WO2018181357A1

WO2018181357A1 - Syringe pump

Info

Publication number: WO2018181357A1
Application number: PCT/JP2018/012504
Authority: WO
Inventors: 孝文野村; 順井出; 裕一筒井
Original assignee: テルモ株式会社
Priority date: 2017-03-27
Filing date: 2018-03-27
Publication date: 2018-10-04

Abstract

This syringe pump delivers a liquid accommodated in a hollow portion of a syringe provided with an outer cylinder, and a plunger capable of moving through the hollow portion of the outer cylinder. The syringe pump is provided with: a placement part on which the syringe can be placed; a slider capable of moving so as to engage with the plunger of the syringe placed on the placement part; and a distance change detection unit which detects change in the distance between the plunger and the slider, while the syringe is in a state of being placed on the placement part.

Description

Syringe pump

The present disclosure relates to a syringe pump used for feeding a liquid into a living body.

There is known a syringe pump that places a syringe containing a liquid such as a chemical solution and controls the flow rate of pushing out the pusher of the syringe, thereby feeding the liquid into the living body of a patient or the like while controlling the flow rate. . In such a syringe pump, when the pusher of the syringe is not fixed for some reason, a problem that siphoning phenomenon in which liquid is excessively administered to the living body or backflow of the liquid may occur due to a difference in height from the living body. was there.

Patent Document 1 describes a syringe pump provided with a pusher gripping detector that detects that a syringe pusher is gripped by a slider as a slider.

JP 2005-287944 A

However, in the syringe pump described in Patent Document 1, a state where a siphoning phenomenon or a backflow can occur is generated by monitoring the output from the pusher gripping detector and detecting that the pusher is not gripped by the slider. However, it was not possible to detect that a siphoning phenomenon or a backflow actually occurred.

The object of the present disclosure is to provide a syringe pump capable of detecting the siphoning phenomenon and the occurrence of liquid backflow in view of the above problems.

A syringe pump as a first aspect of the present invention is a syringe pump for feeding a liquid contained in the hollow portion of a syringe having an outer cylinder and a pusher that can move through the hollow portion of the outer cylinder. , A placement portion on which the syringe can be placed, a slider movable so as to engage with the pusher of the syringe placed on the placement portion, and the syringe placed on the placement portion And a distance change detection unit that detects a change in the distance between the pusher and the slider.

The syringe pump as one embodiment of the present invention is a placement detector that detects that the placement portion can place the outer cylinder, and the placement portion detects the placement of the outer cylinder. When the distance change detection unit detects that the outer cylinder is placed by the placement detection unit, the distance change detection unit starts detection.

In the syringe pump as an embodiment of the present invention, the distance change detection unit detects an increase in the distance as the change in the distance.

In a syringe pump according to an embodiment of the present invention, the distance change detection unit is attached to the slider and detects a change in distance to the pusher based on the position of the slider.

In the syringe pump as one embodiment of the present invention, the distance change detection unit includes an imaging unit, and is based on a change in the area of the pusher between a plurality of images acquired at different timings by the imaging unit. Then, a change in the distance is detected.

The syringe pump as one embodiment of the present invention further includes a liquid feeding stop unit that stops the liquid feeding when the change in the distance is detected by the distance change detecting unit.

According to the syringe pump of the present disclosure, it is possible to detect the siphoning phenomenon and the occurrence of liquid backflow.

It is a front view of a syringe pump as one embodiment of the present invention. It is a front view of the syringe pump shown in FIG. 1 of the state which mounted the syringe. It is a block diagram of the syringe pump shown in FIG. It is a flowchart which shows the liquid feeding stop process which the syringe pump shown in FIG. 1 performs. It is a flowchart which shows the siphoning phenomenon etc. determination processing which the syringe pump shown in FIG. 1 performs. 6A is a schematic diagram showing the positional relationship between the slider and the pusher at the first time, and FIG. 6B is obtained by the imaging unit of the syringe pump in the state of FIG. 6A. It is a figure which shows an example of the image performed. FIG. 7A is a schematic diagram showing the positional relationship between the slider and the pusher at the second time, and FIG. 7B is acquired by the imaging unit of the syringe pump in the state of FIG. 7A. It is a figure which shows an example of the image performed.

