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WO2019140572A1 - 一种伤口敷料及其制备方法 - Google Patents

一种伤口敷料及其制备方法 Download PDF

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Publication number
WO2019140572A1
WO2019140572A1 PCT/CN2018/073026 CN2018073026W WO2019140572A1 WO 2019140572 A1 WO2019140572 A1 WO 2019140572A1 CN 2018073026 W CN2018073026 W CN 2018073026W WO 2019140572 A1 WO2019140572 A1 WO 2019140572A1
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Prior art keywords
fiber
wound dressing
fibers
gel
thermoplastic
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PCT/CN2018/073026
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English (en)
French (fr)
Inventor
张俊丰
董杰
莫晋文
陈伟伟
Original Assignee
惠州华阳医疗器械有限公司
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Priority to PCT/CN2018/073026 priority Critical patent/WO2019140572A1/zh
Publication of WO2019140572A1 publication Critical patent/WO2019140572A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents

Definitions

  • the present invention relates to a dressing, in particular a wound dressing and a method of making the same.
  • wound dressings based on wet healing theory, such as alginate dressings, carboxymethyl cellulose dressings and chitosan dressings, are widely used in acute and chronic wound care.
  • the wound dressing contacts the wound exudate, it forms a soft gel that provides an ideal moist environment for wound healing.
  • the dressing when the dressing is used after being removed from the wound, the dressing cannot be completely removed due to the structural problem of the nonwoven fabric itself. The collapse or rupture of the dressing causes a portion of the dressing to remain in the wound, posing a risk that the wound must be flushed.
  • the present invention overcomes the deficiencies of the prior art by providing a wound dressing composition capable of gelling after contact with human wound exudate, and a wound dressing capable of maintaining the integrity of the dressing after removal after use. And a preparation method.
  • a wound dressing consisting of two or more kinds of fibers containing gel fiber, textile fiber and thermoplastic fiber, the gel fiber content is 50% to 100%, and the textile fiber content is 0%. 50%, the thermoplastic fiber content is 0% to 20%; the wound dressing has a gram weight of 60-200 g/cm2, a thickness of 0.5-5.0 mm, and a 0.9% saline solution having a liquid absorption of not less than 10 g/100 cm2.
  • the gel fiber is sodium carboxymethyl cellulose, chemically modified cellulose fiber, pectin fiber, alginate fiber, chitosan fiber, hyaluronic acid fiber, polysaccharide fiber. Or one of the gum fibers.
  • the cellulose fibers are having a degree of substitution of at least 0.05 carboxymethyl groups per glucose unit.
  • the gel fiber is an absorbent having at least 2 g of a 0.9% saline solution per gram of fiber.
  • the textile fiber is one of a tencel fiber, a viscose fiber, a nylon fiber, a polyester fiber, a nylon fiber, and a cotton fiber.
  • thermoplastic fiber is one or more of PE fiber, PP fiber, PET fiber, PS fiber, ABS fiber, PE/PET fiber, PE/PP fiber.
  • a method of preparing a wound dressing comprising the above wound dressing, the method for preparing a wound dressing comprising the steps of:
  • the mixed fiber provided has a gel fiber content of 50% to 100%, a textile fiber content of 0% to 50%, a thermoplastic fiber content of 0% to 20%, and the gel fiber, textile fiber and thermoplastic Fiber blending;
  • the wound dressing after the needle punching is hot-rolled and set, and the temperature during hot rolling is not less than 110 °C.
  • the wound dressing is a composition, which is simple in preparation method, and the wound dressing composition can gel after contacting the human wound exudate, and can maintain the integrity of the dressing after being removed after use. Sex.
  • a wound dressing provided by an embodiment of the present invention comprises two or more kinds of fibers including gel fiber, textile fiber and thermoplastic fiber, wherein the gel fiber content is 50% to 100%, and the textile fiber content is 0%. ⁇ 50%, the thermoplastic fiber content is 0% to 20%; the wound dressing has a gram weight of 60-200 g/cm2, a thickness of 0.5-5.0 mm, and a 0.9% saline solution having a liquid absorption of not less than 10 g/100 cm2.
  • the gel fiber is sodium carboxymethyl cellulose, chemically modified cellulose fiber, pectin fiber, alginate fiber, chitosan fiber, hyaluronic acid fiber, polysaccharide fiber or gum.
  • pectin fiber sodium carboxymethyl cellulose
  • alginate fiber sodium carboxymethyl cellulose
  • chitosan fiber alginate fiber
  • hyaluronic acid fiber polysaccharide fiber or gum.
  • the cellulosic fibers are having a degree of substitution of at least 0.05 carboxymethyl groups per glucose unit.
  • the gel fiber is absorbent having at least 2 grams of 0.9% saline solution per gram of fiber.
  • the textile fiber is one of a tencel fiber, a viscose fiber, a nylon fiber, a polyester fiber, a nylon fiber, and a cotton fiber.
  • thermoplastic fiber is one or more of PE fiber, PP fiber, PET fiber, PS fiber, ABS fiber, PE/PET fiber, PE/PP fiber.
  • a method of preparing a wound dressing comprising the above wound dressing, the method for preparing a wound dressing comprising the steps of:
  • the mixed fiber provided has a gel fiber content of 50% to 100%, a textile fiber content of 0% to 50%, a thermoplastic fiber content of 0% to 20%, and the gel fiber, textile fiber and thermoplastic Fiber blending;
  • the wound dressing after the needle punching is hot-rolled and set, and the temperature during hot rolling is not less than 110 °C.
  • the wound dressing is a composition which is simple to prepare and which is capable of gelling upon contact with human wound exudate and which maintains the integrity of the dressing upon removal after use.
  • the present invention forms a wound dressing having a three-dimensional network structure by blending, acupuncture and hot rolling a gel fiber, a textile fiber and a thermoplastic fiber.
  • the three components of the dressing have their own functions, the gel fiber has high liquid absorption property, can form a soft gel, and provides an ideal moist environment for wound healing; the textile fiber can increase the wet strength of the dressing, improve the wicking effect; thermoplastic After the fiber is hot rolled, a three-dimensional network structure is formed, which increases the wet strength and reduces the fiber drop.
  • the wound dressing prepared by the method has the advantages of high liquid absorption, less fiber drop, less gel shrinkage, high wet strength, good compliance, and can be removed as a whole.
  • the technical effects brought by the invention have the advantages of high liquid absorption, less fiber drop, small shrinkage ratio, enhanced wet strength and good compliance.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

