WO2012050583A1 - Fil de guidage ou de renfort à filetage double pour ballonnet de renforcement vertébral à usage multiple - Google Patents
Fil de guidage ou de renfort à filetage double pour ballonnet de renforcement vertébral à usage multiple Download PDFInfo
- Publication number
- WO2012050583A1 WO2012050583A1 PCT/US2010/052717 US2010052717W WO2012050583A1 WO 2012050583 A1 WO2012050583 A1 WO 2012050583A1 US 2010052717 W US2010052717 W US 2010052717W WO 2012050583 A1 WO2012050583 A1 WO 2012050583A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- balloon
- thread
- threaded
- guidance wire
- distal
- Prior art date
Links
- 230000003416 augmentation Effects 0.000 title description 3
- 238000011282 treatment Methods 0.000 claims abstract description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 28
- 230000009969 flowable effect Effects 0.000 claims description 11
- 230000004323 axial length Effects 0.000 claims description 8
- 239000004033 plastic Substances 0.000 abstract description 6
- 229920003023 plastic Polymers 0.000 abstract description 6
- 206010017076 Fracture Diseases 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 208000010392 Bone Fractures Diseases 0.000 description 5
- 208000001132 Osteoporosis Diseases 0.000 description 5
- 230000001054 cortical effect Effects 0.000 description 5
- 239000003550 marker Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 206010010214 Compression fracture Diseases 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010029174 Nerve compression Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003000 extruded plastic Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 208000028755 loss of height Diseases 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229940124583 pain medication Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/885—Tools for expanding or compacting bones or discs or cavities therein
- A61B17/8852—Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc
- A61B17/8855—Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc inflatable, e.g. kyphoplasty balloons
Definitions
- Osteoporosis is a disease that gradually weakens bones and causes them to become brittle. Left untreated, osteoporosis can progress painlessly until a bone breaks. I n some cases, osteoporosis can cause compression fractures in the spine. This occurs when the bony block, or vertebral body, in the spine collapses. This causes severe pain, deformity, and loss of height. It ca n also lead to nerve compression.
- PM MA polymethylmethacrylate
- Kyphoplasty is a procedure that involves making small incisions and placing a catheter into the vertebral space where the fracture is located. A cavity is created inside the bone (e.g. drilled) and a balloon, called a bone tamp, is inserted. The balloon may be support by a guidance wire that is passed through a central lumen of the catheter. The balloon is then inflated with contrast medium until it expands to a desired height, deflated and removed. The balloon is used to expand and reposition the compressed bone, and to create a cavity for cement. The cavity created by the balloon may then be filled with PM MA, binding the fracture. Kyphoplasty substantially restores height to the spine, thus reducing deformity (also pain relief).
- the tool may include a balloon catheter that may be a two (or more) lumen catheter.
- An outer lumen may be used for inflation of the balloon and an inside lumen for guiding a double-threaded guidance wire.
- a thread in the distal part of the guidance wire may be provided with outer diameter of the distal thread being less than the inner diameter of an inner tube of the catheter.
- the construction of the thread i.e., outer diameter, inner diameter, flank lead, length
- the counter piece e.g., a distal threaded nut
- the counter piece for the distal thread of the guidance wire may be disposed inside the balloon of the catheter and connected to the inner tube. This nut can also be used as a radiopaque marker inside the balloon.
- the guidance wire may also have a proximal thread with an outer diameter greater than an outer diameter distal thread.
- the construction of the thread e.g., outer diameter, inner diameter, flank lead, length
- the counter piece e.g., a proximal threaded nut
- the proximal threaded nut may be disposed inside a luer connector (e.g., a connector for balloon inflation) of the catheter and positioned coaxial to the inner tube.
- the length of the proximal threaded nut may be longer than the distal threaded nut to account for changes of the balloon catheter during inflation.
- the double-threaded guidance wire may remain connected to the balloon during inflation to prevent the balloon and the inner tube from lengthening, substantially avoiding plastic deformation in an axial direction.
- the double-threaded guidance wire may be removed from the tool during balloon inflation. Thereafter, the double-threaded guidance wire can be reinserted into the tool to connect to the thread in the balloon to restore the pre-inflation nominal balloon axial length and stiffness before inflation.
- the double-threaded guidance wire can be reinserted into the tool to connect to the thread in the balloon to restore the pre-inflation nominal balloon axial length and stiffness before inflation.
