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WO2014086453A8 - Azaheterobicyclic compounds - Google Patents

Azaheterobicyclic compounds Download PDF

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Publication number
WO2014086453A8
WO2014086453A8 PCT/EP2013/003356 EP2013003356W WO2014086453A8 WO 2014086453 A8 WO2014086453 A8 WO 2014086453A8 EP 2013003356 W EP2013003356 W EP 2013003356W WO 2014086453 A8 WO2014086453 A8 WO 2014086453A8
Authority
WO
WIPO (PCT)
Prior art keywords
azaheterobicyclic
compounds
diseases
inflammatory
cancer
Prior art date
Application number
PCT/EP2013/003356
Other languages
French (fr)
Other versions
WO2014086453A1 (en
Inventor
Kai Schiemann
Frank Stieber
Christina Esdar
Original Assignee
Merck Patent Gmbh
Cancer Research Technology Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Cancer Research Technology Limited filed Critical Merck Patent Gmbh
Publication of WO2014086453A1 publication Critical patent/WO2014086453A1/en
Publication of WO2014086453A8 publication Critical patent/WO2014086453A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention provides novel substituted azaheterobicyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.
PCT/EP2013/003356 2012-12-07 2013-11-07 Azaheterobicyclic compounds WO2014086453A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12008195.5 2012-12-07
EP12008195 2012-12-07

Publications (2)

Publication Number Publication Date
WO2014086453A1 WO2014086453A1 (en) 2014-06-12
WO2014086453A8 true WO2014086453A8 (en) 2014-08-21

Family

ID=47325770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/003356 WO2014086453A1 (en) 2012-12-07 2013-11-07 Azaheterobicyclic compounds

Country Status (2)

Country Link
AR (1) AR093841A1 (en)
WO (1) WO2014086453A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201790806A1 (en) 2014-11-05 2017-11-30 Флексус Байосайенсиз, Инк. IMMUNOREGULATING AGENTS
UY36390A (en) * 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP6882299B2 (en) * 2015-12-17 2021-06-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Polycyclic TLR7 / 8 antagonists and their use in the treatment of immune disorders
EP3404021A4 (en) * 2016-01-12 2019-09-11 Nippon Chemiphar Co., Ltd. CALCIUM CHANNEL INHIBITOR TYPE T TENSION-DEPENDENT
US10947214B2 (en) 2016-08-08 2021-03-16 Merck Patent Gmbh TLR7/8 antagonists and uses thereof
KR20190063745A (en) * 2017-11-30 2019-06-10 (주)인핸스드바이오 NEW COMPOUNDS FOR INHIBITING BINDING BETWEEN p34 PROTEIN AND NEDD4-1 PROTEIN AND USE THEREOF
US20220313701A1 (en) * 2019-05-02 2022-10-06 Constellation Pharmaceuticals, Inc. Modulators of trex1

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1165283A (en) * 1967-01-17 1969-09-24 Science Union & Cie New Purine Derivatives and processes for prepararing them
AU3053999A (en) * 1998-03-31 1999-10-25 Kyowa Hakko Kogyo Co. Ltd. Nitrogenous heterocyclic compounds
WO2003022214A2 (en) * 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds
EP3421471B1 (en) * 2006-04-25 2021-05-26 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
WO2008017161A1 (en) * 2006-08-09 2008-02-14 Merck Frosst Canada Ltd. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2009029609A1 (en) * 2007-08-27 2009-03-05 Wyeth Imidazopyridine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
GB0818241D0 (en) * 2008-10-06 2008-11-12 Cancer Res Technology Compounds and their use
KR20130005263A (en) * 2009-12-30 2013-01-15 아르퀼 인코포레이티드 Substituted naphthalenyl-pyrimidine compounds

Also Published As

Publication number Publication date
WO2014086453A1 (en) 2014-06-12
AR093841A1 (en) 2015-06-24

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