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WO2010117285A3 - Process for the preparation of grignard compounds - Google Patents

Process for the preparation of grignard compounds Download PDF

Info

Publication number
WO2010117285A3
WO2010117285A3 PCT/PL2010/000024 PL2010000024W WO2010117285A3 WO 2010117285 A3 WO2010117285 A3 WO 2010117285A3 PL 2010000024 W PL2010000024 W PL 2010000024W WO 2010117285 A3 WO2010117285 A3 WO 2010117285A3
Authority
WO
WIPO (PCT)
Prior art keywords
organic solvent
preparation
grignard compounds
metallic magnesium
organic
Prior art date
Application number
PCT/PL2010/000024
Other languages
French (fr)
Other versions
WO2010117285A2 (en
Inventor
Wieslaw Szeja
Jan Helman
Krzysztof Kiraga
Sebastian Derfla
Original Assignee
Zaklady Farmaceutyczne Polpharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zaklady Farmaceutyczne Polpharma Sa filed Critical Zaklady Farmaceutyczne Polpharma Sa
Publication of WO2010117285A2 publication Critical patent/WO2010117285A2/en
Publication of WO2010117285A3 publication Critical patent/WO2010117285A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a process for the preparation of Grignard compounds using a continuous method which involves the reaction of an organic halide dissolved in an organic solvent with metallic magnesium which, together with the activator solution in an organic solvent, fills the flow reactor or optionally a system of flow reactors, and subsequently, the resulting reaction mixture is fed into the terminal flow reactor containing metallic magnesium in order to achieve complete conversion of the organic halide, whereby preferably the organic solvent is re-circulated to flow reactors in a form of vapour.
PCT/PL2010/000024 2009-04-07 2010-03-29 Process for the preparation of grignard compounds WO2010117285A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PLP.387728 2009-04-07
PL387728A PL387728A1 (en) 2009-04-07 2009-04-07 Method of obtaining Grignard compounds

Publications (2)

Publication Number Publication Date
WO2010117285A2 WO2010117285A2 (en) 2010-10-14
WO2010117285A3 true WO2010117285A3 (en) 2010-12-02

Family

ID=42735268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2010/000024 WO2010117285A2 (en) 2009-04-07 2010-03-29 Process for the preparation of grignard compounds

Country Status (2)

Country Link
PL (1) PL387728A1 (en)
WO (1) WO2010117285A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102649796A (en) * 2011-02-24 2012-08-29 四川滇虹医药开发有限公司 Preparation method for important intermediates of butoconazole nitrate
CN103880596B (en) * 2012-12-21 2015-12-23 凌沛学 A kind of preparation method of Nitric acid butoconazole intermediate of applicable suitability for industrialized production
FR3012145B1 (en) * 2013-10-18 2015-12-18 Yriel CONTINUOUS PROCESS FOR THE PREPARATION OF BORONIC ACIDS AND THEIR DERIVATIVES
CN106588958B (en) * 2015-10-14 2018-09-28 上虞新和成生物化工有限公司 A kind of continuous production system and method for preparing alkynol di Grignard reagent
DE102016206211B4 (en) * 2016-04-13 2018-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Continuous process for the preparation of Grignard adducts and apparatus for carrying it out
CN111138461B (en) * 2019-12-05 2023-01-20 海利尔药业集团股份有限公司 Continuous preparation method of o-chlorobenzyl chloride Grignard reagent
US20240181422A1 (en) * 2021-04-22 2024-06-06 Tokuyama Corporation Method for producing organic compound, and device for producing organic compound
CN116162051B (en) * 2023-03-16 2024-05-31 福州大学 A method for continuously producing vitamin A intermediate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2464685A (en) * 1946-12-02 1949-03-15 Diamond Alkali Co Continuous grignard method
US3911037A (en) * 1973-11-21 1975-10-07 Nalco Chemical Co Continuous Grignard reactors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2464685A (en) * 1946-12-02 1949-03-15 Diamond Alkali Co Continuous grignard method
US3911037A (en) * 1973-11-21 1975-10-07 Nalco Chemical Co Continuous Grignard reactors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JENNINGS ET AL: "A novel, continuous high-yield synthesis of Grignard reagents", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH LNKD- DOI:10.1016/0022-328X(87)80384-4, vol. 325, no. 1-2, 12 May 1987 (1987-05-12), pages 25 - 29, XP026611033, ISSN: 0022-328X, [retrieved on 19870512] *

Also Published As

Publication number Publication date
WO2010117285A2 (en) 2010-10-14
PL387728A1 (en) 2010-10-11

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