[go: up one dir, main page]

WO2016060538A1 - Valve de compensation et de régulation de la pression intraoculaire - Google Patents

Valve de compensation et de régulation de la pression intraoculaire Download PDF

Info

Publication number
WO2016060538A1
WO2016060538A1 PCT/MX2014/000165 MX2014000165W WO2016060538A1 WO 2016060538 A1 WO2016060538 A1 WO 2016060538A1 MX 2014000165 W MX2014000165 W MX 2014000165W WO 2016060538 A1 WO2016060538 A1 WO 2016060538A1
Authority
WO
WIPO (PCT)
Prior art keywords
valve
rod
spring
contact
valve seat
Prior art date
Application number
PCT/MX2014/000165
Other languages
English (en)
Spanish (es)
Inventor
Manuel Humberto Gallardo Inzunza
Original Assignee
Manuel Humberto Gallardo Inzunza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manuel Humberto Gallardo Inzunza filed Critical Manuel Humberto Gallardo Inzunza
Publication of WO2016060538A1 publication Critical patent/WO2016060538A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery

Definitions

  • the present invention relates to devices for use in the treatment of glaucoma, and specifically to a device for reducing intraocular pressure.
  • Glaucoma is an eye disease that is characterized as a neuropathy in which various mechanisms causing deterioration or death of ganglion cells, one of the important factors and so far controllable factor is that of intraocular pressure, for this reason the intention is to keep it at a normal level.
  • One of the theories of damage to cells is that caused by elevated intraocular pressure that, through mechanical theory, causes compression of nerve fibers and consequently damages the optic nerve, which can undoubtedly lead to irreversible damage. to the ganglion cells, nerve fibers and optic nerve atrophy and as a consequence damage and reduction to the visual field until it can be completely lost.
  • aqueous humor which is mostly produced in the cilar processes behind the iris. This fluid leaves (is dislodged) from the eye through channels in the front of the eye, in a area called the angle of the anterior chamber or simply the angle.
  • a normal eye has generally been considered an intraocular pressure (10-20 mm Hg) as normally appropriate, through circulation within the eye of aqueous humor, which is secreted from the ciliary body, passes through the pupil to the anterior chamber of the eyeball, and seeps out of the eyeball through the trabeculum and the Schlemm Canal.
  • the excretory path of aqueous humor is blocked, the aqueous humor cannot leave the eyeball at an adequate speed, the intraocular pressure rises, the eyeball hardens, and direct damage occurs to subsequently develop atrophy of the optic nerve which It's called glaucoma.
  • a characteristic optic neuropathy develops, resulting in progressive death of retinal ganglion cells, restriction of the visual field, and finally blindness occurs.
  • the advanced stages of the disease are also characterized by significant pain.
  • Glaucoma treatment if started early in the course of the disease, can prevent further deterioration and preserve most of the ocular functions.
  • the goal of glaucoma treatment is to reduce intraocular pressure to a level that is considered safe for particular vision, but is not so low as to cause ocular malfunction or retinal complications.
  • Typical ophthalmic implants have a valve mechanism to regulate the flow of aqueous humor from the anterior chamber; Defects in and / or failure of such valve mechanisms can lead to excessive loss of aqueous humor from the eyeball and possible hypotonia. Implants also tend to become clogged over time, either from the inside by the tissue, such as the iris, being aspirated at the entrance, or from the outside by the proliferation of cells, for example, by scar formation. In addition, the typical operation of implant insertion is complicated, of a high traumatic level, expensive and time consuming.
  • US Patent 3,788,327 shows a state-of-the-art implant that uses a valve mechanism to regulate the flow of aqueous humor from the eyeball to its exterior.
