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WO2013033638A3 - Use of nuclear magnetic resonance and near infrared to analyze biological samples - Google Patents

Use of nuclear magnetic resonance and near infrared to analyze biological samples Download PDF

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Publication number
WO2013033638A3
WO2013033638A3 PCT/US2012/053528 US2012053528W WO2013033638A3 WO 2013033638 A3 WO2013033638 A3 WO 2013033638A3 US 2012053528 W US2012053528 W US 2012053528W WO 2013033638 A3 WO2013033638 A3 WO 2013033638A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic resonance
nuclear magnetic
near infrared
biological samples
nir
Prior art date
Application number
PCT/US2012/053528
Other languages
French (fr)
Other versions
WO2013033638A2 (en
Inventor
Maureen LANAN
Amr Ali
Original Assignee
Biogen Idec Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Ma Inc. filed Critical Biogen Idec Ma Inc.
Priority to DK12775862.1T priority Critical patent/DK2751725T3/en
Priority to EP12775862.1A priority patent/EP2751725B1/en
Priority to US14/241,647 priority patent/US9360421B2/en
Priority to JP2014528671A priority patent/JP6196220B2/en
Publication of WO2013033638A2 publication Critical patent/WO2013033638A2/en
Publication of WO2013033638A3 publication Critical patent/WO2013033638A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/13—Standards, constitution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics

Landscapes

  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computing Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pulmonology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

In one aspect, the disclosure provides methods for using NMR and NIR to evaluate biological samples. In some embodiments, the methods include a step of performing a Nuclear Magnetic Resonance (NMR) analysis on a sample to obtain an NMR spectrum, a step of performing a Near Infrared Spectroscopy (NIR) analysis on the sample to obtain an NIR spectrum, and/or a step of performing a data fusion analysis to evaluate the NIR spectrum.
PCT/US2012/053528 2011-09-01 2012-08-31 Use of nuclear magnetic resonance and near infrared to analyze biological samples WO2013033638A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DK12775862.1T DK2751725T3 (en) 2011-09-01 2012-08-31 USE OF NUCLEAR MAGNETIC RESONANCE AND NEAR-INFRARED FOR ANALYSIS OF BIOLOGICAL SAMPLES
EP12775862.1A EP2751725B1 (en) 2011-09-01 2012-08-31 Use of nuclear magnetic resonance and near infrared to analyze biological samples
US14/241,647 US9360421B2 (en) 2011-09-01 2012-08-31 Use of nuclear magnetic resonance and near infrared to analyze biological samples
JP2014528671A JP6196220B2 (en) 2011-09-01 2012-08-31 Use of nuclear magnetic resonance and near infrared for biological sample analysis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161530163P 2011-09-01 2011-09-01
US61/530,163 2011-09-01
US201161581778P 2011-12-30 2011-12-30
US61/581,778 2011-12-30

Publications (2)

Publication Number Publication Date
WO2013033638A2 WO2013033638A2 (en) 2013-03-07
WO2013033638A3 true WO2013033638A3 (en) 2013-09-26

Family

ID=47071430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/053528 WO2013033638A2 (en) 2011-09-01 2012-08-31 Use of nuclear magnetic resonance and near infrared to analyze biological samples

Country Status (5)

Country Link
US (1) US9360421B2 (en)
EP (1) EP2751725B1 (en)
JP (1) JP6196220B2 (en)
DK (1) DK2751725T3 (en)
WO (1) WO2013033638A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11300531B2 (en) 2014-06-25 2022-04-12 Aspect Ai Ltd. Accurate water cut measurement
US20190011383A1 (en) * 2015-05-26 2019-01-10 Aspect Ai Ltd. Apparatus and method for quality detection of a processed product
KR102487983B1 (en) 2015-11-16 2023-01-11 삼성전자주식회사 Apparatus and Method for construction of disease prediction model, and Apparatus for disease prediction.
WO2018056161A1 (en) * 2016-09-21 2018-03-29 コニカミノルタ株式会社 Measurement data management system, measurement data management method, and optical characteristic measurement device
CA3041142C (en) 2016-12-16 2021-06-15 Farmers Edge Inc. Classification of soil texture and content by near-infrared spectroscopy
US10837926B2 (en) * 2017-09-01 2020-11-17 Case Western Reserve University Multi-modal spectroscopic analysis
GB201806752D0 (en) * 2018-04-25 2018-06-06 Ge Healthcare Bioprocess R&D Ab Method in bioprocess system
EP3809118B1 (en) * 2019-10-17 2023-06-21 Evonik Operations GmbH Method of prediction a property value of a material using principal component analysis
CN111122635B (en) * 2019-12-10 2023-05-12 北京农业智能装备技术研究中心 Online evaluation method and system for edible fungus drying state
US11781972B2 (en) 2020-11-05 2023-10-10 X Development Llc Techniques for selection of light source configurations for material characterization
CN112986175B (en) * 2021-03-05 2023-06-30 江西省产品质量监督检测院(江西省缺陷产品召回中心) Method for rapidly detecting melamine tableware adulteration by utilizing infrared spectrum
CN114405540A (en) * 2022-03-02 2022-04-29 北京化工大学 A method and device for identifying the active site of titanium-silicon molecular sieve for catalytic oxidation of olefins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610836A (en) * 1996-01-31 1997-03-11 Eastman Chemical Company Process to use multivariate signal responses to analyze a sample
US6420869B1 (en) * 2000-10-17 2002-07-16 Baker Hughes Incorporated Method and apparatus for estimating NMR properties by near infrared spectra

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARROS A. S. ET AL: "Principal component transform - Outer product analysis in the PCA context", CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 93, no. 1, 15 August 2008 (2008-08-15), pages 43 - 48, XP022734039, ISSN: 0169-7439, [retrieved on 20080407], DOI: 10.1016/J.CHEMOLAB.2008.03.009 *
VESELA A. ET AL: "Infrared spectroscopy and outer product analysis for quantification of fat, nitrogen, and moisture of cocoa powder", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 601, no. 1, 26 September 2007 (2007-09-26), pages 77 - 86, XP022274069, ISSN: 0003-2670, DOI: 10.1016/J.ACA.2007.08.039 *
WEBB G. A. ET AL: "MAGNETIC RESONANCE IN FOOD SCIENCE: A VIEW TO THE FUTURE", 2001, THE ROYAL SOCIETY OF CHEMISTRY, article RUTLEDGE D. N. ET AL: "Interpreting Near Infrared Spectra of Solutions by Outer Product Analysis with Time Domain - NMR", pages: 179 - 192, XP008163847 *

Also Published As

Publication number Publication date
US20140353503A1 (en) 2014-12-04
WO2013033638A2 (en) 2013-03-07
US9360421B2 (en) 2016-06-07
EP2751725A2 (en) 2014-07-09
DK2751725T3 (en) 2021-01-25
EP2751725B1 (en) 2020-12-09
JP6196220B2 (en) 2017-09-13
JP2014525587A (en) 2014-09-29

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