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WO2017121019A1 - Composition antimicrobienne - Google Patents

Composition antimicrobienne Download PDF

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Publication number
WO2017121019A1
WO2017121019A1 PCT/CN2016/075291 CN2016075291W WO2017121019A1 WO 2017121019 A1 WO2017121019 A1 WO 2017121019A1 CN 2016075291 W CN2016075291 W CN 2016075291W WO 2017121019 A1 WO2017121019 A1 WO 2017121019A1
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WO
WIPO (PCT)
Prior art keywords
copper
mbit
bbit
bit
bacterial
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PCT/CN2016/075291
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English (en)
Chinese (zh)
Inventor
仲汉根
季红进
Original Assignee
江苏辉丰农化股份有限公司
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Publication of WO2017121019A1 publication Critical patent/WO2017121019A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing carboxylic groups or thio analogues thereof, directly attached by the carbon atom to a cycloaliphatic ring; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper

Definitions

  • the present invention relates to the field of agricultural plant protection, and more particularly to a bactericidal composition having improved properties, and more particularly to a bactericidal composition comprising a benzisothiazolinone and a copper-containing formulation.
  • Benzoisothiazolinones are a new type of broad-spectrum fungicide mainly used for the prevention and treatment of various bacterial and fungal diseases such as cereal crops, vegetables and fruits.
  • the mechanism of bactericidal action mainly includes destroying the nuclear structure of the pathogen, causing it to lose the heart part and failing to death and interfering with the metabolism of the pathogenic cells, causing its physiological disorder and ultimately leading to death. It can effectively protect plants from pathogens in the early stage of disease occurrence. Increasing the dosage after disease occurrence can obviously control the spread of pathogens, thus achieving the dual functions of protection and eradication.
  • Copper preparation pesticides have a good preventive effect on common fungal and bacterial diseases.
  • the copper preparations commonly used in agriculture are mainly divided into organic copper and inorganic copper.
  • the inorganic copper mainly includes copper sulfate or basic copper sulfate, cuprous oxide and copper hydroxide.
  • the common organic copper in agriculture is mainly copper complex, which is common. There are copper succinate, copper acetate, copper octoate, copper ruthenate, copper amide or copper rosinate.
  • Copper sulphate can be used to kill fungi. It is mixed with lime water to form Bordeaux mixture, which is used as a fungicide to control fungi on crops such as lemon and grape. Dilute solutions are used for sterilization in aquariums and for removing snails. Since copper ions are toxic to fish, the amount must be strictly controlled. Most fungi can be killed with very low concentrations of copper sulfate, and E. coli can also be controlled. In addition, the aquaculture industry is also used as the main raw material for trace element copper in feed additives.
  • Copper hydroxide is a blue powder and is a protective broad-spectrum fungicide. It is suitable for the main fungi and bacterial diseases of crops such as melon, fruit and vegetables. After preparation, the drug solution is stable and the diffusion performance is good. After spraying, it has strong adhesion and is resistant to rain. It can release copper ions stably and slowly. Generally, it is not easy to produce phytotoxicity to crops, and bacteria are not easy to produce drug resistance. At the same time, it can treat fungi and bacterial diseases, and it is safe for humans and animals.
  • the bactericide of multi-site action of basic copper sulphate has a fine particle size, good dispersibility, and is resistant to rain and wash, and can firmly adhere to the surface of the plant to form a protective film.
  • the basic copper sulphate relies on water on the surface of the plant. Acidification, the gradual release of copper ions, inhibition of fungal spore germination and mycelial development, can effectively control the fungal and bacterial diseases of crops.
  • Cuprous oxide is a protective fungicide that effectively inhibits the growth of mycelium, destroys its reproductive organs, and prevents spread. Used for seed treatment and foliar spray. Seed dressing to control powdery mildew, leaf spot, blight, scab and rot, can be used for spinach Soaking seeds, beets, tomatoes, peppers, peas, pumpkins, kidney beans and melon seeds can also be sprayed to control fruit tree diseases. It can also be used for seed dressing to kill cockroaches and snails.