Hereinafter, an embodiment of the present invention will be described with reference to the drawings. In each figure, the same code | symbol is attached | subjected to the common structure part. For convenience of explanation, the siphoning phenomenon and the back flow of the liquid are hereinafter simply referred to as “siphoning phenomenon etc.”.

[Syringe pump 1]
FIG. 1 is a front view of a syringe pump 1 as an embodiment of the present invention. FIG. 2 is a front view of the syringe pump 1 in a state where the syringe 50 is placed. As shown in FIG. 2, the syringe pump 1 is configured as a pump that sends the liquid stored in the hollow portion 52 of the syringe 50.

As shown in FIGS. 1 and 2, the syringe pump 1 includes a placement portion 11 on which a syringe 50 can be placed. As shown in FIG. 2, the syringe 50 that can be placed on the placement portion 11 is inserted into the hollow portion 52 from the base end side of the outer tube 51 and the cylindrical outer tube 51 that defines the hollow portion 52 inside. The hollow portion 52 can be moved along the extending direction A of the outer cylinder 51 (hereinafter simply referred to as “extending direction A”) while closely contacting the inner circumferential surface of the outer cylinder 51 without any gap. And a pusher 55. The outer cylinder 51 has an outer cylinder flange 53 at the proximal end, and defines an outlet hole 54 that communicates the hollow portion 52 and the outside at the distal end. The outlet hole 54 communicates with a flow path 61 defined by a flexible tube 60 attached to the tip of the outer cylinder 51. The pusher 55 has a pusher flange 56 at the proximal end. A liquid such as a chemical solution is accommodated in the hollow portion 52 of the syringe 50.

In detail, the mounting part 11 can mount the outer cylinder 51 of the syringe 50. As shown in FIG. 1 and FIG. 2, when the outer cylinder 51 of the syringe 50 is placed on the placement portion 11, the syringe pump 1 stores a part of the outer cylinder flange 53 and places the outer cylinder 51 into the syringe pump. 1 is provided with a slit 15 that is fixed in the extending direction A.

As shown in FIGS. 1 and 2, the syringe pump 1 includes a slider 12 and a pusher fixing portion 13. The slider 12 is movable so as to engage with the pusher 55 of the syringe 50 placed on the placement unit 11. Specifically, the slider 12 is located on the proximal end side of the pusher 55 with respect to the pusher flange 56 of the syringe 50 placed on the placement unit 11, and is movable along the extending direction A. The pusher fixing portion 13 is constituted by a pusher fixing member attached to the slider 12, and fixes the pusher 55 of the syringe 50 placed on the placement portion 11 to the slider 12. In this embodiment, the presser fixing portion 13 can fix the presser flange 56 of the placed syringe 50 to the slider 12 so as to be sandwiched between the slider 12. In the state where the pusher flange 56 is fixed by the pusher fixing portion 13, the distance between the pusher 55 and the slider 12 is kept constant, and the slider 12 moves along the extending direction A of the slider 12. And move together. At this time, the outer cylinder 51 placed on the placement portion 11 is fixed in the extending direction A with respect to the syringe pump 1 because a part of the outer cylinder flange 53 is housed in the slit 15. Therefore, when the slider 12 moves to the distal end side of the syringe 50, the pusher 55 moves to the distal end side with respect to the outer cylinder 51, and the liquid stored in the hollow portion 52 is discharged from the outlet hole 54. Therefore, the liquid accommodated in the hollow portion 52 can be fed into the living body through the flow path 61 partitioned by the tube 60.