  • the main deficiency and disadvantage of this device is the existence of a hole or cavity, between the upper part of its liquid-releasing mechanism and the exit hole that is located outside the eye that is in direct contact with the environment and the eyelids; since said cavity is highly prone to the sedimentation of organic and inorganic matter that will restrict or prevent the free movement of the mechanism of release and / or generate an obstruction (plugging) in the exit duct of aqueous humor, which will result in deficiency in its functioning and ability to drain aqueous humor and causing increased pressure Ntraocular.
  • this device and drainage capacity is insecure since it is conditioned on the freedom of movement in its releasing mechanism, the free conduction of the fluid and the absence of obstacles in the duct that dislodges the aqueous humor towards the outside of the eye and It does not have any mechanism or measures that prevent the formation of these restrictions and / or obstructions.
  • This device has a high risk of endophthalmitis, since the blockage of the duct that exists in the upper part of the releasing mechanism will cause a stagnation of the aqueous humor inside and therefore the bacteria will find here a favorable niche for their rapid development and Your entry into the eye.
  • the device of the invention is not subject to the absorption capacity of any tissue and performs an eviction of aqueous humor without obstructions between its mechanism and the outside, and, that its implant process is as traumatic as possible, if allowed with only ambulatory surgery, that is why the device or valve of the invention is supported in its simplicity of design and components;
  • the valve comprises an inner part or chassis and a rod that is displaced outwardly on the corneal surface (on the epithelium), the valve stem is subject to a tension caused by a compression spring or repulsion between two permanent magnets, this spring or the magnetic repulsion is calibrated to a given tension (10-20 mm Hg), and when the eyeball reaches a tension value greater than that of the spring or repulsion, it achieves the displacement of the rod outside the cornea, to Thus, in this way, the aqueous humor causing high infraocular pressure is drained out of the eye. Once the pressure is regulated, the stem returns to its initial position by tightly closing the valve and thus preventing any
  • the present invention provides an infraocular pressure compensating and regulating valve installed in a cornea of an eye, comprising: a valve body having a valve seat at one end; a mobile element that is in contact with the valve seat under normal conditions of infraocular pressure in the eye, the mobile element is configured so that it can be separated from the valve seat when the infraocular pressure exceeds an infraocular pressure limit; and an element to keep the mobile element in contact with the valve seat.
  • the valve body has an outer part with fasteners to retain the valve to the cornea, and the infraocular pressure limit is 10 to 20 mm Hg.
  • the element for keeping the mobile element in contact with the valve seat is a spring placed in an inner part of the valve body, and the mobile element is a rod comprising a tubular body with an internal channel therein.
  • the stem has perforations in its upper part to allow the exit of aqueous humor to the outside of the valve.
  • the element for keeping the moving element in contact with the valve seat is constituted by two permanent magnets with the same polarity placed in an inner part of the valve body and the mobile element is a rod that comprises a tubular body with an internal channel in it, the rod has perforations in its upper part to allow humor to escape aqueous outside the valve.
  • the mobile element is a rod comprising a tubular body with an internal channel therein and the element for keeping the mobile element in contact with the valve seat is constituted by two springs placed in contact with one end of the body Valve opposite the end where the valve seat is and a ring located on the stem, the stem has perforations in its upper part to allow the aqueous humor to flow out of the valve.
  • the element for keeping the mobile element in contact with the valve seat is a spring having a first and a second end, the spring is placed in an inner part of the valve body, and the mobile element is a head which has at its bottom a ring to hold a first end of the spring; The second end of the spring is fixed to a fastener located in the inner part of the valve body.
