plunger 7 is formed of a rubber member having a surface coated with a thin silicone oil so that the plunger 7 can slide smoothly in the storage chamber 50. In addition, in order to improve the slidability of the plunger 7, for example, the surface of the plunger 7 may be subjected to fluorine processing.

The metal piston 6 is disposed in the hole 40 in the base end side housing 4, and the piston 6 is slidably held in the hole 40. The piston 6 is formed in a generally axial shape extending along the axial direction of the hole 40, and has a first end 6 a that contacts the plunger 7 disposed in the syringe portion 5, and an opposite side of the first end 6 a. And a second end 6b that defines a combustion chamber 41 to be described later. Further, around the piston 6 on the second end portion 6b side, a combustion product resulting from the combustion of ignition powder described later is sealed in the combustion chamber 41, and the piston 6 can slide smoothly in the hole 40. An O-ring 6c configured as described above is arranged.

Furthermore, an initiator 20 is arranged on the side opposite to the side where the syringe part 5 is attached in the proximal end side housing 4. As shown in FIG. 1A, the initiator 20 is provided at the proximal end of the housing 2. Then, the combustion chamber 41 formed at one end of the hole 40 is closed by the initiator 20. Here, the space defined by the initiator 20 and the second end 6 b of the piston 6 in the hole 40 is a combustion chamber 41. Then, when a voltage is applied to the initiator 20, the igniter that the initiator 20 has burns. If it does so, the combustion product produced by combustion of ignition powder will flow into the combustion chamber 41, and the pressure in the combustion chamber 41 will rise. In this way, injection energy for injecting the injection liquid ML stored in the storage chamber 50 is generated. The initiator 20 serves as a drive unit that generates the emission energy.

Here, the igniting agent used in the syringe 1 is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), titanium and potassium perchlorate. Gunpowder containing (TiPP), Gunpowder containing aluminum and potassium perchlorate (APP), Gunpowder containing aluminum and bismuth oxide (ABO), Gunpowder containing aluminum and molybdenum oxide (AMO), Gunpowder containing aluminum and copper oxide (ACO) ), Explosives containing aluminum and iron oxide (AFO), or explosives composed of a combination of these explosives. These explosives generate high-temperature and high-pressure plasma at the time of combustion immediately after ignition, but exhibit a characteristic that the generated pressure rapidly decreases because the combustible organisms do not contain gas components when they become room temperature. In addition, you may use explosives other than these as an ignition powder.

Further, nothing is arranged in the combustion chamber 41 shown in FIG. 1, but a gas generating agent that burns and generates gas by the combustion product generated by the combustion of the ignition agent is arranged in the combustion chamber 41. May be. Assuming that a gas generating agent is disposed in the combustion chamber 41, an example is a single base smokeless explosive comprising 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine, and 1.2% by mass of potassium sulfate. It is also possible to use various gas generating agents that are used in gas generators for airbags and gas generators for seat belt pretensioners. The combined use of such a gas generating agent is different from the case of only the above-mentioned igniting agent, and the predetermined gas generated at the time of combustion contains a gas component even at room temperature, so the rate of decrease in generated pressure is small. Furthermore, although the combustion completion time at the time of combustion of the gas generating agent is extremely long as compared with the igniting agent, the size, size and shape of the gas generating agent when disposed in the combustion chamber 41, particularly the surface shape. By adjusting this, it is possible to change the combustion completion time of the gas generating agent. In this way, by adjusting the amount, shape, and arrangement of the gas generating agent, the generated pressure in the combustion chamber 41 can be adjusted as appropriate.

In the syringe 1 configured as described above, the distal end side housing 3 is further screwed into the syringe unit 5 and attached to the syringe unit 5. The distal end side housing 3 is attached to the syringe part 5 with the gasket 3a interposed therebetween. In the distal end side housing 3, a nozzle portion 8 and a rim 9 are formed integrally with the distal end side housing 3. Here, the nozzle portion 8 and the rim 9 are provided so as to protrude from a predetermined end portion 2 a which is a predetermined end portion on the distal end side (the storage chamber 50 side) of the housing 2. The nozzle portion 8 and the rim 9 may be provided so as to protrude from the predetermined end portion 2a as separate parts from the distal end side housing 3.