- a reusable tool that includes a handle having a proximal thread.
- a catheter structure may be included that has an outer body and an inner body. The outer body may be connected to a fitting of the handle.
- An expandable structure may be connected to the outer body, where the expandable structure has a distal thread affixed within an interior thereof.
- a guidance wire maybe disposed within the inner body, where the guidance wire has a first threaded portion adapted to engage the proximal thread and a second threaded portion adapted to engage the distal thread.
- a reusable tool for treating a vertebral body may include a handle having an inflation port and a proximal thread.
- a dual-lumen catheter may be connected to a fitting of the handle and a balloon connected to the outer body.
- the balloon may have a distal thread affixed within an interior thereof.
- a guidance wire may be disposed within an inner lumen of the dual- lumen catheter, where the guidance wire has a first threaded portion adapted to engage the proximal thread in the handle and a second threaded portion adapted to engage the distal thread in the balloon.
- a tool for treating a vertebral body that includes a handle having an inflation port, a luer fitting and a proximal thread disposed with a body of the handle.
- a catheter body may be attached to the luer fitting of the handle.
- a balloon may be connected to the catheter body, where the balloon has a distal thread affixed within an interior thereof.
- the tool may further include a dual- threaded guidance wire having a first threaded portion adapted to engage the proximal thread and a second threaded portion adapted to engage the distal thread.
- a method for treating bone with a tool having a catheter tube assembly may include fixing a double-threaded guidance wire to a distal threaded nut of an inflatable structure, and deploying the inflatable structure inside a first location of the bone.
- the inflatable structure may be inflated to create a cavity within a treatment area of the bone, after which the inflatable structure is deflated and removed from inside the bone.
- the inflatable structure may then be reused and reinserted within the treatment area or inside a second location of the bone.
- FIG. 1 is a view of a reusable tool having an balloon structure
- FIG. 2 is a cross-sectional view of a catheter tube assembly of the reusable tool of FIG. 1;
- FIG. 3 is a view of the reusable tool of FIG. 1 showing additional details of a double-threaded guidance wire;
- FIG. 4 is a cross-sectional view of a proximal threaded nut
- FIG. 5 is a cross-sectional view of a distal threaded nut
- FIG. 6 is a cross-sectional view of the double-threaded guidance wire
- FIG. 7 illustrates an implementation to inflate the balloon structure with the double-threaded guidance wire attached thereto
- FIG. 8 is operational flow diagram of exemplary processes that are performed as part of a procedure using the implementation of FIG. 7;
- FIG. 9 illustrates an implementation to inflate the balloon structure where the double-threaded guidance wire is removed during inflation of the balloon structure and reinserted to withdraw the balloon structure;
- FIG. 10 operational flow diagram of exemplary processes that are performed as part of a procedure using the implementation of Fig. 9. DETAILED DESCRIPTION
- the tool 100 includes a catheter tube assembly 104 made from, e.g., metal or extruded plastic materials.
- the catheter tube may be generally flexible.
- the distal end of the catheter tube assembly 104 carries a balloon structure 106, which is made, e.g., from a deformable plastic or other compliant material.
- the balloon structure 106 is deployed and expanded inside bone, e.g., in a vertebral body, to compact cancellous bone and/or displace cortical bone.
- the catheter tube assembly 104 includes an outer catheter body 108 and an inner catheter body 110.
- the inner catheter body 110 extends through and beyond the outer catheter body 108 into the balloon structure 106.
- the proximal ends of the inner catheter body 110 and the outer catheter body 108 are jointly coupled to the distal end of a luer fitting 114 on a y-shaped luer connector 102, which serves as a handle for the tool 100.
- the proximal end of the inner catheter body 110 extends within the luer connector 102 beyond the coupled proximal ends of the outer catheter body 108.
- the extended proximal end of the inner catheter body 110 is coupled to the luer connector 102 at a location proximal to an inflation port 120.
- the distal end of the inner catheter body 110 extends beyond the distal end of the outer catheter body 108.
- the balloon structure 106 is coupled at its proximal end to the distal end of the outer catheter body 108.
- the balloon structure 106 is coupled at its distal end to the double-threaded guidance wire 112 that extends beyond the distal end of the inner catheter body 110.
- the double-threaded guidance wire 112 is coupled at its proximal end to a rotatable luer cap 116.
