WO2018141791A1 - Improved process - Google Patents
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- WO2018141791A1 WO2018141791A1 PCT/EP2018/052393 EP2018052393W WO2018141791A1 WO 2018141791 A1 WO2018141791 A1 WO 2018141791A1 EP 2018052393 W EP2018052393 W EP 2018052393W WO 2018141791 A1 WO2018141791 A1 WO 2018141791A1
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- WIPO (PCT)
- Prior art keywords
- vitamin
- alginate
- process according
- gel
- gum
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 39
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 82
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 43
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 43
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 43
- 239000011718 vitamin C Substances 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 238000009472 formulation Methods 0.000 claims abstract description 18
- 150000003700 vitamin C derivatives Chemical class 0.000 claims abstract description 17
- 150000001875 compounds Chemical class 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 241000238557 Decapoda Species 0.000 claims description 15
- 241000251468 Actinopterygii Species 0.000 claims description 14
- 239000007921 spray Substances 0.000 claims description 14
- 239000000499 gel Substances 0.000 claims description 12
- 239000000725 suspension Substances 0.000 claims description 12
- 229920001817 Agar Polymers 0.000 claims description 11
- 108010010803 Gelatin Proteins 0.000 claims description 11
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical group OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 claims description 11
- 235000010419 agar Nutrition 0.000 claims description 11
- 229920000159 gelatin Polymers 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000019322 gelatine Nutrition 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- 239000001814 pectin Substances 0.000 claims description 11
- 235000010987 pectin Nutrition 0.000 claims description 11
- 229920001277 pectin Polymers 0.000 claims description 11
- 229920002678 cellulose Polymers 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 9
- 229920000161 Locust bean gum Polymers 0.000 claims description 9
- 239000008272 agar Substances 0.000 claims description 9
- 235000010443 alginic acid Nutrition 0.000 claims description 9
- 239000000783 alginic acid Substances 0.000 claims description 9
- 229960001126 alginic acid Drugs 0.000 claims description 9
- 229920000615 alginic acid Polymers 0.000 claims description 9
- 150000004781 alginic acids Chemical class 0.000 claims description 9
- 235000010407 ammonium alginate Nutrition 0.000 claims description 9
- 239000000728 ammonium alginate Substances 0.000 claims description 9
- KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 claims description 9
- 235000010410 calcium alginate Nutrition 0.000 claims description 9
- 239000000648 calcium alginate Substances 0.000 claims description 9
- 229960002681 calcium alginate Drugs 0.000 claims description 9
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 9
- 235000010418 carrageenan Nutrition 0.000 claims description 9
- 239000000679 carrageenan Substances 0.000 claims description 9
- 229940113118 carrageenan Drugs 0.000 claims description 9
- 235000010420 locust bean gum Nutrition 0.000 claims description 9
- 239000000711 locust bean gum Substances 0.000 claims description 9
- 235000010408 potassium alginate Nutrition 0.000 claims description 9
- 239000000737 potassium alginate Substances 0.000 claims description 9
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 9
- 235000010413 sodium alginate Nutrition 0.000 claims description 9
- 239000000661 sodium alginate Substances 0.000 claims description 9
- 229940005550 sodium alginate Drugs 0.000 claims description 9
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 9
- 229920001525 carrageenan Polymers 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 238000010907 mechanical stirring Methods 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 239000004368 Modified starch Substances 0.000 claims description 2
- 235000019426 modified starch Nutrition 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 229920002148 Gellan gum Polymers 0.000 description 9
- 239000001856 Ethyl cellulose Substances 0.000 description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 6
- 235000019325 ethyl cellulose Nutrition 0.000 description 6
- 229920001249 ethyl cellulose Polymers 0.000 description 6
- 229920000609 methyl cellulose Polymers 0.000 description 6
- 235000010981 methylcellulose Nutrition 0.000 description 6
- 239000001923 methylcellulose Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000001879 gelation Methods 0.000 description 5
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- -1 CaC Chemical class 0.000 description 2
- 241000206672 Gelidium Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229920001206 natural gum Polymers 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 150000004804 polysaccharides Chemical class 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 241000143060 Americamysis bahia Species 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Definitions
- Typical gel-forming compounds include natural gums, starches, pectins, gellan, agar-agar and gelatin. Often, they are based on polysaccharides or proteins.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Birds (AREA)
- Marine Sciences & Fisheries (AREA)
- Mycology (AREA)
- Insects & Arthropods (AREA)
- Dispersion Chemistry (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a new process for the production of a more stable vitamin C (or derivative of vitamin C) formulation.