Here, the nozzle portion 8 has a main body 8a having a diameter smaller than that of the syringe portion 5 side of the distal end side housing 3. The main body 8a has a proximal end portion 82a whose diameter gradually decreases from the predetermined end portion 2a toward the distal end side along the axial direction, and a distal end portion 81a formed on the distal end side from the proximal end portion 82a, including. And in the nozzle part 8, the injection port 8b is formed in the front-end | tip part 81a of the main body 8a. The injection liquid ML pressurized by the plunger 7 flows through the flow path formed in the distal end side housing 3 and is injected from the injection port 8b. Specifically, when the pressure in the combustion chamber 41 rises due to burning of the ignition agent of the initiator 20, the piston 6 slides toward the distal end side of the syringe 1. Then, as the piston 6 slides, the plunger 7 presses the injection liquid ML stored in the storage chamber 50. As a result, the injection liquid ML flows through the flow path formed in the distal end side housing 3, and is injected from the injection port 8b toward the injection target region.

Note that a plurality of injection ports 8b may be formed at the tip end portion 81a of the main body 8a, or one injection port 8b may be formed. When a plurality of injection ports are formed, a flow path corresponding to each injection port is formed in the main body 8a of the nozzle portion 8 so that the injection liquid ML is fed as evenly as possible to each injection port. Is done. Further, when a plurality of injection ports are formed, it is preferable that the injection ports are arranged at equal intervals around the central axis of the syringe 1 as shown in FIG.

A rim 9 is formed around the nozzle portion 8 in the distal end side housing 3. The rim 9 protrudes from the predetermined end 2a and is formed in a cylindrical shape. In this embodiment, the interval (width) between the inner peripheral surface and the outer peripheral surface of the rim 9 does not change along the axial direction and is constant. .

And, a predetermined gap 10 is formed between the rim 9 and the nozzle portion 8. In the syringe 1 according to the present invention, the gap 10 is provided between the rim 9 and the nozzle portion 8 as described above, and the injection target region is injected by the rim 9 when the injection liquid ML is injected into the target injection target region. Is pressed, a part of the injection target area enters the gap 10 at this time. In other words, the gap 10 accommodates a part of the injection target area. The rim 9 serves as a pressing portion that presses the injection target area. This will be described in detail below.

FIG. 2 is a diagram for explaining a contact state between the injection target region and the tip portion 81a of the nozzle portion 8 when the injection liquid ML is injected into the injection target region of the target object. In the present invention, injection of the injection liquid ML is performed in a state where the injection target area is pressed by the rim 9. Here, Fig.2 (a) represents the state which the surface of the injection | pouring object area | region and the front-end | tip part of the rim | limb 9 contact | abutted, FIG.2 (b) is from the state represented by Fig.2 (a). Further, the state where the injection target area is pressed by the rim 9 is shown. FIG. 2C shows a state where the initiator 20 is operated in the state shown in FIG. 2B and the injection of the injection liquid ML is completed.

2B, when the injection target area is pressed by the rim 9, a part of the injection target area enters the gap 10. Here, if the nozzle portion 8 is not disposed inside the cylindrical rim 9, the injection target region tends to rise in an arcuate shape inside the rim 9. On the other hand, in the syringe 1 of the present invention in which the nozzle portion 8 is arranged inside the rim 9, the injection target region that is going to rise in an arch shape toward the syringe 1 is the tip of the nozzle portion 8 inside the rim 9. While being pressed against the portion 81 a, the injection target region existing inside the rim 9 enters the gap 10. In the syringe 1 of the present invention, the injection target area and the nozzle portion 8 are brought into contact in this manner. In the state shown in FIG. 2 (b), the injection target region is sufficiently pressed by the rim 9, and a desired contact state described later is formed between the injection target region and the nozzle portion 8. To do.

