WO2016188426A1 - Fluid channel calibration device, fluid infusion apparatus, and calibration and manufacturing methods - Google Patents

Abstract

A fluid channel calibration device used in a fluid infusion apparatus used for administering a medicament to a patient, the fluid infusion apparatus having the fluid channel calibration device and used for administrating the medicament to the patient, and calibration and manufacturing methods. The fluid channel calibration device comprises a calibration mechanism joined with a fluid channel and is used for changing the flow of a fluid flowing out of an outlet extremity of the fluid channel, thus calibrating a deviation between the flow of the fluid in the fluid channel and a standard flow value. The device, apparatus, and methods therefor allow the calibration of the deviation in the flow of the fluid in the fluid channel, thus increasing the yield of fluid channel processing.

Description

Fluid channel calibration device, fluid infusion device, and calibration and manufacturing method

This application claims priority to Chinese Patent Application No. 201510270365.0, entitled "Fluid Channel Calibration Device, Fluid Infusion Device, and Calibration and Manufacturing Method" issued by the State Intellectual Property Office of China on May 25, 2015. The entire contents are incorporated herein by reference.

Technical field

The present invention relates to the field of fluid delivery, and in particular to a fluid channel calibration device for use in a fluid infusion device for administering a patient, and a fluid channel calibration device for administering a patient Fluid infusion device, fluid channel calibration method for use in a fluid infusion device for administering a patient, and method of manufacturing a fluid infusion device for administering a patient with a fluid channel calibration device.

Background technique

As people demand more and more control parameters for fluid infusion (eg, drug infusion, etc.), correspondingly, the processing parameters of fluid infusion devices are becoming more and more demanding. In the field of drug infusion, microchannels are required for drug delivery. However, since the parameters of the inner diameter of the microchannel are relatively high, they are generally on the order of micrometers (μm). However, for the existing processing methods, the yield of microchannel production is low, and the difficulty factor for mass production of microchannels accurately and stably is relatively large.

Summary of the invention

In order to solve the above technical problems, the present invention provides a calibration device for a fluid channel for use in a fluid infusion device for administering a patient, the device comprising a calibration mechanism engaged with a fluid channel, by calibration The mechanism is capable of varying the flow of fluid from the outlet end of the fluid passage to calibrate the deviation of the flow of fluid in the fluid passage from a predetermined flow standard value to increase the yield of microchannel production.

According to a first aspect of an embodiment of the present invention, there is provided a fluid channel calibration device for use in a fluid infusion device for administering a patient, the device comprising:

a calibration mechanism having a portion engaged with a fluid passage for varying a flow of fluid flowing from an outlet end of the fluid passage to calibrate flow and flow of fluid in the fluid passage The deviation between the standard values.

In some embodiments, the calibration mechanism can vary the flow of fluid exiting the outlet end of the fluid passage by varying the flow area of the fluid through the calibration mechanism.

In some embodiments, the calibration mechanism can include a calibration block disposed at an outlet end of the fluid passage for varying a flow of fluid flowing from the outlet end of the fluid passage.

In some embodiments, the calibration block can have a through hole that allows fluid in the fluid passage to flow out, wherein the diameter of the through hole is determined according to the amount of change in the flow area and the inner diameter of the fluid passage.

In some embodiments, the calibration mechanism can include a calibration ring disposed on a channel surface of the fluid channel for compressing an inner diameter of the fluid channel.

In some embodiments, the diameter of the calibration ring can be determined based on the amount of change in the flow area and the inner diameter of the fluid passage.

In some embodiments, the calibration mechanism can include a calibration block disposed at an outlet end of the fluid channel, having a flow area on a surface in communication with an outlet of the fluid channel, the flow area configured to have an allowable a through hole through which the fluid of the fluid passage flows out; a selection mechanism operatively coupled to the calibration block, configured to select a portion of the flow area to communicate with an outlet of the fluid passage.

