WO2012040801A2

WO2012040801A2 - Synergistic combination of imidacloprid and bifenthrin, its process for preparation and uses and method for use

Info

Publication number: WO2012040801A2
Application number: PCT/BR2011/000343
Authority: WO
Inventors: Luis Donizete Borges; Leandro Anderlin Garcia; Carlos Eduardo Fabri; Antônio MOREIRA LIMA; Roberta de Fátima DE GODOY; Ricardo Camara Werlang
Original assignee: Fmc Química Do Brasil Ltda.
Priority date: 2010-09-29
Filing date: 2011-09-26
Publication date: 2012-04-05
Also published as: WO2012040801A3; BRPI1003363A2; UY33640A; AR083437A1

Abstract

The present invention refers to an agrochemically synergistic formulation imidacloprid and bifenthrin for the treatment of seeds and control and/or combat pest and diseases in crops. Are also described their process of preparation, use and method of use and the use of imidacloprid and bifenthrin in preparation of agrochemically synergistic formulation of the invention.

Description

SYNERGISTIC COMBINATION OF IMIDACLOPRID AND BIFENTHRIN, ITS PROCESS FOR PREPARATION AND USES AND METHOD FOR USE

BACKGROUND OF THE INVENTION

The present invention refers to the synergistic combination of active ingredients imidacloprid and bifenthrin, for the control of pests in soybean, corn and cotton, by the treatment of seeds.

Imidacloprid is an insecticide known to control a variety of pests. US patent 4.742.060 provides a description of imidacloprid and some of its uses. Imidacloprid is known for providing some control of the aphid hemipterans family, especially those known popularly as aphids. However, many other pests are part of the complex of pests of major crops such as for example, soybean, cotton, beans, wheat, rice, potatoes, tomatoes, citrus, tobacco and corn.

Bifenthrin is an insecticide known for controlling a variety of pests. US patent 4.238.505 offers a description of bifenthrin and some of its uses. Bifenthrin is generally known as 2-methylbifenil-3 ylmethyl (z)- (1 RS,3RS)-3-(2-chlorine-3,3,3-trifluoroprop-1 -enil)-2,2-dimethylcyclopropane- carboxilate, registry number CAS 82657-04-3. Bifenthrin is described in The Pesticide Manual, page 88 (entry 76), C.D.S. Thomas, 13^th issue, 2003. Bifenthrin is known for offering some control over lepdopterous insects of the Noctuidae family, especially those popularly known as caterpillars.

The present invention can be used to control the following pests, which attack the initial phase in the following cultures:

Soybean culture: Aracanthus mourei, Cerotoma arcuata,

Diabrotica speciosa, Elasmopalpus lignossellus, Julus spp, Megascelis spp, Phyllophaga thtticophaga, Sternechus subsignatus.

Cotton culture: Aphis gossypii, Diabrotica speciosa, Elasmopalpus lignossellus.

Wheat culture: Diloboderus abderus, Phyllophaga thtticophaga,

Phyllophaga cuyabana e Dichelops furcatus, Rhopalosiphum graminum. Corn culture: Colaspis spp, Diabrotica speciosa, Elasmopalpus lignossellus, Phyllophaga tritticophaga e Dichelops furcatus.

The soil pests include typical underground pests and surface pests closely related to soil dependant on it. They are insects and other small animals that feed on underground organs of plants, with cases in which aerial organs are also consumed.

The control of soil pests is a complex task in view of the difficulty to locate, track and hit the target. For the same reasons, the study of soil pests is of greater difficulty and is slower compared to the study of pests in the aerial part.

Mankind began to be aware of the damage caused by soil insects from the time that agriculture moved from the subsistence phase to a more technical and intensive phase, leading to increased planting areas and, consequently, greater availability of food for subterranean insects (Gassen & Gassen 1996).

The insect pests in the soil can cause losses of up to 100% in production, depending on the species and level of infestation they occur in crops. Among the damage caused by this group of pests, we highlight those arising from the attack and death of plants, leading to reduced crop stand, reduction or excess shoots (tillering), the lodging of the plants, which can affect both productivity and the commercial value of the produce (Avila and Parra, 2004).