Then, when a voltage is applied to the initiator 20 in the state shown in FIG. 2B, combustion products generated by the combustion of the igniting agent flow into the combustion chamber 41, and the pressure in the combustion chamber 41 increases. Then, the injection liquid ML is pressed by the plunger 7, and the injection liquid ML is ejected from the ejection port 8b toward the injection target area. As a result, the syringe 1 reaches the state shown by FIG.

Thus, in the syringe 1, when the injection liquid ML is injected into the injection target area of the target object, the injection liquid ML is injected from the injection port 8 b in a state where the injection target area and the tip portion 81 a of the nozzle portion 8 are in contact with each other. Is ejected. At this time, if an appropriate contact state is formed between the injection target region and the nozzle portion 8 and the appropriate contact state is not maintained during injection of the injection solution ML, the injection solution ML is accurately injected. There is a risk that it cannot be delivered to the target part of the region.

Therefore, in the syringe 1 according to the present invention, the width of the portion in contact with the injection target region in the tip portion of the rim 9 is narrower than the width of the portion in contact with the injection target region in the tip portion 81a of the nozzle portion 8. A rim 9 is formed. Thereby, when injecting injection liquid ML into the injection target area | region of a target object, the contact between the injection target area | region and nozzle part 8 which enables exact delivery of the injection liquid ML to the target site | part of an injection target area | region The injection can be performed in a state where the state (hereinafter, also referred to as “desired contact state”) is suitably formed and maintained. This will be described with reference to FIGS. 3A and 3B.

3A and 3B show a contact state between the living body skin and the distal end portion 81a of the nozzle portion 8 when the living body skin is pressed by the rim 9. Here, when the injection target region is a living body, unevenness due to pores (body hair), keratin, or the like exists on the skin that is the surface of the injection target region. Therefore, the contact state between the front end surface of the rim 9 and the skin can change due to the unevenness. Then, even if the pressing force is the same, the pressing state by the rim 9 against the skin may change, and thus the contact state between the skin of the living body and the tip portion 81a of the nozzle portion 8 changes. There is a fear.

Here, FIG. 3A illustrates a case where a desired contact state is not formed between the skin and the nozzle portion 8 due to unevenness existing in the skin of the living body. In this case, unlike the syringe 1 according to the present invention, the width of the portion in contact with the injection target region in the tip portion of the rim 9 is larger than the width of the portion in contact with the injection target region in the tip portion 81a of the nozzle portion 8. A rim 9 is formed to be thicker. Note that the above-mentioned width at the distal end portion of the rim 9 is a distance between the inner peripheral surface and the outer peripheral surface at the distal end surface of the rim 9, and is represented by a width D21 in FIG. . In addition, the above-described width at the distal end portion 81a of the nozzle portion 8 is the diameter of the distal end portion 81a and is represented by the width D1 in FIG. That is, in FIG. 3A, the rim 9 is formed such that the width D21 of the tip portion of the rim 9 is thicker than the width D1 of the tip portion 81a of the nozzle portion 8. If it does so, as shown to FIG. 3A, the adhesiveness of the front-end | tip part of the rim | limb 9 and skin will fall by the unevenness | corrugation of skin. That is, since the pressing load is dispersed at the front end surface of the rim 9, as a result, the stress is not concentrated on the skin and the skin cannot be sufficiently pressed by the rim 9. As a result, the swell of the skin hardly appears in the gap 10, and a desired contact state is not formed between the skin and the nozzle portion 8. As described above, even if the rim 9 and the gap 10 are provided in the syringe 1, the rim 9 is set so that the width at the tip portion of the rim 9 is larger than the width at the tip portion 81 a of the nozzle portion 8. Is formed, a desired contact state cannot be suitably formed and maintained between the injection target region and the nozzle portion 8.

On the other hand, as shown in FIG. 3B, the width D22 of the portion in contact with the injection target region at the tip of the rim 9 is larger than the width D1 of the portion in contact with the injection target region at the tip 81a of the nozzle portion 8. When the rim 9 is formed so as to be thin, the adhesion between the tip of the rim 9 and the skin is improved as compared with the case shown in FIG. 3A. As a result, the skin of the living body can be sufficiently pressed by the rim 9, so that a desired contact state can be formed between the skin and the nozzle portion 8.

