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WO2008070861A3 - Methods and compositions for treating systemic lupus erythematosus - Google Patents

Methods and compositions for treating systemic lupus erythematosus Download PDF

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Publication number
WO2008070861A3
WO2008070861A3 PCT/US2007/086861 US2007086861W WO2008070861A3 WO 2008070861 A3 WO2008070861 A3 WO 2008070861A3 US 2007086861 W US2007086861 W US 2007086861W WO 2008070861 A3 WO2008070861 A3 WO 2008070861A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
lupus erythematosus
systemic lupus
methods
treating systemic
Prior art date
Application number
PCT/US2007/086861
Other languages
French (fr)
Other versions
WO2008070861A2 (en
Inventor
Julie Lynne Christensen
Original Assignee
Cellerant Therapeutics Inc
Julie Lynne Christensen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellerant Therapeutics Inc, Julie Lynne Christensen filed Critical Cellerant Therapeutics Inc
Publication of WO2008070861A2 publication Critical patent/WO2008070861A2/en
Publication of WO2008070861A3 publication Critical patent/WO2008070861A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present disclosure relates to compositions and method for treating a patient suffering from systemic lupus erythematosus and related conditions, comprising subjecting said patient to myeloablation and administering to said patient hematopoietic stem cells.
PCT/US2007/086861 2006-12-07 2007-12-07 Methods and compositions for treating systemic lupus erythematosus WO2008070861A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86908506P 2006-12-07 2006-12-07
US60/869,085 2006-12-07

Publications (2)

Publication Number Publication Date
WO2008070861A2 WO2008070861A2 (en) 2008-06-12
WO2008070861A3 true WO2008070861A3 (en) 2008-07-24

Family

ID=39201592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/086861 WO2008070861A2 (en) 2006-12-07 2007-12-07 Methods and compositions for treating systemic lupus erythematosus

Country Status (1)

Country Link
WO (1) WO2008070861A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
WO2017210360A1 (en) * 2016-05-31 2017-12-07 Cardiovax, Llc Methods for diagnosing and treating systemic lupus erythematosus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0451611A2 (en) * 1990-03-30 1991-10-16 Sandoz Ltd Human hematopoietic stem cell
WO2003012060A2 (en) * 2001-08-01 2003-02-13 Jewish Hospital Healthcare Services, Inc. Cellular compositions which facilitate engraftment of hematopoietic stem cells while minimizing the risk of gvhd

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0451611A2 (en) * 1990-03-30 1991-10-16 Sandoz Ltd Human hematopoietic stem cell
WO2003012060A2 (en) * 2001-08-01 2003-02-13 Jewish Hospital Healthcare Services, Inc. Cellular compositions which facilitate engraftment of hematopoietic stem cells while minimizing the risk of gvhd

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
BRODSKY ROBERT A ET AL: "Hematopietic stem cell transplantation for systemic lupus erythematosus", RHEUMATIC DISEASES CLINICS OF NORTH AMERICA, W.B. SAUNDERS, PHILADELPHIA, PA, US, vol. 26, no. 2, May 2000 (2000-05-01), pages 377 - 387, XP009098283, ISSN: 0889-857X *
BRYDER DAVID ET AL: "Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.", THE AMERICAN JOURNAL OF PATHOLOGY AUG 2006, vol. 169, no. 2, August 2006 (2006-08-01), pages 338 - 346, XP002476779, ISSN: 0002-9440 *
BURT RICHARD K ET AL: "Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus.", JAMA : THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 1 FEB 2006, vol. 295, no. 5, 1 February 2006 (2006-02-01), pages 527 - 535, XP002475502, ISSN: 1538-3598 *
EL-BADRI NAGWA S ET AL: "Successful prevention of autoimmune disease by transplantation of adequate number of fully allogeneic hematopoietic stem cells", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 70, no. 6, 27 September 2000 (2000-09-27), pages 870 - 877, XP009098213, ISSN: 0041-1337 *
FOUILLARD L ET AL: "Control of severe systemic lupus erythematosus after high-dose immunusuppressive therapy and transplantation of CD34 + purified autologous stem cells from peripheral blood", LUPUS, vol. 8, no. 4, 1999, pages 320 - 323, XP009098209, ISSN: 0961-2033 *
IKEHARA S ET AL: "LONG-TERM OBSERVATIONS OF AUTOIMMUNE-PRONE MICE TREATED FOR AUTOIMMUNE DISEASE BY ALLOGENEIC BONE MARROW TRANSPLANTATION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 86, no. 9, 1989, pages 3306 - 3310, XP002475498, ISSN: 0027-8424 *
JONES OLCAY Y ET AL: "Nonmyeloablative bone marrow transplantation of BXSB lupus mice using fully matched allogeneic donor cells from green fluorescent protein transgenic mice", JOURNAL OF IMMUNOLOGY, vol. 172, no. 9, 1 May 2004 (2004-05-01), pages 5415 - 5419, XP002475499, ISSN: 0022-1767 *
LEVITE M ET AL: "Beneficial effects of bone marrow transplantation on the serological manifestations and kidney pathology of experimental systemic lupus erythematosus", CELLULAR IMMUNOLOGY, vol. 162, no. 1, 1995, pages 138 - 145, XP002475500, ISSN: 0008-8749 *
MUSSO M ET AL: "Autologous peripheral blood stem and progenitor (CD34+) cell transplantation for systemic lupus erythematosus complicated by Evans syndrome", LUPUS, vol. 7, no. 7, 1998, pages 492 - 494, XP009098210, ISSN: 0961-2033 *
OYAMA Y ET AL: "Allogeneic stem cell transplantation for autoimmune diseases: Nonmyeloablative conditioning regimens.", BONE MARROW TRANSPLANTATION, vol. 32, no. Supplement 1, August 2003 (2003-08-01), pages S81 - S83, XP002475503, ISSN: 0268-3369 *
PETRI MICHELLE ET AL: "High-dose cyclophosphamide and stem cell transplantation for refractory systemic lupus erythematosus.", JAMA : THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 1 FEB 2006, vol. 295, no. 5, 1 February 2006 (2006-02-01), pages 559 - 560, XP009098266, ISSN: 1538-3598 *
RICHARD BURT: "Allogeneic blood stem cell transplantation in Systemic Lupus Erythematosus", 16 January 2006 (2006-01-16), XP002476777, Retrieved from the Internet <URL:http://www.clinicaltrials.gov/ct2/show/NCT00278590?term=allogeneic+lupus&rank=1> [retrieved on 20080415] *
SHIZURU J.: "Allogeneic blood stem cell transplantation for patients with life-threatening Systemic Lupus Erythematosus", 12 May 2006 (2006-05-12), XP002476778, Retrieved from the Internet <URL:http://www.clinicaltrials.gov/ct2/show/NCT00325741?term=allogeneic+lupus&rank=2> [retrieved on 20080415] *
SHIZURU JUDITH A ET AL: "Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system.", ANNUAL REVIEW OF MEDICINE 2005, vol. 56, 2005, pages 509 - 538, XP002475497, ISSN: 0066-4219 *
SMITH-BERDAN STEPHANIE ET AL: "Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nom-nyeloablative transplantation of purified allogeneic hematopoietic stem cells", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 110, no. 4, August 2007 (2007-08-01), pages 1370 - 1378, XP009098269, ISSN: 0006-4971 *

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Publication number Publication date
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