As shown in FIGS. 1 and 2, the syringe pump 1 includes a syringe clamp 14 as an outer cylinder fixing portion that fixes an outer cylinder 51 of a syringe 50 placed on the placement portion 11. In this embodiment, the syringe clamp 14 is movable along a direction B orthogonal to the extending direction A, and the outer cylinder 51 of the syringe 50 placed is sandwiched between the placement portion 11. Can be fixed. By fixing the outer cylinder 51 with the syringe clamp 14, a part of the outer cylinder flange 53 is less likely to be detached from the slit 15, so that the outer cylinder 51 is more firmly fixed to the syringe pump 1.

As shown in FIGS. 1 and 2, the syringe pump 1 includes a notch-shaped tube guide portion 16 at a position on the distal end side of the syringe 50 when the syringe 50 is placed on the placement portion 11. Yes. The tube guide portion 16 is used for passing and positioning the tube 60 attached to the tip of the syringe 50 in a state where the syringe 50 is placed on the placement portion 11.

FIG. 3 is a block diagram of the syringe pump 1. As shown in FIG. 3, the syringe pump 1 includes a circuit in addition to the mounting portion 11, the slider 12, the pusher fixing portion 13, the syringe clamp 14, and the slit 15 described above with reference to FIGS. 1 and 2. Unit 20, operation input unit 31, display unit 32, sound output unit 33, placement detection unit 34, outer cylinder fixing detection unit 35, slider drive unit 36, imaging unit 37, and tube clamp 38. The circuit unit 20 is located inside the syringe pump 1 and includes a communication unit 21, a timer unit 22, a storage unit 23, and a control unit 24.

The communication unit 21 includes an interface that transmits and receives information to and from an information processing apparatus such as an external computer by wireless communication or wired communication.

The timekeeping unit 22 measures time and records time, and can be realized by, for example, RTC (Real （Time （Clock). The timer unit 22 may be realized as one function of the control unit 24.

The storage unit 23 includes a storage device, for example, and stores various information and programs. Specifically, the storage unit 23 stores a program for executing determination processing such as liquid feeding stop processing and siphoning phenomenon executed by the control unit 24. The storage unit 23 drives the slider drive unit 36 based on the parameter information such as the set value of the flow rate of the liquid sent by the syringe pump 1 and the set value of the dose, and the parameter information, and controls to send the liquid. Stores programs and the like.

The control unit 24 includes a processor that realizes a specific function by, for example, reading specific information and programs stored in the storage unit 23, and controls the operation of the entire syringe pump 1. Specifically, the control unit 24 reads information and a program stored in the storage unit 23 and executes various processes such as a liquid feed stop process, a siphoning phenomenon determination process, and a liquid feed process. The control unit 24 transmits / receives information to / from an external information processing apparatus via the communication unit 21. The control unit 24 executes various processes based on information input from the operation input unit 31, and outputs information associated with the execution of the various processes from the display unit 32 and the sound output unit 33.

As shown in FIGS. 1 and 2, the operation input unit 31 includes an operation panel as an input interface on which various operation buttons are arranged. The operation buttons arranged on the operation panel as the operation input unit 31 are a power button for switching on / off the operating power of the syringe pump 1, a start button for starting liquid feeding, and a stop button for stopping liquid feeding. Etc. The operation input unit 31 may include an input interface such as a touch panel, a keyboard, or a mouse that is provided integrally with the display unit 32. The operation input unit 31 outputs the input information to the control unit 24.

As shown in FIGS. 1 and 2, the display unit 32 includes a display device such as a liquid crystal display or an organic EL display. Based on the signal from the control unit 24, the display unit 32 sets a set value or an actual value of the flow rate of the liquid to be fed, a set value or an actual value of the dose of the liquid to be fed, various alarm information, and the like. Is displayed.

The sound output unit 33 includes, for example, a speaker, and notifies various alarm information and the like by sound and voice based on a signal from the control unit 24.

