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WO2008087611A3 - Pyrrolidine- and piperidine- bis-amide derivatives - Google Patents

Pyrrolidine- and piperidine- bis-amide derivatives Download PDF

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Publication number
WO2008087611A3
WO2008087611A3 PCT/IB2008/050192 IB2008050192W WO2008087611A3 WO 2008087611 A3 WO2008087611 A3 WO 2008087611A3 IB 2008050192 W IB2008050192 W IB 2008050192W WO 2008087611 A3 WO2008087611 A3 WO 2008087611A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrrolidine
piperidine
alkyl
bis
amide derivatives
Prior art date
Application number
PCT/IB2008/050192
Other languages
French (fr)
Other versions
WO2008087611A2 (en
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Hamed Aissaoui, Christoph Boss, Markus Gude, Ralf Koberstein, Thierry Sifferlen filed Critical Actelion Pharmaceuticals Ltd
Publication of WO2008087611A2 publication Critical patent/WO2008087611A2/en
Publication of WO2008087611A3 publication Critical patent/WO2008087611A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to pyrrolidine- and piperidine-derivatives of formula (I), wherein Y represents (CH2)n; n represents 0 or 1; A represents B represents phenyl, wherein the phenyl-ring is unsubstituted or mono- or di- or tri- substituted, wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, trifluoromethyl, cyano, and halogen; R1 represents an imidazothiazole-group selected from: R2 represents (C1-4)alkyl, bromine or -NH2; and R3 represents hydrogen or (C1-4)alkyl; and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.
PCT/IB2008/050192 2007-01-19 2008-01-18 Pyrrolidine- and piperidine- bis-amide derivatives WO2008087611A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB2007/050180 2007-01-19
IB2007050180 2007-01-19

Publications (2)

Publication Number Publication Date
WO2008087611A2 WO2008087611A2 (en) 2008-07-24
WO2008087611A3 true WO2008087611A3 (en) 2009-06-04

Family

ID=39636451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/050192 WO2008087611A2 (en) 2007-01-19 2008-01-18 Pyrrolidine- and piperidine- bis-amide derivatives

Country Status (1)

Country Link
WO (1) WO2008087611A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011073316A1 (en) * 2009-12-18 2011-06-23 Novartis Ag 4-aryl-butane-1,3-diamides
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
JP6346862B2 (en) * 2012-02-07 2018-06-20 エオラス セラピューティクス， インコーポレイテッド Substituted proline / piperidine as an orexin receptor antagonist
NZ703448A (en) 2012-06-04 2017-07-28 Actelion Pharmaceuticals Ltd Benzimidazole-proline derivatives
EP2875029B8 (en) * 2012-07-18 2021-12-15 University of Notre Dame du Lac 5,5-heteroaromatic anti-infective compounds
WO2014057435A1 (en) 2012-10-10 2014-04-17 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
JP2016510810A (en) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Azetidine amide derivatives as orexin receptor antagonists
CN105793257B (en) 2013-12-03 2018-11-13 爱杜西亚药品有限公司 The crystalline form and application thereof of benzimidazole cycle compound
UA119151C2 (en) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
EA029725B1 (en) 2013-12-04 2018-05-31 Идорсиа Фармасьютиклз Лтд Use of benzimidazole-proline derivatives
JP6663909B2 (en) 2014-08-13 2020-03-13 エオラス セラピューティクス， インコーポレイテッド Difluoropyrrolidine as an orexin receptor modulator
HUE059280T2 (en) 2016-02-12 2022-11-28 Astrazeneca Ab Halogen-substituted piperidines as orexin receptor modulators
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
AR129309A1 (en) 2022-05-13 2024-08-07 Idorsia Pharmaceuticals Ltd DERIVATIVES OF HYDRAZINE-N-CARBOXAMIDE CYCLIC SUBSTITUTED WITH THIAZOLOARYL-METHYL

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096302A1 (en) * 2000-06-16 2001-12-20 Smithkline Beecham P.L.C. Piperidines for use as orexin receptor antagonists
WO2003041711A1 (en) * 2001-11-10 2003-05-22 Smithkline Beecham P.L.C. Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor
WO2003051368A1 (en) * 2001-12-19 2003-06-26 Smithkline Beecham Plc N-aroyl cyclic amine derivatives as orexin receptor antagonists
WO2004041791A1 (en) * 2002-11-06 2004-05-21 Glaxo Group Limited N-aryl acetyl cyclic amine derivatives as orexin antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096302A1 (en) * 2000-06-16 2001-12-20 Smithkline Beecham P.L.C. Piperidines for use as orexin receptor antagonists
WO2003041711A1 (en) * 2001-11-10 2003-05-22 Smithkline Beecham P.L.C. Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor
WO2003051368A1 (en) * 2001-12-19 2003-06-26 Smithkline Beecham Plc N-aroyl cyclic amine derivatives as orexin receptor antagonists
WO2004041791A1 (en) * 2002-11-06 2004-05-21 Glaxo Group Limited N-aryl acetyl cyclic amine derivatives as orexin antagonists

Also Published As

Publication number Publication date
WO2008087611A2 (en) 2008-07-24

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