Description
IMPROVED PROCESS
The present invention relates to a new process for the production of a more stable vitamin C (or derivative of vitamin C) formulation.
Vitamin C is crucial in farmed fish and shrimp. Fish and shrimp are unable to synthesize vitamin C themselves, so it must be obtained through their diets.
Vitamin C is needed for:
'Growth and development
•Reproduction
•Wound healing
•Resistance to disease and immune system strength
Vitamin C has also some issue with its stability and therefore needs to be protected.
It is also common in the field of aquaculture to use a derivative of vitamin C instead of vitamin C. A very common and widely used derivative of vitamin C is L-ascorbyl-2-mono- phosphate.
L-ascorbyl-2-monophosphate is a more stable derivative form of vitamin C, which is has excellent properties and which is now used in many fish and shrimp farms.
This vitamin C derivative is L-ascorbyl-2-monophosphate, which is represented by the following formula (I)
Surprisingly it was found that when the vitamin C (or the derivative) is mixed with at least one gum and then suspended in water before added on to the feed form, a more stable feed form is obtained. Additionally, this process can be carried with a minimal technical equipment. In fact, it could be carried out with kitchen appliances or even without any electrical equipment.
Therefore, the present invention relates to a process (P) for producing a feed formulation comprising the following steps
(i) a gel is formed by adding vitamin C and/or at least one derivative of vitamin C is added to at least one gel-forming compound chosen from the group consisting of the at least one gel-forming compound is chosen from the group consisting of alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, gellan, carrageenan, locust bean gum, pectin gelatin and modified cellulose (such as methyl cellulose, ethyl cellulose, etc), and the mixture is gelled,
(ii) the gel of step (i) is mixed with (commercially available) fish or shrimp feed.
The so obtained formulation is more stable in regard to the loss of vitamin C (and/or derivative of vitamin C) while immersed in water.
This is a very important advantage for the fish or shrimp farmer.
Due to the simplicity of this process, it is possible to use simple household (kitchen) appliances (such as an electric mixer) or just an eggbeater.
It is clear that the process can also be carried out with equipment, which is used industrially.
The so obtained improved formulation is a feed formulation for fish and/or shrimps. Therefore, all ingredients as well as their amounts used in the process according to the present invention are such ingredients and amounts thereof, which are approved for such feed for- mulations.
The various steps of the process are discussed in further details.
Step (i): (vitamin C and/or at least one derivative of vitamin C is added to a gel-forming compound and the mixture is gelled)
The first step is done according to the prior art.
Typical gel-forming compounds include natural gums, starches, pectins, gellan, agar-agar and gelatin. Often, they are based on polysaccharides or proteins.
Suitable gel-forming compounds are for example:
alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, gellan, carrageenan, locust bean gum, pectin gelatin and modified cellulose (such as methyl cellulose, ethyl cellulose, etc). Therefore the present invention relates to a process (P1 ), which is process (P), wherein step (i) the at least one gel-forming compound is chosen from the group consisting of alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, gellan, carrageenan, locust bean gum, pectin gelatin and modified cellulose (such as methyl cellulose, ethyl cellulose, etc).
The gelation process of the gelling agent can be initiated as commonly known. Very often the gelation is initiated by cations (such as Ca2+, Mg2+, Na+ and K+), which are added to the gel-forming compounds as an aqueous solution of a salt (such as CaC , MgC , NaCI, and KCI).
Usually and preferably the vitamin C and/or the vitamin C derivate is added to water and then the gel-forming compound is added and finally the gelling process is carried out. It is also possible to add the solution of vitamin C and/or the vitamin C derivates to the gel- forming compound.
In case a vitamin C derivate is not very well water-soluble (such as for example L-ascorbyl- 2-monophosphate) then it has to transformed into a water-soluble form.