As shown in FIGS. 1 and 2, the placement detection unit 34 is a sensor that is attached to the placement unit 11 and detects that the outer cylinder 51 of the syringe 50 is placed on the placement unit 11. . The placement detection unit 34 outputs the detected information to the control unit 24.

As shown in FIGS. 1 and 2, the outer cylinder fixing detection unit 35 is a sensor that is attached to, for example, the syringe clamp 14 and detects that the outer cylinder 51 of the syringe 50 is fixed by the syringe clamp 14. . The outer cylinder fixing detection unit 35 outputs the detected information to the control unit 24.

The slider driving unit 36 includes, for example, a motor, and moves the slider 12 along the extending direction A (see FIG. 2) based on a signal from the control unit 24.

The imaging unit 37 is a camera that acquires an image, and includes at least an optical system and an imaging element. The imaging device acquires an image by converting an image of a subject formed on the light receiving surface into an image signal via an optical system. For example, a CCD (Charge-Coupled Device) image sensor or a CMOS (Complementary Metal-Oxide Semiconductor) image sensor is used as the imaging device. The image acquired by the imaging unit 37 is output to the control unit 24.

As shown in FIG. 1, the imaging unit 37 is attached to the slider 12. The imaging unit 37 according to the present embodiment detects a change in the distance between the pusher 55 of the syringe 50 and the slider 12 in a state where the syringe 50 is placed on the placement unit 11. Details of the imaging unit 37 as the distance change detection unit will be described later.

As shown in FIGS. 1 and 2, the tube clamp 38 is attached, for example, at the position of the tube guide portion 16, and can sandwich the tube 60. Specifically, the tube clamp 38 is based on a signal from the control unit 24 and is in an open state in which the flow path 61 defined by the tube 60 that has passed through the tube guide part 16 is opened, and in a closed state in which the flow path 61 is closed. The state can be switched. In other words, in the closed state, the tube clamp 38 serves as a liquid feeding stop unit that closes the flow path 61 of the tube 60 and stops liquid feeding from the syringe 50.

[Syphoning phenomenon etc. judgment processing]
With reference to the flowchart shown in FIG.4 and FIG.5, the liquid supply stop process including determination processes, such as a siphoning phenomenon which the syringe pump 1 performs, is demonstrated.

First, the control unit 24 of the syringe pump 1 determines whether or not the placement detection unit 34 has detected placement of the outer cylinder 51 of the syringe 50 on the placement unit 11 (step S11). When it determines with the control part 24 not having detected mounting (No of step S11), it returns to the process of step S11. On the other hand, when the control unit 24 determines that the placement is detected (Yes in Step S11), the control unit 24 starts a determination process such as a siphoning phenomenon (Step S12).

When the control unit 24 starts the siphoning phenomenon determination process, it first monitors the change in the distance between the pusher 55 and the slider 12 (step S21). That is, the control unit 24 monitors whether or not a change in the distance between the pusher 55 and the slider 12 is detected by the imaging unit 37 serving as a distance change detection unit. A change in the distance between the pusher 55 and the slider 12 is detected based on a change in the area of the pusher 55 between a plurality of images acquired by the imaging unit 37 at different timings. Specifically, since the imaging unit 37 is attached to the slider 12, a change in the distance to the pusher 55 with respect to the position of the slider 12 is detected.

A specific example in which a change in the distance between the pusher 55 and the slider 12 is detected will be described with reference to FIGS. 6 and 7. FIG. 6A is a schematic diagram showing a positional relationship between the slider 12 and the pusher 55 at the first time, and FIG. 6B is an image I ₁ acquired by the imaging unit 37 at the first time. It is a figure which shows an example. FIG. 7A is a schematic diagram showing the positional relationship between the slider 12 and the pusher 55 at the second time, and FIG. 7B shows the image I ₂ acquired by the imaging unit 37 at the second time. It is a figure which shows an example. The outer cylinder 51 of the syringe 50 shown in FIGS. 6 and 7 is placed on the placement portion 11 (see FIG. 1 and the like), and a part of the outer cylinder flange 53 is housed in the slit 15 (see FIG. 1 and the like). ing. The pusher flange 56 is not fixed to the pusher fixing portion 13. The first time and the second time are times measured by the timer unit 22 (see FIG. 3), respectively, and the second time is a time later than the first time.