Among the pests mentioned above, we highlight the Elasmopalpus lignosselus, popularly known as "lesser cornstalk borer", which is a polyphagous pest that attacks fourteen families of plants, representing about sixty species. Most plants are vulnerable to attack from germination to approximately thirty days after planting. The attack caused the destruction of the region where growth is below ground level, which destroys all or part of the meristematic tissues responsible for conducting water and nutrients (Viana et al, 2000).

Another pest that causes severe damage underground is popularly known as "grub", especially those belonging to the genus Phyllophaga: Phyllophaga cuyabana and Phyllophaga tritticophaga. There is also the "grub" known as "white grub," from the Diloboderus genre. The damages are caused by the larvae, which feed on the roots and can cause death of plants, especially newly germinated.

Julus hesperum, popularly known as "millipede", also causes damage at the beginning of culture, because it feeds on seeds, cotyledons and seedlings. The lice usually are concentrated in the plantation rows, where they penetrate the soil more easily and get food.

Aracanthus mourei, known as "torraozinho" in Brazil due being the color of a clod of earth, attacks the initial phase of culture and starts at the edges of fields. Typical signs are leaves with jagged edges or holes reducing the area of plant photosynthesis.

Among the initial pests of the aerial part, we highlight the

Dibrotica speciosa, which is an insect of less than 0,01 m (1cm) in length.

The damage to plants is caused by larvae and adults. The larvae damage the roots, and adults attack leaves, buds, flowers and pods, causing punctures and cuts in the edges.

The so-called "darkling beetles" that are beetles metallic green in color and smooth appearance, also feed on buds, leaves, especially the more tender, and flower buds. The best known are classified as Megascelis spp.

Sternechus subsignatus, popularly called "soybean stalk weevil", is an insect of the Curculionidae family, which has a great capacity to cause damage to the soybean crop, since both the adult and the larva damage soybeans.

Bedbugs like Dichelops furcatus may also cause damage mainly to maize and wheat. Both adults and nymphs suck sap from plants causing wilt, dryness and tillering.

SUMMARY OF THE INVENTION

The present invention relates to a specific synergistic combination in premix comprising bifenthrin + imidacloprid, coded as "BF 425-04", useful for seed treatment and pest control in the initial crop of soybeans, corn and cotton.

The use of a combination of bifenthrin + imidacloprid is described in the pest control of the aerial part in soy culture (patent application PI

- _, "BF 404-06", FMC). This application is known as foliar pulverization for pest control.

The new proposal of the present invention aims at the use of the combination of active ingredients bifenthrin + imidacloprid in the treatment of seeds.

There are innumerous advantages in opting for seed treatment with insecticides to control pests in crops. By using the seed treatment, it is a localized application of chemicals, with a smaller amount of active ingredient per hectare, compared to foliar application. Seed treatment is an option for preventive control of pests, a fact that provides the reduction of active ingredient per hectare. Seed treatment is done in treatment centers for seeds, hence increased safety during handling. It is a more cost-effective alternative when compared with foliar application.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to a solid or liquid formulation, where the solid form is appropriate for wettable powder (WP) type and/or water dispersible granules (WDG), and the liquid form is suitable as emulsifiable concentrate (EC), concentrated suspension (CS), suspo- emulsion (SE) and / or concentrated emulsion (CE), preferably as CS, but not excluding other types of formulations.

The ratio for the quantity of imidacloprid to the quantity of bifenthrin is of around 0.01-4 to around 0.01 -4, respectively. In a particularity of the invention, the ideal ratio of imidacloprid:bifenthrin is of around 1 ,22:1.