Furthermore, according to the syringe 1 according to the present invention, such a desired contact state can be stably formed and maintained. Because, when the adhesion between the distal end portion of the rim 9 and the skin is improved, the pressing state by the rim 9 against the injection target region is easily maintained, so that the injection target region deformed as described above inside the rim 9 It is because it can fix favorably in the aspect after a deformation | transformation. Further, at this time, the deformation mode of the injection target region fixed inside the rim 9 is mainly influenced by the geometric shape of the main body 8a of the rim 9 and the nozzle portion 8, and thus is caused by a user's technique difference and the like. Thus, it is difficult for a situation in which the contact state between the injection target region and the nozzle portion 8 changes to occur.

Furthermore, the injection target region that has entered the gap 10 presses the outer peripheral surface of the tip portion 81a so as to surround the tip portion 81a of the nozzle portion 8. If it does so, since the nozzle part 8 is fixed by such an injection object area | region, it will become easy to maintain a desired contact state.

According to the syringe 1 described above, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion 8. As a result, the injection solution ML can be accurately and stably administered to the target site in the injection target region with good reproducibility.

Further, as shown in FIGS. 1B and 1C, in the syringe 1 according to the present embodiment, the rim 9 has an area of its distal end surface (this is an area A2 in FIGS. 1B and 1C). ) Is formed to be larger than the area of the tip surface of the nozzle portion 8 (this is represented as the area A1 in FIGS. 1B and 1C). Thus, when the area of the front end surface of the rim 9 is made larger than the area of the front end surface of the nozzle portion 8, when the injection target region is pressed by the rim 9, the pressing state is easily maintained stably. Become. According to this, for example, it is possible to suppress as much as possible the situation in which the tilt of the syringe 1 occurs in the course of the injection operation. Therefore, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion 8, and therefore, the injection solution ML can be stably administered.

However, the present invention is not limited to the syringe 1 including the rim 9 formed so that the area of the front end surface thereof is larger than the area of the front end surface of the nozzle portion 8, and the area of the front end surface of the rim 9 is It may be smaller than the area of the tip surface of the nozzle portion 8. Such an embodiment is illustrated by the syringe 1 depicted in FIG. In the syringe 1 illustrated in FIG. 4, a rim 9 that protrudes from the predetermined end 2 a and is formed in a cylindrical shape is intermittently formed around the nozzle portion 8 instead of the entire circumference. As a result, the area of the tip surface of the rim 9 (this is represented as the area A3 in FIGS. 4B and 4C) is the area of the tip surface of the nozzle portion 8 (this is shown in FIG. 4B). ), (C), expressed as area A1). In such a syringe 1, the pressure applied to the injection target region by the distal end surface of the rim 9 is increased, so that a situation in which the syringe slips or the like during the injection operation is suppressed as much as possible. Is done.

<Modification 1 of Example 1>
Next, a first modification of the first embodiment described above will be described with reference to FIGS. In the present modification, detailed description of the substantially same configuration as that of the first embodiment will be omitted. Fig.5 (a) is sectional drawing of the syringe 1 which concerns on this modification, FIG.5 (b), (c) is the figure which looked at the syringe 1 which concerns on this modification from the front end side.

As shown in FIG. 5 (a), in the syringe 1 according to this modification, the rim 9 has a tapered portion 9a. Specifically, a tapered portion 9a is formed on the inner peripheral surface of the cylindrical rim 9, and the taper portion 9a causes the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 to approach the tip side along the axial direction. It is gradually reduced. Note that a tapered portion may be formed on the outer peripheral surface of the cylindrical rim 9 so that the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 gradually decreases toward the tip end side along the axial direction. .

