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WO2011091807A1 - Anticoagulant and glutathione for treatment of cancer - Google Patents

Anticoagulant and glutathione for treatment of cancer Download PDF

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Publication number
WO2011091807A1
WO2011091807A1 PCT/EG2010/000004 EG2010000004W WO2011091807A1 WO 2011091807 A1 WO2011091807 A1 WO 2011091807A1 EG 2010000004 W EG2010000004 W EG 2010000004W WO 2011091807 A1 WO2011091807 A1 WO 2011091807A1
Authority
WO
WIPO (PCT)
Prior art keywords
glutathione
cytochrome
cancer
anticoagulant
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EG2010/000004
Other languages
French (fr)
Inventor
Abdelrahman Shata Mohammed Shata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2011091807A1 publication Critical patent/WO2011091807A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • A61K38/063Glutathione

Definitions

  • the target is how to clear and heal by a certain treatment or medication the hereditary diseases of cancer.
  • the xenobiotices are substances parallel to the foreign bodies in the meaning from the side of attacking mechanism to the human certain organs, which well be delayed and destroyed by the defense mechanism and immune system as one of the most important vital processes occurring continuously thousand of times at human system.
  • Cytochrome P450s are immunity workers which work at two completely deferent directions and opposite benefits. - Specific way from general malignancy starting substances :
  • eating of half cooked liver will lead to non completed digestion of hepatic proteins and absorption of many amino acids attached together by poly peptide chains into circulation may occur.
  • the immunity system will deal with them as foreign bodies because the body doesn't recognize any protein except when it destructed into amino acids.
  • the undifferentiated stem cells may mutate according to the genetic code of those amino acids resulting in increasing amount of cells acting exactly the same action of those amino acids.
  • the protein may binds to cytochrome p450s without the attachment of glutathione to this complex ( look at the details in the next subtitle ).
  • the planning pathway of the war zone beginning from entering the body terminal to their destruction is as next :
  • xenobiotic bodies enter the body and they will be hosted by cytochrome P450s to be converted to reactive metabolites which will bind as soon as possible with glutathione (which are normal bodies present in blood and is secreted from liver ) which will convert the xenobiotics cytochrome complex to non toxic material and harmless to the body by the excretion of this complex with glutathione in urine.
  • glutathione which are normal bodies present in blood and is secreted from liver
  • the result will be nothing but three, to produce cell injury directly, binding with a substance called hapten which will produces also cell injury, or activation of mutation process leading to formation of malignancy.
  • a medical information says that the anticoagulant medication exhausts the cytochrome P450s leading to their consumption. So, we will use warrfarine as one of the anticoagulant medications to make the cytochrome P450s busy with it in replacement of supplying the malignant compounds.
  • the immunity also plays a very important role to accelerate the process of healing. So, the most important thing to feed the immunity is the feeling of care by the patient's family.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The cancer may treated by using of anticoagulant medications as warrfarine to consume as most as possible of cytochrome P450s and then, administration of glutathione in specific doses to consume the remaining of cytochrome P 450s in replacement of supplying the malignant compound. The patient will be hosted in isolated stabilized room with medical attention because of the side effect of the applied medications.