As shown in FIG. 6 (a) and FIG. 7 (a), the than the distance L ₁ between the slider 12 and the impactor 55 at the first time, the slider 12 and the impactor 55 at the second time If the distance L ₂ between has become far away. At this time, the outer cylinder 51 is fixed to the syringe pump 1 in the extending direction A because a part of the outer cylinder flange 53 is accommodated in the slit 15 (see FIG. 1 and the like). Accordingly, from the first time to the second time, the pusher 55 moves in the distal direction with respect to the outer cylinder 51, and a siphoning phenomenon occurs.

As shown in FIG. 6 (b) and 7 (b), than the area _{S 1} of the impactor 55 in the image _{I 1} of the imaging unit 37 acquires the first time, the imaging unit 37 in the second time The area S ₂ of the pusher 55 in the acquired image I ₂ is smaller. This is because the distance between the slider 12 and the pusher 55, that is, the distance to the pusher 55 with respect to the position of the slider 12 increases, in the image acquired from the imaging unit 37 attached to the slider 12. This is because the area of the pusher 55 becomes smaller. As described above, the change in the distance between the pusher 55 and the slider 12 is caused by the area of the pusher 55 between the two images acquired at the first time and the second time which are different timings by the imaging unit 37. Detection can be based on changes.

The control unit 24 returns to the process of step S21 when a change in the distance between the presser 55 and the slider 12 is not detected (No in step S22). On the other hand, when a change in the distance is detected (Yes in step S22), the control unit 24 determines that a siphoning phenomenon or a liquid backflow has occurred (step S23) and ends the determination process such as the siphoning phenomenon. .

When the control unit 24 determines that the siphoning phenomenon or the back flow of the liquid is generated as a result of the siphoning phenomenon determination process (step S23), the tube clamp 38 (see FIG. The liquid supply is stopped by closing 61 (step S13), and the liquid supply stop process is terminated.

As described above, the syringe pump 1 according to the present embodiment detects a change in the distance between the pusher 55 of the syringe 50 and the slider 12 in a state where the syringe 50 is placed on the placement unit 11. Can do. Therefore, occurrence of a siphoning phenomenon or the like can be detected.

When detecting that the outer cylinder 51 of the syringe 50 is placed by the placement unit 11, the syringe pump 1 of the present embodiment starts detecting the change in the distance between the pusher 55 of the syringe 50 and the slider 12. To do. Therefore, the occurrence of a siphoning phenomenon or the like can be detected more reliably. Since detection of a change in the distance between the pusher 55 and the slider 12 is not started in a state where the syringe 50 is not placed, unnecessary detection can be avoided.

The present disclosure is not limited to the configuration specified in each of the above-described embodiments, and various modifications can be made without departing from the contents described in the claims. For example, the functions included in each component, each step, etc. can be rearranged so that there is no logical contradiction, and multiple components, steps, etc. can be combined or divided into one It is.

In the syringe pump 1 of the present embodiment, the imaging unit 37 is used as the distance change detection unit, but another distance sensor or the like may be used instead of the imaging unit 37. In the present embodiment, the tube clamp 38 is used as the liquid feeding stop unit. However, other means may be used as long as the liquid feeding from the syringe 50 can be stopped.

In the syringe pump 1 of the present embodiment, the liquid feeding is stopped when a change in the distance between the pusher 55 of the syringe 50 and the slider 12 is detected, but instead of stopping the liquid feeding or the liquid feeding. In addition to stopping, the control unit 24 may output alarm information via the display unit 32, the sound output unit 33, or the communication unit 21.

