[go: up one dir, main page]

WO2008150001A1 - Adipocluster - Google Patents

Adipocluster Download PDF

Info

Publication number
WO2008150001A1
WO2008150001A1 PCT/JP2008/060501 JP2008060501W WO2008150001A1 WO 2008150001 A1 WO2008150001 A1 WO 2008150001A1 JP 2008060501 W JP2008060501 W JP 2008060501W WO 2008150001 A1 WO2008150001 A1 WO 2008150001A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell
adipose tissue
preparation
neural stem
stem cell
Prior art date
Application number
PCT/JP2008/060501
Other languages
French (fr)
Japanese (ja)
Inventor
Takashi Nagase
Toshiyuki Kikuchi
Yuko Fujita
Shoko Murase
Original Assignee
Biomaster, Inc.
National Hospital Organization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomaster, Inc., National Hospital Organization filed Critical Biomaster, Inc.
Priority to JP2009517921A priority Critical patent/JP5388297B2/en
Publication of WO2008150001A1 publication Critical patent/WO2008150001A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

An object is to examine whether or not the requirement of a clone property is needed in the preparation of a neural stem cell preparation. Another object is to provide a method for preparing a neural stem cell in a simple manner. Thus, disclosed is a method for producing cells containing a cell derived from a Musashi-positive adipose tissue, which comprises the steps of: providing a cell derived from an adipose tissue; and subjecting the cell to the floating culture for a sufficient period for producing an aggregate.
PCT/JP2008/060501 2007-06-08 2008-06-06 Adipocluster WO2008150001A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009517921A JP5388297B2 (en) 2007-06-08 2008-06-06 Adipo cluster

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-153424 2007-06-08
JP2007153424 2007-06-08

Publications (1)

Publication Number Publication Date
WO2008150001A1 true WO2008150001A1 (en) 2008-12-11

Family

ID=40093805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060501 WO2008150001A1 (en) 2007-06-08 2008-06-06 Adipocluster

Country Status (2)

Country Link
JP (1) JP5388297B2 (en)
WO (1) WO2008150001A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015033558A1 (en) * 2013-09-04 2015-03-12 株式会社大塚製薬工場 Method for preparing pluripotent stem cells
JP2015511487A (en) * 2012-03-13 2015-04-20 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ Reprogramming of cells by 3D culture
WO2016013352A1 (en) * 2014-07-23 2016-01-28 学校法人日本大学 Method for producing dedifferentiated fat cell
JP2019503474A (en) * 2015-11-06 2019-02-07 ヴェンタナ メディカル システムズ， インク． Representative diagnostic method
CN115501393A (en) * 2022-09-21 2022-12-23 中国人民解放军总医院第一医学中心 Hydrogel for repairing nerve defect, preparation method and use thereof
CN115697347A (en) * 2020-07-08 2023-02-03 北京荣祥再生医学研究所有限公司 Method for regulating expression level of MUSASHI1 in cell
WO2023159019A1 (en) * 2022-02-15 2023-08-24 The General Hospital Corporation Neural progenitor cell compositions and methods of using the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537849A (en) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション Fat-derived stem cells and lattice
WO2003008592A1 (en) * 2001-07-19 2003-01-30 Yasuhiko Tabata Polyfunctional stem cells originating in adipose tissue
WO2003045137A1 (en) * 2001-11-29 2003-06-05 Japan Science And Technology Agency Method of constructing spinal injury model monkey and utilization thereof
WO2008018190A1 (en) * 2006-08-09 2008-02-14 Biomaster, Inc. Fat-derived neural crest cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537849A (en) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション Fat-derived stem cells and lattice
WO2003008592A1 (en) * 2001-07-19 2003-01-30 Yasuhiko Tabata Polyfunctional stem cells originating in adipose tissue
WO2003045137A1 (en) * 2001-11-29 2003-06-05 Japan Science And Technology Agency Method of constructing spinal injury model monkey and utilization thereof
WO2008018190A1 (en) * 2006-08-09 2008-02-14 Biomaster, Inc. Fat-derived neural crest cells

