WO2008018783A3 - Porphyrin activation by different spectrum electromagnetical waves-new malignant tumour treatment possibilities - Google Patents
Porphyrin activation by different spectrum electromagnetical waves-new malignant tumour treatment possibilities Download PDFInfo
- Publication number
- WO2008018783A3 WO2008018783A3 PCT/LT2007/000006 LT2007000006W WO2008018783A3 WO 2008018783 A3 WO2008018783 A3 WO 2008018783A3 LT 2007000006 W LT2007000006 W LT 2007000006W WO 2008018783 A3 WO2008018783 A3 WO 2008018783A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hpd
- gamma
- solutions
- fluorescence
- rays
- Prior art date
Links
- 238000001228 spectrum Methods 0.000 title abstract 3
- 230000004913 activation Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000004032 porphyrins Chemical class 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 230000005251 gamma ray Effects 0.000 abstract 2
- 239000005361 soda-lime glass Substances 0.000 abstract 2
- 208000032612 Glial tumor Diseases 0.000 abstract 1
- 206010018338 Glioma Diseases 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000005865 ionizing radiation Effects 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 230000010355 oscillation Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
It is proved that hematoporphyrine derivatives (HpD) may be activated not only by visible or ultraviolet light, but also by electromagnetic oscillations of shorter wave length. While irradiating HpD solutions of different concentration with 405 nm light, we can see a visible crimson fluorescence. If at first HpD solutions (1 ml, 0,00001-0,0008 mg/ml) are irradiated by gamma rays (2 Gy, source - 60Co),and then are irradiated by 405 nm blue light, the fluorescence disappears. If to cover the said HpD solutions with calcium soda- lime glass at the time of gamma rays action, the fluorescence remains. The rats that were vaccinated with glioma C6, after injection of HpD and affecting the tumours with small gamma ray dose, a statistically reliable cured tumour regression was observed. During the time of irradiation the covered with calcium soda lime glass tumour growth was not impeded and the effect of treatment would disappear. The results let come to the conclusion that HpD is activated by those ionizing radiation spectrum rays that correspond positrons annihilation gamma quantum line 0,511 MeV in 60Co energetical gamma spectrum. With quantum of this energy, to activate HpD, only 0,020,2 Gy gamma ray dose is needed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07793797A EP2124936A2 (en) | 2006-08-11 | 2007-08-10 | Porphyrin activation by different spectrum electromagnetical waves-new malignant tumour treatment possibilities |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2006070A LT5434B (en) | 2006-08-11 | 2006-08-11 | Activation of porphyrins with bands of different electromagnetic spectra - new possibilities in the treatment of malignant tumors |
| LT2006070 | 2006-08-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2008018783A2 WO2008018783A2 (en) | 2008-02-14 |
| WO2008018783A3 true WO2008018783A3 (en) | 2008-04-03 |
| WO2008018783B1 WO2008018783B1 (en) | 2008-05-22 |
Family
ID=38038441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/LT2007/000006 WO2008018783A2 (en) | 2006-08-11 | 2007-08-10 | Porphyrin activation by different spectrum electromagnetical waves-new malignant tumour treatment possibilities |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2124936A2 (en) |
| LT (1) | LT5434B (en) |
| WO (1) | WO2008018783A2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003094767A1 (en) * | 2002-03-25 | 2003-11-20 | The General Hospital Corporation | Methods of adjuvant photodynamic therapy to enhance radiation sensitization |
-
2006
- 2006-08-11 LT LT2006070A patent/LT5434B/en not_active IP Right Cessation
-
2007
- 2007-08-10 EP EP07793797A patent/EP2124936A2/en not_active Withdrawn
- 2007-08-10 WO PCT/LT2007/000006 patent/WO2008018783A2/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003094767A1 (en) * | 2002-03-25 | 2003-11-20 | The General Hospital Corporation | Methods of adjuvant photodynamic therapy to enhance radiation sensitization |
Non-Patent Citations (10)
| Title |
|---|
| BLOZNELTE-PLESNIENE L ET AL: "Gammadynamic treatment in advanced malignant tumors", MEDICINA, KAUNO MEDICINOS UNIVERSITETAS (KAUNAS UNIVERSITY OF MEDICINE),, LT, vol. 38, no. 2, 2002, pages 186 - 189, XP008086158, ISSN: 1010-660X * |
| DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1988, KOSTRON H ET AL: "PHOTODYNAMIC THERAPY IS POTENTIATED BY COBALT-60 AND INTRATUMORAL INJECTION OF HEMATOPORPHYRIN DERIVATIVE", XP002464824, Database accession no. PREV198987018676 * |
| JOURNAL OF NEURO-ONCOLOGY, vol. 6, no. 2, 1988, pages 185 - 192, ISSN: 0167-594X * |
| KAVARNOS G ET AL: "VISIBLE-LIGHT AND X IRRADIATIONS OF CHINESE HAMSTER LUNG CELLS TREATED WITH HEMATOPORPHYRIN DERIVATIVE", RADIATION RESEARCH, ACADEMIC PRESS INC, US, vol. 137, no. 2, January 1994 (1994-01-01), pages 196 - 201, XP001005337, ISSN: 0033-7587 * |
| KOSTRON H ET AL: "THE INTERACTION OF HERMATOPORPHYRIN DERIVATIVE, LIGHT, AND IONIZINGRADIATION IN A RAT GLIOMA MODEL", CANCER, AMERICAN CANCER SOCIETY, PHILADELPHIA, PA, US, vol. 57, no. 5, 1 March 1986 (1986-03-01), pages 964 - 970, XP001005504, ISSN: 0008-543X * |
| LUKSIENE Z ET AL: "On the combination of photodynamic therapy with ionizing radiation.", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY. B, BIOLOGY 1999 SEP-OCT, vol. 52, no. 1-3, September 1999 (1999-09-01), pages 35 - 42, XP001005453, ISSN: 1011-1344 * |
| LUKSIENE ZIVILE ET AL: "Radiosensitization of tumours by porphyrins", CANCER LETTERS, vol. 235, no. 1, April 2006 (2006-04-01), pages 40 - 47, XP002464823, ISSN: 0304-3835 * |
| LUKSIENE ZIVILE: "Experimental evidence on possibility to radiosensitize aggressive tumors by porphyrins.", MEDICINA (KAUNAS, LITHUANIA) 2004, vol. 40, no. 9, 2004, pages 868 - 874, XP008086167, ISSN: 1648-9144 * |
| ORTALLI I ET AL: "Combined effects of hematin and Mossbauer gamma rays in the inhibition of osteosarcoma cell proliferation", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 18, no. 6C, November 1998 (1998-11-01), pages 4925, XP008086506, ISSN: 0250-7005 * |
| SCHAFFER M ET AL: "Photofrin II as an efficient radiosensitizing agent in an experimental tumor", ONKOLOGIE, vol. 24, no. 5, 2001, pages 482 - 485, XP008087420, ISSN: 0378-584X * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008018783A2 (en) | 2008-02-14 |
| EP2124936A2 (en) | 2009-12-02 |
| LT2006070A (en) | 2007-04-25 |
| WO2008018783B1 (en) | 2008-05-22 |
| LT5434B (en) | 2007-07-25 |
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