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WO2015075489A2 - Injecteur à cartouche préchargé permettant de stocker et d'injecter des lentilles intraoculaires hydrophobes - Google Patents

Injecteur à cartouche préchargé permettant de stocker et d'injecter des lentilles intraoculaires hydrophobes Download PDF

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Publication number
WO2015075489A2
WO2015075489A2 PCT/HU2013/000109 HU2013000109W WO2015075489A2 WO 2015075489 A2 WO2015075489 A2 WO 2015075489A2 HU 2013000109 W HU2013000109 W HU 2013000109W WO 2015075489 A2 WO2015075489 A2 WO 2015075489A2
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
iol
injector
inner space
tubular inner
Prior art date
Application number
PCT/HU2013/000109
Other languages
English (en)
Other versions
WO2015075489A3 (fr
Inventor
Péter HANGYA
László KONTUR
Original Assignee
Medicontur Orvostechnikai Kft.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicontur Orvostechnikai Kft. filed Critical Medicontur Orvostechnikai Kft.
Priority to PCT/HU2013/000109 priority Critical patent/WO2015075489A2/fr
Publication of WO2015075489A2 publication Critical patent/WO2015075489A2/fr
Publication of WO2015075489A3 publication Critical patent/WO2015075489A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/1678—Instruments for inserting intraocular lenses into the eye with a separate cartridge or other lens setting part for storage of a lens, e.g. preloadable for shipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/167—Instruments for inserting intraocular lenses into the eye with pushable plungers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/1675—Instruments for inserting intraocular lenses into the eye with a lubricated inner surface, e.g. the lubricant being coated on the inner surface or being injected through a port

