WO2013052018A2 - Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône - Google Patents
Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône Download PDFInfo
- Publication number
- WO2013052018A2 WO2013052018A2 PCT/TR2011/000223 TR2011000223W WO2013052018A2 WO 2013052018 A2 WO2013052018 A2 WO 2013052018A2 TR 2011000223 W TR2011000223 W TR 2011000223W WO 2013052018 A2 WO2013052018 A2 WO 2013052018A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cornea
- filling material
- keratoconus
- tunnel
- treatment
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims description 30
- 238000000034 method Methods 0.000 title claims description 13
- 201000002287 Keratoconus Diseases 0.000 title claims description 12
- 210000004087 cornea Anatomy 0.000 claims description 42
- 239000012530 fluid Substances 0.000 claims description 10
- 238000006116 polymerization reaction Methods 0.000 claims description 9
- AMFGWXWBFGVCKG-UHFFFAOYSA-N Panavia opaque Chemical compound C1=CC(OCC(O)COC(=O)C(=C)C)=CC=C1C(C)(C)C1=CC=C(OCC(O)COC(=O)C(C)=C)C=C1 AMFGWXWBFGVCKG-UHFFFAOYSA-N 0.000 claims description 7
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 6
- LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 description 5
- 239000003479 dental cement Substances 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 238000002679 ablation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
- 231100001231 less toxic Toxicity 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- UEKHZPDUBLCUHN-UHFFFAOYSA-N 2-[[3,5,5-trimethyl-6-[2-(2-methylprop-2-enoyloxy)ethoxycarbonylamino]hexyl]carbamoyloxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOC(=O)NCCC(C)CC(C)(C)CNC(=O)OCCOC(=O)C(C)=C UEKHZPDUBLCUHN-UHFFFAOYSA-N 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 206010020675 Hypermetropia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- -1 Polyethylene Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229940116336 glycol dimethacrylate Drugs 0.000 description 1
- 201000006318 hyperopia Diseases 0.000 description 1
- 230000004305 hyperopia Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00825—Methods or devices for eye surgery using laser for photodisruption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/147—Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
- A61F2009/00893—Keratoconus
Definitions
- This invention is related to use of a filling material by reducing the curvature of the cornea during the treatment of use with keratoconus.
- the curvature occurring in the corneas causes eye deterioration.
- the applications done to cure this consists of the use of rigid contact lens, placing a ring inside the cornea or cornea transplantation.
- the myopic or hypermetropia defects are corrected and fiber optic cable or micro- incisive tools are placed in the cornea and thus ablation is formed in the cornea or a pouch is formed by removing tissues.
- the cornea curvature is corrected by placing rigid lens, solution or combinations in to the formed up pouch. Filling solution or the cornea center or filling the pouches that are formed up in radial style is also used.
- the discs which were formed after conducting the polymerization in the oven were implanted by forming a pouch within the central cornea.
- the GMA hydro-gels did not cause any minimal or other inflammations to the cornea.
- the synthetic polymers in addition to showing that the synthetic polymers are not toxic to the cornea the polymerization was formed up out of the cornea and in an oven. In this study the reactions of GMA hydro-gels were observed.
- the most distinctive aspect of our study is being able to fill the fluid matter without causing tissue loss and by protecting the central cornea; and being able to realize the photo-polymerization.
- tissue loss is not formed in our patent by application of stromal ablation. Tunnel is formed up by Femtosecond laser.
- the fluid filling matter that is given through the channel is exposed to photo-polymerization by a LED light and facilitated to link to stromal cornea tissue and to harden. This aimed to use for the treatment of keratoconus, being different from other patents and studies.
- the material that is used in our study was bisphenol A diglycidylmethacrylate and triethyleneglycol dimethacrylate (BisGMA and TEGDMA) combination.
- This invention is related to the method of using of a filling material by reducing the curvature of the cornea specific to the person for the treatment of the keratoconus eyes.
- the subject of the invention is established by the filling material used in the method that is fluid restorative material.
- a tunnel is formed up in the cornea by Femtosecond laser and this fluid filling material is given from the entry point of this tunnel.
- the dimension, diameter and the amount of the filling matter is adjusted as per the severity of keratoconus. As the severity of keratoconus increases the dimension of the tunnel and the amount of the filling material is increased accordingly. Certain amount of filling material is given to the tunnel that is formed up on the areas where the cornea is thin and straight up and at least by 4 mm from the center of the cornea.
- the second phase in order to pressure on the straight parts of the cornea by the rigid contact lens, it is placed on the cornea.
- photo-polymerization is done by LED light by pressuring on the contact lens and thus the stabilization of the cornea is supplied.
- FIGURE 1- Schematic view of the tunnel formation.
- FIGURE 2- Schematic view of filling material's filing operation.
- FIGURE 3- Schematic view of the use of rigid contact lenses for pressurizing.
- FIGURE 4- Schematic view of the photo-polymerization operation by LED.
- the aspects of the figures are assigned numbers one by one and the provisions to these numbers are given below;
- This invention is related to the use of a filling material (5) for the treatment of keratoconus eyes by reducing the curvature of the cornea (1).
- the filling material (5) used in the subject method of this invention is established by the fluid restorative material.
- a tunnel (3) is formed up within the cornea (1) by the femtosecond laser and this filling material (5) is given from the tunnel entry (2).
- the suiting rigid contact lens (6) is pressed on the surface of the cornea (1). Following that approximately in 20 seconds photo-polymerization is realized by LED light (7).
- the filling material (5) reveals similar features to the dental fillings known in the technique.
- the subject filling material is established by the compound of (5), bis- GMA and TEGDMA (bis-phenol A diglycidylmethacrylate and triethyleneglycol dimethacrylate).
- the fluid restoratives that are used as dental filling materials may be used for this purpose.
- a tunnel (3) is formed up by femtosecond laser within the cornea (1) and this filling material (5) is given from the entry of this tunnel (2).
- the suiting rigid contact lens (6) is pressed on the surface of the cornea (1) in order to provide the ideal correction on the Cornea (1).
- photo-polymertization is realized approximately in 20 seconds by LED light (7).
- Intra- stromal photo-polymerization is names as intra-curing.
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Eyeglasses (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/TR2011/000223 WO2013052018A2 (fr) | 2011-10-06 | 2011-10-06 | Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/TR2011/000223 WO2013052018A2 (fr) | 2011-10-06 | 2011-10-06 | Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013052018A2 true WO2013052018A2 (fr) | 2013-04-11 |
Family
ID=46298653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2011/000223 WO2013052018A2 (fr) | 2011-10-06 | 2011-10-06 | Procédé d'utilisation d'une substance de remplissage pour réduire la courbure cornéenne lors du traitement du kératocône |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2013052018A2 (fr) |
-
2011
- 2011-10-06 WO PCT/TR2011/000223 patent/WO2013052018A2/fr active Application Filing
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