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WO2008108927A3 - Methods and compositions for stabilizing polypeptides - Google Patents

Methods and compositions for stabilizing polypeptides Download PDF

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Publication number
WO2008108927A3
WO2008108927A3 PCT/US2008/002261 US2008002261W WO2008108927A3 WO 2008108927 A3 WO2008108927 A3 WO 2008108927A3 US 2008002261 W US2008002261 W US 2008002261W WO 2008108927 A3 WO2008108927 A3 WO 2008108927A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
stabilizing polypeptides
stabilizing
polypeptides
Prior art date
Application number
PCT/US2008/002261
Other languages
French (fr)
Other versions
WO2008108927A2 (en
Inventor
Gabriel Sosne
David Crockford
Original Assignee
Regenerx Biopharmaceuticals
Gabriel Sosne
David Crockford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenerx Biopharmaceuticals, Gabriel Sosne, David Crockford filed Critical Regenerx Biopharmaceuticals
Publication of WO2008108927A2 publication Critical patent/WO2008108927A2/en
Publication of WO2008108927A3 publication Critical patent/WO2008108927A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method of stabilizing a polypeptide outside of a body by combining the polypeptide with an aqueous solution containing substantially physiological levels of electrolytes and salts.
PCT/US2008/002261 2007-03-06 2008-02-21 Methods and compositions for stabilizing polypeptides WO2008108927A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90505107P 2007-03-06 2007-03-06
US60/905,051 2007-03-06

Publications (2)

Publication Number Publication Date
WO2008108927A2 WO2008108927A2 (en) 2008-09-12
WO2008108927A3 true WO2008108927A3 (en) 2008-12-04

Family

ID=39738962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/002261 WO2008108927A2 (en) 2007-03-06 2008-02-21 Methods and compositions for stabilizing polypeptides

Country Status (1)

Country Link
WO (1) WO2008108927A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
WO2016064078A1 (en) * 2014-10-22 2016-04-28 주식회사 지트리비앤티 Composition containing thymosin beta 4, and pharmaceutical formulation comprising same
US9867868B2 (en) * 2015-08-18 2018-01-16 G-Treebnt Co., Ltd. Pharmaceutical composition for treating or preventing corneal wound comprising thymosin β4 and citric acid
KR102487614B1 (en) * 2015-10-06 2023-01-12 에이치엘비테라퓨틱스 주식회사 Preparation of an ophthalmic composition comprising thymosin beta 4
KR102115158B1 (en) * 2016-11-29 2020-05-26 주식회사 지트리파마슈티컬 Formulation comprising thymosin beta 4
KR102340750B1 (en) * 2017-03-03 2021-12-21 에이치엘비테라퓨틱스 주식회사 Stabilized topical composition comprising thymosin beta 4 as an active ingredient
IT201900000561A1 (en) * 2019-01-14 2020-07-14 Medivis S R L Chemically and physically stable topical ophthalmic formulations based on Nepafenac

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHI E.Y. ET AL.: "Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation", PHARM. RES., vol. 20, no. 9, September 2003 (2003-09-01), pages 1325 - 1336, XP002475010 *
GOLDSTEIN A.L. ET AL.: "Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues", TRENDS IN MOLECULAR MEDICINE, vol. 11, no. 9, September 2005 (2005-09-01), pages 421 - 429, XP005065335 *
PHILP D. ET AL.: "Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice in aged mice", WOUND REPAIR AND REGENERATION, vol. 11, no. 1, January 2003 (2003-01-01) - February 2003 (2003-02-01), pages 19 - 24, XP002441696 *
WANG W. ET AL.: "Antibody Structure, Instability, and Formulation", J. PHARM. SCI., vol. 96, no. 1, January 2007 (2007-01-01), pages 1 - 26, XP009084505 *

Also Published As

Publication number Publication date
WO2008108927A2 (en) 2008-09-12

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