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WO2011009039A3 - Produit pharmaceutique pour administration par voie orale comprenant mgbg et procédés de traitement de maladie - Google Patents

Produit pharmaceutique pour administration par voie orale comprenant mgbg et procédés de traitement de maladie Download PDF

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Publication number
WO2011009039A3
WO2011009039A3 PCT/US2010/042253 US2010042253W WO2011009039A3 WO 2011009039 A3 WO2011009039 A3 WO 2011009039A3 US 2010042253 W US2010042253 W US 2010042253W WO 2011009039 A3 WO2011009039 A3 WO 2011009039A3
Authority
WO
WIPO (PCT)
Prior art keywords
mgbg
pharmaceutical
methods
oral delivery
treating disease
Prior art date
Application number
PCT/US2010/042253
Other languages
English (en)
Other versions
WO2011009039A2 (fr
Inventor
John Mckearn
Jeremy Blitzer
Original Assignee
Pathologica Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201080041853.XA priority Critical patent/CN102686222B/zh
Priority to BR112012000862A priority patent/BR112012000862A8/pt
Priority to AU2010273277A priority patent/AU2010273277B2/en
Priority to HK13103363.8A priority patent/HK1176548B/xx
Priority to NZ597488A priority patent/NZ597488A/en
Priority to EP18210165.9A priority patent/EP3473247A1/fr
Priority to EP10800602.4A priority patent/EP2453886B1/fr
Priority to DK10800602.4T priority patent/DK2453886T3/en
Application filed by Pathologica Llc filed Critical Pathologica Llc
Priority to CA2768018A priority patent/CA2768018C/fr
Priority to ES10800602T priority patent/ES2715173T3/es
Priority to JP2012520810A priority patent/JP6112449B2/ja
Publication of WO2011009039A2 publication Critical patent/WO2011009039A2/fr
Publication of WO2011009039A3 publication Critical patent/WO2011009039A3/fr
Priority to AU2016266049A priority patent/AU2016266049B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2022—Organic macromolecular compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

L'invention porte sur de nouvelles compositions pharmaceutiques orales de MGBG et d'analogues de polyamine associés, d'inhibiteurs de la biosynthèse de polyamine, d'inhibiteurs de polyamine de AMD-I et de régulateurs d'ostéopontine, et sur leur application pour le traitement d'une maladie.
PCT/US2010/042253 2009-07-16 2010-07-16 Produit pharmaceutique pour administration par voie orale comprenant mgbg et procédés de traitement de maladie WO2011009039A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP10800602.4A EP2453886B1 (fr) 2009-07-16 2010-07-16 Produit pharmaceutique pour administration par voie orale comprenant mgbg et procédés de traitement de maladie
AU2010273277A AU2010273277B2 (en) 2009-07-16 2010-07-16 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease
HK13103363.8A HK1176548B (en) 2009-07-16 2010-07-16 Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
NZ597488A NZ597488A (en) 2009-07-16 2010-07-16 Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
EP18210165.9A EP3473247A1 (fr) 2009-07-16 2010-07-16 Composition pour administration par voie orale comprenant la mgbg pour utilisation dans le traitement de la sclérose en plaque
CN201080041853.XA CN102686222B (zh) 2009-07-16 2010-07-16 包含mgbg的口服递送药物以及治疗疾病的方法
ES10800602T ES2715173T3 (es) 2009-07-16 2010-07-16 Producto farmacéutico para administración oral que comprende MGBG y métodos de tratamiento de enfermedades
DK10800602.4T DK2453886T3 (en) 2009-07-16 2010-07-16 ORGANIC ADMINISTRATION COMPREHENSIVE MGBG AND DISEASE METHODS
CA2768018A CA2768018C (fr) 2009-07-16 2010-07-16 Produit pharmaceutique pour administration par voie orale comprenant mgbg et procedes de traitement de maladie
BR112012000862A BR112012000862A8 (pt) 2009-07-16 2010-07-16 composição farmacêutica oral, composição farmacêutica oral de baixa dose para administração crônica, método de tratamento ou retardo do inicio ou desenvolvimento de uma condição, método de tratamento da dor em um indivíduo que necessita deste medicamento, método de tratamento de uma condição em um indivíduo que necessita deste medicamento
JP2012520810A JP6112449B2 (ja) 2009-07-16 2010-07-16 Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法
AU2016266049A AU2016266049B2 (en) 2009-07-16 2016-12-01 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22606009P 2009-07-16 2009-07-16
US61/226,060 2009-07-16
US29009509P 2009-12-24 2009-12-24
US61/290,095 2009-12-24

Publications (2)

Publication Number Publication Date
WO2011009039A2 WO2011009039A2 (fr) 2011-01-20
WO2011009039A3 true WO2011009039A3 (fr) 2011-06-16

Family

ID=43450234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/042253 WO2011009039A2 (fr) 2009-07-16 2010-07-16 Produit pharmaceutique pour administration par voie orale comprenant mgbg et procédés de traitement de maladie

Country Status (11)

Country Link
US (4) US8258186B2 (fr)
EP (2) EP3473247A1 (fr)
JP (4) JP6112449B2 (fr)
CN (2) CN104997762B (fr)
AU (2) AU2010273277B2 (fr)
BR (1) BR112012000862A8 (fr)
CA (1) CA2768018C (fr)
DK (1) DK2453886T3 (fr)
ES (1) ES2715173T3 (fr)
NZ (3) NZ628513A (fr)
WO (1) WO2011009039A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121586B1 (fr) 2007-03-09 2017-03-08 Pathologica LLC Mgbg pour la regulation de l'osteopontine et traiter la sclérose en plaques
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
CA2768018C (fr) 2009-07-16 2019-08-27 Pathologica Llc Produit pharmaceutique pour administration par voie orale comprenant mgbg et procedes de traitement de maladie
PT2665471T (pt) * 2011-01-19 2018-03-21 Pathologica Llc Formas de dosagem farmacêutica orais de libertação controlada que compreendem mgbg
WO2013083813A2 (fr) * 2011-12-07 2013-06-13 Universität Zürich Modulateurs de la spermine/spermidine n'-acétyltransférase (ssat) et protéines associées à la ssat pour une utilisation dans la prévention ou le traitement de la polyarthrite rhumatoïde
WO2014062552A1 (fr) * 2012-10-15 2014-04-24 Nestec Sa Méthodes pour entretenir la santé oculaire et atténuer des maladies ophtalmiques chez les animaux
AU2014205529B2 (en) * 2013-01-08 2018-08-09 Pathologica Llc Methods and compositions for treatment of demyelinating diseases
CN109069594B (zh) 2016-03-25 2022-03-08 阿米内克斯疗法公司 生物可用多胺
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CN104997762A (zh) 2015-10-28
US20120289604A1 (en) 2012-11-15
CN102686222B (zh) 2015-06-24
WO2011009039A2 (fr) 2011-01-20
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US9616035B2 (en) 2017-04-11
JP2012533565A (ja) 2012-12-27
JP6112449B2 (ja) 2017-04-12
CA2768018A1 (fr) 2011-01-20
BR112012000862A2 (pt) 2017-10-31
CN102686222A (zh) 2012-09-19
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BR112012000862A8 (pt) 2018-01-09
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