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WO2011028579A3 - Aligning cells on wrinkled surface - Google Patents

Aligning cells on wrinkled surface Download PDF

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Publication number
WO2011028579A3
WO2011028579A3 PCT/US2010/046670 US2010046670W WO2011028579A3 WO 2011028579 A3 WO2011028579 A3 WO 2011028579A3 US 2010046670 W US2010046670 W US 2010046670W WO 2011028579 A3 WO2011028579 A3 WO 2011028579A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
texture
preparing
steps
wrinkled surface
Prior art date
Application number
PCT/US2010/046670
Other languages
French (fr)
Other versions
WO2011028579A2 (en
Inventor
Mark L. Baum
James B. Panther Ii
Michelle Khine
Kara Mccloskey
Original Assignee
The Regents Of The University Of California
Shrink Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Shrink Technologies, Inc. filed Critical The Regents Of The University Of California
Publication of WO2011028579A2 publication Critical patent/WO2011028579A2/en
Publication of WO2011028579A3 publication Critical patent/WO2011028579A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A method is provided for preparing a tissue patch comprising the steps of placing one or more cells on a surface having a texture, which texture has an average height of from about 100 nanometers to about 5 micrometers; allowing the cells to migrate or divide on the surface; and removing the cell population from the textured surface, thereby forming tissue patch. Also provided a method to prepare the surface which method comprises the steps of: a) depositing a metal onto a pre-stressed thermoplastic material; b) reducing the surface area of the receptive material by at least about 60%; and c) preparing the surface via lithography.
PCT/US2010/046670 2009-08-26 2010-08-25 Aligning cells on wrinkled surface WO2011028579A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23724509P 2009-08-26 2009-08-26
US61/237,245 2009-08-26

Publications (2)

Publication Number Publication Date
WO2011028579A2 WO2011028579A2 (en) 2011-03-10
WO2011028579A3 true WO2011028579A3 (en) 2011-05-19

Family

ID=43649906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/046670 WO2011028579A2 (en) 2009-08-26 2010-08-25 Aligning cells on wrinkled surface

Country Status (1)

Country Link
WO (1) WO2011028579A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064816A1 (en) 2007-11-13 2009-05-22 The Regents Of The University Of California Processes for rapid microfabrication using thermoplastics and devices thereof
US8828302B2 (en) 2011-02-07 2014-09-09 The Regents Of The University Of California Preparation and use of nanowrinkles
US9452564B2 (en) 2011-02-07 2016-09-27 The Regents Of The University Of California Multi-scale wrinkles for functional alignment of stem cells and cardiac derivatives
US9625819B2 (en) 2011-05-27 2017-04-18 The Regents Of The University Of California Photolithography on shrink film
CN102335449B (en) * 2011-10-11 2013-10-02 天津工业大学 Method for prepaing nanometer composite gel dressing containing baicalin and soapstone
US10238769B2 (en) 2011-10-11 2019-03-26 Fibralign Corporation Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly
US9994812B2 (en) 2012-04-04 2018-06-12 University Of Washington Through Its Center For Commercialization Systems and method for engineering muscle tissue
JP2016505276A (en) * 2013-01-23 2016-02-25 リー、ロナルドLI, Ronald Engineered physical alignment of stem cell-derived cardiomyocytes
US11273235B2 (en) 2013-10-10 2022-03-15 Fibralign Corporation Method and device for lymphedema treatment
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
WO2016030481A1 (en) * 2014-08-27 2016-03-03 Universiteit Maastricht Scaffold comprising buckled fibers
SG10202008596SA (en) * 2016-03-03 2020-10-29 Nat Univ Singapore Versatile, flexible and biocompatible elastomeric microtubes
SG11201907697SA (en) 2017-02-28 2019-09-27 Nat Univ Singapore Microtube sensor for physiological monitoring
WO2019075397A1 (en) * 2017-10-12 2019-04-18 The George Washington University Three-dimensional bioprinting of cardiac patch with anisotropic and perfusable architecture
CN108926741B (en) * 2018-06-20 2021-05-25 复旦大学附属华山医院 A kind of preparation method of amniotic membrane biological patch

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020072794A1 (en) * 2000-12-11 2002-06-13 Shlomo Gabbay Implantable patch prosthesis having one or more cusps for improved competency and method for using same
US20040234576A1 (en) * 2003-05-08 2004-11-25 Tepha, Inc., State Of Incorporation Delaware Polyhydroxyalkanoate medical textiles and fibers
US20070254103A1 (en) * 2001-04-04 2007-11-01 Chienna B.V. Coating for medical devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020072794A1 (en) * 2000-12-11 2002-06-13 Shlomo Gabbay Implantable patch prosthesis having one or more cusps for improved competency and method for using same
US20070254103A1 (en) * 2001-04-04 2007-11-01 Chienna B.V. Coating for medical devices
US20040234576A1 (en) * 2003-05-08 2004-11-25 Tepha, Inc., State Of Incorporation Delaware Polyhydroxyalkanoate medical textiles and fibers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C. ALPERIN ET AL., BIOMATERIALS, vol. 26, 2005, pages 7377 - 7386 *
M.SHIN ET AL., BIOMATERIALS, vol. 25, 2004, pages 3717 - 3723 *
MASAYUKI YAMATO ET AL., PROG. POLYM. SCI., vol. 32, 2007, pages 1123 - 1133 *

Also Published As

Publication number Publication date
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