一种伤口敷料以及制备方法，由含有凝胶纤维、纺织纤维、热塑性纤维两种或两种以上纤维组成，凝胶纤维含量为50％~100％，纺织纤维含量为0％~50％，热塑性纤维含量为0％~20％；伤口敷料克重为60-200g/cm 2，厚度为0.5~5.0mm，吸液量不小于10g/100cm 2的0.9％盐水溶液。制备方法包括提供的混合纤维中，将凝胶纤维、纺织纤维和热塑性纤维进行混纺；将混纺后的伤口敷料进行针刺；将针刺后的伤口敷料进行热扎定型。伤口敷料组合物接触人体伤口渗出液后能够凝胶化，并且在使用后揭除时能保持敷料的完整性。

Description

[根据细则37.2由ISA制定的发明名称]　一种伤口敷料及其制备方法 技术领域
本发明涉及一种敷料，尤其是一种伤口敷料以及制备方法。
背景技术
目前基于湿性愈合理论研发的高吸收性能的功能性伤口敷料，如藻酸盐敷料，羧甲基纤维素敷料和壳聚糖敷料等无纺敷料，广泛应用于急慢性伤口护理。伤口敷料接触到伤口渗出液后，能形成柔软的凝胶，为伤口愈合提供理想的湿润环境。但是，当敷料使用后，需从伤口揭除时，由于无纺布本身的结构问题，导致敷料无法整体揭除。敷料的塌陷或破裂使得敷料的一部分可能残留在伤口中造成风险，必须冲洗伤口。
因此，基于上述缺陷，市场上急需提供一种在接触人体伤口渗出液后能够凝胶化的伤口敷料组合物，并且在使用后揭除时能保持敷料的完整性的伤口敷料以及制备方法。
发明内容
基于此，本发明在于克服现有技术的缺陷，提供一种在接触人体伤口渗出液后能够凝胶化的伤口敷料组合物，并且在使用后揭除时能保持敷料的完整性的伤口敷料以及制备方法。
其技术方案如下：一种伤口敷料，由含有凝胶纤维、纺织纤维、热塑性纤维两种或两种以上纤维组成，所述凝胶纤维含量为50％～100％，纺织纤维含量为0％～50％，热塑性纤维含量为0％～20％；所述伤口敷料克重为60～200g/cm2，厚度为0.5～5.0mm，吸液量不小于10g/100cm2的0.9％盐水溶液。
作为上述技术方案的进一步优化，所述凝胶纤维为羧甲基纤维素钠纤维、化学改性纤维素纤维、果胶纤维、藻酸盐纤维、壳聚糖纤维、透明质酸纤维、多糖纤维或树胶纤维的其中一种。
作为上述技术方案的进一步优化，所述纤维素纤维为具有每葡萄糖单元至少0.05个羧甲基的取代度。
作为上述技术方案的进一步优化，所述凝胶纤维为具有每克纤维至少2克0.9％盐水溶液的吸收性。
作为上述技术方案的进一步优化，所述纺织纤维为、天丝纤维、粘胶纤维、尼龙纤维、涤纶纤维、锦纶纤维、棉纤维的其中一种。
作为上述技术方案的进一步优化，所述热塑性纤维为PE纤维、PP纤维、PET纤维、PS纤维、ABS纤维、PE/PET纤维、PE/PP纤维的其中一种或多种结合。
一种伤口敷料的制备方法，其包括上述的一种伤口敷料，所述一种伤口敷料的制备方法包括以下步骤：