  • Acrylate copper sulphate is a mixture of succinic acid copper, glutaric acid copper and copper adipate copper, which is a protective fungicide.
  • the exchange of copper ions with the cations on the surface of the pathogen membrane causes the protein on the cell membrane of the pathogen to coagulate, and at the same time, part of the copper ions penetrate into the cells of the pathogen to bind with certain enzymes, affecting its activity. It can be used to control bacterial bacterial leaf spot and has a stimulating effect on plant growth.
  • Copper acetate is formed by complexing acetic acid with copper.
  • 20% copper acetate wettable powder is commonly used to control the diseases of various crops.
  • the control targets include squatting, anthracnose, wilt, virus disease, etc. .
  • Suitable crops include cucumber, watermelon, onion, tomato, pepper, eggplant and other vegetables and cotton, rice and other crops.
  • Copper octoate and copper ruthenate are bacterial and fungal diseases that mainly control crops. Such as citrus canker disease, cucumber bacterial leaf spot, rice bacterial leaf streak and so on.
  • Complex ammonia copper is a mixed agricultural fungicide with tetraammonium complex copper salt. It has strong systemic absorption and is mainly protective. It has a certain eradication effect. It is mainly used to control citrus canker disease, watermelon wilt, and rice stalk. Sick and so on. It has a certain promoting effect on the growth of crops such as cotton and watermelon. Mainly through the copper ions to play a bactericidal effect, the copper ions exchange with the cations such as K + ions and H + ions on the surface of the pathogenic bacteria cell membrane, so that the proteins on the cell membrane of the pathogenic bacteria are coagulated, and some copper ions penetrate into the cells of the pathogenic bacteria to bind with certain enzymes.
  • ammonium copper can prevent and cure various diseases caused by fungi, bacteria and molds, and can promote deep roots and leaves, increase chlorophyll content, enhance photosynthesis and drought resistance, and have obvious effects of increasing yield.
  • Copper rosinate is a new type of copper bactericidal pesticide with high efficiency, low toxicity and broad spectrum. It has the characteristics of long-lasting effect and convenient use. It overcomes many shortcomings of the original Bordeaux mixture and is an ideal fungicide for replacing Bordeaux mixture. And there is a dual role of preventive protection and treatment. It can be used to control common plant diseases caused by various fungi and bacteria, and has obvious stimulating growth effect on vegetables. It can be alternated with other fungicides and has good spraying effect. It is used to control various vegetable diseases such as melon downy mildew, epidemic disease, black star disease, anthracnose, bacterial angular spot disease, eggplant blight, tomato late blight.
  • the purpose of the invention is to screen out different germicidal sources for the resistance of the bactericide in practical application and the problem of soil residue.
  • the compound fungicide is compounded to obtain a new fungicide composition to improve the control effect of the fungicide, delay the generation of resistance, reduce the application amount, and reduce the cost of prevention.
  • Another object of the present invention is to provide a process for the preparation of a bactericidal composition comprising two active ingredients A and B and for the control of crop diseases in the agricultural sector.
  • the object of the invention can be achieved by the following measures:
  • a synergistic fungicidal composition comprising two active components A and B, wherein active component A is a structural compound having formula (I), and active component B is selected from inorganic copper containing Or one of organic copper bactericides.
  • R is selected from H or a C 1 - C 8 alkyl group.
  • the organocopper bactericide in active component B is a copper-containing complex.
  • the inorganic copper bactericide in the active component B is selected from the group consisting of copper sulfate, basic copper sulfate, cuprous oxide or copper hydroxide, and the organic copper bactericide is selected from the group consisting of succinic acid.
  • the organic copper bactericide is selected from the group consisting of succinic acid.
