WO2011008111A1 - Préparation pour régénération de défauts osseux postopératoires, post-traumatiques, et procédé pour l'implantation de cette préparation - Google Patents
Préparation pour régénération de défauts osseux postopératoires, post-traumatiques, et procédé pour l'implantation de cette préparation Download PDFInfo
- Publication number
- WO2011008111A1 WO2011008111A1 PCT/PL2009/000075 PL2009000075W WO2011008111A1 WO 2011008111 A1 WO2011008111 A1 WO 2011008111A1 PL 2009000075 W PL2009000075 W PL 2009000075W WO 2011008111 A1 WO2011008111 A1 WO 2011008111A1
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- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- favourably
- amount
- weight
- amounts
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 53
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 37
- 230000008929 regeneration Effects 0.000 title claims abstract description 12
- 238000011069 regeneration method Methods 0.000 title claims abstract description 12
- 230000007547 defect Effects 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims abstract description 10
- 238000002513 implantation Methods 0.000 title claims abstract description 5
- 230000002980 postoperative effect Effects 0.000 title claims description 5
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 239000005312 bioglass Substances 0.000 claims abstract description 14
- 238000005469 granulation Methods 0.000 claims abstract description 13
- 230000003179 granulation Effects 0.000 claims abstract description 13
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 10
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 10
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 10
- 239000011230 binding agent Substances 0.000 claims abstract description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 9
- 239000008280 blood Substances 0.000 claims abstract description 8
- 210000004369 blood Anatomy 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract 7
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 abstract description 3
- 230000008025 crystallization Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 238000001356 surgical procedure Methods 0.000 abstract description 3
- 229910052586 apatite Inorganic materials 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 230000000399 orthopedic effect Effects 0.000 abstract description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 abstract description 2
- 238000002278 reconstructive surgery Methods 0.000 abstract description 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 206010052428 Wound Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 238000006065 biodegradation reaction Methods 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000031295 Animal disease Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229910020169 SiOa Inorganic materials 0.000 description 1
- 239000005313 bioactive glass Substances 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
Definitions
- the subject of the invention is a preparation for regeneration of postoperative and post-traumatic bone defects and method for implantation of this preparation, employed in many branches of medicine especially in orthopedics, dental surgery, reconstructive surgery, periodenthology and implantology.
- xenogeneic grafts or implants e.g. compositions of horse bone and cattle bone create a risk of transmission of animal diseases, e.g. BSE (Bovine Spongiform Encephalopathy).
- BSE Bovine Spongiform Encephalopathy
- pathogenic micro-organisms There is also a potential risk of transmission of pathogenic micro-organisms.
- the objective of this invention is creating a new therapeutically effective preparation for regeneration bone defects, which will show low biotoxicity and small systematic side effects at surgical application.
- This invention helps to fulfill the above task.
- the preparation components have been marked with letters A, B, C, TCP.
- the essence of this preparation is application of a deproteinized human bone (A), deprived of the smallest molecules of protein, with granulation from 0,3 to 0,5mm, bioglass (B) with granulation from 0,3 to 0,5mm and binder (C) favourably in the form of a patient's own blood in the amount of 20-25% in relation to the quantitative sum of the above components.
- A human bone
- tissue bank in the form of hydroxyapatite, with appropriate granulation, as well as in the form of trochlea.
- the second component of the preparation bioglass (B), in the form of powder with granulation 0,3-0, 5mm, can be obtained with use of zol-gel method in the system CaO-SiCh-PiOs.
- This component can also be used as a high silica component (80% mol. SiOa) or/and as a high calcium component (54% mol. CaO).
- TCP tricalcium phosphate
- This invention enables a faster regeneration of human bone tissue defects arising from intended activities, such as surgical activities, or unintended activities - injuries and disease process.
- Application of the above preparation results in a fast and complete regeneration of anatomic profile and physiological function.
- This invention helps to speed up the process of regeneration of damaged bone, and it contributes to compensation of biodegradation during the process of healing, due to active surfaces of the applied filler.
- an appropriate amount of the preparation is being mixed with binder i.e. the blood from operative wound (the mixture should be homogeneous).
- binder i.e. the blood from operative wound
- the mixture which has consistency of Plasticine
- the obtained mixture which has consistency of Plasticine, is implanted into bone defects.
- Application of a patient's own blood enriches the implanted preparation with organic components, e.g. collagen type 1, proteins, polysaccharides, lipids, necessary for osteogenesis and for preventing the preparation components from moving inside the operative wound.
- the components contained in a regenerating bone amount to 25% of the bone's weight.