The control unit 24 of the syringe pump 1 of the present embodiment determines whether or not the placement detection unit 34 detects placement of the syringe 50 on the placement unit 11 in the process of step S11. Although the configuration is adopted, instead of the process of step S11 or in addition to the process of step S11, the outer cylinder fixing detector 35 determines whether or not the outer cylinder 51 is fixed by the syringe clamp 14, and is fixed. If it is determined that it is determined, a determination process such as a siphoning phenomenon may be started. As a result, since the determination process such as the siphoning phenomenon can be started on the condition that the outer cylinder 51 is more firmly fixed to the syringe pump 1, the occurrence of the siphoning phenomenon or the like can be detected more reliably. be able to.

When the change of the distance between the pusher 55 and the slider 12 is detected in the processing of steps S22 and S23, the control unit 24 of the syringe pump 1 of the present embodiment generates a siphoning phenomenon or a liquid backflow. However, instead of the processing of steps S22 and S23 or in addition to the processing of steps S22 and S23, when an increase in the distance between the pusher 55 and the slider 12 is detected, It may be determined that the siphoning phenomenon has occurred. Thereby, the control part 24 can detect reliably that liquid feeding has generate | occur | produced from the syringe 50 to the biological body side.

Although the control unit 24 of the syringe pump 1 of the present embodiment is configured to detect a change in the distance between the pusher 55 and the slider 12, the amount of change in the value of the distance between the pusher 55 and the slider 12. May be detected. Thereby, the quantity of the liquid sent by the siphoning phenomenon or the back flow of the liquid can be detected.

1: Syringe pump 11: Placement unit 12: Slider 13: Pusher fixing unit 14: Clamp 15 for syringe 15: Slit 16: Tube guide unit 20: Circuit unit 21: Communication unit 22: Timing unit 23: Storage unit 24: Control Unit 31: Operation input unit 32: Display unit 33: Sound output unit 34: Placement detection unit 35: Outer cylinder fixing detection unit 36: Slider drive unit 37: Imaging unit (distance change detection unit)
38: Clamp for tube (liquid feeding stop part)
50: Syringe 51: Outer cylinder 52: Hollow part 53: Outer cylinder flange 54: Outlet hole 55: Pusher 56: Pusher flange 60: Tube 61: Channel A: Extension direction of the outer cylinder of the mounted syringe B: Direction in which syringe clamp can be moved I ₁ : Image acquired by imaging unit at first time I ₂ : Image acquired by imaging unit at second time L ₁ : Between slider and pusher at first time Distance L ₂ : distance between the slider and the pusher at the second time S ₁ : area of the pusher in the image at the first time S ₂ : the pusher in the image at the second time area

Claims

A syringe pump for feeding a liquid contained in the hollow part of a syringe having an outer cylinder and a pusher capable of moving the hollow part of the outer cylinder,
A placement section capable of placing the syringe; and
A slider movable so as to engage with the pusher of the syringe placed on the placement portion;
A syringe pump comprising: a distance change detection unit that detects a change in the distance between the pusher and the slider in a state where the syringe is placed on the placement unit.
The mounting section can mount the outer cylinder,
A placement detector for detecting that the outer cylinder is placed by the placement portion;
The syringe pump according to claim 1, wherein the distance change detection unit starts detection when it is detected that the outer cylinder is placed by the placement detection unit.
The syringe pump according to claim 1 or 2, wherein the distance change detection unit detects an increase in the distance as the change in the distance.
The syringe pump according to any one of claims 1 to 3, wherein the distance change detection unit is attached to the slider and detects a change in distance to the pusher based on a position of the slider.
The distance change detection unit includes an imaging unit, and detects a change in the distance based on a change in the area of the presser between a plurality of images acquired at different timings by the imaging unit. 4. The syringe pump according to 4.
The syringe pump according to any one of claims 1 to 5, further comprising a liquid feeding stop unit that stops the liquid feeding when the change in the distance is detected by the distance change detecting unit.