  • the C 1 -C 8 alkyl group in the present invention means a linear or branched alkyl group having 1 to 8 carbon atoms, and includes a C 1 alkyl group (e.g., methyl group) and a C 2 alkyl group (e.g., ethyl group). , C 3 alkyl (such as n-propyl, isopropyl), C 4 alkyl (such as n-butyl, isobutyl, tert-butyl, sec-butyl), C 5 alkyl (such as n-pentyl, etc.) , C 6 alkyl, C 7 alkyl, C 8 alkyl. It includes, but is not limited to, C 1 -C 6 alkyl, C 1 -C 5 alkyl, C 1 -C 4 alkyl, and the like.
  • R is selected from H or a C 1 -C 4 alkyl group.
  • R is selected from the group consisting of H, -CH 3 or -C 4 H 9 .
  • A is 1,2-benzisothiazolin-3-one (abbreviated as BIT in the specification).
  • R is CH 3
  • A is 2-methyl-1,2-benzisothiazolin-3-one (abbreviated as MBIT in the specification).
  • A is 2-butyl-1,2-benzisothiazolin-3-one
  • the "butyl group” in the formula may be selected from n-butyl group. Isobutyl, tert-butyl, sec-butyl, collectively referred to as 2-butyl-1,2-benzisothiazolin-3-one (in the specification, n-butyl-1,2-benzisothiazoline) -3-ketone abbreviation BBIT).
  • the copper octoate in the present invention is a complex copper, which may be a linear copper ortho-octanoate or other form of a octyl group containing a branched alkyl group. Acid copper.
  • the copper ruthenate in the present invention is a complex copper, and may be a linear copper orthosilicate or other form of copper ruthenate containing a branched alkyl group.
  • the inventors have found through experiments that the composition of the present invention is effective for controlling bacterial or fungal diseases of crops, and more importantly, the application amount is reduced and the use cost is lowered.
  • the compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can expand the bactericidal spectrum, and can delay the generation and development of pathogen resistance to a certain extent, and component A and group There is no cross-resistance between points B.
  • the weight ratio between the two components in the bactericidal composition of the present invention is from 1:30 to 15:1, preferably from 1:25 to 10:1, further preferably from 1:20 to 10:1, more preferably 1:20. 1:1.
  • the weight ratio between the two components of the components A and B can be further optimized to 1:20 to 8:1, and a particularly preferred ratio is 1:20 ⁇ 5:1.
  • the weight ratio between the two components can be 1:30, 1:29, 1:28, 1:27, 1:26, 1:25, 1:24, 1:24, 1: 22, 1:21, 1:20, 1:19, 1:18, 1:17, 1:16, 1:15, 1:14, 1:13, 1:12, 1:11, 1:10, 1:9, 1:8, 1:7, 1:6, 1:5, 1:4, 1:3, 1:2, 1:1, 2:1, 3:1, 4:1, 5: 1, 6:1, 7:1, 8:1, 9:1, 10:1, 11:1, 12:1, 13:1, 14:1, 15:1, 2:3, 3:2 2:5, 5:2, 3:4, 4:3, 5:2, 2:5, 5:3, 3:5, 5:4, 4:5 are selected among these ratios. These ratios are understood to be weight ratios and may also include molar ratios.
  • composition of the present invention can be made into a pesticide-acceptable dosage form from the active ingredient and agrochemical adjuvant or adjuvant. Further, the composition comprises from 5 to 80% by weight of the active ingredient and from 95 to 20% by weight of the pesticide adjuvant to form a pesticide-acceptable dosage form.
  • the present invention provides the use of a bactericidal composition comprising component A and component B for controlling crop diseases in the agricultural sector, in particular for controlling fungi or bacteria of certain crops.
  • composition may specifically comprise an agrochemical adjuvant or an auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant or a fertilizer.
  • auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant or a fertilizer.
  • auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant or a fertilizer.
  • auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant or a fertilizer.
  • Common auxiliaries can be mixed during the application.
  • auxiliaries or auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders. .
  • the composition of the present invention can be processed into a preparation of various dosage forms with a fertilizer, or co-administered or mixed with a fertilizer.