Definitions

  • the present invention relates to a surgical injector, more particularly, the present invention relates to a preloaded injector with cartridge for storing and injecting hydrophobic intraocular lenses (IOLs).
  • IOLs intraocular lenses
  • IOL is an artificial lens implanted in the eye, for example, as a replacement for the natural crystalline lens after cataract surgery or to alter the optical properties of an eye in which the natural lens remains.
  • IOLs include an optic, and preferably at least one flexible fixation member or haptic which extends from the optic and becomes affixed in the eye to secure the lens in position.
  • the optic normally includes an optically clear lens. Implantation of such IOLs into the eye involves making an incision in the eye. It is advantageous, to reduce trauma and accelerate healing, to have an incision size as small as possible. Many IOLs are foldable so that the IOL can be inserted through a smaller incision into the eye. A variety of instruments have been proposed to aid in inserting such a foldable lens in the eye.
  • IOL inserter devices so called injectors
  • injectors have recently been developed with reduced diameter nozzles which allow for a much smaller incision to be made in the cornea than is possible using forceps only.
  • Smaller incision sizes e. g., less than about 3mm
  • larger incisions e. g., about 3.2 to 5+mm
  • Hydrophilic IOLs have to be sterilized by steam and stored in a fluid solvent sealed in a wet container. Before injected into the eye they have to be loaded to the injector which is usually sterilized by ETO and stored in dry packaging. In contrast, hydrophobic IOLs can be sterilized and stored in dry condition in a cartridge together with the injector in a joint dry packaging.
  • a construction allowing the biggest part of the folding energy to be transferred into the IOL material by a levered rotational movement before pushing the plunger results in a higher compression rate of the IOL at the end of the nozzle and therefore is of advantage in minimizing the incision size.
  • Patent specification US2007150054 illustrates a folding arrangement in which small sized hydrophilic IOLs can be folded prior to injection by a rotational movement.
  • the IOL is primarily stored in a vial before it has to be loaded into the cartridge. Therefore this arrangement is suitable for hydrophilic IOLs only and can be ruled out in case of any hydrophobic IOL.
  • the specification described in patent EP1481652 is explicitly designed for hydrophobic IOLs. It uses a plunger made from a solid material material which does not fill the interior space of the cartridge. The plunger is not compressible and does not adapt to the tapering of the nozzle.
  • hydrophobic IOLs are preferred over hydrophilic IOLs, whereas it is much more difficult to create a well-functioning injection system for hydrophobic lenses, very often resulting in constructions that require an IOL with haptic properties not optimal from the physiological point of view.
  • Soft tip plunger constructions are widely used in injectors for hydrophilic IOLs.
  • the problem with the combination of the more rigid hydrophobic IOLs and soft tip plungers is that the hardness of the tip material and the hydrophobic IOL material have to be balanced exactly. If the tip is too soft the IOL will not be forwarded efficiently in the nozzle because it will push back the tip material and parts of the hydrophobic IOL might be squeezed into the tip material or wedged in-between the tip and the cartridge wall. On the other hand: If the tip material is too hard it will just not be compressible enough to travel all the way to the end of a nozzle with the desired narrow opening.
  • the ideal hardness of a soft tip for hydrophilic IOLs lies between 10-20 Shore hardness, while a soft tip designed to push hydrophobic IOLs ideally requires 30-40 Shore hardness. This is the reason why injectors with soft tip designed for injecting hydrophilic IOLs are generally not capable of safely injecting hydrophobic IOLs.
  • hydrophobic IOLs require a soft tip made of harder material creates a disadvantage regarding the compressibility and the smallest feasible opening of the cartridge nozzle. As a consequence we can generally postulate that it must be of advantage if the original uncompressed volume of the soft tip is as small as possible in order to minimize the rate of compression needed for the targeted nozzle size.
  • One way to minimize the volume of the soft tip is to minimize the interior volume of the loading barrel in the cartridge by bringing the interior shape of the cartridge closer to the shape of the IOL. In this case the soft tip that has to fill in this space and to adapt to the tapering of this space will not bring along that much of unnecessary volume that has to be compressed.
  • compressing and pushing a non-circular shaped soft tip with leading edge carrying protrusions into a circular or oval shaped nozzle inevitably leads to an unequal compression of the soft tip material.
  • the invention relates to a preloaded injector with cartridge for storing and injecting hydrophobic intraocular lenses (IOLs).
  • the injector comprises an injector body accommodating a plunger adapted to reciprocate within the injector body along a longitudinal axis.
  • a cartridge with a nozzle tube is attached to the injector body, and furnished with a winglet adapted to hinge between an open and a closed position.
  • the cartridge is adapted to hold the IOL in a released state in case of the open position and to cause the IOL to fold in case of the closed position.
  • the interior of the cartridge 20 and/ or the interior of the nozzle tube 22 is adapted to form a tubular inner space 52 with a non-circular cross section varying along the longitudinal axis, in which the size and/ or shape of the cross section of the tubular inner space 52 turns to asymmetric at least at one point within a section 90 of the tubular inner space 52 along the longitudinal axis.
  • the plunger is provided with a soft tip made of an elastic material, with a shape of non-circular leading edge and /or protruding parts that may discontinue to the back, fitting dynamically into the aforementioned interior of the cartridge and the nozzle tube during injection.
  • This construction allows the IOL to be folded for injection without any prior manipulation of the IOL and safely prevents the IOL from jamming or being wedged or torn during the injection.
  • inlet channels are provided in the cartridge leading the viscoelastic material in front and behind the IOL for a better flow around of the IOL preventing the IOL to stick to the internal surface of the cartridge.
  • FIGURE 1 shows the parts of an embodiment of the injector in
  • FIGURE 2 depicts the complete injector in perspective view
  • FIGURE 3 shows the position of the IOL in the open cartridge
  • FIGURE 4 shows the position of the IOL in the open cartridge in a side view
  • FIGURE 5 shows the position of the IOL in the closed cartridge
  • FIGURE 6 illustrates the channels in the cartridge in perspective view
  • FIGURE 7 depicts the entering of the viscoelastic material to the
  • FIGURE 8 illustrates the cross sections of the cartridge and the nozzle tube along the longitudinal axis with the IOL;
  • FIGURES 9A, 9B, 9C illustrate a possible embodiment of the tubular inner space;
  • FIGURES 10A and 10B illustrate a possible embodiment of the soft tip
  • FIGURE 1 1 shows the cross sections of the cartridge and the nozzle
  • the injector may comprise a plunger 2, an injector body 12, an adapter 16, a rotatable member 18, a cartridge 20 with a nozzle tube 22 and a stopper 26.
  • the injector body 12 accommodates the plunger 2 adapted to reciprocate within the injector body 12 along a longitudinal axis.
  • the plunger 2 is furnished with a locker 10 and with a spring 4. Additionally a soft tip 6 is inserted to one end of the plunger 2.
  • the injector body 12 may be provided with a finger hold flange 8 and a docking portion 14 at its front end.
  • the adapter 16 can be a sleeve with rails providing connections between the rotatable member 18 and the injector body 12.
  • the rotatable member 18 can be a ring but any other form of construction is suitable that can turn around the axis 28 of the injector.
  • the cartridge 20 and the nozzle tube 22 are molded in a single piece in this embodiment but they can be formed in two distinct pieces too.
  • the cartridge 20 with a nozzle tube 22 can be attached to the injector body 12.
  • the IOL 24 is placed in the cartridge 20.