- the interior diameter of the outer catheter body 108 is larger than the exterior diameter of the inner catheter body 110.
- An interior passage 122 is thereby defined between them.
- the interior passage 122 conveys a pressurized flowable medium, e.g., sterile water, radiopaque fluid, gas, or other flowable substance into the balloon structure 106, to expand it.
- the inner catheter body 110 defines an interior lumen 124 within the interior passage 122.
- the double-threaded guidance wire 112 extends through the interior lumen 124.
- the luer cap 116 rotates about a proximal luer fitting 118 on the luer connector 102. Twisting the luer cap 116 rotates the double- threaded guidance wire 112 within the inner catheter body 110. The torque caused by twisting the luer cap 116 is transmitted to a first threaded portion 126 of the double- threaded guidance wire 112 that engages a proximal threaded nut 128 within the luer connector 102 (see, reference A).
- the proximal threaded nut 128 may be conical in shape to remain fixed against a pull force of the guidance wire 122 (described below), thus providing a form closure inside the luer connector 102.
- the proximal threaded nut 128 may also be attached to the luer connector 102 by, e.g., glue, threads, a pin, etc., such that it remains secure.
- the torque is also transmitted to a second threaded portion 132 of the double-threaded guidance wire 112 that engages a distal threaded nut 130 within the balloon structure 106 (see, reference B).
- the distal threaded nut 130 may be used as a radiopaque marker inside the balloon structure 106.
- a marker 134 may be provided that is fixed to a portion of the inner catheter body 110 that extends within the balloon structure 106.
- the marker 134 may be a radiopaque marker viewed using plain film x-ray, fluoroscopic x-ray, MRI or CT scanning.
- the threads of the nuts 128 and 130, and the guidance wire 112 can be designed both with a left-hand thread or both with a right-hand thread.
- the threads can also be designed in opposite direction (one left-hand thread and the other right-hand thread).
- the interaction of the double-threaded guidance wire 112, proximal threaded nut 128, distal threaded nut 130 and the balloon structure 106 is described below with reference to FIGS. 7-10.
- the proximal threaded nut 128 may have a length of 15-40 mm.
- the diameter of the hole of the proximal threaded nut 128 may be approximately 1.6 mm.
- the distal threaded nut 130 may be inside the balloon structure 106 and have a length of 2-3 mm.
- the diameter of the hole of the distal threaded nut 130 may be approximately 1.0 mm.
- the material from which the balloon structure 106 is made may possess various physical and mechanical properties to optimize its functional capabilities to compact cancellous bone.
- Such properties may include the ability to expand in volume, the ability to deform in a desired way when expanding and assume a desired shape inside bone, and/or the ability to withstand abrasion, tearing, and puncture when in contact with cancellous and/or cortical bone.
- the expanded shape inside bone may be selected to optimize the formation of a cavity that, when filled with a selected material (e.g., PMMA, calcium phosphate, bone chips, etc.), provides support across the region of the bone being treated.
- a selected material e.g., PMMA, calcium phosphate, bone chips, etc.
- the selection of the shape of the balloon structure 106 inside bone may take into account the cancellous bone volume which should be compacted to achieve the desired therapeutic result.
- Another consideration for the selection of the shape of the balloon structure 106 is the amount that the targeted fractured bone region has been displaced or depressed.
- the balloon structure 106 may have a predetermined length, such as 10 mm, 15 mm or 20 mm, selected based on the amount of displacement.
- the expansion of the balloon structure 106 inside a bone can elevate or push the fractured cortical wall back to or near its anatomic position occupied before fracture occurred.
- FIG. 7 there is illustrated an implementation of the tool 100 wherein the double-threaded guidance wire 112 remains fixed to the balloon structure 106 during inflation of the balloon structure 106.
- FIG. 8 illustrates an associated operational flow diagram 300 of exemplary processes that are performed as part of a procedure using the tool 100 in such an implementation.
- the double-threaded guidance wire 112 is fixed to the distal threaded nut 130 of the balloon structure 106 (see, reference 200).
- the balloon structure 106 may be folded such that the tool 100 has an axial length L.
- the balloon structure 106 is then inflated with the double- threaded guidance wire 112 fixed to the distal threaded nut 130 (see, reference 202).