  • Suitable fertilizers include one or more of a large number of elements such as nitrogen, phosphorus, potassium, or the like, or one or more trace elements of copper, iron, manganese, zinc, boron, calcium, magnesium, sulfur, or the like, or A mixture of one or two of a fertilizer containing humic acid, amino acid, or the like.
  • the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
  • the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
  • the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
  • composition of the present invention can be prepared into various pesticide-acceptable dosage forms including, but not limited to, emulsifiable concentrates, suspending agents, wettable powders, water-dispersible granules, powders, granules, aqueous preparations, aqueous emulsions, microemulsions, poison baits.
  • the dosage form of the invention employs a wettable powder, a suspending agent, a water-dispersible granule, an aqueous emulsion or a microemulsion.
  • the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
  • composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
  • the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
  • ketones such as cyclohexanone
  • highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
  • vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
  • the active component A When preparing a liquid dosage form, the active component A may be first dissolved in a basic substance to form a benzisothiazoline metal salt.
  • Suitable basic materials include: alkali metal carbonates, alkali metal hydroxides (such as sodium hydroxide, potassium hydroxide), alkali metal alkoxy carbonates, alkali metal alkoxides or magnesium methoxide.
  • the two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound.
  • the synergistic effect is manifested by allowing for a reduced application rate, a broader fungicidal control profile, quicker effect, longer lasting control effect, better control of plant harmful fungi by only one or a few applications, and broadening of possible application. Intervals. These properties are particularly desirable in the practice of plant fungi control.
  • the bactericidal composition of the invention can be applied to the agricultural field for controlling crop diseases, and the specific diseases targeted include, but are not limited to, peach perforated bacterial perforation, tobacco wildfire, rice sheath blight, cucumber bacterial angular spot, cucumber Downy mildew, rice bacterial stripe disease, rice bacterial base rot, corn bacterial wilt, watermelon wilt, grape downy mildew, tomato bacterial wilt, eggplant bacterial wilt, rice blast, rice bacterium Stripe disease, pepper anthracnose, litchi ulcer disease, grape anthracnose, tobacco bacterial wilt, cucumber anthracnose, celery spot blotch, lotus root blight, strawberry powdery mildew, lettuce downy mildew, celery gray mold, Apricot bacterial perforation, peach tree canker, onion downy mildew, cotton bacterial leaf spot, cucumber bacterial leaf blight and so on.
  • the other characteristics exhibited by the bactericidal composition of the present invention are mainly as follows: 1.
  • the compounding of the composition of the present invention has obvious synergistic effect; 2. Since the chemical composition of the two single agents of the present composition is greatly different, the effect The mechanism is completely different, there is no cross-resistance, and the problem of resistance caused by the separate use of the two single agents can be delayed; 3.
  • the composition of the present invention is safe and safe for crops. It has been proved by experiments that the bactericidal composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.
  • the active ingredient active group A and the active component B, and the auxiliary agent and the filler are uniformly mixed according to the formula, and are pulverized into a wettable powder by a jet stream, and then added with a certain amount of water to be mixed and extruded, granulated, and dried and sieved.
  • a water dispersible granule product A water dispersible granule product.
  • Active component A BIT
  • active component B to prepare water-dispersible granules
  • Example 1 31% BIT ⁇ copper sulfate water dispersible granules
  • Example 2 16% BIT ⁇ copper sulfate water dispersible granules
  • Example 3 31% BIT ⁇ basic copper sulfate water dispersible granules
  • Example 4 16% BIT ⁇ basic copper sulfate water dispersible granules
  • Example 5 31% BIT ⁇ cuprous oxide water dispersible granules
  • Example 6 16% BIT ⁇ cuprous oxide water dispersible granules
  • Example 7 31% BIT ⁇ copper hydroxide water dispersible granules
  • Example 8 16% BIT ⁇ copper hydroxide water dispersible granules
  • BIT 15% 1% copper hydroxide, 5% fatty alcohol polyoxyethylene ether, 4% calcium dodecylbenzenesulfonate, 3% magnesium carbonate, and 100% kaolin.