In L formulations of the invention, the concentration of bifenthrin is about 1 to about 699g/L and imidacloprid is about 699 to about 1 g/L. Preferably, the concentration of bifenthrin is about 135 g/L and imidacloprid is about 165 g/L. The concentration of the sum of the active ingredients in the final formulation can range typically from about 10 g/L to about 700g/L, preferably around 300 g/L

The remainder of the composition up to 1 (one) liter may be comprised of suitable additive and/or excipient vehicles, which can be selected from the group consisting of surfactants, defoamers, antifreeze agents, rheology modifiers, dispersants, humidifiers, bacteriostatic agents, dyes, antiagglomerating agents, stabilizers, bonding agents and mixtures thereof.

The vehicle should be normally inert, of organic or inorganic material, and of natural or synthetic source. The vehicle, if solid, can be clay, silicates, silica, resins, waxes, cellulosic fibers, fertilizer or the like and may be used separately or together. If liquid, the vehicle may be water, alcohols in the C1 to C14 chains, glycols, acetates, ketones, glycerides, saturated or unsaturated hydrocarbons, fatty acid esters, vegetable oils, mineral oils, or the like and may be used separately or together. Preferably, water is used as a vehicle.

The surfactants may be ionic, non ionic, cationic and/or polymeric.

The anionic surfactants for use in the present invention may be: dodecylbenzene sulfonate, linear or branched in the acid form or neutralized, nitrogen derivatives, sulfonated aromatic polymers in acid form or neutralized, sulfonated naphthalene formaldehyde in acid form or neutralized, phosphated alkylphenols, lignosulfonated in acid form or neutralized. Of these, preferably the calcium, sodium or magnesium lignosulfonate and nonylphenol phosphate in acid or neutralized form.

The non-ionic surfactants for use in the present invention may be, alkoxyl, such as alkoxyl sorbitan esters, alkoxyl alcohols, alkoxyl vegetable oils, alkoxyl fatty acids, among others, fatty esters such as esters of polyethylene glycol, glycerol or polyglycerol esters, sorbitan esters; amides such as fatty amides of ethanolamine or ethyleneamines, fatty Imidazolines, among others. Preferably, it is used alkoxyl alcohols of capric, caprylic, isodecyl, isotridecyl, decyl, lauric, stearyl, oleic, nonyl phenyl chain, with a degree of alkoxylation of 1-16 moles of ethylene oxide and/or propylene oxide, alkoxyl vegetable oils such as alkoxyl castor oil at a degree of alkoxylation of 5-54 moles of ethylene oxide or propene oxide, alkoxyl sorbitan esters with a degree of alkoxylation between 5 and 80 moles of ethylene oxide and/or propylene oxide.

The cationic surfactants which can be used in this invention are of alkyl trimethyl ammonium chlorides, dialkyl dimethyl ammonium chloride, alkyl dimethyl hydroxyethyl ammonium chloride, cetyl trimethyl ammonium, distearyl dimethyl ammonium chloride, quaternary esters, among others.

The polymeric surfactants that can be used in this invention are block copolymers of ethylene oxide and propylene oxide, mainly of butyl chain, polyacrylate copolymers, copolymers of methyl methacrylate, emulsion of of vinyl and acrylic copolymers, among others.

The adhesion agents may be emulsions of polymer resin or polyvinyl, acrylic, vinyl copolymers, among others.

The present invention also refers to a process for preparing the formulations of the invention, for example, the concentrated suspension type formulation, which comprises the following steps:

In a container, mix the water, the surfactants and the additives;

To this mixture add the Bifenthrin in the molten form, where it remains agitated suffering a process of recrystallization;

After the process of recrystallization is complete, the

Imidacloprid is added;

- After completing the addition of all raw materials, the formulation suffers a grinding process, where there will be a greater interaction between the molecules and reduction in the particle size of the active ingredients, thus increasing the synergy between the molecules and thus increasing its field efficiency.

- After grinding, the formulation still suffers a process of de-aeration and compaction to increase their physical stability, thus obtaining a stable and synergistic agrochemical formulation. The product is packaged in bottles or canisters in high-density polyethylene and made available to the market.

Yet another embodiment of the invention is the use of imidacloprid and bifenthrin in the preparation of formulations for the control and/or combat of pests and diseases in crops.