  • Figure 1 is a sectional view of an eye showing the location of the valve of the invention
  • Figure 2 shows a side view of the valve of the invention in a first embodiment
  • Figure 3 shows a longitudinal sectional view of the first embodiment of the valve of the invention
  • Figure 4 shows a side view of the valve of the invention in a second embodiment
  • Figure 5 shows a longitudinal sectional view of the second embodiment of the valve of the invention
  • Figure 6 shows a side view of the valve of the invention in a third embodiment
  • Figure 7 shows a longitudinal sectional view of the third embodiment of the valve of the invention.
  • Figure 8 shows a side view of the valve of the invention in a fourth embodiment
  • Figure 9 shows a longitudinal sectional view of the fourth embodiment of the valve of the invention.
  • an eye 10 is shown indicating the eyeball 1 1, the optic nerve 12 and the cornea 13 in which the intraocular pressure compensating and regulating valve 14 is implanted.
  • Said valve 14 allows the release of aqueous humor outward of the eye, when a threshold pressure is exceeded at which the valve 14.
  • a first embodiment of the intraocular pressure compensating and regulating valve 100 is illustrated in Figures 2 and 3, and comprises a valve body or armature 1 10, a rod 120 and a spring 130.
  • the valve body 1 10 has a body hollow tubular 1 1 1 and a flange 1 12 at one end of the tubular body 1 1 1.
  • the rod 120 comprises a tubular body 121 with an internal channel 122 which has at one of its ends, a conical part 123 that rests in a seat 1 13 also conical in the part where the flange 1 12 is located in the valve body 1 10.
  • the tubular body 121 of the rod 120 below the conical part 123, has radial perforations 124 in communication with the internal channel 122 of the tubular body 1 1 1 of the rod 120.
  • the valve body 1 10 includes a spring 130 in the inner part of the hollow tubular body 1 1 1, to hold the stem 120 pressed so that the conical part 123 is seated in the seat 1 13 of the valve body 1 10.
  • the hollow tubular body 1 1 1 includes fasteners 1 14 for retaining or securing the valve 100 to the cornea.
  • the spring 130 is snapped to the rod 120 and the other end of the spring is not snapped to the rod but there is a gap with the rod 120 between 5 to 10 microns so that the rod 120 can move out of the valve body 1 10.
  • the valve 100 Under normal conditions of intraocular pressure (10-20 mm Hg), the valve 100 remains closed and there is no outward flow of aqueous humor. However, when the intraocular pressure exceeds the limit at which the spring 130 is calibrated, the stem 120 is displaced overcoming the force of the spring 130 and with it the conical part 123 of the stem 120 is separated from the seat 1 13 of the valve body 1 10 allowing the aqueous humor to flow through the internal channel 122 and the radial perforations 124 of the stem 120 achieving the exit of humor accuse the outside. Once the pressure is regulated, the stem 120 returns to its initial position by tightly closing the valve 1 00 and thus preventing any foreign objects from entering the eye (dust, microorganisms, etc.).
  • the intraocular pressure compensating and regulating valve 200 comprises a valve body 210 or armature, a stem 220 and two circular magnets (230 and 231).
  • the valve body 210 has a hollow tubular body 21 1 and a flange 212 at one end of the tubular body 21 1.
  • the rod 220 comprises a tubular body 221 with an internal channel 222 having at one of its ends, a conical part 223 that rests in a seat also conical 213 in the part where the flange 212 is located in the valve body 210.
  • the tubular body of the rod 220, below the conical part 223, has radial perforations 224 in communication with the internal channel 222 of the tubular body 221 of the rod 220.
  • the valve body 210 includes a first circular permanent magnet 230 placed the inner part of the hollow tubular body 21 1 at the end where the flange 212 of the valve body 210 is located.
  • a second circular permanent magnet 231 is placed on the stem 220 a level of the other end of the valve body 210 so that the magnets (230 and 231) are separated a distance.
