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WO2014012156A1 - Composition pour l'hygiène intime prolongée, procédé de production et utilisation - Google Patents

Composition pour l'hygiène intime prolongée, procédé de production et utilisation Download PDF

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Publication number
WO2014012156A1
WO2014012156A1 PCT/BR2013/000088 BR2013000088W WO2014012156A1 WO 2014012156 A1 WO2014012156 A1 WO 2014012156A1 BR 2013000088 W BR2013000088 W BR 2013000088W WO 2014012156 A1 WO2014012156 A1 WO 2014012156A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
regulator
oligosaccharide
growth
flora
Prior art date
Application number
PCT/BR2013/000088
Other languages
English (en)
Portuguese (pt)
Inventor
Priscila RAMOS RODRIGUES GUIMARÃES
Original Assignee
Sanofi Aventis Farmacêutica Ltda.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Farmacêutica Ltda. filed Critical Sanofi Aventis Farmacêutica Ltda.
Priority to MX2014014896A priority Critical patent/MX2014014896A/es
Publication of WO2014012156A1 publication Critical patent/WO2014012156A1/fr
Priority to CR20140570A priority patent/CR20140570A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/986—Milk; Derivatives thereof, e.g. butter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to the field of personal care compositions. More particularly, the invention discloses a composition for promoting an individual's prolonged intimate personal hygiene, as well as its process of obtaining and use.
  • vaginal ecosystem is known to be unstable and subject to many variations that depend on diet, sexual activity, hormone production, medication use and also on genital hygiene. Despite this, unfortunately the knowledge is not the same for the vulvar region. It is reasonable to suppose, however, that hygiene probably plays a much stronger role.
  • proper (vulvar) intimate hygiene is essential to help maintain cleanliness and acid pH balance of the region, greatly affected by the daily life of the modern woman who spends a lot of time outside the home and wears clothes that promote lack of aeration and exaggerated compression.
  • proper hygiene of the female intimate region is a great ally in helping to protect women.
  • the cleaning of the female intimate region is best done with liquid soap, as most bar soaps have neutral or alkaline pH, and can be shared by others in the same house.
  • the products should have mild detergency (high detergency rate may dry out vulvar skin), be hypoallergenic and with physiological pH (slightly acidic and not neutral or alkaline).
  • Body hygiene is undoubtedly a necessity for all, and especially women, for their genital area. Although this practice is usual and daily, many women still have doubts about the form, frequency and the correct occasion to perform it.
  • the female external genitalia is formed by numerous skin folds and is located in a region that makes aeration very difficult. Both features favor humidity, increased temperature and the difficulty of removing debris.
  • the skin of the intimate region as well as the rest of the body due to the disposition of its cells (keratinocytes) and the production of substances (ceramides, fatty acids, triglycerides, free steroids, cholesterol, fat esters, squalene) form a "Skin barrier” that prevents the loss of water and other elements. This barrier is as much a physical barrier as it is antimicrobial with immunological function, establishes a sensory interface and promotes the maintenance of physiological pH (Cutaneous Acid Cloak).
  • the cutaneous acid mantle is one of the main responsible for the balance of the microbiological ecosystem and the perfect functioning of the skin cells. Like other parts of our body, maintaining pH in restricted ranges is critical for biochemical reactions to proceed smoothly. The disruption of the skin barrier and acid mantle may favor tissue damage and compromise the balance of the vulvar ecosystem triggering irritative and infectious processes. There are several factors that can compromise genital and skin homeostasis by activating the production of pro-inflammatory cytokines, cell adhesion molecules, DNA synthesis, among others.
  • Factors such as family history of dry skin, conditions such as eczema and psoriasis, use of dry skin medications, aging, sun exposure, wind and low humidity, inadequate soap and cleanser promote skin dryness and ease skin lesions. by the formation of continuity solution between the keratinocytes. In addition, a chronic inflammatory process is established that will increase the risk of infections.
  • Genital hygiene is necessary to prevent accumulation of secretions, dead cells and debris. It is natural to assume that poor hygiene can cause foul smell, itching, secretion buildup, and vulvar and vaginal infection.