S1、提供的混合纤维中，凝胶纤维含量为50％～100％，纺织纤维含量为0％～50％、热塑性纤维含量为0％～20％，将所述凝胶纤维、纺织纤维和热塑性纤维进行混纺；
S2、将混纺后的伤口敷料进行针剌，针刺后进入下一步骤；
S3、将针剌后的伤口敷料进行热轧定型，热轧时温度不小于110℃。
本发明的有益效果为：该伤口敷料是一种组合物，其制备方法简单，该伤口敷料组合物接触人体伤口渗出液后能够凝胶化，并且在使用后揭除时能保持敷料的完整性。
具体实施方式
本发明实施例提供的一种伤口敷料，由含有凝胶纤维、纺织纤维、热塑性纤维两种或两种以上纤维组成，所述凝胶纤维含量为50％～100％，纺织纤维含量为0％～50％，热塑性纤维含量为0％～20％；所述伤口敷料克重为60～200g/cm2，厚度为0.5～5.0mm，吸液量不小于10g/100cm2的0.9％盐水溶液。
一种实施例中，所述凝胶纤维为羧甲基纤维素钠纤维、化学改性纤维素纤维、果胶纤维、藻酸盐纤维、壳聚糖纤维、透明质酸纤维、多糖纤维或树胶纤 维的其中一种。
一种实施例中，所述纤维素纤维为具有每葡萄糖单元至少0.05个羧甲基的取代度。
一种实施例中，所述凝胶纤维为具有每克纤维至少2克0.9％盐水溶液的吸收性。
一种实施例中，所述纺织纤维为、天丝纤维、粘胶纤维、尼龙纤维、涤纶纤维、锦纶纤维、棉纤维的其中一种。
作为上述技术方案的进一步优化，所述热塑性纤维为PE纤维、PP纤维、PET纤维、PS纤维、ABS纤维、PE/PET纤维、PE/PP纤维的其中一种或多种结合。
一种伤口敷料的制备方法，其包括上述的一种伤口敷料，所述一种伤口敷料的制备方法包括以下步骤：
S1、提供的混合纤维中，凝胶纤维含量为50％～100％，纺织纤维含量为0％～50％、热塑性纤维含量为0％～20％，将所述凝胶纤维、纺织纤维和热塑性纤维进行混纺；
S2、将混纺后的伤口敷料进行针剌，针刺后进入下一步骤；
S3、将针剌后的伤口敷料进行热轧定型，热轧时温度不小于110℃。
该伤口敷料是一种组合物，其制备方法简单，该伤口敷料组合物接触人体伤口渗出液后能够凝胶化，并且在使用后揭除时能保持敷料的完整性。
本发明在现有技术的基础上，将凝胶纤维、纺织纤维和热塑性纤维通过一定比例混纺、针刺、热轧形成具有三维网状结构的伤口敷料。该敷料三组分各具功能，凝胶纤维具有高吸液性能，能形成柔软的凝胶，为伤口愈合提供理想的湿润环境；纺织纤维能增加敷料的湿态强度，改善芯吸效果；热塑性纤维热轧后形成立体网状结构，增加湿态强度，减少纤维掉落。该方法制备出的伤口敷料具有吸液量高、纤维掉落少、凝胶收缩少、湿态强度高、顺应性好、可以整体揭除的优点。
本发明带来的技术效果：吸液量高、纤维掉落少、收缩比例小、湿态强度 增强、顺应性好。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。

