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WO2009063495A3 - Substituted indole and its derivatives as cannabinoid modulators - Google Patents

Substituted indole and its derivatives as cannabinoid modulators Download PDF

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Publication number
WO2009063495A3
WO2009063495A3 PCT/IN2008/000582 IN2008000582W WO2009063495A3 WO 2009063495 A3 WO2009063495 A3 WO 2009063495A3 IN 2008000582 W IN2008000582 W IN 2008000582W WO 2009063495 A3 WO2009063495 A3 WO 2009063495A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
substituted indole
compounds
cannabinoid modulators
indole
Prior art date
Application number
PCT/IN2008/000582
Other languages
French (fr)
Other versions
WO2009063495A2 (en
Inventor
Brijesh Kumar Srivastava
Pankaj Ramanbhai Patel
Original Assignee
Cadila Healthcare Ltd
Brijesh Kumar Srivastava
Pankaj Ramanbhai Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Brijesh Kumar Srivastava, Pankaj Ramanbhai Patel filed Critical Cadila Healthcare Ltd
Publication of WO2009063495A2 publication Critical patent/WO2009063495A2/en
Publication of WO2009063495A3 publication Critical patent/WO2009063495A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to novel substituted indole and indole derivatives to pharmaceutical compositions comprising the same, and to uses thereof. Compounds of the invention share pharmacological properties with cannabinoids and have a common wide range of beneficial therapeutic indications, hi particular, compounds of the invention are useful analgesic and anti-inflammatory agents by modulating the CB2 receptor.
PCT/IN2008/000582 2007-09-20 2008-09-11 Substituted indole and its derivatives as cannabinoid modulators WO2009063495A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1827/MUM/2007 2007-09-20
IN1827MU2007 2007-09-20

Publications (2)

Publication Number Publication Date
WO2009063495A2 WO2009063495A2 (en) 2009-05-22
WO2009063495A3 true WO2009063495A3 (en) 2009-08-06

Family

ID=40639284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000582 WO2009063495A2 (en) 2007-09-20 2008-09-11 Substituted indole and its derivatives as cannabinoid modulators

Country Status (1)

Country Link
WO (1) WO2009063495A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2892880B1 (en) 2012-09-07 2017-11-22 Novartis AG Indole carboxamide derivatives and uses thereof
CN108794379A (en) * 2017-04-26 2018-11-13 华东师范大学 1H- indole-2-carboxamide derivatives and its preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0576357A1 (en) * 1992-06-23 1993-12-29 Sanofi Pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0576357A1 (en) * 1992-06-23 1993-12-29 Sanofi Pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HYNES JOHN ET AL: "C-3 AMIDO-INDOLE CANNABINOID RECEPTOR MODULATORS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 12, 1 January 2002 (2002-01-01), pages 2399 - 2402, XP001167092, ISSN: 0960-894X *

Also Published As

Publication number Publication date
WO2009063495A2 (en) 2009-05-22

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Legal Events

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DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
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