Further, as shown in FIGS. 5B and 5C, in the syringe 1 according to the present modification, the rim 9 has an area of the tip surface (this is an area A4 in FIGS. 5B and 5C). ) Is formed to be smaller than the area of the tip surface of the nozzle portion 8 (this is represented as the area A1 in FIGS. 5B and 5C). Thus, in the case where the syringe 1 is configured such that the area of the front end surface of the rim 9 is smaller than the area of the front end surface of the nozzle portion 8, the interval between the inner peripheral surface and the outer peripheral surface of the rim 9 is assumed to be an axis. If the rim 9 does not change along the direction, the rim 9 becomes thin over the entire length, so that it is difficult to ensure the mechanical strength of the rim 9. On the other hand, as shown in FIG. 5, after the tapered portion 9a is formed on the rim 9, the area of the tip surface of the rim 9 is made smaller than the area of the tip surface of the nozzle portion 8. The tip of the rim 9 can be made as thin as possible while ensuring the mechanical strength of the rim 9.

And also with such a syringe 1, a desired contact state can be suitably formed and maintained between the injection target region and the nozzle portion 8. This will be described with reference to FIG.

6 shows the contact state between the living body skin and the tip portion 81a of the nozzle portion 8 when the living body skin is pressed by the rim 9, as in FIG. 3B. As shown in FIG. 6, the distance between the inner peripheral surface and the outer peripheral surface of the rim 9 (the width of the rim 9) is from D22 to D23 from the predetermined end portion 2a toward the front end side along the axial direction. It is gradually reduced. And according to the syringe 1 which concerns on this modification, as shown in FIG. 6, the rim | limb 9 will bite into skin comparatively deeply. This is because, when the pressing force is the same, the load applied to the skin surface by the distal end surface of the rim 9 is concentrated as the distal end portion of the rim 9 becomes thinner (as the area of the distal end surface of the rim 9 becomes smaller). Even when the skin is pressed in this way, the injection target area is deformed inside the rim 9 as in the first embodiment, and a desired contact state is formed between the skin and the nozzle portion 8. Is done.

And according to such a syringe 1, a desired contact state can be stably formed and maintained between the injection target region and the nozzle portion 8. This is because when the rim 9 bites into the injection target region relatively deeply, the pressing state of the rim 9 against the injection target region is easily maintained stably. According to this, even if, for example, the tilt of the syringe 1 occurs during the injection operation, the injection target region deformed as described above inside the rim 9 is good in the state after the deformation. Can be fixed to. In addition, it is possible to suppress as much as possible a situation in which a side slip or the like of the syringe 1 occurs in the course of the injection operation.

That is, a desired contact state is suitably formed and maintained between the injection target area and the nozzle portion 8, and thus the administration of the injection liquid ML to the target site in the injection target area is accurately and stably reproduced. It is possible to perform well.

<Modification 2 of Example 1>
Next, a second modification of the first embodiment will be described with reference to FIGS. In the present modification, detailed description of the substantially same configuration as that of the first embodiment will be omitted. Fig.7 (a) is sectional drawing of the syringe 1 which concerns on this modification, FIG.7 (b), (c) is the figure which looked at the syringe 1 which concerns on this modification from the front end side.

In the syringe 1 described in the description of the first embodiment, the main body 8a of the nozzle portion 8 has a proximal end portion 82a whose diameter gradually decreases from the predetermined end portion 2a toward the distal end side along the axial direction, and a proximal end portion A distal end portion 81a which is formed on the distal end side of the portion 82a and whose diameter does not change over the entire length. On the other hand, in the syringe 1 according to this modification, the main body 8a of the nozzle portion 8 is formed on the distal end side with respect to the proximal end portion 82a similar to the syringe 1 according to the first embodiment and the proximal end portion 82a. And a distal end portion 811a that gradually decreases in diameter toward the distal end side along the axial direction.