L-ascorbyl-2-monophosphate for example is transformed into a water-soluble salt.
Step (i) is usually carried out at ambient temperature. There is no need to heat the mixture.
Step (ii): {the gel of step (i) is mixed with (commercially available) fish or shrimp feed)
In this step, the gel, which is obtained from step (i), is added to the feed formulation. The feed can be any kind of feed (also commercially), which is to be fortified by vitamin C and/or a derivative of vitamin C (or the feed is added to the by vitamin C and/or a derivative of vitamin C).
The mixing is carried out under stirring (mechanical stirring or stirring by hand).
The so obtained fortified feed formulation can be used as such or if needed can be further fortified and/or brought in any other suitable application form.
Furthermore, more is also possible that the process according to the present invention can have additional steps. It is also possible that the formulation can be dried after the gelation. This can be of an advantage when the process is carried out not at one single location and/or at the same point in time. The spray-dried form can be stored and this form is storage stable.
Therefore, the present invention relates to a process (P2) for producing a feed formulation comprising the following steps
a. vitamin C and/or at least one derivative of vitamin C is added to at least one gel- forming compound chosen from the group consisting of the at least one gel- forming compound is chosen from the group consisting of alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, gellan, carrageenan, locust bean gum, pectin gelatin and modified cellulose (such as methyl cellulose, ethyl cellulose, etc) and gelled,
b. the gelled form of step a is spray dried
c. the spray dried form of step b is mixed together with at least one gum and this mixture is suspended in water
d. the suspension of step c is mixed with (commercially available) fish or shrimp feed.
Therefore, the present invention relates to a process (P3) for producing a feed formulation consisting of the following steps
a. vitamin C and/or at least one derivative of vitamin C is added to at least one gel- forming compound chosen from the group consisting of the at least one gel- forming compound is chosen from the group consisting of alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, gellan, carrageenan, locust bean gum, pectin gelatin and modified cellulose (such as methyl cellulose, ethyl cellulose, etc) and gelled,
b. the gelled form of step a is spray dried
c. the spray dried form of step b is mixed together with at least one gum and this mixture is suspended in water
d. the suspension of step c is mixed with (commercially available) fish or shrimp feed.
Steps (a) and (c) are in analogy the steps (i) and (ii) of process (P) and (P1 ).
The 4 steps (especially the 2 additional ones) are discussed in more details. Step (a): (vitamin C and/or at least one derivative of vitamin C is added to at least one gel- forming compound and gelled)
The first step is done according to the prior art.
Typical gel-forming compounds include natural gums, starches, pectins, gellan, agar-agar and gelatin. Often, they are based on polysaccharides or proteins.
Suitable gel-forming compounds are for example:
alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, gellan, carrageenan, locust bean gum, pectin gelatin and modified cellulose (such as methyl cellulose, ethyl cellulose, etc).
The gelation process of the gelling agent can be initiated as commonly known. Very often the gelation is initiated by cations (such as Ca2+, Mg2+, Na+ and K+), which are added to the gel-forming compounds as an aqueous solution of a salt (such as CaC , MgC , NaCI, and KCI).
Usually and preferably the vitamin C and/or the vitamin C derivate is added to water and then the gel-forming compound is added and finally the gelling process is carried out. It is
also possible to add the solution of vitamin C and/or the vitamin C derivates to the gel- forming compound.
In case a vitamin C derivate is not very well water-soluble (such as for example L-ascorbyl- 2-monophosphate) then it has to transformed into a water-soluble form.
L-ascorbyl-2-monophosphate for example is transformed into a water-soluble salt.
Step (a) is usually carried out at ambient temperature. There is no need to heat the mixture. The amount of vitamin C and/or vitamin C derivate included in the gel can be adjusted according to solubility of vitamin C and/or vitamin C derivate.
Step (b): (the gelled form of step a is spray dried)
The gel, which is obtained from step (a) can now, be spray dried using commonly known spray drying processes.
A very suitable way to do so is by using a bench-top spray drier (about 120°C - 170°C inlet temperature and 50 - 90 °C outlet temperature).
The so obtained product can be stored it needed.