In some embodiments, the selection mechanism can include a stop configured to block a portion of the flow area.

In some embodiments, the calibration block can include a plurality of flow areas configured to have different flow areas from each other, the stops configured to block one or more circulation of the calibration block The selection mechanism can further include: a knob operatively coupled to the stop and configured to be rotated to selectively block the one or more of the plurality of flow regions .

In some embodiments, the through hole of the flow area of the calibration block can be configured to have a uniform diameter; the selection mechanism can further include: a knob operatively coupled to the stop, configured to be rotated to cause the The stop gradually increases or decreases the occluded area of the flow area.

According to a second aspect of an embodiment of the present invention, there is provided a fluid infusion device for administering a patient with a fluid channel calibration device, the fluid infusion device comprising: a housing, for example, a housing Suitable for wearing on the patient's skin for portable use, or for wearing on a belt a reservoir or the like; a reservoir disposed in the housing for storing the infused fluid; a delivery assembly disposed in the housing in communication with the reservoir, having a reservoir in the reservoir a fluid passage to the fluid assembly of the injection assembly; a fluid passage calibration device for calibrating the fluid passage of the delivery assembly; an injection assembly in communication with the delivery assembly for passing fluid output by the delivery assembly An injection needle extending from the housing is in fluid communication with the patient. Wherein, the fluid channel calibration device may be any one of the fluid channel calibration devices described in the above embodiments.

According to a third aspect of an embodiment of the present invention, there is provided a fluid channel calibration method for use in a fluid infusion device for administering a patient, the method comprising: determining a flow and flow standard of a fluid in a fluid channel Deviation between values; providing a fluid channel calibration device by which the deviation is calibrated. Wherein, the fluid channel calibration device may be any one of the fluid channel calibration devices described in the above embodiments.

According to a fourth aspect of an embodiment of the present invention, there is provided a method of manufacturing a fluid infusion device for administering a patient with a fluid channel calibration device, the method comprising: providing a housing; providing a storage infusion a reservoir of fluid, wherein the reservoir is disposed within the housing; a delivery assembly is provided, disposed within the housing, in communication with the reservoir, having a fluid in the reservoir a fluid channel delivered to the injection assembly; a fluid channel calibration device for calibrating a fluid channel of the delivery assembly; providing fluid for outputting the delivery assembly via an injection needle extending from the housing An injection assembly in fluid communication with the patient, wherein the injection assembly is in communication with the delivery assembly. Wherein, the fluid channel calibration device may be any one of the fluid channel calibration devices described in the above embodiments.

The device, the device and the calibration and manufacturing method provided by the embodiments of the present invention can quickly calibrate the flow rate of the fluid in the fluid channel by changing the flow area of the fluid passing through the calibration mechanism, and can also be conveniently Realize the adjustment of the flow selection.

DRAWINGS

1 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient according to a first embodiment of the present invention;

2 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient according to a second embodiment of the present invention;

3 is a fluid infusion set for administering a patient according to a third embodiment of the present invention. Schematic diagram of the fluid channel calibration device used in the preparation;

4 is a schematic cross-sectional view of a calibration block in communication with a fluid passage in accordance with a third embodiment of the present invention;

5 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient according to a fourth embodiment of the present invention;

Figure 6 is a schematic cross-sectional view of a calibration block in communication with a fluid passage in accordance with a fourth embodiment of the present invention;

7 is a flow diagram of a fluid channel calibration method for use in a fluid infusion device for administering a patient in accordance with an embodiment of the present invention;

8 is a flow diagram of a method of making a fluid infusion device for administering a patient with a fluid channel calibration device in accordance with an embodiment of the present invention.

detailed description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings.