  • the lower portion of the stopper 26 can be plugged into a hole 30 of the injector body 12 through the adapter 16 preventing the plunger 2 to reciprocate in the injector body 12 prior to injecting.
  • the reassembling steps of the injector are as follows. - attaching the cartridge 20 with the IOL 24 to the injector body 12, inserting the plunger 2 into the injector body 12,
  • the injector can be seen after reassembling.
  • the plunger 2, the adapter 16 and the rotatable member 18 are fixed to the injector body 12 and are immobilized by the stopper 26.
  • the rotatable member 18 is depicted in a transparent manner in order to show the position of the IOL 24 in the cartridge 20.
  • the IOL 24 is kept in the cartridge 20 in a released state and together with the injector they are ready for packaging, sterilization and clinical use.
  • FIG. 3 shows the cartridge 20 with the nozzle tube 22 holding the IOL 24.
  • the cartridge 20 has a winglet 50 that can hinge on the cartridge 20.
  • the winglet 50 is open i.e. the cartridge is in open position so the IOL 24 is in a released state.
  • the opposite edges of the IOL 24 are held by guiding rails 21 , 23 provided in the interior of the cartridge 20.
  • Figure 4 is a side view of the cartridge 20 with the IOL 24. From this view, the open winglet 50 and the IOL 24 in the released state can be seen.
  • Figure 5 shows the closed position of the cartridge 20 in which the winglet 50 is closed causing the IOL 24 to fold.
  • the interior of the cartridge 20 together with the interior of the nozzle tube 22 form a tubular inner space 52 co-axial to the longitudinal axis.
  • Figure 6 illustrates an axial and cross section showing that the cartridge 20 is provided with two inlet channels 60, 62 for the inlet of viscoelastic material.
  • one of the inlet channels 60 leads the viscoelastic material in front of the IOL 24, and the other inlet channel 62 leads the viscoelastic material behind the IOL 24 placed in the cartridge 20.
  • the viscoelastic material can flow around the IOL 24.
  • the inlet channels 60, 62 are aligned in the middle plane of the IOL 24 in the cartridge 20.
  • the inlet channels 60, 62 are connected by a distributing channel 64 distributing the viscoelastic material.
  • Figure 7 depicts in a perspective view the operation of entering the viscoelastic material to the cartridge 20.
  • a hole 40 is provided across the rotatable member 18 and the adapter 16 to the cartridge 20 in which the cannula of a syringe 70 is placed for entering the viscoelastic material.
  • Figure 8 illustrates the tubular inner space 52 extending from the interior of the cartridge 20 into the interior of the nozzle tube 22 comprising the IOL 24.
  • the tubular inner space 52 forms an asymmetric cross section at least at one section thereof.
  • the tubular inner space 52 has two sides 81, 82.
  • the figure shows how the size of the two sides 81, 82 can vary along the longitudinal axis.
  • the variation of the asymmetric tubular inner space 52 is illustrated by seven cross sections from 1-1 to 7-7. As it is seen on the set of cross sections the shape and the size of the cross section of one of the sides 82 decreases faster than that of the other side 81 along the longitudinal axis. This is because the cross section of the tubular inner space 52 is asymmetric at sections 2-2 to 6-6 of the figure. In this way the IOL is compressed gradually.
  • Figures 9A, 9B and 9C illustrate the tubular inner space 52 as a spherical body for a better understanding of the variation of its cross section along the longitudinal axis.
  • Figures 9A and 9B are perspective views and Figure 9C shows the same tubular inner space 52 in a side and front view.
  • Figures 9C shows that at least at one point within a section 90 of the tubular inner space 52 along the longitudinal axis, the cross section turns to asymmetrical, i.e. the size and shape of the cross section of the two sides 81, 82 of the tubular inner space 52 becomes different, because the size of one of the sides 82 of the tubular inner space 52 is smaller than that of the other part 81.
  • each side 81, 82 of the tubular inner space 52 comprises the guiding rail 21, 23 of the cartridge 20 holding the opposite edges of the 1OL 24 in which the length of one of the guiding rails 23 is shorter than that of the other guiding rail 21 relative to the longitudinal axis of the cartridge as it is illustrated in Figure 9B.
  • Figures 10A 10B illustrate a possible embodiment of the soft tip 6.
  • Figure 10A shows the soft tip 6 in a side and front view
  • Figure 10B shows it in a perspective view.
  • the soft tip 6 is provided with two protrusions 66, 68 at its leading edge 67. Leading edge 67 will get contact to the IOL 24 in the cartridge 20.
  • the shape of the protrusions 66, 68 fits exactly to the guiding rails 21, 23 illustrated in Figure 3 and Figures 9A, 9B, 9C.
  • the protrusions 66, 68 are provided with a shape discontinuing to the back, i.e. they diminish from the leading edge 67 before the end of the tip 6.
  • the soft tip 6 is made of an elastic material with a hardness of Shore 20-50, advantageously Shore 30 - 40.
  • the soft tip 6 is provided with a groove 69 on the outer surface thereof parallel to the longitudinal axis, preferably deeper than the outer baseline (65) of the protrusions (66, 68).
  • the groove 69 serves as a spatial reserve that can partly absorb the material of the protrusions 66, 68 while they are compressed successively during compression of the soft tip when the size of the cross section of the tubular inner space 52 decreases in course of the injection. This way, the compression of the protrusions 66, 68 will not lead to a detachment of the leading edge 67 of the soft tip 6 from the interior wall of the cartridge 20, thus preventing wedging or jamming of the IOL 24.
  • Figure 1 1 is similar to Figure 8 but it illustrates the compression of the soft tip 6 travelling through the tubular inner space 52. As the sections 1-1 to 7-7 show, the soft tip 6 fills in entirely the tubular inner space 52 across the whole length thereof. It is also seen, that protrusions 66, 68 are being compressed gradually, one by one moving from the interior of the cartridge 20 to the interior of the nozzle tube 22. At section 1-1 the size of the protrusions 66, 68 is equal but at section 2-2 one of them begins to diminish. At section 3-3, only one of the protrusions 66 can be seen and at the end, in section 7-7, no protrusion is seen. This ensures that the leading edge carrying protrusions 66, 68 of the soft tip 6 is compressed successively.
  • the first protrusion 66 is already absorbed by the soft tip body before the other 68 starts to be compressed. This way there is no fold, cavity or recess created around and/or between the protrusions 66, 68 pressed into the tip body which could trap for example the trailing haptic end of the IOL 24.
  • the process of injection is as follows. As a first step viscoelastic material is injected into the cartridge 20 through the hole 40. As a second step the cartridge 20 is closed by turning around the rotatable member 18 and the IOL 24 is folded from a released state into a folded one. The asymmetric shape of the cartridge 20 forming the guiding rails 21, 23 keep the opposite edges of the IOL 24 in the desired position. As a third step the stopper 26 has to be removed. The fourth step is removing the whole adapter 16 carrying the rotatable member 18, leaving a closed cartridge 20 in a very slim and light, ready-to-push injector, carrying no unnecessary elements that impair its handling or the surgeon's vision onto the patient's eye.
  • the plunger 2 is pushed into the injector body 12 whereby the soft tip 6 reaches the IOL 24 and makes it move from the cartridge 20 through the nozzle tube 22 into the patient's eye.
  • the protrusions 66, 68 of the soft tip 6 dynamically fit into the interior of the cartridge 20 and the nozzle tube 22.
  • the non-circular shape of the interior space of the cartridge 20 creates two guiding rails 21, 23 for the IOL 24 ensuring initially that the IOL 24 is held safely in the open storing position and folded in the closed position of the cartridge 20 prior to injection.
  • the soft tip 6 of the plunger 2 is being pushed forward with its special, non-circular shaped leading edge carrying the protrusions 66, 68 filling in the entire interior of the cartridge 20 behind the IOL 24 including the guiding rails 21, 23, preventing wedging or jamming of the IOL 24.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