Step (c): (the spray-dried form of step b is mixed together with at least one gum and this mixture is suspended in water)
The spray-dried product obtained from step b is suspended in water and usually and preferably, at least one gum is added to the suspension. This gum can be natural or synthetic. Suitable gums are for example guar gum, xanthan gum, modified starch, and carboxyl me- thyl cellulose, and hydroxyl ethyl cellulose.
The suspension is produced usually under stirring.
Step (c) is usually carried out at ambient temperature. There is no need to heat the mixture. The ratio of the spray-dried product obtained from step b to the gum added in step c can be adjusted according to the targeted vitamin C and/or vitamin derivate concentration in fish/shrimp feed.
Step (d): (the suspension of step c is mixed with (commercially available) fish or shrimp feed)
In this step the suspension, which is obtained from step (c), is added to the feed formulation. The feed can be any kind of feed (also commercially), which is to be fortified by vitamin C and/or a derivative of vitamin C (or the feed is added to the by vitamin C and/or a derivative of vitamin C).
The mixing is carried out under stirring (mechanical stirring or stirring by hand).
The so obtained fortified feed formulation can be used as such or if needed can be further fortified and/or brought in any other suitable application form.
The following Example illustrates the invention further without limiting it. All percentages and parts, which are given, are related to the weight and the temperatures are given in °C, when not otherwise stated.
Fig. 1 : Retention of Stay-C in feed pellets at the end of 10, 30 and 60 min immersion in water
Examples
Example 1 : 0.1 g of sodium citrate and 10 g of Stay-C® (from DSM) were dissolved in 75 g of deionized water in a glass beaker and mixed. Afterwards 0.08 g of low acyl gellan gum was slowly added into water with continuous mixing for 30 min.
Then 15 g of a 2% aqueous CaC solution was added drop by drop into solution to initiate gel formation with continuous mixing for 15 min.
Afterwards 100 g of the so prepared gel solution was pumped to a bench-top spray drier under mixing at 150°C inlet temperature and 66°C outlet temperature. The spray dried gel powder was collected and stored.
Then 10 g of this so spray-dried Stay-C® gel powder, 0.7 g of guar gum powder, and 0.3 g of xanthan gum powder were added together into 89 g of deionized water and mixed at 600 rpm for 20-30 min to obtain homogeneous suspension.
Finally 25 g of commercial shrimp feed was mixed with 0.5 g (20g/kg feed) of the prepared suspension in a round bottom flask by hand shaking followed by 15-30 min rotating in a rotatory evaporator to absorb the residual suspension on the flask.
The so obtained fortified feed formulation was then tested in view of the vitamin C stability. For that purpose, an immersion test was carried out.
The immersion test, the test feed (inventive embodiments) and the control feed were immersed into 1500 g of deionized water in a glass beaker and kept static throughout immersion test. The L-Ascorbate-2-Monophosphate level in the water was analyzed at 10, 30 and 60 min. Feed pellets were weighed and analyzed for dry matter content. Retention percent- age were then calculated.
The control feed was produced as follows: 10 g of Stay-C® was dissolved into 90 g of deionized water. 0.5 g solution was then sprayed onto 25 g of commercial feed, the same level of Stay C® as test feed.
The results of the test was summarized in Figure 1 , where it can be seen that the feed formulation which is produced according to process of the present invention shows an significantly improved stability!
Claims
1. Process for producing a feed formulation comprising the following steps
(i) a gel is formed by adding vitamin C and/or at least one derivative of vitamin C is added to at least one gel-forming compound chosen from the group consisting of alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, car- rageenan, locust bean gum, pectin gelatin and modified cellulose, and
(ii) the gel of step (i) is mixed with (commercially available) fish or shrimp feed.
2. Process according to claim 1 , wherein the steps of the process are carried out by using household kitchen appliances.
3. Process according to any of the preceding claims, wherein the vitamin C derivative is L-ascorbyl-2-monophosphate.
4. Process according to any of the preceding claims, wherein step (ii) the mixing is carried out under stirring (mechanical stirring or stirring by hand).