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
BUNNELL B.A. ET AL.: "Common transcriptional gene profile in neurospheres-derived from pATSCs, pBMSCs, and pNSCs", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 343, 2006, pages 762 - 771, XP024924774 *
CRANE J.F. AND TRAINOR P.A.: "Neural crest stem and progenitor cells", ANN. REV. CELL DEVELOP. BIOL., vol. 22, 2006, pages 267 - 286 *
DICKER A. ET AL.: "Functional studies of mesenchymal stem cells derived from adult human adipose tissue", EXP. CELL RES., vol. 308, 2005, pages 283 - 290, XP004997316 *
FERNANDES K.J.L. ET AL.: "A dermal niche for multipotent adult skin-derived precursor cells", NATURE CELL BIOL., vol. 6, no. 11, November 2004 (2004-11-01), pages 1082 - 1093, XP002494290 *
HARRISON J. ET AL.: "Colonization and maintenance of murine embryonic stem cells on poly (alpha-hydroxy esters)", BIOMATERIALS, vol. 25, 2004, pages 4963 - 4970, XP004504183 *
KANG S.K. ET AL.: "Neurogenesis of Rhesus adipose stromal cells", J. CELL SCI., vol. 117, no. 18, 2004, pages 4289 - 4299 *
KOIKE M. ET AL.: "A round-bottom 96-well polystyrene plate coated with 2-methacryloyloxyethyl phosphorylcholine as an effective tool for embryoid body formation", CYTOTECHNOLOGY, vol. 47, 2005, pages 3 - 10, XP019236867 *
NAGASE T. ET AL.: "Adipocluster: Mouse, Rat Hikashibo karano Jinsoku na Shinkei Zenkusaibo Kaishuho no Kaihatsu", DAI 16 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM.YOKOSHU, October 2007 (2007-10-01), pages 96 *
NAGASE T. ET AL.: "Hito Shibo Soshiki Yurai neurosphere Saibo no Mouse Hai eno Ishoku no Kokoromi", DAI 15 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM.YOKOSHU, December 2006 (2006-12-01), pages 108 *
NAGASE T. ET AL.: "Neurospheres from human adipose tissue transplanted into cultured mouse embryos can contribute to craniofacial morphogenesis: A preliminary report", J. CRANIOFACIAL SURGERY, vol. 18, no. 1, January 2007 (2007-01-01), pages 49 - 53, XP003020988 *
NAGASE T. ET AL.: "Shibo Soshiki Yurai neurosphere no Mouse Taiji Ishoku", REGENERATIVE MEDICINE, vol. 6, 19 February 2007 (2007-02-19), pages 297 *
NAGASE T. ET AL.: "Shibo Yurai Shinkei Zenkusaibo no Jinsoku Kaishuho no Kaihatsu", DAI 61 KAI JAPANESE SOCIETY OF NATIONAL MEDICAL SERVICES KOEN SHOROKUSHU, 22 November 2007 (2007-11-22), pages 481 *
NING H. ET AL.: "Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells", DIFFERENTIATION, vol. 74, 2006, pages 510 - 518, XP026770202, DOI: doi:10.1111/j.1432-0436.2006.00081.x *
SCHAUB G.A. ET AL.: "Hydrophobic attachment of trypanosoma cruzi to the rectal cuticle of Triatoma infestans and its influence on methacyclogenesis-A review", TOKAI J. EXP. CLIN. MED., vol. 23, no. 6, 1999, pages 321 - 327 *
SINGEC I. ET AL.: "Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology", NATURE METHODS, vol. 3, no. 10, October 2006 (2006-10-01), pages 801 - 806 *
WEI L. ET AL.: "Embryonic stem cell survival, migration and differentiation after transplantation into rats subjected to barrel cortex ischemia", ABSTRACT VIEW, 31ST ANNUAL MEETING, SOCIETY FOR NEUROSCIENCE'S, 2001, Retrieved from the Internet <URL:http://www.sfn.scholarone.com/itin2001> *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015511487A (en) * 2012-03-13 2015-04-20 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ Reprogramming of cells by 3D culture
US9650602B2 (en) 2012-03-13 2017-05-16 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Reprogramming cells by three-dimensional cultivation
US11155782B2 (en) 2013-09-04 2021-10-26 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JPWO2015033558A1 (en) * 2013-09-04 2017-03-02 株式会社大塚製薬工場 Method for preparing pluripotent stem cells
US9765296B2 (en) 2013-09-04 2017-09-19 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JP2018023401A (en) * 2013-09-04 2018-02-15 株式会社大塚製薬工場 Method for preparing pluripotent stem cells
WO2015033558A1 (en) * 2013-09-04 2015-03-12 株式会社大塚製薬工場 Method for preparing pluripotent stem cells
US10370639B2 (en) 2013-09-04 2019-08-06 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
WO2016013352A1 (en) * 2014-07-23 2016-01-28 学校法人日本大学 Method for producing dedifferentiated fat cell
JP5991687B2 (en) * 2014-07-23 2016-09-14 学校法人日本大学 Method for producing dedifferentiated adipocytes
JP2019503474A (en) * 2015-11-06 2019-02-07 ヴェンタナ メディカル システムズ， インク． Representative diagnostic method
JP7094880B2 (en) 2015-11-06 2022-07-04 ヴェンタナ メディカル システムズ， インク． Representative diagnostic method
US11959838B2 (en) 2015-11-06 2024-04-16 Ventana Medical Systems, Inc. Representative diagnostics
CN115697347A (en) * 2020-07-08 2023-02-03 北京荣祥再生医学研究所有限公司 Method for regulating expression level of MUSASHI1 in cell
CN115697347B (en) * 2020-07-08 2024-04-19 北京荣祥再生医学研究所有限公司 Method for regulating MUSASHI expression level in cell
WO2023159019A1 (en) * 2022-02-15 2023-08-24 The General Hospital Corporation Neural progenitor cell compositions and methods of using the same
CN115501393A (en) * 2022-09-21 2022-12-23 中国人民解放军总医院第一医学中心 Hydrogel for repairing nerve defect, preparation method and use thereof
CN115501393B (en) * 2022-09-21 2023-10-24 中国人民解放军总医院第一医学中心 Hydrogel for repairing nerve defects and preparation method and application thereof

