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WO2014057498A3 - Process for the preparation of cobicistat intermediates - Google Patents

Process for the preparation of cobicistat intermediates Download PDF

Info

Publication number
WO2014057498A3
WO2014057498A3 PCT/IN2013/000608 IN2013000608W WO2014057498A3 WO 2014057498 A3 WO2014057498 A3 WO 2014057498A3 IN 2013000608 W IN2013000608 W IN 2013000608W WO 2014057498 A3 WO2014057498 A3 WO 2014057498A3
Authority
WO
WIPO (PCT)
Prior art keywords
cobicistat
intermediates
preparation
processes
quality
Prior art date
Application number
PCT/IN2013/000608
Other languages
French (fr)
Other versions
WO2014057498A2 (en
Inventor
Shankar Rama
Lakshmana Rao Vadali
Ramesh Babu Konda
Ravikanth Jaldu
Govardhana Phani Sharma VEMAVARAPU
Vijay Kumar Palla
Eswara Reddy YERVA
Original Assignee
Mylan Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Ltd. filed Critical Mylan Laboratories Ltd.
Publication of WO2014057498A2 publication Critical patent/WO2014057498A2/en
Publication of WO2014057498A3 publication Critical patent/WO2014057498A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/06—Compounds containing sulfur atoms only bound to two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to cobicistat intermediates, processes and further conversion to cobicistat with improved yield and quality.
PCT/IN2013/000608 2012-10-08 2013-10-07 Process for the preparation of cobicistat intermediates WO2014057498A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4173CH2012 2012-10-08
IN4173/CHE/2012 2012-10-08

Publications (2)

Publication Number Publication Date
WO2014057498A2 WO2014057498A2 (en) 2014-04-17
WO2014057498A3 true WO2014057498A3 (en) 2014-06-19

Family

ID=49876942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000608 WO2014057498A2 (en) 2012-10-08 2013-10-07 Process for the preparation of cobicistat intermediates

Country Status (1)

Country Link
WO (1) WO2014057498A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103694196A (en) * 2012-09-27 2014-04-02 上海迪赛诺化学制药有限公司 Cytochrome P450 monooxygenase inhibitor intermediate, and preparation methods and application thereof
US9975864B2 (en) 2013-12-03 2018-05-22 Mylan Laboratories Limited Preparation of cobicistat intermediates
CN105732538B (en) * 2014-12-09 2018-04-13 杭州普晒医药科技有限公司 Than Si Tapamo hydrochlorates and preparation method thereof, pharmaceutical composition and purposes
WO2016128885A1 (en) * 2015-02-09 2016-08-18 Laurus Labs Private Limited A process for preparation of cobicistat
US10351556B2 (en) * 2015-02-18 2019-07-16 Msn Laboratories Private Limited Process for the preparation of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2s)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4YL] methyl} carbamoyl) amino]-4-(morpholin-4-yl)butanoyl]amino)-1,6-diphenylhexan-2-yl]carbamate
CN105884760B (en) * 2016-06-13 2019-01-04 厦门市蔚嘉化学科技有限公司 A kind of preparation method than his intermediate of department
CN107513046B (en) * 2016-06-15 2019-12-13 江苏欧信制药有限公司 Synthesis method of Coxstat
CN110668951B (en) * 2018-12-21 2022-09-30 安徽贝克生物制药有限公司 Synthesis process of selegiline hydrochloride
CN110642721B (en) * 2018-12-21 2022-09-30 安徽贝克生物制药有限公司 Preparation method of selegiline hydrochloride
CN112110842A (en) * 2020-09-08 2020-12-22 乐威医药（江苏）股份有限公司 One-pot production process of chiral sulfonyl cyclopropylamine derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115000A2 (en) * 2009-04-03 2010-10-07 Gilead Sciences, Inc. Methods and intermediates for preparing pharmaceutical agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019893B1 (en) 2007-02-23 2014-07-30 Джилид Сайэнс, Инк. Pharmaceutical composition and method for treating hiv infection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115000A2 (en) * 2009-04-03 2010-10-07 Gilead Sciences, Inc. Methods and intermediates for preparing pharmaceutical agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 30 September 2009 (2009-09-30), Aurora Fine Chemicals LLC, 7929-Silverton Avenue, Suite 609, SANDIEGO, CA, 92126, USA: "Aurora Building Blocks", XP002719126, Database accession no. 1178000-69-5 *
JOANNE HANNAM ET AL: "Rapid and Selective Synthesis of Substituted 1,2,5-Thiadiazolidine 1,1-Dioxides", SYNLETT, vol. 2006, no. 6, 1 April 2006 (2006-04-01), pages 833 - 836, XP055097678, ISSN: 0936-5214, DOI: 10.1055/s-2006-939039 *

Also Published As

Publication number Publication date
WO2014057498A2 (en) 2014-04-17

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