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WO2013052018A2 - Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône - Google Patents

Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône Download PDF

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Publication number
WO2013052018A2
WO2013052018A2 PCT/TR2011/000223 TR2011000223W WO2013052018A2 WO 2013052018 A2 WO2013052018 A2 WO 2013052018A2 TR 2011000223 W TR2011000223 W TR 2011000223W WO 2013052018 A2 WO2013052018 A2 WO 2013052018A2
Authority
WO
WIPO (PCT)
Prior art keywords
cornea
filling material
keratoconus
tunnel
treatment
Prior art date
Application number
PCT/TR2011/000223
Other languages
English (en)
Inventor
Faik Orucoglu
Original Assignee
Faik Orucoglu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faik Orucoglu filed Critical Faik Orucoglu
Priority to PCT/TR2011/000223 priority Critical patent/WO2013052018A2/fr
Publication of WO2013052018A2 publication Critical patent/WO2013052018A2/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F9/00825Methods or devices for eye surgery using laser for photodisruption
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/147Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00861Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872Cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00885Methods or devices for eye surgery using laser for treating a particular disease
    • A61F2009/00893Keratoconus

Definitions

  • This invention is related to use of a filling material by reducing the curvature of the cornea during the treatment of use with keratoconus.
  • the curvature occurring in the corneas causes eye deterioration.
  • the applications done to cure this consists of the use of rigid contact lens, placing a ring inside the cornea or cornea transplantation.
  • the myopic or hypermetropia defects are corrected and fiber optic cable or micro- incisive tools are placed in the cornea and thus ablation is formed in the cornea or a pouch is formed by removing tissues.
  • the cornea curvature is corrected by placing rigid lens, solution or combinations in to the formed up pouch. Filling solution or the cornea center or filling the pouches that are formed up in radial style is also used.
  • the discs which were formed after conducting the polymerization in the oven were implanted by forming a pouch within the central cornea.
  • the GMA hydro-gels did not cause any minimal or other inflammations to the cornea.
  • the synthetic polymers in addition to showing that the synthetic polymers are not toxic to the cornea the polymerization was formed up out of the cornea and in an oven. In this study the reactions of GMA hydro-gels were observed.
  • the most distinctive aspect of our study is being able to fill the fluid matter without causing tissue loss and by protecting the central cornea; and being able to realize the photo-polymerization.
  • tissue loss is not formed in our patent by application of stromal ablation. Tunnel is formed up by Femtosecond laser.
  • the fluid filling matter that is given through the channel is exposed to photo-polymerization by a LED light and facilitated to link to stromal cornea tissue and to harden. This aimed to use for the treatment of keratoconus, being different from other patents and studies.
  • the material that is used in our study was bisphenol A diglycidylmethacrylate and triethyleneglycol dimethacrylate (BisGMA and TEGDMA) combination.
  • This invention is related to the method of using of a filling material by reducing the curvature of the cornea specific to the person for the treatment of the keratoconus eyes.
  • the subject of the invention is established by the filling material used in the method that is fluid restorative material.
  • a tunnel is formed up in the cornea by Femtosecond laser and this fluid filling material is given from the entry point of this tunnel.
  • the dimension, diameter and the amount of the filling matter is adjusted as per the severity of keratoconus. As the severity of keratoconus increases the dimension of the tunnel and the amount of the filling material is increased accordingly. Certain amount of filling material is given to the tunnel that is formed up on the areas where the cornea is thin and straight up and at least by 4 mm from the center of the cornea.
  • the second phase in order to pressure on the straight parts of the cornea by the rigid contact lens, it is placed on the cornea.
  • photo-polymerization is done by LED light by pressuring on the contact lens and thus the stabilization of the cornea is supplied.
  • FIGURE 1- Schematic view of the tunnel formation.
  • FIGURE 2- Schematic view of filling material's filing operation.
  • FIGURE 3- Schematic view of the use of rigid contact lenses for pressurizing.
  • FIGURE 4- Schematic view of the photo-polymerization operation by LED.
  • the aspects of the figures are assigned numbers one by one and the provisions to these numbers are given below;
  • This invention is related to the use of a filling material (5) for the treatment of keratoconus eyes by reducing the curvature of the cornea (1).
  • the filling material (5) used in the subject method of this invention is established by the fluid restorative material.
  • a tunnel (3) is formed up within the cornea (1) by the femtosecond laser and this filling material (5) is given from the tunnel entry (2).
  • the suiting rigid contact lens (6) is pressed on the surface of the cornea (1). Following that approximately in 20 seconds photo-polymerization is realized by LED light (7).
  • the filling material (5) reveals similar features to the dental fillings known in the technique.
  • the subject filling material is established by the compound of (5), bis- GMA and TEGDMA (bis-phenol A diglycidylmethacrylate and triethyleneglycol dimethacrylate).
  • the fluid restoratives that are used as dental filling materials may be used for this purpose.
  • a tunnel (3) is formed up by femtosecond laser within the cornea (1) and this filling material (5) is given from the entry of this tunnel (2).
  • the suiting rigid contact lens (6) is pressed on the surface of the cornea (1) in order to provide the ideal correction on the Cornea (1).
  • photo-polymertization is realized approximately in 20 seconds by LED light (7).
  • Intra- stromal photo-polymerization is names as intra-curing.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Eyeglasses (AREA)
PCT/TR2011/000223 2011-10-06 2011-10-06 Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône WO2013052018A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/TR2011/000223 WO2013052018A2 (fr) 2011-10-06 2011-10-06 Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TR2011/000223 WO2013052018A2 (fr) 2011-10-06 2011-10-06 Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône

Publications (1)

Publication Number Publication Date
WO2013052018A2 true WO2013052018A2 (fr) 2013-04-11

Family

ID=46298653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2011/000223 WO2013052018A2 (fr) 2011-10-06 2011-10-06 Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône

Country Status (1)

Country Link
WO (1) WO2013052018A2 (fr)

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