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WO2009081170A3 - Peptide fusion proteins - Google Patents

Peptide fusion proteins Download PDF

Info

Publication number
WO2009081170A3
WO2009081170A3 PCT/GB2008/004279 GB2008004279W WO2009081170A3 WO 2009081170 A3 WO2009081170 A3 WO 2009081170A3 GB 2008004279 W GB2008004279 W GB 2008004279W WO 2009081170 A3 WO2009081170 A3 WO 2009081170A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
peptide fusion
peptide
binding domain
polypeptide
Prior art date
Application number
PCT/GB2008/004279
Other languages
French (fr)
Other versions
WO2009081170A2 (en
Inventor
Peter Artymiuk
Richard Ross
Jon Sayers
Original Assignee
Asterion Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asterion Limited filed Critical Asterion Limited
Publication of WO2009081170A2 publication Critical patent/WO2009081170A2/en
Publication of WO2009081170A3 publication Critical patent/WO2009081170A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

We disclose fusion proteins comprising a peptide comprising a binding domain for a receptor which is linked to a polypeptide comprising the binding domain to which said peptide binds.
PCT/GB2008/004279 2007-12-24 2008-12-24 Peptide fusion proteins WO2009081170A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0725201.8 2007-12-24
GB0725201A GB0725201D0 (en) 2007-12-24 2007-12-24 Peptide fusion proteins

Publications (2)

Publication Number Publication Date
WO2009081170A2 WO2009081170A2 (en) 2009-07-02
WO2009081170A3 true WO2009081170A3 (en) 2009-12-03

Family

ID=39048740

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/004279 WO2009081170A2 (en) 2007-12-24 2008-12-24 Peptide fusion proteins

Country Status (2)

Country Link
GB (1) GB0725201D0 (en)
WO (1) WO2009081170A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808402D0 (en) * 2008-05-09 2008-06-18 Asterion Ltd Tsh
CN106999552B (en) * 2014-10-02 2021-12-28 威斯塔解剖学和生物学研究所 Methods and compositions for treating cancer
CN104926945B (en) * 2015-05-27 2018-03-23 江苏省原子医学研究所 A kind of oncotherapy polypeptide and its application with FSHR targetings
CL2018001347A1 (en) * 2018-05-18 2019-03-15 Centro De Biotecnologia Y Biomedicina Spa 94% Recombinant bovine stimulating follicle hormone, a composition that comprises it and a method to induce superovulation and synchronization of heat in cattle using said hormone

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015665A2 (en) * 1997-09-22 1999-04-01 University Of Maryland, Baltimore Mutants of thyroid stimulating hormone and methods based thereon
WO2001096565A2 (en) * 2000-06-16 2001-12-20 Asterion Limited Binding agents: chimeric ligand/receptor proteins
WO2006010891A2 (en) * 2004-07-26 2006-02-02 Asterion Limited Linkers
WO2006036877A2 (en) * 2004-09-27 2006-04-06 Cornell Research Foundation, Inc. Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin b-subunit and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015665A2 (en) * 1997-09-22 1999-04-01 University Of Maryland, Baltimore Mutants of thyroid stimulating hormone and methods based thereon
WO2001096565A2 (en) * 2000-06-16 2001-12-20 Asterion Limited Binding agents: chimeric ligand/receptor proteins
WO2006010891A2 (en) * 2004-07-26 2006-02-02 Asterion Limited Linkers
WO2006036877A2 (en) * 2004-09-27 2006-04-06 Cornell Research Foundation, Inc. Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin b-subunit and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MEEHAN THOMAS P ET AL: "Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex", JOURNAL OF MOLECULAR ENDOCRINOLOGY, vol. 34, no. 2, April 2005 (2005-04-01), pages 489 - 503, XP002525301, ISSN: 0952-5041 *
NARAYAN P ET AL: "Genetic Engineering of Single-Chain Gonadotropins and Hormone-Receptor Fusion Proteins", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 21, no. 1, 1 May 2000 (2000-05-01), pages 59 - 66, XP004466910, ISSN: 1046-2023 *
PUETT D ET AL: "The tie that binds: design of biologically active single-chain human chorionic gonadotropins and a gonadotropin-receptor complex using protein engineering.", BIOLOGY OF REPRODUCTION JUN 1998, vol. 58, no. 6, June 1998 (1998-06-01), pages 1337 - 1342, XP002525299, ISSN: 0006-3363 *
SCHUBERT REBECCA L ET AL: "Specificity of cognate ligand-receptor interactions: Fusion proteins of human chorionic gonadotropin and the heptahelical receptors for human luteinizing hormone, thyroid-stimulating hormone, and follicle-stimulating hormone.", ENDOCRINOLOGY, vol. 144, no. 1, January 2003 (2003-01-01), pages 129 - 137, XP002525300, ISSN: 0013-7227 *
WILKINSON IAN R ET AL: "A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 13, no. 9, 1 September 2007 (2007-09-01), pages 1108 - 1113, XP009089546, ISSN: 1078-8956 *

Also Published As

Publication number Publication date
WO2009081170A2 (en) 2009-07-02
GB0725201D0 (en) 2008-01-30

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