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WO2011000945A3 - Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns - Google Patents

Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns Download PDF

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Publication number
WO2011000945A3
WO2011000945A3 PCT/EP2010/059471 EP2010059471W WO2011000945A3 WO 2011000945 A3 WO2011000945 A3 WO 2011000945A3 EP 2010059471 W EP2010059471 W EP 2010059471W WO 2011000945 A3 WO2011000945 A3 WO 2011000945A3
Authority
WO
WIPO (PCT)
Prior art keywords
degenerative
cns
inflammatory
aminoalkamides
treatment
Prior art date
Application number
PCT/EP2010/059471
Other languages
French (fr)
Other versions
WO2011000945A9 (en
WO2011000945A2 (en
Inventor
Nicholas Kelly
Anja Wellejus
Signe Humle JØRGENSEN
Morten Sloth Weidner
Original Assignee
Nensius Research A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nensius Research A/S filed Critical Nensius Research A/S
Publication of WO2011000945A2 publication Critical patent/WO2011000945A2/en
Publication of WO2011000945A3 publication Critical patent/WO2011000945A3/en
Publication of WO2011000945A9 publication Critical patent/WO2011000945A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

An aminoalkarnide of the formula I for use as a medicament to treat inflammatory, degenerative or demyelinating diseases of the CNS in a subject in need thereof.
PCT/EP2010/059471 2009-07-03 2010-07-02 Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns WO2011000945A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09164583.8 2009-07-03
EP09164583 2009-07-03
US22311109P 2009-07-06 2009-07-06
US61/223,111 2009-07-06

Publications (3)

Publication Number Publication Date
WO2011000945A2 WO2011000945A2 (en) 2011-01-06
WO2011000945A3 true WO2011000945A3 (en) 2011-02-24
WO2011000945A9 WO2011000945A9 (en) 2011-04-07

Family

ID=41136872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/059471 WO2011000945A2 (en) 2009-07-03 2010-07-02 Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns

Country Status (2)

Country Link
TW (1) TW201113280A (en)
WO (1) WO2011000945A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2968508B1 (en) * 2010-12-09 2013-01-04 Crea PYROTECHNIC DEVICE WITH SECURED FIREFIGHTING
WO2018053517A1 (en) * 2016-09-19 2018-03-22 The Texas A&M University System Inhibitors of ldlr-pcsk9 protein-protein interaction and methods of their use
JOP20190245A1 (en) 2017-04-20 2019-10-15 Novartis Ag Sustained release delivery systems comprising traceless linkers
AR116566A1 (en) 2018-10-03 2021-05-19 Novartis Ag SUSTAINED ADMINISTRATION OF ANGIOPOYETIN-SIMILAR POLIPEPTIDES 3

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702537A1 (en) * 1976-01-23 1977-07-28 Corvi Camillo Spa NEW PIPERAZINE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
EP0582164A1 (en) * 1992-07-31 1994-02-09 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
WO1996032386A1 (en) * 1995-04-14 1996-10-17 Boehringer Ingelheim Kg Aryl glycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
WO2000008006A2 (en) * 1998-08-07 2000-02-17 Eli Lilly And Company Limited Piperidine and piperazine derivatives, process for their preparation and pharmaceutical compounds containing them
WO2006018188A2 (en) * 2004-08-17 2006-02-23 F. Hoffmann-La Roche Ag Substituted hydantoins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1150759B (en) 1982-04-05 1986-12-17 Corvi Camillo Spa ORGANOMETALLIC COMPLEXES OF N-CYCLOHEXY-PIPERAZINO-ACETAMIDES OR PROPIONAMIDS, THEIR PREPARATION AND USE AS ANTI-ULCER-ANTISECRETIVE-DAMPING DRUGS
EP0585500A1 (en) 1992-09-04 1994-03-09 Merrell Dow Pharmaceuticals Inc. Diaryl piperazineacetamides as antimuscarinic agents
JP2002504134A (en) 1997-06-16 2002-02-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Use of a dolafradine analog to treat pain
ATE455108T1 (en) 2001-02-16 2010-01-15 Aventis Pharma Inc HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702537A1 (en) * 1976-01-23 1977-07-28 Corvi Camillo Spa NEW PIPERAZINE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
EP0582164A1 (en) * 1992-07-31 1994-02-09 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
WO1996032386A1 (en) * 1995-04-14 1996-10-17 Boehringer Ingelheim Kg Aryl glycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
WO2000008006A2 (en) * 1998-08-07 2000-02-17 Eli Lilly And Company Limited Piperidine and piperazine derivatives, process for their preparation and pharmaceutical compounds containing them
WO2006018188A2 (en) * 2004-08-17 2006-02-23 F. Hoffmann-La Roche Ag Substituted hydantoins

Also Published As

Publication number Publication date
WO2011000945A9 (en) 2011-04-07
WO2011000945A2 (en) 2011-01-06
TW201113280A (en) 2011-04-16

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