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WO2008021250A3 - Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins - Google Patents

Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins Download PDF

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Publication number
WO2008021250A3
WO2008021250A3 PCT/US2007/017815 US2007017815W WO2008021250A3 WO 2008021250 A3 WO2008021250 A3 WO 2008021250A3 US 2007017815 W US2007017815 W US 2007017815W WO 2008021250 A3 WO2008021250 A3 WO 2008021250A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
family member
compositions
cells over
modulating apoptosis
Prior art date
Application number
PCT/US2007/017815
Other languages
French (fr)
Other versions
WO2008021250A2 (en
Inventor
Jay Jie-Qiang Wu
David M Hockenbery
Ling Wang
Jianxin Guo
Original Assignee
Hutchinson Fred Cancer Res
Vm Discovery Inc
Jay Jie-Qiang Wu
David M Hockenbery
Ling Wang
Jianxin Guo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res, Vm Discovery Inc, Jay Jie-Qiang Wu, David M Hockenbery, Ling Wang, Jianxin Guo filed Critical Hutchinson Fred Cancer Res
Publication of WO2008021250A2 publication Critical patent/WO2008021250A2/en
Publication of WO2008021250A3 publication Critical patent/WO2008021250A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compounds for modulating apoptosis in cells over expressing Bcl-2 Family member proteins. The present invention also relates to pharmaceutical compositions containing these compounds, and methods of using the compounds.
PCT/US2007/017815 2006-08-10 2007-08-10 Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins WO2008021250A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83691806P 2006-08-10 2006-08-10
US60/836,918 2006-08-10

Publications (2)

Publication Number Publication Date
WO2008021250A2 WO2008021250A2 (en) 2008-02-21
WO2008021250A3 true WO2008021250A3 (en) 2009-04-02

Family

ID=39082642

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017815 WO2008021250A2 (en) 2006-08-10 2007-08-10 Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins

Country Status (1)

Country Link
WO (1) WO2008021250A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2194783T (en) * 2007-08-10 2017-10-25 Vm Discovery, Inc. Compositions and methods for apoptosis modulators
WO2011041737A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Gain-of-function bcl-2 inhibitors
WO2011041731A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Method of inhibiting bcl-2-related survival proteins
US8481553B2 (en) * 2010-04-06 2013-07-09 Brigham Young University Antimetastatic compounds
US9321735B2 (en) 2010-07-20 2016-04-26 Vestaron Corporation Insecticidal triazines and pyrimidines
JP5955531B2 (en) * 2011-11-07 2016-07-20 千葉県 Anticancer drug
CN103224466A (en) * 2013-04-15 2013-07-31 北京大学 Compound with beta-secretase inhibition function, its preparation method and application
WO2016135139A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 2,3-dihydrocyclopenta[b]quinoline derivatives as mth1 inhibitors for the therapy of cancer
WO2016135140A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh 4-aminoquinazoline derivatives as mth1 inhibitors for the therapy of cancer
WO2016135138A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Oxoquinoline derivatives as mth1 inhibitors for the therapy of cancer
WO2016135137A1 (en) 2015-02-23 2016-09-01 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Substituted 4-(phenylamino)quinoline derivatives as mth1 inhibitors for the therapy of cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003054A1 (en) * 1993-07-23 1995-02-02 Lxr Biotechnology Inc. Methods of treating apoptosis and associated conditions
US5807880A (en) * 1993-09-30 1998-09-15 Yamanouchi Pharmaceutical Co., Ltd. Azole derivative and pharmaceutical composition thereof
WO2005033048A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003054A1 (en) * 1993-07-23 1995-02-02 Lxr Biotechnology Inc. Methods of treating apoptosis and associated conditions
US5807880A (en) * 1993-09-30 1998-09-15 Yamanouchi Pharmaceutical Co., Ltd. Azole derivative and pharmaceutical composition thereof
WO2005033048A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists

Also Published As

Publication number Publication date
WO2008021250A2 (en) 2008-02-21

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