  • Example 9 31% BIT ⁇ succinic acid copper copper dispersible granules
  • Example 10 16% BIT ⁇ succinic acid copper copper dispersible granules
  • Example 11 31% BIT ⁇ copper acetate water dispersible granules
  • Example 12 16% BIT ⁇ copper acetate water dispersible granules
  • Example 13 31% BIT ⁇ copper octoate dispersible granules
  • Example 14 16% BIT copper octoate dispersible granules
  • Example 15 31% BIT ⁇ copper citrate water dispersible granules
  • Example 16 16% BIT ⁇ copper citrate water dispersible granules
  • Example 17 31% BIT ⁇ copper-copper water dispersible granules
  • Example 18 16% MBIT ⁇ branched copper water dispersible granules
  • Example 19 31% BIT ⁇ copper rosinate dispersible granules
  • Example 20 16% MBIT ⁇ copper rosinate dispersible granules
  • Active component A MBIT
  • active component B to prepare water-dispersible granules
  • Example 21 31% MBIT ⁇ copper sulfate water dispersible granules
  • Example 22 16% MBIT ⁇ copper sulfate water dispersible granules
  • Example 23 31% MBIT ⁇ basic copper sulfate water dispersible granules
  • Example 24 16% MBIT ⁇ basic copper sulfate water dispersible granules
  • Example 25 31% MBIT ⁇ cuprous oxide water dispersible granules
  • Example 26 16% MBIT ⁇ cuprous oxide water dispersible granules
  • Example 27 31% MBIT ⁇ copper hydroxide water dispersible granules
  • Example 28 16% MBIT ⁇ copper hydroxide water dispersible granules
  • Example 29 31% MBIT ⁇ succinic acid copper copper dispersible granules
  • Example 30 16% MBIT ⁇ succinic acid copper copper dispersible granules
  • MBIT was 15%, succinic acid copper was 1%, and the remaining components were prepared in accordance with the method of Example 10.
  • Example 31 31% MBIT ⁇ copper acetate water dispersible granules
  • Example 32 16% MBIT ⁇ copper acetate water dispersible granules
  • MBIT was 15%, copper acetate was 1%, and the remaining components were prepared in the same manner as in Example 12.
  • Example 33 31% MBIT ⁇ copper octoate dispersible granules
  • Example 34 16% MBIT ⁇ copper octoate dispersible granules
  • Example 35 31% MBIT ⁇ copper citrate water dispersible granules
  • Example 36 16% MBIT ⁇ copper citrate water dispersible granules
  • Example 37 31% MBIT ⁇ copper copper water dispersible granules
  • Example 38 16% MBIT ⁇ copper copper water dispersible granules
  • MBIT was 15%, copper ammonia was 1%, and the remaining components were prepared in the same manner as in Example 18.
  • Example 39 31% MBIT ⁇ copper rosinate dispersible granules
  • Example 40 16% MBIT ⁇ copper rosinate dispersible granules
  • Active component A BBIT
  • active component B to prepare water-dispersible granules
  • Example 41 31% BBIT ⁇ copper sulfate water dispersible granules
  • Example 42 16% BBIT ⁇ copper sulfate water dispersible granules
  • Example 43 31% BBIT ⁇ basic copper sulfate water dispersible granules
  • Example 44 16% BBIT ⁇ basic copper sulfate water dispersible granules
  • Example 45 31% BBIT ⁇ cuprous oxide water-dispersible granules
  • Example 46 16% BBIT ⁇ cuprous oxide water dispersible granules
  • Example 47 31% BBIT ⁇ copper hydroxide water dispersible granules
  • Example 48 16% BBIT ⁇ copper hydroxide water dispersible granules
  • Example 49 31% BBIT ⁇ succinic acid copper copper dispersible granules
  • Example 50 16% BBIT ⁇ succinic acid copper copper dispersible granules
  • Example 51 31% BBIT ⁇ copper acetate water dispersible granules
  • Example 52 16% BBIT ⁇ copper acetate water dispersible granules
  • Example 53 31% BBIT ⁇ copper octoate water dispersible granules
  • Example 54 16% BBIT ⁇ copper octoate dispersible granules
  • Example 55 31% BBIT ⁇ copper citrate water dispersible granules
  • Example 56 16% BBIT ⁇ copper citrate water dispersible granules
  • Example 57 31% BBIT ⁇ copper copper water dispersible granules
  • Example 58 16% BBIT ⁇ copper copper water dispersible granules
  • Example 59 31% BBIT ⁇ copper rosinate dispersible granules
  • Example 60 16% BBIT ⁇ copper rosinate dispersible granules
  • the active ingredient active group A and the active component B, and the components such as a dispersing agent, a wetting agent, a thickener and water are uniformly mixed according to the formula, and after being sanded and/or sheared at a high speed, a semi-finished product is obtained. After the analysis, the water is mixed and evenly filtered to obtain the finished product.