Embodiments of the present invention provide a fluid channel calibration device for use in a fluid infusion device for administering a patient, the fluid channel calibration device can be used to calibrate various fluids (eg, for humans, animals, etc.) The flow of fluid, fluid, etc., through which the patient is administered, is a closed conduit. Wherein, the flow rate is the amount of fluid flowing through the cross section of the fluid passage per unit time, and the amount of fluid can be calculated by volume. In some embodiments, the fluid can include a liquid drug, such as insulin, and the like. In the case where the infused fluid is insulin, the unit of flow rate can be unit/hour, wherein the conversion ratio of the unit/ml in the unit/hour is 100:1, that is, 1 ml is 100 units. The fluid channel calibration device can include a calibration mechanism having a portion that engages the fluid channel, the portion can be engaged with the fluid channel at a plurality of locations, for example, at the inlet end, the outlet end, or at the inlet end and the outlet of the fluid channel Engage or install a calibration mechanism anywhere between the ends. The engagement of the calibration mechanism with the fluid passage is also In a variety of ways, for example, a fixed connection or a detachable connection may be employed. The fluid passages according to embodiments of the present invention are fluid passages having a small bore diameter that can be used for administration to a patient, and may have a cross-sectional shape that is substantially circular or other shapes that are easy to manufacture in a manufacturing process. The pore diameter of the fluid channel may be any one or more (for example, 2 or more) ranging from 1 μm to 200 μm, for example, the pore diameter may be 1 μm, 2 μm, 3 μm, 5 μm, 7 μm, 10 μm, 20 μm, 30 μm, 50 μm, Any one or more of 100 μm, 150 μm, and 200 μm.

The calibration mechanism can change the flow of fluid flowing out of the outlet end of the fluid passage by a change in the flow area of the fluid passing through or through the calibration mechanism, for example, the flow area of the fluid passing through the calibration mechanism can be reduced to reduce the flow from the fluid passage The flow of fluid out of the outlet end. For example, in the process of detecting the flow rate of the fluid in the fluid passage, it is found that the flow rate of the fluid is greater than a preset flow standard value, that is, the deviation of the flow rate of the fluid in the fluid passage from the standard value of the flow rate is positive, A calibration mechanism capable of reducing the flow area of the fluid therethrough is accordingly selected to calibrate the deviation of the positive value.

[First Embodiment]

1 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient according to a first embodiment of the present invention. The fluid channel calibration device 100 can include a calibration block 101 having a through hole 102 that allows fluid in the fluid channel 103 to flow out. For example, the calibration block 101 can be disposed in the fluid channel 103 (although in the embodiment shown in FIG. 1, the cross section of the fluid channel 103 is circular, but in other embodiments, the cross section of the fluid channel can be other shapes that are easy to manufacture. The outlet end of the fluid channel 103 can be joined in a consolidating manner, wherein the fluid in the fluid channel 103 flows in the direction indicated by the arrow in FIG. The fluid channel 103 is sealed from the junction of the calibration block 101, for example, a recess 104 can be provided that is in close engagement with the outer surface of the fluid channel 103 and can receive the outlet end of the fluid channel 103, ensuring that the fluid delivered in the fluid channel 103 is only calibrated. The through hole 102 of the block 101 flows out.

In the calibration block 101 shown in FIG. 1, the through hole 102 is disposed at the center of the calibration block 101, and the number is one. In some other embodiments, the through holes may be disposed at other positions of the calibration block, and the number may be plural, for example, two or more. The through hole 102 on the calibration block 101 can Processing by laser drilling or the like. The diameter of the through hole 102 can be determined according to the deviation between the flow rate of the fluid in the fluid passage 103 to be calibrated and the set flow rate standard value, and the deviation of the flow rate can be further made by the amount of change in the flow area flowing through the calibration block 101. Calculation. In the case where the flow rate of the fluid in the fluid passage 103 is greater than a preset flow standard value, this is also a frequent occurrence in the microchannel machining process, and the flow deviation of the fluid in the fluid passage is positive, and the flow calibration can be selected to be reduced. The calibration block 101 of the flow area of the block fluid calibrates the deviation of the positive value, for example, the diameter of the through hole 102 on the calibration block 101 can be made smaller than the inner diameter of the fluid passage 103.