- the inflation of the balloon structure 106 may, e.g., compress or create a cavity within cancellous bone and/or elevate the cortical wall of the spine.
- the tool 100 substantially remains at the axial length L in the inflated state.
- the balloon structure 106 is then deflated and the catheter tube assembly 104 may be removed at 308. Because the double-threaded guidance wire 112 remains fixed to the balloon structure 106 through the threaded engagement of the second threaded portion 132 to the distal threaded nut 130, the balloon structure 106 remains substantially at its original axial length L.
- the catheter tube assembly 104 may be reused and reinserted (at 302) and the balloon structure 106 reinflated for subsequent use.
- the tool 100 may be reused either in the same vertebral body or another vertebral body in the same patient because the balloon structure 106 remains supported by the double-threaded guidance wire 112 and, as such, has a known size.
- FIG. 10 is an associated operational flow diagram 500 of exemplary processes that are performed as part of a procedure using the tool 100 in such an implementation.
- the double-threaded guidance wire 112 is fixed to the distal threaded nut 130 of the balloon structure 106 (see, reference 400). In the delivered state, the balloon structure 106 may be folded.
- the double-threaded guidance wire 112 is removed, and the balloon structure 106 is then inflated at 506 (see, reference 402).
- the inflation of the balloon structure 106 compresses or creates a cavity within cancellous bone and/or elevates the cortical wall.
- the inflation of the expanding balloon structure 106 also expands the balloon structure 106 in the axial direction by an amount (designated by AL) to create an expansion area 136 that is unsupported.
- the balloon structure 106 is then deflated and the double- threaded guidance wire 112 is reinserted into catheter tube assembly 104 at 510 (see, reference 404).
- the double-threaded guidance wire 112 may be rotated such that the second threaded portion 132 engages the distal threaded nut 130 in the balloon structure 106.
- the double-threaded guidance wire 112 is pulled back to engage the first threaded portion 126 within the proximal threaded nut 128. As such, the length of the balloon structure 106 is restored to the original starting position, as indicated by the arrows and dashed lines.
- the catheter tube assembly 104 may be removed.
- the process ends 516.
- the catheter tube assembly 104 may be reinserted (at 502) and the process repeats for the subsequent insertion(s).
- the tool 100 may be reused either in the same vertebral body or another vertebral body in the same patient.
- the interaction of the double-threaded guidance wire 112, proximal threaded nut 128 and distal threaded nut 130 locks the guidance wire 112 into a position such that the balloon structure 106 is returned to its original length after inflation. It is noted that any locking mechanism that returns the balloon structure 106 its original length after inflation may be used in the tool 100.
- distal threaded nut 130 has been described as being within the balloon structure 106, the distal threaded nut may be either inside or outside of the balloon structure 106.
- the thread may be part of a rivet that is outside the balloon structure 106 and forms part of a tip of the balloon structure 106.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
L'invention concerne un dispositif de cathéter qui comprend un fil de guidage à filetage double qui permet d'utiliser un dispositif (c.-à-d. traitement de plusieurs niveaux) de création de cavité souple de diverses manières. Selon l'invention, le fil de guidage à filetage double peut être raccordé à la partie Luer du dispositif et une partie distale du ballonnet en utilisant un engagement fileté pour éviter de rallonger le tube interne, éviter de rallonger le ballonnet, et pour limiter la déformation plastique du système dans le sens axial. Dans d'autres modes de réalisation de l'invention, le fil de guidage à filetage double peut être raccordé de nouveau à la partie distale du ballonnet avec un filet distal du fil de guidage à filetage double pour une restitution de la longueur nominale.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013533827A JP5913331B2 (ja) | 2010-10-14 | 2010-10-14 | 多重使用椎骨拡大(va)バルーンのための二重ねじ付きガイドワイヤ又は補強ワイヤ |
PCT/US2010/052717 WO2012050583A1 (fr) | 2010-10-14 | 2010-10-14 | Fil de guidage ou de renfort à filetage double pour ballonnet de renforcement vertébral à usage multiple |