Claims (7)

  1. 一种伤口敷料，其特征在于：由含有凝胶纤维、纺织纤维、热塑性纤维两种或两种以上纤维组成，所述凝胶纤维含量为50％～100％，纺织纤维含量为0％～50％，热塑性纤维含量为0％～20％；所述伤口敷料克重为60～200g/cm2，厚度为0.5～5.0mm，吸液量不小于10g/100cm2的0.9％盐水溶液。
  2. 根据权利要求1所述的一种伤口敷料，其特征在于，所述凝胶纤维为羧甲基纤维素钠纤维、化学改性纤维素纤维、果胶纤维、藻酸盐纤维、壳聚糖纤维、透明质酸纤维、多糖纤维或树胶纤维的其中一种。
  3. 根据权利要求2所述的一种伤口敷料，其特征在于，所述纤维素纤维为具有每葡萄糖单元至少0.05个羧甲基的取代度。
  4. 根据权利要求2所述的一种伤口敷料，其特征在于，所述凝胶纤维为具有每克纤维至少2克0.9％盐水溶液的吸收性。
  5. 根据权利要求1所述的一种伤口敷料，其特征在于，所述纺织纤维为、天丝纤维、粘胶纤维、尼龙纤维、涤纶纤维、锦纶纤维、棉纤维的其中一种。
  6. 根据权利要求1所述的一种伤口敷料，其特征在于，所述热塑性纤维为PE纤维、PP纤维、PET纤维、PS纤维、ABS纤维、PE/PET纤维、PE/PP纤维的其中一种或多种结合。
  7. 一种伤口敷料的制备方法，其包括如权利要求1-6任一所述的一种伤口敷料，其特征在于，所述一种伤口敷料的制备方法包括以下步骤：
    S1、提供的混合纤维中，凝胶纤维含量为50％～100％，纺织纤维含量为0％～50％、热塑性纤维含量为0％～20％，将所述凝胶纤维、纺织纤维和热塑性纤维进行混纺；
    S2、将混纺后的伤口敷料进行针剌，针刺后进入下一步骤；
    S3、将针剌后的伤口敷料进行热轧定型，热轧时温度不小于110℃。
PCT/CN2018/073026 2018-01-17 2018-01-17 一种伤口敷料及其制备方法 WO2019140572A1 (zh)

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WO2024047258A1 (de) 2022-09-02 2024-03-07 Giesecke+Devrient Currency Technology Gmbh Sicherheitselement mit farberzeugenden nanostrukturen und herstellverfahren dafür

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