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WO2008081096A3 - Derives quinolinyliques, leur procede de preparation. les compositions pharmaceutiques qui les contiennent et leur utilisation comme agents hypoglycemiants et hypoli pemiants - Google Patents

Derives quinolinyliques, leur procede de preparation. les compositions pharmaceutiques qui les contiennent et leur utilisation comme agents hypoglycemiants et hypoli pemiants Download PDF

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Publication number
WO2008081096A3
WO2008081096A3 PCT/FR2007/001957 FR2007001957W WO2008081096A3 WO 2008081096 A3 WO2008081096 A3 WO 2008081096A3 FR 2007001957 W FR2007001957 W FR 2007001957W WO 2008081096 A3 WO2008081096 A3 WO 2008081096A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
hypoglycemiant
hypolipemiant
agents
compositions containing
Prior art date
Application number
PCT/FR2007/001957
Other languages
English (en)
Other versions
WO2008081096A2 (fr
Inventor
Rene Gree
Melanie Liutkus
Frederic Caijo
Julien Brioche
Thomas Jennequin
Catherine Dacquet
Alain Ktorza
Daniel-Henri Caignard
Original Assignee
Servier Lab
Rene Gree
Melanie Liutkus
Frederic Caijo
Julien Brioche
Thomas Jennequin
Catherine Dacquet
Alain Ktorza
Daniel-Henri Caignard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Rene Gree, Melanie Liutkus, Frederic Caijo, Julien Brioche, Thomas Jennequin, Catherine Dacquet, Alain Ktorza, Daniel-Henri Caignard filed Critical Servier Lab
Publication of WO2008081096A2 publication Critical patent/WO2008081096A2/fr
Publication of WO2008081096A3 publication Critical patent/WO2008081096A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

Composés de formule (I) dans laquelle : R1 représente un groupement alkyle substitué ou non par un ou plusieurs groupements COOR3 ou NR4R5; R2 représente un groupement phényle substitué ou non; n vaut 0, 1, 2, 3, 4, 5, 6, 7 ou 8. Médicaments.
PCT/FR2007/001957 2006-11-30 2007-11-29 Derives quinolinyliques, leur procede de preparation. les compositions pharmaceutiques qui les contiennent et leur utilisation comme agents hypoglycemiants et hypoli pemiants WO2008081096A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0610458A FR2909379B1 (fr) 2006-11-30 2006-11-30 Nouveaux derives heterocycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR0610458 2006-11-30

Publications (2)

Publication Number Publication Date
WO2008081096A2 WO2008081096A2 (fr) 2008-07-10
WO2008081096A3 true WO2008081096A3 (fr) 2008-08-21

Family

ID=38283326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001957 WO2008081096A2 (fr) 2006-11-30 2007-11-29 Derives quinolinyliques, leur procede de preparation. les compositions pharmaceutiques qui les contiennent et leur utilisation comme agents hypoglycemiants et hypoli pemiants

Country Status (3)

Country Link
AR (1) AR063988A1 (fr)
FR (1) FR2909379B1 (fr)
WO (1) WO2008081096A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447071B2 (en) 2014-02-07 2016-09-20 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2414353A1 (fr) 2009-04-01 2012-02-08 Basf Se Composés d'isoxazoline pour lutter contre les ravageurs invertébrés
DK2797416T3 (en) 2011-12-28 2017-10-30 Global Blood Therapeutics Inc SUBSTITUTED BENZALDEHYD COMPOUNDS AND METHODS OF USING THEM IN INCREASED TISSUE OXIDATION
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
AU2014237348C1 (en) 2013-03-15 2019-02-07 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
SG11201507320QA (en) 2013-03-15 2015-10-29 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
TW201731509A (zh) 2015-12-04 2017-09-16 全球血液治療公司 針對２-羥基-６-（（２-（１-異丙基-１ｈ-吡唑-５-基）吡啶-３-基）甲氧基）-苯甲醛之劑量方案
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345083A (en) * 1978-09-18 1982-08-17 Mcneilab, Inc. (1-Methyl-2-quinolinylidene) derivatives of guanidine
WO2005105724A1 (fr) * 2004-05-03 2005-11-10 Merck Patent Gmbh Derives de l'acide hexenoique, procedes de preparation de ces derives, compositions pharmaceutiques les contenant et applications therapeutiques associees
WO2005105764A1 (fr) * 2004-05-03 2005-11-10 Merck Patent Gmbh Derives de l'acide butanoique, leurs procedes de preparation, compositions pharmaceutiques les contenant, et leurs applications therapeutiques
FR2881137A1 (fr) * 2005-01-27 2006-07-28 Servier Lab Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345083A (en) * 1978-09-18 1982-08-17 Mcneilab, Inc. (1-Methyl-2-quinolinylidene) derivatives of guanidine
WO2005105724A1 (fr) * 2004-05-03 2005-11-10 Merck Patent Gmbh Derives de l'acide hexenoique, procedes de preparation de ces derives, compositions pharmaceutiques les contenant et applications therapeutiques associees
WO2005105764A1 (fr) * 2004-05-03 2005-11-10 Merck Patent Gmbh Derives de l'acide butanoique, leurs procedes de preparation, compositions pharmaceutiques les contenant, et leurs applications therapeutiques
FR2881137A1 (fr) * 2005-01-27 2006-07-28 Servier Lab Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447071B2 (en) 2014-02-07 2016-09-20 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Also Published As

Publication number Publication date
FR2909379A1 (fr) 2008-06-06
WO2008081096A2 (fr) 2008-07-10
FR2909379B1 (fr) 2009-01-16
AR063988A1 (es) 2009-03-04

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