Un injecteur à cartouche préchargé permettant de stocker et d'injecter des lentilles intraoculaires hydrophobes, IOL, comprend : un corps d'injecteur (12) logeant un piston plongeur (2) conçu pour effectuer un mouvement de va-et-vient dans le corps d'injecteur (12) ; et une cartouche (20) pourvue d'un tube de buse (22) fixé au corps d'injecteur (12) et d'une ailette (50) conçue pour faire charnière entre une position ouverte et une position fermée. L'intérieur de la cartouche (20) et/ou l'intérieur du tube de buse (22) sont conçus pour former un espace intérieur tubulaire (52) ayant une section transversale non circulaire variant le long de l'axe longitudinal. La taille et/ou la forme de la section transversale de l'espace intérieur tubulaire (52) deviennent asymétriques en au moins un point à l'intérieur d'une section (90) de l'espace intérieur tubulaire (52) le long de l'axe longitudinal.
PCT/HU2013/000109 2013-11-20 2013-11-20 Injecteur à cartouche préchargé permettant de stocker et d'injecter des lentilles intraoculaires hydrophobes WO2015075489A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/HU2013/000109 WO2015075489A2 (fr) 2013-11-20 2013-11-20 Injecteur à cartouche préchargé permettant de stocker et d'injecter des lentilles intraoculaires hydrophobes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/HU2013/000109 WO2015075489A2 (fr) 2013-11-20 2013-11-20 Injecteur à cartouche préchargé permettant de stocker et d'injecter des lentilles intraoculaires hydrophobes