8 shows a contact state between the living body skin and the tip portion 81a of the nozzle portion 8 when the living body skin is pressed by the rim 9, similarly to FIG. 3B. As shown in FIG. 8, the diameter of the tip 811a (the width of the tip 811a) is gradually reduced from D1 to D11 toward the tip along the axial direction. Further, the rim 9 is formed so that the width D22 of the front end portion of the rim 9 is narrower than the width D11 of the front end surface of the nozzle portion 8. And according to the syringe 1 which concerns on this modification, as shown in FIG. 8, the front-end | tip part 811a of the nozzle part 8 becomes easy to bite into skin. If it does so, the nozzle part 8 will become easy to be fixed by the injection object area | region surrounding the outer peripheral surface of the front-end | tip part 811a, and a desired contact state will become easy to be maintained between the injection object area | region and the nozzle part 8. FIG.

<Other examples>
According to the syringe 1 according to the present invention, for example, in the field of regenerative medicine for humans, as shown in Japanese Patent Application Laid-Open No. 2008-206477, a person skilled in the art appropriately determines the site to be transplanted and the purpose of recellularization. Possible cells such as endothelial cells, endothelial progenitor cells, bone marrow cells, proosteoblasts, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, other regenerative medicine fields Any cell considered in can be injected with the syringe 1. More specifically, a liquid (cell suspension) containing the cells is stored in the storage chamber 50, and predetermined cells are injected and transplanted to the site to be transplanted by applying pressure thereto.

Furthermore, the syringe 1 according to the present invention can be used for delivery of DNA or the like as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 1 according to the present invention is more preferable than the case of delivery using a needle because the influence on cells, scaffold tissue, scaffold, and the like can be suppressed.

Furthermore, the syringe 1 according to the present invention is also preferably used when delivering various genes, tumor suppressor cells, lipid envelopes, etc., or administering an antigen gene to enhance immunity against pathogens. In addition, in various disease treatment fields (fields described in JP 2008-508881, JP 2010-503616, etc.), immunomedical fields (fields described in JP 2005-523679, etc.), etc. The syringe 1 can be used, and the field in which the syringe 1 can be used is not intentionally limited.

DESCRIPTION OF SYMBOLS 1 ... Syringe 2 ... Housing 3 ... Front end side housing 4 ... Base end side housing 5 ... Syringe part 6 ... Piston 7 ... Plunger 8 ... ... Nozzle 8a ... Main body 81a ... Tip 8b ... Injection port 9 ... Rim 10 ... Gap 20 ... Initiator

Claims

A needleless syringe that injects the injection target substance into the injection target area by ejecting the injection target substance in a state where the injection target area is pressed without going through the injection needle,
A housing part for housing the injection target substance provided in a housing of the needleless syringe;
A drive unit that is provided in the housing and generates injection energy for injecting the injection target substance stored in the storage unit;
A nozzle part provided to protrude from a predetermined end part which is a predetermined end part on the housing part side of the housing, wherein the injection target substance to which the ejection energy generated by the driving part is applied is injected. An injection port that is ejected toward a target region is formed, and when the injection target substance is ejected from the injection port, a nozzle portion configured to come into contact with the injection target region;
A pressing part that protrudes from the predetermined end so as to surround the nozzle part and to form a predetermined gap between the nozzle part and the injection target substance is injected from the injection port. A pressing portion configured to contact the injection target region with the tip portion,
With
The width of the portion in contact with the injection target region in the tip portion of the pressing portion is formed to be narrower than the width of the portion in contact with the injection target region in the tip portion of the nozzle portion,
When the injection target area is pressed by the pressing portion, the predetermined gap is configured to accommodate a part of the injection target area.
Needleless syringe.
The pressing portion is formed in a cylindrical shape, and has a tapered shape in which the interval between the inner peripheral surface and the outer peripheral surface gradually decreases toward the distal end side along the axial direction.
The needleless syringe according to claim 1.
The pressing part is formed such that the area of the end face of the tip part is larger than the area of the end face of the tip part of the nozzle part.
The needleless syringe according to claim 1 or 2.
The pressing part is formed such that the area of the end face of the tip part is smaller than the area of the end face of the tip part of the nozzle part.
The needleless syringe according to claim 2.
The nozzle portion is formed such that its width gradually decreases toward the tip side.
The needleless syringe according to any one of claims 1 to 4.