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WO2011055968A3 - Kit for detecting bacterial infection comprising novel monoclonal antibodies - Google Patents

Kit for detecting bacterial infection comprising novel monoclonal antibodies Download PDF

Info

Publication number
WO2011055968A3
WO2011055968A3 PCT/KR2010/007710 KR2010007710W WO2011055968A3 WO 2011055968 A3 WO2011055968 A3 WO 2011055968A3 KR 2010007710 W KR2010007710 W KR 2010007710W WO 2011055968 A3 WO2011055968 A3 WO 2011055968A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidoglycan
kit
bacterial infection
monoclonal antibodies
detecting bacterial
Prior art date
Application number
PCT/KR2010/007710
Other languages
French (fr)
Other versions
WO2011055968A2 (en
Inventor
Jong-Gyun Kim
Sang-Koo Park
Byung-Hyun Choi
Jae-Sun Lee
Soo-Kwang Kim
Yoon-Seon Jang
Won-Jae Kwag
Original Assignee
Yuhan Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corporation filed Critical Yuhan Corporation
Publication of WO2011055968A2 publication Critical patent/WO2011055968A2/en
Publication of WO2011055968A3 publication Critical patent/WO2011055968A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4722—Proteoglycans, e.g. aggreccan

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides a kit for detecting bacterial infection comprising a monoclonal antibody specifically binding to a peptidoglycan-recognition protein; and a monoclonal antibody specifically binding to a complex of peptidoglycan and the peptidoglycan-recognition protein. Using the kit, bacterial infection can be detected with high specificity and binding affinity. For example, the antibodies can even detect 20 pg of peptidoglycan selectively. The present invention also provides monoclonal antibodies, i.e., a monoclonal antibody specifically binding to a peptidoglycan-recognition protein and a monoclonal antibody specifically binding to a complex of peptidoglycan and the peptidoglycan-recognition protein, useful for a kit for detecting bacterial infection.
PCT/KR2010/007710 2009-11-05 2010-11-03 Kit for detecting bacterial infection comprising novel monoclonal antibodies WO2011055968A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0106308 2009-11-05
KR1020090106308A KR101251023B1 (en) 2009-11-05 2009-11-05 Kit for detecting bacterial infection comprising novel monoclonal antibodies

Publications (2)

Publication Number Publication Date
WO2011055968A2 WO2011055968A2 (en) 2011-05-12
WO2011055968A3 true WO2011055968A3 (en) 2011-09-29

Family

ID=43970533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/007710 WO2011055968A2 (en) 2009-11-05 2010-11-03 Kit for detecting bacterial infection comprising novel monoclonal antibodies

Country Status (2)

Country Link
KR (1) KR101251023B1 (en)
WO (1) WO2011055968A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
EP2814844B1 (en) 2012-02-15 2017-08-02 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1)
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
JP6400480B2 (en) 2012-02-15 2018-10-03 ノヴォ ノルディスク アー／エス Antibody that binds to peptidoglycan recognition protein 1
DK3172232T5 (en) 2014-07-17 2024-11-18 Novo Nordisk As Site directed mutagenesis of trem-1 antibodies for decreasing viscosity
US10626176B2 (en) 2014-10-31 2020-04-21 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind B7-H4
MX2020010204A (en) 2018-04-02 2021-01-29 Bristol Myers Squibb Co Anti-trem-1 antibodies and uses thereof.
JP7660796B2 (en) 2022-08-17 2025-04-14 ▲華▼中科技大学同▲済▼医学院附属▲協▼和医院 Micro magnetic orthodontic accelerator with adjustable magnetic field
CN115825415B (en) * 2022-09-28 2023-07-14 珠海重链生物科技有限公司 Blocker and in vitro immunodiagnostic product and use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090029973A (en) * 2007-09-19 2009-03-24 주식회사유한양행 Proteins involved in the transmission of peptidoglycan recognition signals, genes encoding them, and bacterial infection detection kits including the same
KR20090072078A (en) * 2007-12-28 2009-07-02 주식회사유한양행 Proteins involved in the transmission of peptidoglycan recognition signals, genes encoding them, and bacterial infection detection kits including the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090029973A (en) * 2007-09-19 2009-03-24 주식회사유한양행 Proteins involved in the transmission of peptidoglycan recognition signals, genes encoding them, and bacterial infection detection kits including the same
KR20090072078A (en) * 2007-12-28 2009-07-02 주식회사유한양행 Proteins involved in the transmission of peptidoglycan recognition signals, genes encoding them, and bacterial infection detection kits including the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KIM, C.-H. ET AL.: "A three-step proteolytic cascade mediates the activation of the peptidoglycan-induced toll pathway in an insect.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 12, 21 March 2008 (2008-03-21), pages 7599 - 7607 *
PARK, J. ET AL.: "A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 12, 24 March 2006 (2006-03-24), pages 7747 - 7755 *
PARK, J.-W. ET AL.: "Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects.", PROC. NATL. ACAD. SCI. USA, vol. 104, no. 16, 17 April 2007 (2007-04-17), pages 6602 - 6607 *
WANG, L. ET AL.: "Sensing of gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.", THE EMBO JOURNAL, vol. 25, no. 20, 5 October 2006 (2006-10-05), pages 5005 - 5014 *

Also Published As

Publication number Publication date
KR101251023B1 (en) 2013-04-03
WO2011055968A2 (en) 2011-05-12
KR20110049334A (en) 2011-05-12

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