In addition to the flow calibration of the through hole 102 on the calibration block 101, the length parameter of the through hole 102 can be considered, for example, by selecting a longer through hole (for example, by selecting a calibration block having a larger thickness). The flow restriction of the fluid in the fluid passage 103 is brought to or further.

[Second Embodiment]

2 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient in accordance with a second embodiment of the present invention. The fluid channel calibration device 200 can include a calibration ring 201 that is capable of compressing the inner diameter of the fluid channel. The calibration ring 201 can be nested in a plurality of positions of the fluid passage 202, for example, at any position or outlet end between the inlet end and the outlet end. In the embodiment shown in FIG. 2, the calibration ring 201 is nested between the inlet end and the outlet end of the fluid passage 202, and the number is one. In other embodiments, the calibration ring can be a plurality of calibration rings that are respectively placed at multiple locations in the fluid channel.

The calibration ring 201 can be fabricated from a material that is slightly stiffer and tougher than the material from which the fluid channel 202 is made, so that the fluid channel 202 can be securely clamped to compress the inner diameter of the fluid channel 202. The diameter of the calibration ring 201 can be determined based on the amount of change in flow area corresponding to the flow deviation of the fluid passage 202 and the inner diameter of the fluid passage 202. The larger the flow deviation of the flow passage 202 (for example, the positive flow deviation), the larger the change amount of the corresponding flow area, and the positive correlation between the two, the calibration ring 201 can be selected to be small relative to the inner diameter of the fluid passage 202. The more the diameter. The more the diameter of the calibration ring 201 is smaller than the inner diameter of the fluid passage 202, the higher the degree of compression of the inner diameter of the fluid passage 202, and thus the greater the amount of change in the flow area of the fluid flowing through the calibration ring 201.

In addition to calibrating the flow rate by the diameter parameter selection, the calibration ring 201 can also take into account the length parameter. For example, the fluid in the fluid channel 202 can be enhanced by lengthening the length of the calibration ring 201 or increasing the number of calibration rings 201 of the same length. Traffic restrictions.

[Third embodiment]

3 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient according to a third embodiment of the present invention; and FIG. 4 is a view of a calibration block according to a third embodiment of the present invention. Schematic diagram of the cross section of the fluid passage. The fluid channel calibration device 300 can include a calibration block 301, a stop 302 operatively coupled to the calibration block 301, and a knob 303 operatively coupled to the stop 302, wherein the calibration block 301 can have a rounded surface mounted in the fluid channel 304 (although in the embodiment shown in FIG. 3, the cross section of the fluid passage 304 is circular, in other embodiments, the cross section of the fluid passage may be other shapes that are easy to manufacture), at the outlet with the fluid passage 304 The outlet fluidly communicating surface has one or more flow-through regions, for example, a flow-through region may be formed by one or more through-holes that allow fluid in the fluid passage 304 to flow out, wherein the fluid in the fluid passage 304 is along the arrow in FIG. The direction shown flows. In such a case, a portion of the stopper selection calibration block 301 that can block a portion of the flow-through region can communicate with the outlet of the fluid passage 304, thereby changing the flow area of the fluid passing through the calibration device 300.

In the embodiment shown in FIG. 3 and FIG. 4, the calibration block 301 includes four flow areas 3011, 3012, 3013, and 3014, each of which has a flow area different from each other, and a calibration block occupying a circular surface, respectively. 1/4 area of 301. For example, as shown in FIG. 4, the diameters of the through holes in the four flow areas 3011, 3012, 3013, and 3014 of the calibration block 301 may be sequentially increased and different from each other. In the calibration block shown in FIG. 4, the number of through holes in each flow area is one. In other embodiments, the number of through holes in the circulation area may be plural, for example, two or more. In other embodiments, the diameters of the through holes of the respective flow areas may not be sequentially increased or decreased sequentially, but may be irregularly arranged different from each other.

