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WO2008143876A3 - Agents and assays for modulating neurodegeneration - Google Patents

Agents and assays for modulating neurodegeneration Download PDF

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Publication number
WO2008143876A3
WO2008143876A3 PCT/US2008/006154 US2008006154W WO2008143876A3 WO 2008143876 A3 WO2008143876 A3 WO 2008143876A3 US 2008006154 W US2008006154 W US 2008006154W WO 2008143876 A3 WO2008143876 A3 WO 2008143876A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurodegeneration
modulating
assays
agents
compounds
Prior art date
Application number
PCT/US2008/006154
Other languages
French (fr)
Other versions
WO2008143876A2 (en
Inventor
Brent R Stockwell
Benjamin G Hoffstrom
Original Assignee
Trustees Of Columia University
Brent R Stockwell
Benjamin G Hoffstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Columia University, Brent R Stockwell, Benjamin G Hoffstrom filed Critical Trustees Of Columia University
Publication of WO2008143876A2 publication Critical patent/WO2008143876A2/en
Publication of WO2008143876A3 publication Critical patent/WO2008143876A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention is directed to methods for modulating neurodegeneration. These methods include administering to a patient in need thereof an effective amount of a compound that modulates protein disulfide isomerase (PDI)-induced cellular toxicity. Compounds and compositions for treating such patients are also provided. The invention further provides assays for identifying such compounds.
PCT/US2008/006154 2007-05-14 2008-05-14 Agents and assays for modulating neurodegeneration WO2008143876A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US93020007P 2007-05-14 2007-05-14
US60/930,200 2007-05-14
US93026707P 2007-05-15 2007-05-15
US60/930,267 2007-05-15
US95874807P 2007-07-09 2007-07-09
US60/958,748 2007-07-09
US6350508P 2008-02-04 2008-02-04
US61/063,505 2008-02-04

Publications (2)

Publication Number Publication Date
WO2008143876A2 WO2008143876A2 (en) 2008-11-27
WO2008143876A3 true WO2008143876A3 (en) 2009-01-22

Family

ID=40122232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/006154 WO2008143876A2 (en) 2007-05-14 2008-05-14 Agents and assays for modulating neurodegeneration

Country Status (1)

Country Link
WO (1) WO2008143876A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010008860A1 (en) * 2008-06-23 2010-01-21 President And Fellows Of Harvard College Modulation of neurodegenerative disease by modulating xbp-1 activity
US9956236B2 (en) 2011-02-07 2018-05-01 Cornell University Methods for increasing immune responses using agents that directly bind to and activate IRE-1
CA2732440C (en) * 2011-02-23 2017-10-31 Universite Laval Cystamine analogues for the treatment of parkinson`s disease
US9873661B2 (en) 2011-10-25 2018-01-23 New York University Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors
CN102408431B (en) * 2011-11-29 2014-07-16 中国中医科学院中药研究所 Preparation method and new application of artemisinin B
US20150018406A1 (en) 2012-03-09 2015-01-15 Cornell University Modulation of breast cancer growth by modulation of xbp1 activity
WO2015048331A1 (en) 2013-09-25 2015-04-02 Cornell University Compounds for inducing anti-tumor immunity and methods thereof
JP2016538243A (en) 2013-10-03 2016-12-08 インヴェニオ セラピューティクス インク.Invenio Therapeutics Inc. Small molecule secrinin and norsecrinin analogs, their use in cancer, inflammatory diseases and infectious diseases
CN104761572B (en) * 2015-03-11 2017-04-12 暨南大学 Flueggea suffruticosa-type alkaloid dimer-type compound or pharmaceutically acceptable salt thereof, preparation method and application thereof
CN107802621A (en) * 2017-12-06 2018-03-16 中国中医科学院中药研究所 The purposes of the anti-neuroinflamation of artemisinin B and treatment nerve degenerative diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118997A1 (en) * 2001-08-10 2003-06-26 Genset, S.A. Human cDNAs and proteins and uses thereof
US20030224360A9 (en) * 1999-12-23 2003-12-04 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224360A9 (en) * 1999-12-23 2003-12-04 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
US20030118997A1 (en) * 2001-08-10 2003-06-26 Genset, S.A. Human cDNAs and proteins and uses thereof

Also Published As

Publication number Publication date
WO2008143876A2 (en) 2008-11-27

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