  • the polarity of the first and second magnets is the same to obtain a repulsive force between them, and thus keep the conical part 223 seated in the seat 213 of the valve body 210.
  • the hollow tubular body 21 1 includes fasteners 214 for retain or hold valve 200 to the cornea.
  • the second magnet 231 is snapped to the rod 220 and the first magnet 230 is not snapped to the rod but there is a gap with the rod 220 between 5 to 10 microns so that the rod 220 can move out of the body of valve 210.
  • the rod 220 When the intraocular pressure exceeds the limit (10-20 mm Hg) at which the repulsive force is calibrated, the rod 220 is displaced by overcoming the force of the repulsion and with it the conical part 223 of the rod 220 is separated from the seat 213 of the body of valve 210 allowing the aqueous humor to flow through the internal channel 222 and the radial perforations 224 of the stem 220 achieving the exit of the accusing humor to the outside. Once the pressure is regulated, the stem 220 returns to its initial position by tightly closing the valve 200 and thus preventing any foreign objects from entering the eye (dust, microorganisms, etc.).
  • a third embodiment of the intraocular pressure compensating and regulating valve 300 is illustrated in Figures 6 and 7, and comprises a valve body 310, a rod 320 and elastic lamellae or springs 330 and 331.
  • the valve body 310 has a hollow tubular body 31 1 and a flange 312 at one end of the tubular body 31 1.
  • the rod 320 comprises a tubular body 321 with a channel internal 322 having at one of its ends, a conical part 323 resting in a seat 313 also conical in the part where the flange 312 is located in the valve body 310.
  • the tubular body 321 of the stem 320, below the conical part 323, has radial perforations 324 in communication with the internal channel 322 of the tubular body 321 of the rod 320.
  • the hollow tubular body 31 1 includes fasteners 314 for retaining or securing the valve 300 to the cornea. Between the hollow tubular body 31 1 of the valve body 310 and the stem 320, there is a separation between 0.5 to 3 microns so that the rod 320 can move out of the valve body 310.
  • valve 300 Under normal conditions of intraocular pressure (10-20 mm Hg), valve 300 remains closed and there is no outward flow of aqueous humor. However, when the intraocular pressure exceeds the limit at which the spring 330 is calibrated, the stem 320 is displaced by overcoming the force of the spring 330 and with it the conical part 323 of the stem 320 is separated from the seat 313 of the valve body 310 allowing the aqueous humor flows through the internal channel 322 and the radial perforations 324 of the rod 320 achieving the exit of the accusing humor abroad. Once the pressure is regulated, the rod 320 returns to its initial position by tightly closing the valve 300 and avoiding thus any entry of foreign objects to the eye (dust, microorganisms, etc.).
  • the intraocular pressure compensating and regulating valve 400 comprises a main body 410, a head 420, a spring 430.
  • the main body 410 is tubular with an internal channel 41 1 and a spring clamp element 412 and a flange 413.
  • the main body 410 includes a clamp element 414 for retaining or securing the valve 400 to the cornea.
  • the head 420 comprises a conical part 421 that rests in a seat also conical at one end of the main body 410.
  • a rear part of the head 420 includes a ring 423 in which a first end 431 of the spring 430 is secured, and a second end 432 of the spring 430 is attached to the fastener element 412.
  • the spring is the internal channel 41 1 of the main body 410.
  • the valve 400 Under normal conditions of intraocular pressure (10-20 mm Hg), the valve 400 remains closed and there is no outward flow of aqueous humor. However, when the intraocular pressure exceeds the limit at which the spring 430 is calibrated, the head 420 is displaced by overcoming the force of the spring 430 and thereby forming a separation between the head 420 and the seat 415 of the main body 410 allowing humor Aqueous flow through the internal channel 41 1 and the separation formed achieving the exit of the accusing humor abroad. Once the pressure is regulated, the head returns to its initial position by tightly closing the valve and thus preventing any entry of objects. strangers to the eye (dust, microorganisms, etc.).