The stop 302 can be configured to block one or more flow areas of the calibration block 301. In the embodiment illustrated in Figure 3, the stop 302 is designed to be the same size as the calibration block 301 and does not allow fluid to permeate or flow through. The obstruction can block three of the four flow areas of the calibration block 301, leaving one flow area communicating with the outlet of the fluid passage 304. In other embodiments, the stop 302 can also be designed to block 2 or 1 of the flow areas therein, leaving 2 or 3 flow areas in communication with the outlet of the fluid passage 304. The rotary knob 303 can perform a circular motion together with the stopper 302 connected thereto, and block the three flow areas in the calibration block 301 by the curvature of the rotation, so that one of the flow areas is kept in communication. The knob 303 shown in FIG. 3 can be rotated 360 degrees, each rotation of 90 degrees, One of the flow-through regions in the calibration block 301 can be selected to be in fluid communication with the fluid channel 304 such that the flow of fluid in the fluid channel 304 through the calibration device 300 changes. Since the flow areas of the respective flow areas of the calibration block 301 are different from each other, the flow area flowing through the calibration device 300 can be discretely changed by rotating the knob 303, and a plurality of different flow rate selections can be obtained, so that a plurality of fluid passages having different deviations can be obtained. Perform calibration. Obviously, according to the embodiment, not only the flow rate of the fluid passage can be calibrated, but also the flow rate can be selected, so that the user can select different fluid infusion speeds according to the needs.

Fourth Embodiment

5 is a schematic structural view of a fluid channel calibration device used in a fluid infusion device for administering a patient according to a fourth embodiment of the present invention; FIG. 6 is a view of a calibration block according to a fourth embodiment of the present invention. Schematic diagram of the cross section of the fluid passage. The fluid channel calibration device 400 can include a calibration block 401, a stop 402 operatively coupled to the calibration block 401, and a knob 403 operatively coupled to the stop 402, wherein the calibration block 401 can be disposed at the exit end of the fluid channel 404 ( The fluid in fluid passage 404 flows in the direction indicated by the arrow in Figure 4, and has a flow-through region on the surface in fluid communication with the outlet of fluid passage 404 that allows fluid to flow out, the flow-through region having a uniform diameter through-hole. As shown in FIG. 6, the 1/4 area 4011 of the calibration block 401 is a flow area having a plurality of through holes of uniform diameter thereon. In some other embodiments, the flow area of the calibration block 401 may be 1/2, 1/3, 3/4, 2/5 area of the calibration block, etc., and the diameter of the through hole on the circulation area may be uniform or may be uniform. It is not uniform.

The stop 402 may be configured to block a portion of the flow area of the calibration block 401. For example, in the case where the flow area 4011 shown in FIG. 6 is a quarter area of the calibration block 401, the stop 402 may be designed to be aligned with the calibration block 401. The contours of the same size that do not allow fluid to permeate or flow through can at least block the 1/4 region 4011 on the circumference of the calibration block 401. The stop 402 can achieve occlusion in a variety of ways. For example, a fixed-size occlusion similar to the stop shown in FIG. 4 can be used to continuously increase the occluded area of the flow area from 0 to 90° by continuously rotating the knob 403 connected to the stop 402, in the opposite direction. Rotating the knob 403 can cause the stop 402 to gradually decrease the occluded area of the flow area from 0 to 90°. For another example, the block 402 can also be a circumferentially retractable covering similar to the foldable fan. By rotating a certain arc of the knob 403, the block 402 can open the corresponding arcing obstruction, thereby gradually increasing or decreasing the calibration. The occluded area of the flow area of block 401, thereby continuously changing The flow area of the fluid passing through the calibration device 400 more accurately calibrates the flow deviation of the fluid in the fluid passage.