The invention also includes the use of the formulations of the invention in controlling and / or to combating pests and diseases in vegetable crops.

Yet another embodiment of the invention is a method of controlling or combating pests and diseases in crops, including the application of the formulations of the invention in these pests, their habitats and/or the vegetable crops.

As mentioned previously, the invention has wide applicability and effectiveness in crops of soybeans, cotton, beans, wheat, rice, potatoes, tomatoes, citrus, tobacco and corn, among others, in controlling and combating the pests Aracanthus mourei, Cerotoma arcuata, Diabrotica speciosa, Elasmopalpus lignossellus, Julus spp Megascelis spp, Phyllophaga tritticophaga, Sternechus subsignatus, Aphis gossypii, Diloboderus abderus, Phyllophaga cuyabana, Dichelops furcatus, Rhopalosiphum graminum Colaspis spp, without limitation, and diseases generated by them.

BF 425-04 is a combination of insecticides that provides better crop stand and thus higher productivity (see Tables 1 , 2, 3 and 4 below). The present invention generates improvements in the health and vigor of young plants, providing important protection against insects during the germination of corn, soybean and cotton, in addition to promoting the best initial roots (see Tables 5 and 6 below), minimizing the risk of pests in the early period of plant development and protecting the seed against soil pests.

In soybean and corn culture, BF 425-04 protects against: Sternechus subsignatus (see Table 7 below), Elasmopalpus lignosselus (see

Tables 8 and 9 below), Julus spp (see Table 10 below), Aracanthus moure (see Table 11 below ) and Megascelis sp (see Table 12 below). It has an excellent cost/benefit and offers compatibility when using sequential applications of fungicides and inoculants. The BF 425-04 invention . (bifenthrin + imidacloprid) is an important tool in managing pest resistance to insecticides, as a mixture of two active ingredients from different chemical groups.

The present invention also generates a product that consists of a single application during the seed treatment operation.

For the research work, the following commercial products were used as market standard for the comparison with BF 425-04:

Cruiser® that is a trademark of the company Syngenta Protecao de Cultivos, Gaucho® that is a trademark of the company Bayer Cropscience and Standak® that is a trademark of the company Basf. Market standard products were chosen according to the evaluated target pests.

TABLE 1 : Summary of 4 tests carried out in the Central-western region of Brazil, comparing the stand of BF 425-04 with control and standard product, for the corn culture, 2007/08 crop.

TABLE 2: Summary of 3 tests carried out in the Central-western region of Brazil, comparing the stand of BF 425-04 with control and standard product, fo

TABLE 3: Summary of five experimental tests carried out in the Central-western region of Brazil, making clear the increase in productivity with the use of BF 425-04 in the soybean culture, 2008/09 crop.

TABLE 4: Summary of four experimental tests carried out in the Central-western region of Brazil, making clear the increase in productivity with the use of BF 425-04 in the corn culture, 2008/09 crop.

TABLE 5: Summary of four tests carried out in the Central- western region of Brazil, comparing the root length of BF 425-04 with control

TABLE 6: Summary of 3 tests carried out in the Central-western region of Brazil, comparing the root length of BF 425-04 with control and standard product, for the soybean culture, 2008/09 crop.

TABLE 7: Experimental test to evaluate the efficiency of BF 425-

04 in the control of Sternechus subsignatus in the soybean culture, Santa z do Sul/RS, 2008/09 crop.

TABLE 8: Experimental test to evaluate the number of plants attacked by Elasmopalpus lignosselus in corn culture, Palmeira de Goias/GO, 2007/08 crop.

TABLE 9: Experimental test to evaluate the number of plants attacked by Elasmopalpus lignosselus in the soybean culture, Rio Verde/GO, 2008/09 crop.

TABLE 10: Experimental test to evaluate the percentage of plants attacked by Julus sp in the soybean culture, Santa Cecilia do Pavao/PR, 2008/09 crop.