  • the female genital region besides being more sensitive, is subject to more intense bacterial colonization, occlusions and compressions due to dress habits and greater friction by the anatomical location, that is, it is more susceptible to maladjustments of its ecosystem. Prolonged use of occlusive pads and clothing that promotes lack of aeration and excessive compression should be avoided.
  • EP 2236127 (Rottapharm S.p.A.) describes an intimate hygiene composition comprising one or more active substances in conjunction with xanthan gum, where it is an agent capable of favoring bioadhesion of the active substances to the skin and mucous membranes.
  • active substances include, without limitation, lactic acid, which contributes to maintaining the physiological pH of the slightly acidic vulva surface, preventing the development of pathogens, and also pasteurized and atomized whey, which together with lactic acid have buffering action and ensures continued acidity of the vulva surface.
  • the present invention differs from said document, among other reasons in that it is directed to other problems rather than adherence of the formulation by the use of xanthan gum.
  • xanthan gum is not used in the present invention, being a polysaccharide very distinct from oligosaccharides.
  • Polysaccharides are made up of a large amount of monosaccharides, while oligosaccharides are made up of only 2 to 10 monosaccharides.
  • the lasting effect for longer periods is provided by the combination of the oligosaccharide, whey and lactic acid ingredients, and adhesion of the product by the addition of a polysaccharide such as xanthan gum is not required.
  • US 6,706,941 discloses an absorbent article where microorganisms of a saprophytic flora of the skin or non-pathogenic microorganisms to the skin may proliferate, thereby suppressing the growth of possibly pathogenic microorganisms around the area of application of the article and reducing odor. and dermatitis. That document is, It is therefore related to the incorporation of a compound containing an alpha 1-2 skeleton, such as glycooligosaccharide which can act as a substrate for enzymes present only in certain bacteria.
  • Said document differs from the knowledge disclosed by the present invention, among other reasons, in that it does not provide a liquid composition that prevents the proliferation of a pathogenic flora, and promotes a prolonged hydration and freshness effect in the sanitized regions.
  • WO 2010/004005 describes pharmaceutical and dermatological compositions comprising a probiotic chosen from oligosaccharides, such as gluco-oligosaccharides (GOS), fructooligosaccharides (FOS), galactooligosaccharides, and an extract. of plant containing isoflavones selected from soybean extracts (Glycine max) and clover extracts (Trifolium sp.), for use in the treatment of bacterial vaginosis and / or for the treatment of the vaginal mucosa.
  • oligosaccharides such as gluco-oligosaccharides (GOS), fructooligosaccharides (FOS), galactooligosaccharides, and an extract. of plant containing isoflavones selected from soybean extracts (Glycine max) and clover extracts (Trifolium sp.)
  • the present invention differs from said document, among other reasons, in that it presents in its composition the association of oligosaccharides not with plant extracts (which may present problems of stability and / or compositional variability due to seasonality), but with lactic acid and whey, which act as a moisturizer and tissue recovery ingredient, thus providing some of the desirable effects mentioned above.
  • the said document neither presents or even suggests a moisturizing effect on the composition of the intimate soap, which promotes an extension of its duration, differing from the present invention.
  • the need persists to develop products in the form of stable liquid composition that provide, especially with prolonged action: the maintenance of a balanced pH in the mucous region where it is applied, regulating the skin acidity; prevent or minimize the proliferation of undesirable microbial / bacterial flora; and provide hydration, aiding tissue recovery.
  • the present invention provides a prolonged intimate hygiene liquid composition
  • a prolonged intimate hygiene liquid composition comprising: pH regulator for the mucosal region; moisturizer; and a component that stimulates the growth of saprophytic flora (resident and beneficial).
  • This combination provides, with prolonged action, the maintenance of a balanced pH in the mucous region where it is applied, regulating the skin acidity; prevents or minimizes proliferation of undesirable microbial / bacterial flora; and provides hydration, aiding tissue recovery. Processes for obtaining them are also disclosed.