Description

ANTICOAGULANT AND GLUTATHIONE FOR TREATMENT OF CANCER
Technical Field :
To begin with my medical research are consist of so many corners that we most know the edges of it.
Simply, I discovered which I believe in some how, the cure of cancer, or even to dilute the distribution of it cross certain tissues leading to their damage and elimination.
The main principle that we dealing with, is how do we join the ideas with caution and prevent any fatal mistakes that may occur during the whole period of examination and testing. Specially, on clinical applications.
Background Art :
Most of the medical researches that runs nowadays are about how to identify the gen in the nucleus that is responsible for the presence and initiation of malignancy.
So, the target is how to clear and heal by a certain treatment or medication the hereditary diseases of cancer.
So, the genetic researches is the most abundant field in the medical cancer researches.
Disclosure of invention :
The xenobiotices are substances parallel to the foreign bodies in the meaning from the side of attacking mechanism to the human certain organs, which well be delayed and destroyed by the defense mechanism and immune system as one of the most important vital processes occurring continuously thousand of times at human system.
Cytochrome P450s are immunity workers which work at two completely deferent directions and opposite benefits. - Specific way from general malignancy starting substances :
There is numerous ways that may stimulate the starting of malignant compound.
For example, eating of half cooked liver, will may lead to non completed digestion of hepatic proteins and absorption of many amino acids attached together by poly peptide chains into circulation may occur.
The immunity system will deal with them as foreign bodies because the body doesn't recognize any protein except when it destructed into amino acids.
If two amino acids attached and absorbed into circulation will lead to antigen antibody reaction.
In some cases, the undifferentiated stem cells may mutate according to the genetic code of those amino acids resulting in increasing amount of cells acting exactly the same action of those amino acids.
The protein may binds to cytochrome p450s without the attachment of glutathione to this complex ( look at the details in the next subtitle ).
If these xenopiotic cytochrome complex bind to a tissue of certain organ, mutation may occur resulting in cancer.
For example, if this mutation occurs in skin, will lead to conversion of the parahydroxy group present in the components of ( Tyrosine ) which are normal chemical substance present in skin, into an active hydroxy group_ the inactive OH of tyrosine will be activated _as soon as this action started, malignant is present.
- Normal influences with normal reactions :
The planning pathway of the war zone beginning from entering the body terminal to their destruction is as next :
At normal conditions, xenobiotic bodies enter the body and they will be hosted by cytochrome P450s to be converted to reactive metabolites which will bind as soon as possible with glutathione ( which are normal bodies present in blood and is secreted from liver ) which will convert the xenobiotics cytochrome complex to non toxic material and harmless to the body by the excretion of this complex with glutathione in urine.
- Normal influences with abnormal reactions :
In abnormal conditions, the reactive metabolites may not find glutathione fast enough, leading to covalent binding to substances such as macromolecules, this new unwanted complex will swim in the body till they find a proper organ to start their activation in, and the end result will be destiny according to unknown reasons yet !.
The Final Results :
The result will be nothing but three, to produce cell injury directly, binding with a substance called hapten which will produces also cell injury, or activation of mutation process leading to formation of malignancy.
After we knew the mechanism and the origin of the malignant formation and growth, we may now guess the cure.
- The suggested medical care and medications :
In isolated stabilized room with medical attention, we will place the patient with extremely caution because of the side effect of the suggested medications.
A medical information says that the anticoagulant medication exhausts the cytochrome P450s leading to their consumption. So, we will use warrfarine as one of the anticoagulant medications to make the cytochrome P450s busy with it in replacement of supplying the malignant compounds.
So, administration of warrfarine will be necessary. Then , intake of large doses of glutathione complex to consume the remaining of the xenobiotic cytochrome P 450s complex leading to decrease the vital functional supply of the malignant compounds. With time, the patient will heal gradually by the welling of god.
The immunity also plays a very important role to accelerate the process of healing. So, the most important thing to feed the immunity is the feeling of care by the patient's family.
The recommended daily allowance of emotional warm care is unlimited.

Claims

Claims
1 - Using of anticoagulant medications, glutathione, and keep the role of cytochrome P450s in the different reactions.
2 - According to claim l ,we may use anticoagulant medication such as warrfarine for the exhaustion of most of cytochrome P450s.
3 - According to claim 2, glutathione concentrated doses will be obligatory for the maintenance of the medical experiment.As it has a role for the excretion of this unwanted complex in urine.
PCT/EG2010/000004 2010-01-31 2010-02-03 Anticoagulant and glutathione for treatment of cancer Ceased WO2011091807A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EG2010010162 2010-01-31
EG2010010162 2010-01-31

Publications (1)

Publication Number Publication Date
WO2011091807A1 true WO2011091807A1 (en) 2011-08-04

Family

ID=44318684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EG2010/000004 Ceased WO2011091807A1 (en) 2010-01-31 2010-02-03 Anticoagulant and glutathione for treatment of cancer

Country Status (1)

Country Link
WO (1) WO2011091807A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204248B1 (en) * 1996-12-31 2001-03-20 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
WO2001080849A1 (en) * 2000-04-26 2001-11-01 Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center Method of treating cancer
US20070026077A1 (en) * 2003-10-17 2007-02-01 Alas Franc Method of producing dosage units of a solid drug form containing warfarin sodium salt as active component
US20080138395A1 (en) * 2005-02-14 2008-06-12 Treusch Gernot Pharmaceutical Composition for the Prevention and Control of Cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204248B1 (en) * 1996-12-31 2001-03-20 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
WO2001080849A1 (en) * 2000-04-26 2001-11-01 Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center Method of treating cancer
US20070026077A1 (en) * 2003-10-17 2007-02-01 Alas Franc Method of producing dosage units of a solid drug form containing warfarin sodium salt as active component
US20080138395A1 (en) * 2005-02-14 2008-06-12 Treusch Gernot Pharmaceutical Composition for the Prevention and Control of Cancer

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