TABLE 1 1 : Experimental test to evaluate the percentage of treatment control of the pest Aracanthus mourae in the soybean culture, Guaravera/PR, 2007/08 crop.

TABELA 12: Experimental test to evaluate the percentage of plants with Megascelis spp damage in the soybean culture, Montividiu/GO, 2007/08 crop.

TABLE 13: Summary of four experimental tests carried out in the Southern region of Brazil, showing the percentage of plants attacked by the bug Dichelops furcatus in the corn culture, 2008/09 crop.

For a better understanding of the invention, described below are some examples of formulations used with the present invention, where the referred examples have the intention of exemplifying and not limiting the invention.

EXAMPLES:

Example 1 - Invention formulation (BF 425-04):

Example 2 - Invention formulations (BF 425-04):

Example 3 - Summary of 4 tests carried out in the Central- western region of Brazil, comparing the stand of BF 425-04 with control and standard product for the corn culture, 2007/08 crop.

The number of plants per meter in the corn crop is very important because on average they have only four plants per meter. Thus, if we lose one plant per meter due to the incidence of pest attack, the stand is reduced by 25% and consequently the production by 25%.

The summary below shows that treatment with BF 425-04 at all tested doses secured the initial plant stand, having an average of four plants per meter, which when compared with the control, shows a gain of 25% in stand per meters, taking into account that four plants were planted per linear meter. The larger stand will reflect in higher productivity.

Example 4 - Summary of 3 tests carried out in the Central- western region of Brazil, comparing the stand of BF 425-04 with control and standard product for the soybean culture, 2008/09 crop.

Nowadays, seed technology has greatly increased compared to years ago. Therefore, it is important to always keep the initial stand that had been seeded, as the price of seeds, especially those with greater technology, is high. Thus, every plant that the producer loses, represents a production and profitability that is declining.

The summary below shows that seeds treated with BF 425-04 were able to protect the stand of soybean culture from initial pests, providing the possibility of retaining all the potential yield of soybeans.

Example 5 - Summary of five experimental tests carried out in the Central-western region of Brazil, showing the increase in productivity with the use of BF 425-04 in the soybean culture, 2008/09 crop.

With the suitable number of plants per hectare, guaranteed by the product BF 425-04 which handled several initial pests of the soybean culture, one can observe the productivity gain in treatment by the product. While the control produced 2.924 kg/hectare, treatment with BF 425-04 produced 3.070 kg/hectare. This difference of 5% equates to 146kg of soya or 2.43 sacks/hectare more, which turning into U.S. dollars, means saying that the producer earned US$ 43.7 more per hectare.

TABLE 16

Example 6 - Summary of four experimental tests carried out in the Central-western region of Brazil, showing the increase in productivity with the use of BF 425-04 in the corn culture, 2008/09 crop.

With the suitable number of plants per hectare, guaranteed by the product BF 425-04 which handled several initial pests of corn culture, one can observe the productivity gain in treated product. While the control produced 7,480kg/hectare, treatment with BF 425-04 produced 8,791 kg/ha.

This difference of 17.5% is equivalent to 1 ,31 1 kg of corn or 21.85 more bags, which turned into U.S. dollars, it means saying that the producer earned approximately US$ 153.00 / hectare more.

TABLE 17

Example 7 - Summary of 4 tests carried out in the Central- western region of Brazil, comparing the root length using BF 425-04 with control and standard product for the corn culture, 2007/08 crop.

The larger root length observed in the BF 425-04 treatments, compared with the control treatment, shows the product efficiency in the control of soil pests and thus justifies the greater productivity of these treatments as we saw in example 6 above. The larger the root, the greater will be the nutrient absorption area.

Example 8 - Summary of 3 tests carried out in the Central- western region of Brazil, comparing the root length using BF 425-04 with control and standard product for the soybean culture, 2008/09 crop.

The greater root length observed in the BF 425-04 treatments, compared with the control treatment, shows the product efficiency in the control of soil pests and thus justifies the greater productivity of these treatments as we saw in example 5 above. The larger the root, the greater the nutrient absorption area.