  • the growth stimulating component of saprophytic flora is alpha-glucan oligosaccharide.
  • an intimate hygiene composition comprising: at least one oligosaccharide; whey; and at least one pH regulator.
  • the composition of the invention provides effects on the intimate region over prolonged periods, with considerable reduction of the proliferation of pathogenic microorganisms in the product application region and, consequently, a healthier intimate region.
  • the composition comprises from 0.1% to 10% by weight of oligosaccharide, from 0.1% to 20%; by weight of whey and from 0.1% to 20% by weight of pH regulator.
  • Another object of the present invention is a process for producing an intimate hygiene composition.
  • the process of the invention comprises the steps of mixing an oligosaccharide in whey and adding a pH regulator and one or more cosmetically acceptable carriers until the pH is in the range of 4.2 to 4.8. It is also an object of the present invention to use a combination of: oligosaccharide; whey; and a pH regulator for the preparation of an intimate hygiene composition.
  • Figure 1 shows the growth of Micrococcus kristinae and Corynebacterium xerosis. Inoculation of 10 5 cells / ml in the presence of the composition of the present invention.
  • Figure 2 shows the growth of Micrococcus kristinae and Corynebacterium xerosis. Inoculation of 10 6 cells / ml in the presence of the composition of the present invention.
  • the present invention provides a prolonged intimate hygiene liquid composition
  • a prolonged intimate hygiene liquid composition comprising: pH regulator for the mucosal region; moisturizer; and a component that stimulates the growth of saprophytic flora (resident and beneficial).
  • This combination provides, with prolonged action, the maintenance of a balanced pH in the mucous region where it is applied, regulating the skin acidity; prevents or minimizes proliferation of undesirable microbial / bacterial flora; and provides hydration, aiding tissue recovery.
  • the present invention provides an intimate hygiene composition comprising at least one oligosaccharide, whey and at least one pH regulator.
  • Body cleansing habits are essential to ensure the health of the whole body against external stimuli such as the proliferation of unwanted and disease causing microorganisms.
  • the set of body cleansing habits characterizes an individual's personal hygiene.
  • Hygiene Personal care is critical in the face of inability to perceive the onslaught of pathogens, which gives hygiene a key role in bodily well-being.
  • intimate hygiene is defined as the use of products that do not harm an individual's external genital regions.
  • composition of the present invention inhibits the growth of non-saprophytic flora, stimulates beneficial flora and prevents opportunistic colonization and is therefore a cosmetic and functional personal hygiene composition.
  • oligosaccharide means saccharides of up to 10 saccharide monomers, obtained from natural or synthetic sugars, such as by enzymatic synthesis involving the transferase enzyme. Can be used as sugars originating sucrose and maltose.
  • Alpha-glucan is a preferred oligosaccharide of the present invention having the following formula: 1-6)
  • Said oligosaccharide is a powder with a white appearance and a slight and characteristic odor. It is soluble in water, polyethylene glycol and glycerol, insoluble in ethanol 50 ° GL and not miscible with vegetable and / or mineral oils. Your CAS number is 27707-45-5.
  • the preferred oligosaccharide of the present invention is a component that selectively stimulates the growth of an individual's (resident and beneficial) saprophyte flora over a pathogenic flora.
  • the alpha1-6 and alpha1-2 bonds of their polymeric structure provide a better hydrolysis. difficult to cause bioselectivity since this substrate restricts the growth of a pathogenic flora.
  • saprophytic flora will prevail.
  • Alpha-glucan is an oligosaccharide that protects the skin's ecosystem by keeping the ecosystem constant or balancing it in such a way as to revert it to its previous or natural state. It acts selectively, eliminating the use of antibiotics to prevent the emergence of unwanted flora. Whey
  • Whey whey or lactose
  • whey is the product derived from the hydromineral fraction of milk. Its main function in composition is to maintain the effect of lactic acid for a longer time as well as moisturize and maintain the hydroelectric balance of the skin, acting as a moisturizing and tissue recovery factor.