  • Active component A (BIT) and active component B to prepare suspension agent
  • Example 61 16% BIT ⁇ copper sulfate suspension
  • Example 62 20% BIT ⁇ copper sulfate suspension
  • Example 63 16% BIT ⁇ basic copper sulfate suspension
  • Example 64 20% BIT ⁇ basic copper sulfate suspension
  • Example 65 16% BIT ⁇ cuprous oxide suspension
  • Example 66 20% BIT ⁇ cuprous oxide suspension
  • Example 67 16% BIT ⁇ copper hydroxide suspension
  • BIT1% copper hydroxide 15%, 5.2g, polynaphthaldehyde sulfonate sodium salt 4%, fatty alcohol polyoxyethylene ether 2%, glycerol 4%, n-octanol 1%, sodium alginate 0.5%, lactic acid 0.5%, water is made up to 100%.
  • Example 68 20% BIT ⁇ copper hydroxide suspension
  • Example 69 16% BIT ⁇ succinic acid copper suspending agent
  • BIT1% acryl acid copper 15%, alkylphenol formaldehyde resin polyoxyethylene ether 3%, calcium lignosulfonate 5%, ethylene glycol 4%, polydimethylsiloxane 0.4%, xanthan gum 0.2%, sodium benzoate 0.2%, water to 100%.
  • Example 70 20% BIT ⁇ succinic acid copper suspending agent
  • Example 71 16% BIT ⁇ copper acetate suspension
  • Example 72 20% BIT ⁇ copper acetate suspension
  • Example 73 16% BIT ⁇ copper octoate suspension
  • Example 74 20% BIT ⁇ copper octoate suspension
  • Example 75 16% BIT ⁇ copper citrate suspension
  • Example 76 20% BIT ⁇ copper citrate suspension
  • Example 77 16% BIT ⁇ copper copper suspension
  • Example 78 20% BIT ⁇ copper copper suspension
  • Example 79 16% BIT ⁇ copper rosinate suspension
  • Example 80 20% BIT ⁇ copper rosinate suspension
  • Example 81 16% MBIT ⁇ copper sulfate suspension
  • Example 82 20% MBIT ⁇ copper sulfate suspension
  • Example 83 16% MBIT ⁇ basic copper sulfate suspension
  • Example 84 20% MBIT ⁇ basic copper sulfate suspension
  • Example 86 20% MBIT ⁇ cuprous oxide suspension
  • MBIT was 15%, 5% cuprous oxide, and the remaining components were prepared in accordance with the procedure of Example 66.
  • Example 88 20% MBIT ⁇ copper hydroxide suspension
  • Example 89 16% MBIT ⁇ succinic acid copper suspending agent
  • Example 90 20% MBIT ⁇ succinic acid copper suspending agent
  • MBIT was 15%, succinic acid copper 5%, and the remaining components were prepared in accordance with the procedure of Example 70.