Publications (2)

Publication Number Publication Date
WO2015075489A2 true WO2015075489A2 (fr) 2015-05-28
WO2015075489A3 WO2015075489A3 (fr) 2015-07-16

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017048211A1 (fr) * 2015-09-16 2017-03-23 Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi Élément auxiliaire pour le stockage et l'injection d'une lentille intraoculaire
US20180221142A1 (en) * 2017-02-07 2018-08-09 Rxsight, Inc. Intraocular lens inserter cartridge with an iol-guiding structure
GB201903237D0 (en) 2019-03-08 2019-04-24 Autolus Ltd Method
US10722346B2 (en) 2017-09-19 2020-07-28 Bausch & Lomb Incorporated Intraocular lens injector assembly having shuttle assembly retaining intraocular lens in storage vial and operably presenting intraocular lens in injector assembly
CN111712215A (zh) * 2017-12-28 2020-09-25 梅迪康特医疗工程有限公司 用于人工晶状体的注射器系统
US11013593B2 (en) 2018-12-02 2021-05-25 Rxsight, Inc. Light adjustable lens tracking system and method

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US20070150054A1 (en) 2005-12-22 2007-06-28 Joel Pynson Apparatus and methods for loading of an IOL injector

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EP1481652A1 (fr) 2003-05-28 2004-12-01 Alcon, Inc Système de délivrance de lentille
US20070150054A1 (en) 2005-12-22 2007-06-28 Joel Pynson Apparatus and methods for loading of an IOL injector

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10660744B2 (en) 2015-09-16 2020-05-26 Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi Ancillary for the storage and the injection of intra ocular lens
JP2018527132A (ja) * 2015-09-16 2018-09-20 ヴェセイェ・ビヨンテクノロジ・ヴェ・イラチ・サナイ・アノニム・シルケティＶｓｙ Ｂｉｙｏｔｅｋｎｏｌｏｊｉ Ｖｅ Ｉｌａｃ Ｓａｎａｙｉ Ａｎｏｎｉｍ Ｓｉｒｋｅｔｉ 眼内レンズの保管及び注入ための補助物
KR20180054727A (ko) * 2015-09-16 2018-05-24 비에스와이 비요테크놀로지 베 일락 사나이 아노님 쉬르케티 안구 내 렌즈의 수용 및 주입을 위한 보조물
KR102238297B1 (ko) 2015-09-16 2021-04-09 비에스와이 비요테크놀로지 베 일락 사나이 아노님 쉬르케티 안구 내 렌즈의 수용 및 주입을 위한 보조물
WO2017048211A1 (fr) * 2015-09-16 2017-03-23 Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi Élément auxiliaire pour le stockage et l'injection d'une lentille intraoculaire
US20180221142A1 (en) * 2017-02-07 2018-08-09 Rxsight, Inc. Intraocular lens inserter cartridge with an iol-guiding structure
CN110290762A (zh) * 2017-02-07 2019-09-27 Rx视觉股份有限公司 具有人工晶状体引导结构的人工晶状体插入器匣
US11083568B2 (en) * 2017-02-07 2021-08-10 Rxsight, Inc. Intraocular lens inserter cartridge with an IOL-guiding structure
US10722346B2 (en) 2017-09-19 2020-07-28 Bausch & Lomb Incorporated Intraocular lens injector assembly having shuttle assembly retaining intraocular lens in storage vial and operably presenting intraocular lens in injector assembly
US12127935B2 (en) 2017-09-19 2024-10-29 Bausch & Lomb Incorporated Intraocular lens injector assembly having shuttle assembly retaining intraocular lens in storage vial and operably presenting intraocular lens in injector assembly
CN111712215A (zh) * 2017-12-28 2020-09-25 梅迪康特医疗工程有限公司 用于人工晶状体的注射器系统
CN111712215B (zh) * 2017-12-28 2023-09-26 梅迪康特医疗工程有限公司 用于人工晶状体的注射器系统
US11013593B2 (en) 2018-12-02 2021-05-25 Rxsight, Inc. Light adjustable lens tracking system and method
GB201903237D0 (en) 2019-03-08 2019-04-24 Autolus Ltd Method

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