  • the whey used in the present invention is atomized (whey) whey.
  • PH regulator is a component that ensures skin acidity, hindering microbial proliferation, as well as maintaining the pH of the skin surface on which the intimate hygiene product will be applied.
  • the pH regulator used in the present invention is lactic acid (or 2-hydroxypropanoic acid).
  • an intimate hygiene composition has been prepared and its beneficial effects tested.
  • composition (INCI nomenclature) 3 percent unit (mg / mL)
  • Lactosoro 1.050% 10.500 mg
  • the physicochemical test proves the maintenance of a stable acidic pH (4.2 to 4.8) at room temperature, which is an essential feature in a composition that can be used in the female external genital region.
  • Another important data about the physicochemical test is the amount of total aerobic bacteria and fungi, which remain within acceptable limits, as well as the absence of pathogenic microorganisms and fecal and total coliforms.
  • Characteristics such as density, foam, fill volume and viscosity were also qualitatively analyzed, remaining at desired values for a liquid composition intended for intimate cleaning.
  • the stability study was carried out with the product in its commercial packaging, stored in an oven at 40 ⁇ 2 ° C / 75% ⁇ 5% RH, and at 30 ⁇ 2 ° C / 75% ⁇ 5% RH for 3 months.
  • the stability test aims to verify, within 24 months, the maintenance of the desirable characteristics of the composition of said composition.
  • the composition maintained its characteristics and microbiological contamination remained below 10 CFU (Colony Forming Units) / g, with no growth of pathogenic bacteria detected.
  • the pH remained acidic (between 4.2 and 4.8), an essential characteristic in a composition for use in the female external genital region.
  • Alpha glucan oligosaccharide favors the growth of saprophytic flora over pathogenic because it has bonds (a1-6) and (a1-2) which are more difficult to hydrolyze, restricting their growth by bioselectivity.
  • bonds (a1-6) and (a1-2) which are more difficult to hydrolyze, restricting their growth by bioselectivity.
  • a comparison was made of the use of alpha glucan oligosaccharide and glucose as a carbon source. The results are in the tables below.
  • Table 5 Classification used for the scores.
  • Table 7 Results of the use of alpha glucan oligosaccharide and glucose by pathogenic flora as carbon source.
  • Table 8 Results of alpha glucan oligosaccharide and glucose utilization by saprophytic flora not established as carbon source.
  • alpha glucan oligosaccharide is a carbon source for most saprophytic microorganisms tested, and not for the pathogenic microorganisms tested.
  • alpha glucan oligosaccharide provides a selective carbon source for desirable plant growth, indirectly acting as a growth inhibitor of these undesirable bacteria.
  • a test was conducted to investigate the inhibitory potential of alpha glucan oligosaccharide by competition by analyzing the growth of a combination of pathogenic or undesirable saprophytic bacteria. Bacteria were inoculated into culture medium (USP tryptone) containing 0.5% alpha glucan oligosaccharide. After 24h of growth, the bacteria was counted.
  • the PCA, Chapman and BHI methods were used for total flora, Staphylococcus aureus and Corynebacterium xerosis, respectively.
  • Staphylococcus aureus and Micrococcus kristinae were inoculated at a concentration of 10 6 cells / ml.
  • Bioselective development of Micrococcus kristinae was observed to the detriment of Staphylococcus aureus. The results are in the table below.
  • Table 9 Growth of Staphylococcus aureus and Micrococcus kristinae.
  • Table 10 Bacterial inoculation time related development. Inoculation of 10 5 cells / ml.
  • Figure 1 shows growth data for Micrococcus kristinae and Corynebacterium xerosis. Inoculation of 10 5 cells / ml. A culture combination was performed by inoculating Micrococcus kristinae and Corynebacterium xerosis at a concentration of 10 6 cells / ml. Table 1 1: Time of inoculation of bacteria related development. Inoculation of 10 6 cells / ml.
  • Figure 2 shows the growth of Micrococcus kristinae and Corynebacterium xerosis. Inoculation of 10 6 cells / ml.
  • the graphs indicate that alpha glucan oligosaccharide preferentially promotes Micrococcus kristinae growth over Corynebacterium xerosis. This competitive inhibition occurs due to a bioselective assimilation of alpha glucan oligosaccharide by Micrococcus kristinae. Therefore, there is a faster and more beneficial metabolism of alpha glucan oligosaccharide by saprophytic flora, favoring its growth over pathogens, inhibiting opportunistic colonization.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)