  • Example 92 20% MBIT ⁇ copper acetate suspension
  • Example 94 20% MBIT ⁇ copper octoate suspension
  • Example 96 20% MBIT ⁇ copper citrate suspension
  • Example 98 20% MBIT ⁇ copper copper suspension
  • MBIT was 15%, copper copper was 5%, and the remaining components were prepared in accordance with the procedure of Example 78.
  • Example 99 16% MBIT ⁇ copper rosinate suspension
  • Example 100 20% MBIT ⁇ copper rosinate suspension
  • Example 101 16% BBIT ⁇ copper sulfate suspension
  • Example 102 20% BBIT ⁇ copper sulfate suspension
  • Example 103 16% BBIT ⁇ basic copper sulfate suspension
  • Example 104 20% BBIT ⁇ basic copper sulfate suspension
  • Example 105 16% BBIT ⁇ cuprous oxide suspension
  • Example 106 20% BBIT ⁇ cuprous oxide suspension
  • Example 108 20% BBIT ⁇ copper hydroxide suspension
  • Example 109 16% BBIT ⁇ succinic acid copper suspending agent
  • Example 110 20% BBIT ⁇ succinic acid copper suspending agent
  • Example 111 16% BBIT ⁇ copper acetate suspension
  • Example 112 20% BBIT ⁇ copper acetate suspension
  • Example 113 16% BBIT ⁇ copper octoate suspension
  • Example 114 20% BBIT ⁇ copper octoate suspension
  • Example 116 20% BBIT ⁇ copper citrate suspension
  • Example 118 20% BBIT ⁇ copper copper suspension
  • Example 119 16% BBIT ⁇ copper rosinate suspension
  • Example 120 20% BBIT ⁇ copper rosinate suspension
  • the active ingredient A and the B active ingredient are sufficiently mixed with various auxiliary agents and fillers, and are pulverized by an ultrafine pulverizer to obtain a wettable powder.
  • Active component A BIT
  • active component B wettable powder
  • Example 121 20% BIT ⁇ copper sulfate wettable powder
  • Example 122 20% BIT ⁇ basic copper sulfate wettable powder
  • Example 123 20% BIT ⁇ cuprous oxide wettable powder
  • Example 124 20% BIT ⁇ copper hydroxide wettable powder
  • Example 125 20% BIT ⁇ succinic acid copper WP
  • Example 126 20% BIT ⁇ copper acetate wettable powder
  • Example 127 20% BIT ⁇ copper octoate wettable powder
  • Example 128 20% BIT ⁇ copper citrate wettable powder
  • Example 129 20% BIT ⁇ lumenium copper wettable powder
  • Example 130 20% BIT ⁇ copper rosinate wettable powder
  • Active component A MBIT
  • active component B active component B
  • Example 131 20% MBIT ⁇ copper sulfate wettable powder
  • Example 132 20% MBIT ⁇ basic copper sulfate wettable powder
  • Example 133 20% MBIT ⁇ cuprous oxide wettable powder
  • Example 134 20% MBIT ⁇ copper hydroxide wettable powder
  • Example 135 20% MBIT ⁇ succinic acid copper WP
  • Example 136 20% MBIT ⁇ copper acetate wettable powder
  • the MBIT was 5%, copper acetate was 15%, and the remaining components were prepared in the same manner as in Example 126.
  • Example 137 20% MBIT ⁇ copper octoate wettable powder
  • Example 138 20% MBIT ⁇ copper citrate wettable powder
  • Example 139 20% MBIT ⁇ lumena copper wettable powder
  • Example 140 20% MBIT ⁇ copper rosinate wettable powder
  • Active component A (BBIT) and active component B to prepare wettable powder
  • Example 141 20% BBIT ⁇ copper sulfate wettable powder
  • Example 142 20% BBIT ⁇ basic copper sulfate wettable powder
  • Example 143 20% BBIT ⁇ cuprous oxide wettable powder
  • Example 144 20% BBIT ⁇ copper hydroxide wettable powder
  • Example 135 20% BBIT ⁇ succinic acid copper WP
  • Example 146 20% BBIT ⁇ copper acetate wettable powder
  • Example 147 20% BBIT ⁇ copper octoate wettable powder
  • Example 148 20% BBIT ⁇ copper citrate wettable powder
  • Example 149 20% BBIT ⁇ lumenium copper wettable powder
  • Example 150 20% BBIT ⁇ copper rosinate wettable powder
  • the control effect is converted into the probability value (y), the liquid height ( ⁇ g/ml) is converted into a logarithmic value (x), the virulence equation is calculated by the least squares method, and the neutral concentration EC50 is suppressed, and the virulence of the drug is calculated according to the method of Sun Yunpei. Exponential Co-toxicity Factor (CTC).