In other embodiments of the present invention, a fixed-size stopper may be fixedly coupled to the calibration block 401 to block the fixed region of the flow-through region, and effects similar to those of the first embodiment or the second embodiment may be achieved.

Embodiments of the present invention also provide a fluid infusion device for administering a patient with a fluid channel calibration device. The fluid infusion device may include: a housing, for example, the housing may be adapted to be worn on a patient's skin for portable use by the patient, or may be worn on a belt, in a pocket, etc.; the reservoir is disposed in the housing, a fluid for storing an infusion; a delivery assembly disposed within the housing in communication with the reservoir, having a fluid passage for delivering fluid in the reservoir to the injection assembly; a fluid passage calibration device for fluid to the delivery assembly The channel is calibrated and an injection assembly is in communication with the delivery assembly for fluidly communicating fluid output from the delivery assembly with the patient via an injection needle extending from the housing. Wherein, the fluid channel calibration device may be any one of the calibration devices described in the various embodiments above. The fluid channel calibration device described above not only calibrates the flow of fluid in the fluid channel, but also enables adjustment of the flow of fluid in the fluid channel, significantly improving the manufacture of fluid infusion devices (eg, insulin infusion devices). The yield is convenient for the infusion equipment to be stably mass-produced.

Embodiments of the present invention also provide a fluid channel calibration method for use in a fluid infusion device for administering a patient. 7 is a flow diagram of a fluid channel calibration method for use in a fluid infusion device for administering a patient in accordance with an embodiment of the present invention. The calibration method may include: step S101, determining a deviation between a flow rate of a fluid in the fluid passage and a flow standard value; and step S102, providing a fluid passage calibration device; and step S103, calibrating the deviation by the fluid passage calibration device. Wherein, the flow rate of the fluid in the fluid passage can be detected by a plurality of tests, and the flow standard value can be a value required by the passage processing technology. The fluid channel calibration device can be any of the calibration devices described in the various embodiments described above. The diameter parameter or the length parameter of the calibration block of the fluid channel calibration device can be determined by a plurality of tests, and the ability of different diameter or length parameters to adjust the flow rate of the fluid channel can be determined through multiple tests, and then detected according to the above test. The flow deviation of the fluid passage selects the corresponding fluid passage calibration device.

Embodiments of the present invention also provide a method of making a fluid infusion device for administering a patient with a fluid channel calibration device. 8 is a manufacturing flow with a flow according to an embodiment of the present invention. A schematic flow diagram of a method of a fluid infusion device for administering a patient to a body channel calibration device. The method may include: step S201, providing a housing, for example, the housing may be adapted to be worn on the patient's skin to facilitate portable use by the patient, or may be worn on a belt, placed in a pocket, etc.; step S202, providing storage infusion a fluid reservoir, wherein the reservoir is disposed in the housing; and in step S203, a delivery assembly is provided, wherein the delivery assembly is disposed in the housing and is in communication with the reservoir, and has a fluid in the reservoir to the injection assembly a fluid passage; step S204, providing a fluid passage calibration device for calibrating the fluid passage of the delivery assembly, wherein the fluid passage calibration device may be any one of the calibration devices described in the various embodiments above, step S205, An injection assembly is provided that fluidly communicates the delivery of the delivery assembly with the patient via an injection needle extending from the housing, wherein the injection assembly is in fluid communication with the delivery assembly. By providing the fluid channel calibration device of the various embodiments described above, the yield of the fluid infusion device can be improved, thereby reducing the manufacturing cost of the fluid infusion device, and facilitating the popularization of the fluid infusion device.

