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WO2012063115A3 - Process for the preparation of rosuvastatin calcium via novel amine intermediate - Google Patents

Process for the preparation of rosuvastatin calcium via novel amine intermediate Download PDF

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Publication number
WO2012063115A3
WO2012063115A3 PCT/IB2011/002633 IB2011002633W WO2012063115A3 WO 2012063115 A3 WO2012063115 A3 WO 2012063115A3 IB 2011002633 W IB2011002633 W IB 2011002633W WO 2012063115 A3 WO2012063115 A3 WO 2012063115A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
novel amine
rosuvastatin calcium
amine intermediate
via novel
Prior art date
Application number
PCT/IB2011/002633
Other languages
French (fr)
Other versions
WO2012063115A2 (en
Inventor
Khushwant Singh
Anand Kumar Singh
Rahul Srivastava
Pramod Kumar
Dharam Vir
Ashutosh Agarwal
Original Assignee
Jubilant Life Sciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Life Sciences Ltd. filed Critical Jubilant Life Sciences Ltd.
Publication of WO2012063115A2 publication Critical patent/WO2012063115A2/en
Publication of WO2012063115A3 publication Critical patent/WO2012063115A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention, relates to novel amine salts of rosuvastatin and its process for the preparation. Moreover, the present invention also relates to improved process for the preparation of rosuvastatin calcium, employing novel amine salts as an intermediate.
PCT/IB2011/002633 2010-11-11 2011-11-09 Process for the preparation of rosuvastatin calcium via novel amine intermediate WO2012063115A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2702/DEL/2010 2010-11-11
IN2702DE2010 2010-11-11

Publications (2)

Publication Number Publication Date
WO2012063115A2 WO2012063115A2 (en) 2012-05-18
WO2012063115A3 true WO2012063115A3 (en) 2012-10-26

Family

ID=45444648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/002633 WO2012063115A2 (en) 2010-11-11 2011-11-09 Process for the preparation of rosuvastatin calcium via novel amine intermediate

Country Status (1)

Country Link
WO (1) WO2012063115A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102967683B (en) * 2012-11-16 2014-10-08 峨眉山天梁星制药有限公司 High-performance liquid chromatography method for methyl(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphos phoranylidenehexanoate
CN105189458A (en) * 2013-03-29 2015-12-23 中化帝斯曼制药有限公司荷兰公司 Amine salts of pitavastatin and rosuvastatin
CN105377817A (en) * 2013-03-29 2016-03-02 中化帝斯曼制药有限公司荷兰公司 Amine salts of pitavastatin and rosuvastatin
EP3022213B1 (en) 2013-07-16 2017-06-21 Suven Life Sciences Limited Process for the preparation of rosuvastatin calcium and preparation of its novel intermediates
JP6596339B2 (en) * 2014-02-06 2019-10-23 株式会社エーピーアイ コーポレーション Method for producing rosuvastatin calcium and intermediates thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
WO2008038132A1 (en) * 2006-09-28 2008-04-03 Aurobindo Pharma Limited Crystalline diamine salts of rosuvastatin
WO2010035284A2 (en) * 2008-09-26 2010-04-01 Matrix Laboratories Ltd An improved process for the preparation of rosuvastatin calcium
WO2010081861A1 (en) * 2009-01-14 2010-07-22 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of rosuvastatin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2648897B2 (en) 1991-07-01 1997-09-03 塩野義製薬株式会社 Pyrimidine derivatives
SI20070A (en) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. NOVEL SALTS OF INHIBITORS OF HMG-CoA REDUCTASE
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
EP1601658A1 (en) 2003-11-24 2005-12-07 Teva Pharmaceutical Industries Limited Crystalline ammonium salts of rosuvastatin
US20100069635A1 (en) 2006-11-29 2010-03-18 Dr. Reddy's Laboratories Ltd. Rosuvastatin dehydroabietylamine salt

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
WO2008038132A1 (en) * 2006-09-28 2008-04-03 Aurobindo Pharma Limited Crystalline diamine salts of rosuvastatin
WO2010035284A2 (en) * 2008-09-26 2010-04-01 Matrix Laboratories Ltd An improved process for the preparation of rosuvastatin calcium
WO2010081861A1 (en) * 2009-01-14 2010-07-22 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of rosuvastatin

Also Published As

Publication number Publication date
WO2012063115A2 (en) 2012-05-18

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