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WO2013115619A3 - Novel antibacterial compound - Google Patents

Novel antibacterial compound Download PDF

Info

Publication number
WO2013115619A3
WO2013115619A3 PCT/KR2013/000879 KR2013000879W WO2013115619A3 WO 2013115619 A3 WO2013115619 A3 WO 2013115619A3 KR 2013000879 W KR2013000879 W KR 2013000879W WO 2013115619 A3 WO2013115619 A3 WO 2013115619A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
food poisoning
composition
pyogenic infection
suppressing
Prior art date
Application number
PCT/KR2013/000879
Other languages
French (fr)
Korean (ko)
Other versions
WO2013115619A2 (en
Inventor
김원곤
김녕
손미진
Original Assignee
한국생명공학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국생명공학연구원 filed Critical 한국생명공학연구원
Publication of WO2013115619A2 publication Critical patent/WO2013115619A2/en
Publication of WO2013115619A3 publication Critical patent/WO2013115619A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G9/00—Cultivation in receptacles, forcing-frames or greenhouses; Edging for beds, lawn or the like
    • A01G9/14—Greenhouses
    • A01G9/1423—Greenhouse bench structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G9/00—Cultivation in receptacles, forcing-frames or greenhouses; Edging for beds, lawn or the like
    • A01G9/14—Greenhouses
    • A01G9/16—Dismountable or portable greenhouses ; Greenhouses with sliding roofs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B7/00—Connections of rods or tubes, e.g. of non-circular section, mutually, including resilient connections
    • F16B7/04—Clamping or clipping connections
    • F16B7/0406—Clamping or clipping connections for rods or tubes being coaxial
    • F16B7/0413—Clamping or clipping connections for rods or tubes being coaxial for tubes using the innerside thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof exhibiting antibacterial activity, an extract comprising the compound from a Penicillium sp. strain, a fraction of the extract, an antibacterial composition comprising the compound or the pharmaceutically acceptable salt thereof as an active ingredient, a pharmaceutical composition for treating food poisoning, a pharmaceutical composition for preventing or treating pyogenic infection, a method of treating food poisoning or pyogenic infection comprising a step of administering the composition, a composition for suppressing the activity of FabI which is an enoyl-ACP reductase, and a method of preparing the compound. The compound of the present invention can be widely used for the development of a medicine to treat food poisoning and pyogenic infection, since the compound exhibits the antibacterial activity of suppressing the growth of Bacillus and Staphylococcus aureus, which cause food poisoning or pyogenic infection, by suppressing the activity of enoyl-ACP reductase.
PCT/KR2013/000879 2012-02-03 2013-02-04 Novel antibacterial compound WO2013115619A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2012-0011507 2012-02-03
KR1020120011507A KR101498671B1 (en) 2012-02-03 2012-02-03 Novel compound having antimicrobial activity

Publications (2)

Publication Number Publication Date
WO2013115619A2 WO2013115619A2 (en) 2013-08-08
WO2013115619A3 true WO2013115619A3 (en) 2013-10-10

Family

ID=48905992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/000879 WO2013115619A2 (en) 2012-02-03 2013-02-04 Novel antibacterial compound

Country Status (2)

Country Link
KR (1) KR101498671B1 (en)
WO (1) WO2013115619A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102198101B1 (en) 2019-02-22 2021-01-04 서울대학교산학협력단 Composition for antibiotics against staphylococcus aureus and mycobacterium

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641804A (en) * 1992-09-15 1997-06-24 Novo Nordisk A/S Fungicidal compound comprising a cyclic polylactone
WO2002066467A1 (en) * 2001-02-22 2002-08-29 Nanodesign Inc. Dibenzo[c]chromen-6-one derivatives as anti-cancer agents
US20050085413A1 (en) * 2001-11-09 2005-04-21 Betty Jin Dimeric pharmaceutical compounds and their use
WO2006007310A2 (en) * 2004-06-18 2006-01-19 Natreon Inc. Compositions of stable bioactive metabolites of docosahexaenoic (dha) and eicosapentaenoic (epa) acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641804A (en) * 1992-09-15 1997-06-24 Novo Nordisk A/S Fungicidal compound comprising a cyclic polylactone
WO2002066467A1 (en) * 2001-02-22 2002-08-29 Nanodesign Inc. Dibenzo[c]chromen-6-one derivatives as anti-cancer agents
US20050085413A1 (en) * 2001-11-09 2005-04-21 Betty Jin Dimeric pharmaceutical compounds and their use
WO2006007310A2 (en) * 2004-06-18 2006-01-19 Natreon Inc. Compositions of stable bioactive metabolites of docosahexaenoic (dha) and eicosapentaenoic (epa) acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIM, NYOUNG ET AL.: "Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, 2012, pages 2503 - 2506 *

Also Published As

Publication number Publication date
KR101498671B1 (en) 2015-03-06
KR20130090295A (en) 2013-08-13
WO2013115619A2 (en) 2013-08-08

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