EP10768669.3A EP2627288A1 (fr) | 2010-10-14 | 2010-10-14 | Fil de guidage ou de renfort à filetage double pour ballonnet de renforcement vertébral à usage multiple |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2010/052717 WO2012050583A1 (fr) | 2010-10-14 | 2010-10-14 | Fil de guidage ou de renfort à filetage double pour ballonnet de renforcement vertébral à usage multiple |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012050583A1 true WO2012050583A1 (fr) | 2012-04-19 |
Family
ID=44072766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/052717 WO2012050583A1 (fr) | 2010-10-14 | 2010-10-14 | Fil de guidage ou de renfort à filetage double pour ballonnet de renforcement vertébral à usage multiple |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2627288A1 (fr) |
JP (1) | JP5913331B2 (fr) |
WO (1) | WO2012050583A1 (fr) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015085836A1 (fr) * | 2013-12-12 | 2015-06-18 | 宁波华科润生物科技有限公司 | Système d'implantation de comblement osseux |
EP2934657A4 (fr) * | 2012-12-20 | 2016-07-27 | Illuminoss Medical Inc | Embout distal pour dispositifs de fixation osseuse |
US9717542B2 (en) | 2006-11-10 | 2017-08-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US9724147B2 (en) | 2006-04-26 | 2017-08-08 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US9775661B2 (en) | 2011-07-19 | 2017-10-03 | Illuminoss Medical, Inc. | Devices and methods for bone restructure and stabilization |
US9855080B2 (en) | 2010-12-22 | 2018-01-02 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US9855145B2 (en) | 2011-07-19 | 2018-01-02 | IlluminsOss Medical, Inc. | Systems and methods for joint stabilization |
US11071572B2 (en) | 2018-06-27 | 2021-07-27 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101598277B1 (ko) * | 2014-06-16 | 2016-02-29 | (주)태연메디칼 | 풍선 방향제어 기능을 갖는 카테터 |
CN107296994A (zh) * | 2017-07-03 | 2017-10-27 | 北京大学深圳医院 | 防感染灌肠器 |
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2010
- 2010-10-14 WO PCT/US2010/052717 patent/WO2012050583A1/fr active Application Filing
- 2010-10-14 EP EP10768669.3A patent/EP2627288A1/fr not_active Withdrawn
- 2010-10-14 JP JP2013533827A patent/JP5913331B2/ja active Active
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Cited By (22)
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US10456184B2 (en) | 2006-04-26 | 2019-10-29 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US11331132B2 (en) | 2006-04-26 | 2022-05-17 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US9724147B2 (en) | 2006-04-26 | 2017-08-08 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US11793556B2 (en) | 2006-11-10 | 2023-10-24 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US9717542B2 (en) | 2006-11-10 | 2017-08-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US11259847B2 (en) | 2006-11-10 | 2022-03-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US10543025B2 (en) | 2006-11-10 | 2020-01-28 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US9855080B2 (en) | 2010-12-22 | 2018-01-02 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US10772664B2 (en) | 2010-12-22 | 2020-09-15 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US10111689B2 (en) | 2010-12-22 | 2018-10-30 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US9775661B2 (en) | 2011-07-19 | 2017-10-03 | Illuminoss Medical, Inc. | Devices and methods for bone restructure and stabilization |
US10292823B2 (en) | 2011-07-19 | 2019-05-21 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US9855145B2 (en) | 2011-07-19 | 2018-01-02 | IlluminsOss Medical, Inc. | Systems and methods for joint stabilization |
US11141207B2 (en) | 2011-07-19 | 2021-10-12 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US11559343B2 (en) | 2011-07-19 | 2023-01-24 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US10575882B2 (en) | 2012-12-20 | 2020-03-03 | Illuminoss Medical, Inc. | Distal tip for bone fixation devices |
US9687281B2 (en) | 2012-12-20 | 2017-06-27 | Illuminoss Medical, Inc. | Distal tip for bone fixation devices |
EP2934657A4 (fr) * | 2012-12-20 | 2016-07-27 | Illuminoss Medical Inc | Embout distal pour dispositifs de fixation osseuse |
WO2015085836A1 (fr) * | 2013-12-12 | 2015-06-18 | 宁波华科润生物科技有限公司 | Système d'implantation de comblement osseux |
US11071572B2 (en) | 2018-06-27 | 2021-07-27 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
US11419649B2 (en) | 2018-06-27 | 2022-08-23 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
US12161373B2 (en) | 2018-06-27 | 2024-12-10 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
Also Published As
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JP5913331B2 (ja) | 2016-04-27 |
JP2013543412A (ja) | 2013-12-05 |
EP2627288A1 (fr) | 2013-08-21 |
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