Abstract

La présente invention concerne une composition liquide pour l'hygiène intime prolongée, comprenant: un régulateur de pH pour la région muqueuse; un hydratant; et un composé qui stimule la croissance de la flore saprophyte (résidente et bénéfique). Cette combinaison assure le maintien prolongé d'un pH équilibré dans la région muqueuse où elle est appliquée, régulant l'acidité cutanée; elle prévient ou réduit la prolifération de la flore microbienne/bactérienne indésirable; et elle produit une hydratation, facilitant la régénération des tissus. L'invention concerne également des procédés pour son obtention.
PCT/BR2013/000088 2012-07-16 2013-03-22 Composition pour l'hygiène intime prolongée, procédé de production et utilisation WO2014012156A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MX2014014896A MX2014014896A (es) 2012-07-16 2013-03-22 Composicion para higiene intima extendida, proceso de produccion y uso.
CR20140570A CR20140570A (es) 2012-07-16 2014-12-11 Composición para higiene íntima extendida, proceso de producción y uso

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRBR1020120175711 2012-07-16
BR102012017571-1A BR102012017571A2 (pt) 2012-07-16 2012-07-16 Composição para higiene íntima prolongada, processo de produção e uso

Publications (1)

Publication Number Publication Date
WO2014012156A1 true WO2014012156A1 (fr) 2014-01-23

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PCT/BR2013/000088 WO2014012156A1 (fr) 2012-07-16 2013-03-22 Composition pour l'hygiène intime prolongée, procédé de production et utilisation

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AR (1) AR091330A1 (fr)
BR (1) BR102012017571A2 (fr)
CL (1) CL2015000101A1 (fr)
CO (1) CO7160048A2 (fr)
CR (1) CR20140570A (fr)
DO (1) DOP2014000276A (fr)
EC (1) ECSP15001584A (fr)
GT (1) GT201500008A (fr)
MX (1) MX2014014896A (fr)
PE (1) PE20150768A1 (fr)
UY (1) UY34910A (fr)
WO (1) WO2014012156A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706941B2 (en) * 2000-10-11 2004-03-16 Uni-Charm Corporation Absorbent article for controlling normal flora of the skin
WO2009103139A1 (fr) * 2008-02-20 2009-08-27 Luis Eduardo Da Cruz Coffret de savons, procédé d'hygiène intime féminine et composition de savon pour période menstruelle
WO2010004005A1 (fr) * 2008-07-10 2010-01-14 Alliospharma Compositions visant a favoriser le developpement et la croissance d'une microflore vaginale benefique
EP2236127A1 (fr) * 2009-04-03 2010-10-06 Rottapharm S.p.A. Produits d'hygiène intime
EP2248907A1 (fr) * 2009-05-08 2010-11-10 Rijksuniversiteit Groningen Gluco-oligosaccharides comprenant des liens (alpha 1-->4) et (alpha 1-->6) glycosidiquues, leur utilisation et procédés de fabrication

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706941B2 (en) * 2000-10-11 2004-03-16 Uni-Charm Corporation Absorbent article for controlling normal flora of the skin
WO2009103139A1 (fr) * 2008-02-20 2009-08-27 Luis Eduardo Da Cruz Coffret de savons, procédé d'hygiène intime féminine et composition de savon pour période menstruelle
WO2010004005A1 (fr) * 2008-07-10 2010-01-14 Alliospharma Compositions visant a favoriser le developpement et la croissance d'une microflore vaginale benefique
EP2236127A1 (fr) * 2009-04-03 2010-10-06 Rottapharm S.p.A. Produits d'hygiène intime
EP2248907A1 (fr) * 2009-05-08 2010-11-10 Rijksuniversiteit Groningen Gluco-oligosaccharides comprenant des liens (alpha 1-->4) et (alpha 1-->6) glycosidiquues, leur utilisation et procédés de fabrication

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"18 INF ORMACION TECNICA.pdf", 23 April 2013 (2013-04-23), Retrieved from the Internet <URL:iwww.lipocol.com/applications/linocolombia/archivosll> *
"Especificaciones do Bioecolia", 23 April 2013 (2013-04-23), Retrieved from the Internet <URL:http://www.linocol.com/aplications/lipocolombia/archiyos/17ESPECIFICACIONES.ndf> [retrieved on 20020725] *
INFORMACION TECNICA DO BIOECOLIA, 1 February 2012 (2012-02-01), Retrieved from the Internet <URL:httn://www.linocol.com/applications/lipocolombia/archivos/18INFORMACION_TECNICA.pdf> [retrieved on 20130423] *
SABONETE INTIMO LIZ MULHER DA HINODE COSMETICOS, 23 April 2013 (2013-04-23), Retrieved from the Internet <URL:httu://redehinode.wordress.com/2008/11/08/sabonete-intimo-liz- mulher> [retrieved on 20081108] *

Also Published As

Publication number Publication date
PE20150768A1 (es) 2015-05-23
DOP2014000276A (es) 2015-03-15
AR091330A1 (es) 2015-01-28
ECSP15001584A (es) 2015-09-30
BR102012017571A2 (pt) 2014-06-10
CO7160048A2 (es) 2015-01-15
MX2014014896A (es) 2015-03-05
UY34910A (es) 2014-02-28
GT201500008A (es) 2017-10-09
CR20140570A (es) 2015-02-04
CL2015000101A1 (es) 2015-06-26

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