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

Valve de compensation et de régulation de la pression intraoculaire, installée dans la cornée d'un œil, et comprenant : un corps de valve muni à une de ses extrémités d'un siège de valve; un élément mobile, en contact avec le siège de valve dans des conditions de pression intraoculaire normales dans l'œil, l'élément mobile étant configuré de manière à pouvoir se séparer du siège de valve lorsque la pression dépasse une limite de pression intraoculaire afin de permettre l'écoulement d'humeur aqueuse à l'extérieur de la valve; et un élément servant à maintenir l'élément mobile en contact avec le siège de valve.
PCT/MX2014/000165 2014-10-17 2014-10-17 Valve de compensation et de régulation de la pression intraoculaire WO2016060538A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201414056018A 2014-10-17 2014-10-17
US14/056,018 2014-10-17

Publications (1)

Publication Number Publication Date
WO2016060538A1 true WO2016060538A1 (fr) 2016-04-21

Family

ID=55746980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2014/000165 WO2016060538A1 (fr) 2014-10-17 2014-10-17 Valve de compensation et de régulation de la pression intraoculaire

Country Status (1)

Country Link
WO (1) WO2016060538A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
SU1738279A1 (ru) * 1989-12-04 1992-06-07 Туркменский Научно-Исследовательский Институт Глазных Болезней Магнитный клапан дл дренировани глаза
WO2003099175A1 (fr) * 2002-05-29 2003-12-04 University Of Saskatchewan Technologies Inc. Shunt et methode de traitement d'un glaucome
ES2299218T3 (es) * 1997-11-20 2008-05-16 Optonol Ltd. Implante de regulacion de flujo.
US20080228127A1 (en) * 2006-11-10 2008-09-18 Glaukos Corporation Uveoscleral shunt and methods for implanting same
DE102010029396A1 (de) * 2010-05-27 2011-12-01 Gudrun Brümmer-Schillke Augenimplantat zur Regulierung des Augeninnendrucks
ES2396088T3 (es) * 2006-04-26 2013-02-19 Eastern Virginia Medical School Sistemas para monitorizar y controlar la presión interna de un ojo o una parte del cuerpo

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
SU1738279A1 (ru) * 1989-12-04 1992-06-07 Туркменский Научно-Исследовательский Институт Глазных Болезней Магнитный клапан дл дренировани глаза
ES2299218T3 (es) * 1997-11-20 2008-05-16 Optonol Ltd. Implante de regulacion de flujo.
WO2003099175A1 (fr) * 2002-05-29 2003-12-04 University Of Saskatchewan Technologies Inc. Shunt et methode de traitement d'un glaucome
ES2396088T3 (es) * 2006-04-26 2013-02-19 Eastern Virginia Medical School Sistemas para monitorizar y controlar la presión interna de un ojo o una parte del cuerpo
US20080228127A1 (en) * 2006-11-10 2008-09-18 Glaukos Corporation Uveoscleral shunt and methods for implanting same
DE102010029396A1 (de) * 2010-05-27 2011-12-01 Gudrun Brümmer-Schillke Augenimplantat zur Regulierung des Augeninnendrucks

Similar Documents

Publication Publication Date Title
US9693900B2 (en) Intraocular pressure compensating and regulating valve
US11478379B2 (en) Pressurized goggle for intraocular pressure modification
ES2251999T3 (es) Dispositivo de stent para tratar glaucoma.
ES2544568T3 (es) Implante ocular
US9655778B2 (en) Position responsive flow adjusting implantable device and method
US6699211B2 (en) Method and apparatus for treatment of glaucoma
ES2349994T3 (es) Dispositivo de drenaje de humor acuoso en casos de glaucoma.
EP1954227B1 (fr) Dispositif de derivation intraoculaire
ES2831089T3 (es) Dispositivo de drenaje para drenar el humor acuoso del globo ocular
US7357778B2 (en) Aqueous drainage and flow regulating implant
ES2611953T3 (es) Un dispositivo quirúrgico oftálmico
WO2010111528A4 (fr) Dérivations assurant la prise en charge de l'écoulement de l'humeur aqueuse, utilisées pour le traitement du glaucome et caractérisées par des performances chirurgicales améliorées
US10758412B2 (en) One piece flat device of for the drainage of aqueous humor from the eye
US7156821B2 (en) Shunt with enclosed pressure-relief valve
US20150018746A1 (en) Device for use in glaucoma surgery
US9681983B2 (en) Debris clearance system for an ocular implant
US20190046356A1 (en) Methods Materials Assemblies Apparatuses and Implants for Surgical Reduction of Intraocular Pressure to Suprachoidal Space Ab Externo and Subconjunctival Space
WO2016060538A1 (fr) Valve de compensation et de régulation de la pression intraoculaire
WO2008030951A2 (fr) Dispositif d'implant de glaucome
KR102554055B1 (ko) 개방 윈도우와 포켓을 구비하는 공막 렌즈
CN105358105A (zh) 小型青光眼分流器
WO2014131423A1 (fr) Implant tubulaire de glaucome de el saadani (egti)
Lewis et al. Which do you prefer: More IOP reduction with external filtration or a reduced risk of bleb infection and hypotony with internal filtration?
Eldie The Short-Term Clinical Observation of the Application of ExPress Glaucoma Filtration Device for the Treatment of Refractory Glaucoma
WO2017209717A2 (fr) Implant-pompe contre le glaucome fonctionnant par mouvements de l'iris pour réduire la pression intraoculaire

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14904139

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14904139

Country of ref document: EP

Kind code of ref document: A1