It should be noted that, although the various aspects of the above-described devices, devices, methods, and the like are described in a particular order and specific structural arrangement, this is for the purpose of illustration only and is not limiting of the invention, the claimed subject matter It is limited to the order and structural arrangement described. It will be appreciated by those skilled in the art that various modifications can be made in the invention and equivalents can be made without departing from the spirit of the invention. Therefore, the claimed subject matter is not limited to the specific embodiments disclosed above, and may include all technical solutions falling within the scope of the claims and equivalent technical solutions. Furthermore, in the claims, all terms are to be understood in the broadest

Claims (13)

A fluid channel calibration device for use in a fluid infusion device for administering a patient, comprising: A calibration mechanism having a portion that engages a fluid passage for varying a flow of fluid exiting the outlet end of the fluid passage to calibrate a deviation between a flow of fluid in the fluid passage and a flow standard value. The device of claim 1 wherein said calibration mechanism changes the flow of fluid from said fluid passage outlet end by varying the flow area of fluid through said calibration mechanism. The apparatus of claim 2 wherein said calibration mechanism includes a calibration block disposed at an outlet end of said fluid passage for varying a flow of fluid flowing from said fluid passage outlet end. The apparatus according to claim 3, wherein said calibration block has a through hole allowing a fluid in said fluid passage to flow out, wherein a diameter of said through hole is changed according to said flow area and said The inner diameter of the fluid passage is determined. The device of claim 2 wherein said calibration mechanism includes a calibration ring disposed on a channel surface of said fluid passage for compressing an inner diameter of said fluid passage. The device according to claim 5, wherein the diameter of the calibration ring is determined according to the amount of change in the flow area and the inner diameter of the fluid passage. The device of claim 2 wherein said calibration mechanism comprises: a calibration block disposed at an outlet end of the fluid passage, having a flow-through region on a surface in communication with an outlet of the fluid passage, the flow-through region being configured to have a through hole allowing fluid of the fluid passage to flow out, A selection mechanism operatively coupled to the calibration block and configured to select a portion of the flow-through region to communicate with an outlet of the fluid passage. The apparatus of claim 7 wherein said selection mechanism comprises: The stop is configured to block a portion of the flow area. The apparatus according to claim 8, wherein said calibration block includes a plurality of flow areas, said plurality of flow areas being configured to have flow areas different from each other, The stop is configured to block one or more flow areas of the calibration block, The selection mechanism further includes: A knob operatively coupled to the stop and configured to be rotated such that the stop selectively obscures one or more of the plurality of flow regions. The apparatus according to claim 8, wherein the through holes of the flow area of the calibration block are configured to have a uniform diameter, The selection mechanism further includes: A knob operatively coupled to the stop and configured to be rotated to cause the stop to gradually increase or decrease an occluded area of the flow area. A fluid infusion device for administering a patient with a fluid channel calibration device, comprising: case; a reservoir disposed in the housing for storing the infused fluid; a delivery assembly disposed within the housing in communication with the reservoir, having a fluid passageway for delivering fluid in the reservoir to an injection assembly; A fluid channel calibration device according to any one of claims 1 to 10 for calibrating a fluid passage of the delivery assembly, An injection assembly in communication with the delivery assembly for fluidly communicating fluid output by the delivery assembly with the patient via an injection needle extending from the housing. A fluid channel calibration method for use in a fluid infusion device for administering a patient, comprising: Determining the deviation between the flow rate of the fluid in the fluid passage and the flow standard value; A fluid passage calibration device according to any one of claims 1 to 10, The deviation is calibrated by the fluid channel calibration device. A method of manufacturing a fluid infusion device for administering a patient with a fluid channel calibration device, comprising: Providing a housing; Providing a reservoir for storing the infused fluid, wherein the reservoir is disposed within the housing; Providing a delivery assembly, wherein the delivery assembly is disposed within the housing in communication with the reservoir, having a fluid passageway for delivering fluid in the reservoir to an injection assembly; Providing a fluid passage calibration device for calibrating a fluid passage of the delivery assembly according to any one of claims 1 to 10. An injection assembly is provided in fluid communication with the patient via an injection needle extending from the housing, the fluid output from the delivery assembly, wherein the injection assembly is in communication with the delivery assembly.

Images