  • CTC Exponential Co-toxicity Factor
  • Measured virulence index (ATI) (standard drug EC50 / test drug EC50) * 100
  • Theoretical virulence index (TTI) A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture
  • CTC Co-toxicity coefficient [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100
  • CTC ⁇ 80 the composition showed antagonism, 80 ⁇ CTC ⁇ 120, the composition showed an additive effect, CTC ⁇ 120, and the composition showed synergistic effect.
  • Test method In the early stage of the disease, the first spray was immediately performed, and after 7 days, the second application was carried out, each treatment of 4 cells, 20 square meters per cell. The incidence of the disease was investigated before the drug and 11 days after the second drug. Each plot was randomly sampled at 5 points, and 5 crops were investigated at each point. The percentage of the lesion area per leaf on the whole plant was counted and graded. Disease index and control effect.
  • Grade 1 less than 5 leaf lesions, less than 1 cm in length;
  • Grade 3 6-10 leaf lesions, some lesions are longer than 1 cm;
  • Grade 5 11-25 leaf lesions, some lesions are connected into pieces, and the lesion area accounts for 10-25% of the leaf area;
  • Grade 7 more than 26 leaf lesions, the lesions are connected into pieces, and the lesion area accounts for 26-50% of the leaf area;
  • Grade 9 The lesions are connected into pieces, and the area of the lesions accounts for more than 50% of the leaf area or the whole leaves are dead.
  • Table 32 BIT combined with basic copper sulphate for controlling rice blast
  • Table 34 BIT and copper hydroxide mixed with tomato bacterial spot disease control effect
  • Table 35 BIT combined with succinated acid and acid copper to control the bacterial perforation of peach trees
  • Table 36 BIT combined with copper acetate to control the effect of citrus canker
  • Table 37 BIT and copper ocyanate mixed with the control effect of cowpea bacterial angular leaf spot
  • Table 38 BIT combined with copper citrate to control the bacterial wilt of watermelon
  • Table 39 BIT and complex ammonia copper mixed with mango bacterial spot disease control effect
  • Table 40 BIT combined with copper rosinate for the control effect of chrysanthemum bacterial angular leaf spot
  • Table 42 MBIT combined with basic copper sulfate to control the control of mango bacterial spot disease

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Abstract

La présente invention concerne une composition antimicrobienne. La composition comprend deux principes actifs, A et B. Le principe actif A est un composé structurel représenté par la formule (I), et le principe actif B est un agent antimicrobien à base de cuivre organique ou de cuivre inorganique. Le rapport pondéral entre les composants est de 1:30 à 15:1. La présente invention concerne également un procédé de préparation et d'utilisation de la composition. Un résultat expérimental a indiqué que la composition antimicrobienne de l'invention est significativement plus efficace. Surtout, les coûts d'application sont réduits grâce à une quantité d'application réduite. La composition antimicrobienne peut éviter efficacement une maladie fongique spécifique sur une culture. En combinant des agents antimicrobiens avec différents mécanismes et modes d'action, la quantité d'application d'un agent antimicrobien individuel peut être réduite efficacement. L'invention est utile pour étendre le spectre antimicrobien, ralentir la croissance fongique et le développement de la résistance fongique, et augmenter les effets préventifs.
PCT/CN2016/075291 2016-01-11 2016-03-02 Composition antimicrobienne WO2017121019A1 (fr)

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