TABLE 19

Example 9 - Experimental test to evaluate the efficiency of BF 425-04 in the control of Sternechus subsignatus in the soybean culture, Santa Cruz do Sul/RS, 2008/09 crop.

As this pest attacks both in its larval stage and in its adult stage, a product with residual control is needed. In a work carried out in Rio Grande do Sul, we found that BF 425-04 provides control of around 70%, which is considered a very good control, because the control had 62% of plants with symptoms of attack, such pressure is considered too high. The performance can be further improved by increasing the doses, because with this work you notice a gain in effectiveness as the dose increases.

Example 10 - Experimental test to evaluate the number of plants attacked by Elasmopalpus lignosselus in the corn culture, Palmeira de Goias/GO, 2007/08 crop.

This pest is difficult to control because the attack causes the destruction of the growth region when below ground level. Thus, the most effective way to control it is through seed treatment. But there are few truly effective products for controlling this pest.

In this test, we found that BF 425-04, at the highest dose tested, 4 days after the emergence of corn, is effective in the control of the elasmo caterpillar not showing any plant attacked per linear meter, while the control shows the attack of one plant per linear meter, which can represent up to 25% loss of stand.

Example 1 1 - Experimental test to evaluate the number of plants attacked by Elasmopalpus lignosselus in the soybean culture, Rio Verde/GO, 2008/09 crop.

This pest is difficult to control because the attack causes the destruction of the growing region while below the ground level. Thus, the most effective way to control it is through seed treatment. However, there are few products really effective for controlling this pest.

The present invention shows a significant reduction of damage caused by the elasmo caterpillar provided by the effectiveness of seed treatment products. The use of BF 425-04, at doses of 300 and 350mL/ 00kg seed, shows satisfactory damage reduction, because the infestation of 5.1 control plants attacked 14 days after the emergency is considered a high pest pressure. Right now, the portions of BF 425-04 at doses of 300 and 350mU100kg of seeds showed 0.8 and 1.9 plants with damage, and 21 days after emergence these results are 0.9 and 0.8 plants with damage per meter, respectively. These results are highly satisfactory and advantageous because of the difficulty of controlling this pest by 100%.

Example 12 - Experimental test to evaluate the percentage of plants attacked by Julus sp in the soybean culture, Santa Cecilia do

Pavao/PR, 2008/09 crop.

The millipede is a pest insect, of which presence has increased in the past years due to the continuing increase of the plantation system directly on the straw. The results show that BF 425-04, at all of the doses tested, demonstrates a great reduction in plants with symptoms of attack.

Whilst the control portion shows 13% of plants attacked, the treatments with

BF 425-04 show damage of around 6%, i,e,, it reduced damage by millipede by half.

Example 13 - Experimental test to evaluate the percentage for control of the treatments for the Aracanthus mourae pest in the soybean culture, Guaravera/PR, 2007/08 crop.

The Aracanthus mourae attack pressure in this experimental area was of 20% at 14 days after the emergence, and 23% at 21 days after the emergence, time at which the pest causes most damage. The treatment with BF 425-04 shows an efficiency in control over 80% at 14 days, and between 75 and 79% of control at 21 days after the emergence, at the doses of 300 and 400mL/100kg of seeds, respectively.

Example 14 - Experimental test to evaluate the percentage of plants damaged by Megascelis spp in the soybean culture, Montividiu/GO, 2007/08 crop.

The Megascelis spp insect, is part of the group of insects that are popularly called defoliating coleopterous. These insects cause initial damage to the soybean culture and the present test shows the efficiency of BF 425-04 in the control of this pest. Doses between 250 and 350mL/100kg of seeds show efficiency for this pest.

Example 15 - Summary of four experimental tests carried out in the Southern region of Brazil, showing the percentage of plants attacked by the Dichelops furcatus bug in the corn culture, 2008/09 crop.

