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WO2013080220A3 - Process for preparation of 3-[2-[4-(6-fluro-1, 2-benzisoxazol-3-yl)-1-piperidtnyl]ethyl]-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyriodo[1, 2-a]pyrimidin-4-one - Google Patents

Process for preparation of 3-[2-[4-(6-fluro-1, 2-benzisoxazol-3-yl)-1-piperidtnyl]ethyl]-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyriodo[1, 2-a]pyrimidin-4-one Download PDF

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Publication number
WO2013080220A3
WO2013080220A3 PCT/IN2012/000771 IN2012000771W WO2013080220A3 WO 2013080220 A3 WO2013080220 A3 WO 2013080220A3 IN 2012000771 W IN2012000771 W IN 2012000771W WO 2013080220 A3 WO2013080220 A3 WO 2013080220A3
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WO
WIPO (PCT)
Prior art keywords
preparation
pyriodo
piperidtnyl
fluro
benzisoxazol
Prior art date
Application number
PCT/IN2012/000771
Other languages
French (fr)
Other versions
WO2013080220A2 (en
Inventor
Rammohan Rao DAVULURI
Ravi Ponnaiah
Praveen Kumar Neela
Guruswamy Batthini
Telegareddy VENKATA NARASIMHARAO
Kosireddy RAVANABABU
Veeranarayana BANDLAMUDI
Original Assignee
Davuluri Rammohan Rao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Davuluri Rammohan Rao filed Critical Davuluri Rammohan Rao
Publication of WO2013080220A2 publication Critical patent/WO2013080220A2/en
Publication of WO2013080220A3 publication Critical patent/WO2013080220A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the preparation of paliperidone from the hydrolysis of paliperidone palmitate in the presence of an acid in a solvent.
PCT/IN2012/000771 2011-11-28 2012-11-26 An improved process for the preparation of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydio-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one. WO2013080220A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4104/CHE/2011 2011-11-28
IN4104CH2011 2011-11-28

Publications (2)

Publication Number Publication Date
WO2013080220A2 WO2013080220A2 (en) 2013-06-06
WO2013080220A3 true WO2013080220A3 (en) 2013-07-25

Family

ID=48536197

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Application Number Title Priority Date Filing Date
PCT/IN2012/000771 WO2013080220A2 (en) 2011-11-28 2012-11-26 An improved process for the preparation of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydio-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one.

Country Status (1)

Country Link
WO (1) WO2013080220A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110914A (en) * 2019-06-19 2020-12-22 上海天慈中商药业有限公司 Preparation method of paliperidone palmitate
CN111533737A (en) * 2020-05-22 2020-08-14 烟台大学 4-Flupaliperidone palmitate and its preparation method and application
CN111440168A (en) * 2020-05-22 2020-07-24 烟台大学 Preparation method and application of 6-methoxy paliperidone palmitate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048272A1 (en) * 2007-08-16 2009-02-19 Pratap Reddy Padi Preparation of paliperidone
WO2009089076A2 (en) * 2008-01-10 2009-07-16 Teva Pharmaceutical Industries Ltd. Processes for the preparation and purification of paliperidone palmitate
WO2011067220A1 (en) * 2009-12-01 2011-06-09 Chemo Ibérica, S.A. A process for the purification of paliperidone
WO2011074017A1 (en) * 2009-12-17 2011-06-23 Alkem Laboratories Ltd. A novel process for the preparation of paliperidone
WO2012164582A1 (en) * 2011-05-31 2012-12-06 Ramamohan Rao Davuluri Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[ 1, 2-a]-pyrimidin-4-one (paliperidone) and paliperidone palmitate.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048272A1 (en) * 2007-08-16 2009-02-19 Pratap Reddy Padi Preparation of paliperidone
WO2009089076A2 (en) * 2008-01-10 2009-07-16 Teva Pharmaceutical Industries Ltd. Processes for the preparation and purification of paliperidone palmitate
WO2011067220A1 (en) * 2009-12-01 2011-06-09 Chemo Ibérica, S.A. A process for the purification of paliperidone
WO2011074017A1 (en) * 2009-12-17 2011-06-23 Alkem Laboratories Ltd. A novel process for the preparation of paliperidone
WO2012164582A1 (en) * 2011-05-31 2012-12-06 Ramamohan Rao Davuluri Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[ 1, 2-a]-pyrimidin-4-one (paliperidone) and paliperidone palmitate.

Also Published As

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WO2013080220A2 (en) 2013-06-06

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