Also Published As

Publication number Publication date
JPWO2008150001A1 (en) 2010-08-26
JP5388297B2 (en) 2014-01-15

Similar Documents

Publication Publication Date Title
WO2008150001A1 (en) Adipocluster
WO2006070370A3 (en) Stem cells culture systems
WO2010026575A3 (en) Adherent cells from placenta tissue and use thereof in therapy
WO2009061442A8 (en) Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells
WO2005080551A3 (en) Stem cells
WO2007127927A3 (en) Differentiation of human embryonic stem cells
WO2009012428A3 (en) Differentiation of human embryonic stem cells
WO2011011302A3 (en) Differentiation of human embryonic stem cells
WO2010059565A3 (en) Allografts combined with tissue derived stem cells for bone healing
WO2010026574A3 (en) Adherent cells from placenta tissue and use thereof in therapy
WO2006136953A3 (en) Method of producing organotypic cell cultures
GB0901623D0 (en) Method for stem cell culture and cells derived therefrom
CA2695225C (en) Differentiation of human embryonic stem cells to pancreatic endocrine
WO2010096588A3 (en) Cell culture media containing combinations of proteins
WO2007008722A3 (en) Method for the isolation of rna from biological sources
WO2009132083A3 (en) Compositions and methods for promoting the generation of pdx1+ pancreatic cells
WO2011011300A8 (en) Differentiation of human embryonic stem cells
SG196836A1 (en) Cancer stem cell population and method for production thereof
WO2008153180A1 (en) Method for production of hepatic-lobule-like cell mass from adipose-tissue-derived cell
WO2010128024A3 (en) Reversibly immortalized cells as well as methods relating hereto
WO2006017134A3 (en) Preprimitive streak and mesendoderm cells
WO2011059920A3 (en) Methods of generating neural stem cells
SG10201803982TA (en) Antibodies and processes for preparing the same
WO2010020876A3 (en) Cell culture method to form aggregates
WO2008086296A3 (en) Acid ceramidase and cell survival

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08777120

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009517921

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08777120

Country of ref document: EP

Kind code of ref document: A1