This pest is very important in the corn culture, since as reported before, in the corn culture we have few plants per linear meter, and each loss represents a high percentage in productivity reduction. This example shows that at 21 days after the emergence of the seedlings, final time when the Dichelops furcatus bugs cause damage to the culture, the average percentage of plants attacked in the control is high (44%). The result for BF 425-04 at the doses over 1350mL/100kg of seeds shows satisfactory efficiency, since only 15% of the plants show light symptoms of damage, since the bug must bite the corn plant to absorb the product and dies.

Claims

1. An agro chemically synergistic formulation, characterized by comprising:

(i) imidacloprid;

(ii) bifenthrin; and

(iii) suitable adjuvants, carriers and/or excipients; wherein the ratio of imidacloprid:bifenthrin in the formulation is about 0,01- 4:0,01-4, preferably about 1 ,22:1.

2. The formulation according to claim 1 , characterized in that it comprises about 1 to about 699g/L of bifenthrin and about 699 to about 1 g/L of imidacloprid, preferably about 135g/L of bifenthrin and about 165g/L of imidacloprid.

3. The formulation according to claim 1 , characterized in that it comprises a total of about 0 to about 700g/L of bifenthrin and imidacloprid, preferably about 300g/L.

4. The formulation according to any one of claims 1 to 3, characterized in that the suitable adjuvants, carriers and/or excipients are selected from the group consisting of: water, surfactants, antifoaming agents, rheology modifiers, dispersing agents, wetting agents, bacteriostatic agents, colorants/dyestuff, antiagglomerating agents, stabilizers, antifreezing agents, adhesive agents, clay, silicates, silica, resins, waxes, cellulosic fibers, fertilizers, C1-C14 alcohols, glycols, acetates, ketones, glycerides, saturated or unsaturated hydrocarbons, fatty acid esters, vegetable oils, mineral oils, and mixtures thereof.

5. The formulation according to any one of claims 1 to 4, characterized in that it is in the solid or liquid form, preferably the solid form is a wet powder (WP) and/or water-dispersed granules (WDG) and the liquid form is an emulsified concentrate (EC), concentrated suspension (CS), suspoemusion (SE) and/or concentrated emulsion (EW).

6. The formulation according to any one of claims 1 to 5, characterized in that it comprises:

7. The formulation according to any one of claims characterized in that it comprises:

8. The formulation according to any one of claims characterized in that it comprises:

9. The formulation according to any one of claims 1 to 6, characterized in that it comprises:

10. The formulation according to any one of claims 1 to 6,

1 1. The formulation according to any one of claims 1 to 6, characterized in that it comprises:

12. The formulation according to any one of claims 1 to 6, characterized in that it comprises:

13. A process for preparing an agrochemically synergic formulation as defined in any one of claims 1 to 12, characterized by comprising the steps of:

mixing, within a vessel, imidacloprid and bifenthrin in a ratio of about 0.01 -4 parts of imidacloprid and about 0.01-4 parts of bifenthrin; with suitable adjuvants, carriers and/or excipients; obtaining the agrochemically synergistic formulation; and packing it into commercial packages.

14. An use of imidacloprid and bifenthrin, characterized by being in the manufacture of an agrochemically synergistic formulation for treating seeds, and controlling and/or combating plagues and diseases caused therefrom in vegetable cultures.

15. An use of the agrochemically synergistic formulation as defined in any one of claims 1 to 12, characterized by being for treating seeds, and controlling and/or combating plagues and diseases caused therefrom in vegetable cultures.

16. The use according to any one of claims 14 and 15, characterized in that the seeds and cultures are selected from soybean, cotton, bean, wheat, irrigated rice, potato, tomato, citrus, tobacco and corn.

17. A method for treating seeds, and controlling and/or combating plagues and diseases in vegetable cultures, characterized by comprising applying the agrochemically synergistic formulation as defined in any one of claims 1 to 12, over said plagues, their habitat and/or vegetable cultures.

18. The method according to claim 17, characterized in that the seeds and cultures are selected from soybean, cotton, bean, wheat, irrigated rice, potato, tomato, citrus, tobacco and corn and the plagues are selected from .