- the components enumerated above, especially collagen increase bone's resistance to mechanical destruction caused by tension that occurs during work, and reduce brittleness of bones. More over collagen and protein fibers accelerate crystallization of hydroxyapatite.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ceramic Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention porte sur une préparation pour la régénération de défauts osseux, laquelle préparation est employée dans de nombreuses branches de la médecine, en particulier en orthopédie, en chirurgie dentaire, en chirurgie reconstructive, en périodonthologie et en implantologie. La préparation a été développée sur la base d'un composé chimique inorganique d'origine naturelle, à savoir un os humain déprotéinisé, et sur la base d'au moins l'un de composés chimiques inorganiques de synthèse, à savoir un bioverre se présentant sous la forme d'un produit granulé à haute teneur en calcium (54 % en mole de CaO), obtenu à l'aide d'un procédé sol-gel dans le système CaO-SiO2-P2O5, d'une densité de 2,9082 g/cm3, avec une composition de phase ayant une phase vitreuse dominante et des commencements de cristallisation d'apatite, traité thermiquement à une température de 800°C, ayant une surface spécifique BET de 57, 8166 m2/g, et/ou un phosphate de tricalcium - TCP se présentant sous la forme d'un produit granulé avec une formule chimique Ca3 (PO4)2. Sont utilisées comme composants des particules déprotéinisées d'os humain, avec avantageusement une granulation de 0,3-0,5 mm, un bioverre avec avantageusement une granulation de 0,3-0,5 mm et/ou un tricalcium de phosphate - TCP avec avantageusement une granulation de 0,3-0,5 mm. La quantité de matière osseuse dans la préparation s'élève avantageusement à 70-80 % du poids de la préparation, la quantité de bioverre dans la préparation s'élève avantageusement à 10-15 % du poids de la préparation, la quantité de TCP dans la préparation s'élève avantageusement à 10-15 % du poids de la préparation. Durant l'implantation, un liant se présentant sous la forme de sang provenant d'une plaie opératoire du patient est introduit dans la préparation. Une quantité de la préparation dans le mélange s'élève avantageusement à 75-80 % du poids du mélange et la quantité de sang propre s'élève avantageusement à 20-25 % du poids du mélange.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2009/000075 WO2011008111A1 (fr) | 2009-07-17 | 2009-07-17 | Préparation pour régénération de défauts osseux postopératoires, post-traumatiques, et procédé pour l'implantation de cette préparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2009/000075 WO2011008111A1 (fr) | 2009-07-17 | 2009-07-17 | Préparation pour régénération de défauts osseux postopératoires, post-traumatiques, et procédé pour l'implantation de cette préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2011008111A1 true WO2011008111A1 (fr) | 2011-01-20 |
Family
ID=41796418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/PL2009/000075 WO2011008111A1 (fr) | 2009-07-17 | 2009-07-17 | Préparation pour régénération de défauts osseux postopératoires, post-traumatiques, et procédé pour l'implantation de cette préparation |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2011008111A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021247348A1 (fr) * | 2020-06-01 | 2021-12-09 | Bone Solutions, Inc. | Composition de biomatériau et méthodes d'utilisation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0577342A1 (fr) * | 1992-06-29 | 1994-01-05 | Queen Mary And Westfield College | Compositions d'hydroxyapatite et procédé pour sa fabrication |
| WO1998040113A1 (fr) * | 1997-03-13 | 1998-09-17 | University Of Florida Tissue Bank, Inc. | Pate pour os |
| US6235225B1 (en) * | 1999-08-10 | 2001-05-22 | Ngk Spark Plug Co., Ltd. | Process for producing biocompatible implant material |
| WO2007084609A2 (fr) * | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Prothese osseuse poreuse |
| EP2080528A1 (fr) * | 2008-01-17 | 2009-07-22 | Tadeusz Cieslik | Préparation pour régénération du tissu osseux perdu par suite d'opérations et de lésions et procédé d'application de cette préparation |
-
2009
- 2009-07-17 WO PCT/PL2009/000075 patent/WO2011008111A1/fr active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0577342A1 (fr) * | 1992-06-29 | 1994-01-05 | Queen Mary And Westfield College | Compositions d'hydroxyapatite et procédé pour sa fabrication |
| WO1998040113A1 (fr) * | 1997-03-13 | 1998-09-17 | University Of Florida Tissue Bank, Inc. | Pate pour os |
| US6235225B1 (en) * | 1999-08-10 | 2001-05-22 | Ngk Spark Plug Co., Ltd. | Process for producing biocompatible implant material |
| WO2007084609A2 (fr) * | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Prothese osseuse poreuse |
| EP2080528A1 (fr) * | 2008-01-17 | 2009-07-22 | Tadeusz Cieslik | Préparation pour régénération du tissu osseux perdu par suite d'opérations et de lésions et procédé d'application de cette préparation |
| US20090186063A1 (en) * | 2008-01-17 | 2009-07-23 | Tadeusz Cieslik | Preparation for regeneration of postoperative, post-traumatic bone defects and method for implantation of this preparation |
Non-Patent Citations (2)
| Title |
|---|
| BERGMAN S A ET AL: "BONE IN-FILL OF NON-HEALING CALVARIAL DEFECTS USING PARTICULATE BIOGLASS AND AUTOGENOUS BONE", BIOCERAMICS, XX, XX, 1 January 1995 (1995-01-01), pages 17 - 24, XP000869797 * |
| HANKER J S ET AL: "SETTING OF COMPOSITE HYDROXYLAPATITE/PLASTER IMPLANTS WITH BLOOD FOR BONE RECONSTRUCTION", PROCEEDINGS OF THE ANNUAL MEETING OF THE ELECTRON MICROSCOPYSOCIETY OF AMERICA, XX, XX, vol. 22, 1 January 1986 (1986-01-01), pages 328/329, XP009025391 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021247348A1 (fr) * | 2020-06-01 | 2021-12-09 | Bone Solutions, Inc. | Composition de biomatériau et méthodes d'utilisation |
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