5. Process according to any of the preceding claims, wherein the process has additional steps.
6. Process according to claim 5, wherein the process comprises the following steps a. vitamin C and/or at least one derivative of vitamin C is added to at least one gel-forming compound chosen from the group consisting of alginic acid, sodium alginate, potas- sium alginate, ammonium alginate, calcium alginate agar, carrageenan, locust bean gum, pectin gelatin and modified cellulose and gelled, and
b. the gelled form of step a is spray dried, and
c. the spray dried form of step b is mixed together with at least one gum and this mixture is suspended in water, and
d. the suspension of step c is mixed with (commercially available) fish or shrimp feed.
7. Process according to claim 5, wherein the process consists of the following steps
a. vitamin C and/or at least one derivative of vitamin C is added to at least one gel-forming compound chosen from the group consisting of alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate agar, carrageenan, locust bean gum, pectin gelatin and modified cellulose and gelled, and
b. the gelled form of step a is spray dried, and
c. the spray dried form of step b is mixed together with at least one gum and this mixture is suspended in water, and
d. the suspension of step c is mixed with (commercially available) fish or shrimp feed.
8. Process according to claim 6 or claim 7, wherein the vitamin C derivative is L-ascorbyl- 2-monophosphate.
9. Process according to anyone of claim 6 - 8, wherein step (b) the spray drying is carried out by a bench-top spray drier.
10. Process according to anyone of claim 7 - 9, wherein step (d) the gum is chosen from the groups consisting of guar gum, xanthan gum, modified starch, and carboxyl methyl cellulose, and hydroxyl ethyl cellulose.
11. Process according to anyone of claim 7 - 10, wherein step (c) the suspension is produced under stirring.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201880009695.6A CN110234239A (en) | 2017-02-03 | 2018-01-31 | Improved method |
| PH12019501686A PH12019501686A1 (en) | 2017-02-03 | 2019-07-22 | Improved process |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17154561 | 2017-02-03 | ||
| EP17154561.9 | 2017-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2018141791A1 true WO2018141791A1 (en) | 2018-08-09 |
Family
ID=57963103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2018/052393 WO2018141791A1 (en) | 2017-02-03 | 2018-01-31 | Improved process |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN110234239A (en) |
| PH (1) | PH12019501686A1 (en) |
| WO (1) | WO2018141791A1 (en) |
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| EP1046345A2 (en) * | 1999-04-23 | 2000-10-25 | Showa Denko Kabushiki Kaisha | Preparation for administration to animals and feeding method thereof |
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| DE19739167A1 (en) * | 1997-09-06 | 1999-03-11 | Baensch Tetra Werke | Gel-like food for aquatic animals |
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| CN103039697B (en) * | 2012-12-04 | 2014-05-07 | 清远海贝生物技术有限公司 | Method for reducing dissolved loss of water-soluble vitamins in aquatic expanded feed |
| CN103783323B (en) * | 2014-02-05 | 2016-05-18 | 褚旭 | A kind of animal complex vitamin premix preparation method |
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- 2018-01-31 CN CN201880009695.6A patent/CN110234239A/en active Pending
- 2018-01-31 WO PCT/EP2018/052393 patent/WO2018141791A1/en active Application Filing
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- 2019-07-22 PH PH12019501686A patent/PH12019501686A1/en unknown
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| US5215767A (en) * | 1991-03-16 | 1993-06-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Additive for aquaculture feed for fish and shellfish and aquaculture feed for fish and shellfish which contains same |
| EP1046345A2 (en) * | 1999-04-23 | 2000-10-25 | Showa Denko Kabushiki Kaisha | Preparation for administration to animals and feeding method thereof |
| WO2001070044A1 (en) * | 2000-03-24 | 2001-09-27 | Aventis Animal Nutrition S.A. | Liquid vitamin composition |
| WO2003086099A1 (en) * | 2002-04-18 | 2003-10-23 | Showa Denko K.K. | Fish-farming solid feed and process for producing same |
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| WO2014083067A1 (en) * | 2012-11-27 | 2014-06-05 | Dsm Ip Assets B. V. | Process for the production of discrete solid extruded particles |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN110234239A (en) | 2019-09-13 |
| PH12019501686A1 (en) | 2020-06-01 |
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