WO2008013477A2 - Dry nutrient mixture for nutritional diet - Google Patents
Dry nutrient mixture for nutritional diet Download PDFInfo
- Publication number
- WO2008013477A2 WO2008013477A2 PCT/RU2007/000382 RU2007000382W WO2008013477A2 WO 2008013477 A2 WO2008013477 A2 WO 2008013477A2 RU 2007000382 W RU2007000382 W RU 2007000382W WO 2008013477 A2 WO2008013477 A2 WO 2008013477A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mixture according
- mixture
- protein
- vegetable protein
- type
- Prior art date
Links
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 11
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
Definitions
- the technical field relates to the field of specialized dietetic nutrition, in particular to dry nutritional mixtures, which can be used in preventive, specialized and sports nutrition, as well as in various conditions requiring correction of metabolic disorders.
- soy protein a hydrated alkaline earth metal phosphate gel
- the known food mixture does not provide the necessary intake of macro- and micronutrients, which does not allow the correction of protein-energy imbalance in the proper volume and quality.
- the basis of the invention is the task of improving the quality of correction and prevention of protein-energy imbalance with a decrease in the level of possible multivalent complications.
- a dry nutritional mixture for dietetic nutrition contains at least one vegetable protein, one water-soluble fat, one carbohydrate, one emulsifier, one flavoring additive, as well as dietary fiber, succinic acid, L - carnitine and / or its derivatives, selenium on an organic carrier (selenspirulina) and vitamin premix in the following ratio of components in 100 g of product: [g] vegetable protein - 17.0-61.0 water-soluble fat - 2.0-8.0 carbohydrate - 20, 0-40.0 emulsifier - 0.1-0.5 flavoring - 0.1-0.8 food fiber fibers - 10.0-50.0 succinic acid - 0.1-1.0
- the mixture additionally contains lactose-free milk protein, which in the composition with vegetable protein can be 17.0-61.0 g per 100 g of product.
- the mixture may additionally contain enzymes to improve the breakdown of nutrients in the gastrointestinal tract, one drug to enhance intestinal motility, and also at least one probiotic to stimulate the immune system, and / or additionally contains biologically active substances, for example , pollen, and as a medicine, extracts of medicinal plants in gelatin or chitosan microcapsules are used, and the mixture can be made in any minutes acceptable for consumption in the form of a dry powder mixture, granules, tablets, capsules or the bar, and the mixture may further comprise sodium carboxymethylcellulose.
- the essence of the invention lies in the fact that the presence in the mixture of the above components allows us to ensure the quality of correction of protein-energy imbalance, since the components used in the mixture complement and enhance the actions of each other.
- plant proteins of the Cypo type are balanced sources of amino acids with a high degree of digestibility, dietary fibers, for example, Fiber, normalize the motor activity of the gastric tract, maintain normal intestinal microflora and have pronounced sorbicanal properties, and L - Cornitin is involved in the energy supply of muscle tissue and normalizes fat metabolism.
- Carbohydrate provides a non-protein calorie composition.
- Water-soluble fat is a source of polyunsaturated fatty acids omega-3, omega-6 and medium chain triglycerides, easily hydrolyzed by pancreatic lipase, and most of them do not need hydrolysis before adsorption. They are absorbed directly into the blood vessels of the portal vein, bypassing the lymphatic system; do not need emulsification with bile acids; quickly oxygenated in tissues. As a result, triglycerides do not enter the adipose tissue, which has a therapeutic and prophylactic effect and prevents obesity. Water-soluble fat is an affordable source of calories in malnourished patients with impaired all stages of fat absorption.
- the antioxidant in the form of selenium plays a significant role in inhibiting the formation of free radicals, which are the most universal pathological mechanisms that underlie most diseases, such as cardiovascular. Activation of the lipid peroxidation of cell membranes is accompanied by an increase in the permeability and fluidity of the latter. Under conditions of increased permeability and instability of the membranes of cardiomyocytes, endothelial and smooth muscle cells of blood vessels, a transdermal exchange of ions occurs, and in particular, excessive accumulation of excitability of cardiomyocytes and vascular cells and, consequently, a tendency to arrhythmias, as well as hypertensive reactions of the vascular system.
- composition of the nutrient mixture of organic compounds of selenium for example, selenocysteine or selenomethionine provides: A) the normal synthesis of the selenium-induced enzyme glutathione peroxidase (GPX) - the main enzyme of the antioxidant defense of the body cells.
- GPX glutathione peroxidase
- flavoring additives known food additives that improve taste can be used, for example, the aromatic additive “Lemon”, “Apelsin”, “Banana”, “Exotic”, etc.
- the composition contains at least one, vitamin A 5 D, E, Ki, C, group B, Biotin PPi, folic acid, choline and / or a mixture thereof, as well as trace elements such as Na, Ca, P, K, Fe and others.
- Succinic acid is a universal intermediate metabolite of cells, increases the body's resistance to the negative effects of the external and internal environment, reduces the energy deficit of the body.
- Succinic acid is a powerful source of reducing equivalents, protons and electrons in mitochondria, promotes rapid resynthesis of adenosine triphosphoric acid (ATP), activating the reactions of the tricarboxylic acid cycle.
- succinic acid is also a signaling substance in the body.
- Vnemitochondrial succinic acid has a cardiotonic effect, activating the neurohumoral system, facilitates the release of oxygen oxyhemoglobin, has antioxidant and antiketogenic effects.
- the ratio of the components of the claimed food mixture is selected depending on the implementation of the appointment or condition of the patient. So, with the effective regulation of excessive appetite and cravings for food, they provide a relatively high concentration of nutrients in combination with a significant content of dietary fiber, the volume of which irritates the mechanoreceptors of the stomach with a feeling of its expansion. When implementing the therapeutic purpose of this mixture in a particular state, appropriate concentrations of the components are selected to regulate a particular biochemical reaction and physiological functions.
- Such a mixture is a food composition including vegetable protein, a carbohydrate, for example, malto dextrin, water-soluble fat, flavoring agent, calcium lactic acid, vitamin mixture, magnesium oxide, succinic acid, selenium on the original carrier, L - carnitine.
- This food composition can be performed by simply mixing the components in the form of a dry powder mixture, granules, tablets, bar or capsule, etc. It is readily soluble in water and therefore can be used when diluted with water as a protein drink.
- the mixture may additionally contain the following components: milk-free lactose-free protein, which together with vegetable protein can be 17-61 g per 100 g of product, enzymes - to improve the breakdown of nutrients in the gastrointestinal tract, at least one drug to enhance intestinal motility as at least one probiotic to stimulate the immune system, biologically active substances, for example, pollen.
- Proteins of the Cypo type or of dairy origin are a concentrated source of complete protein, similar in composition to an "ideal" protein and meet the requirements of the FAO / WHO for replaceable and irreplaceable amino acids (adjusted amino acid coefficient of protein digestibility - 1.0 ie maximum possible).
- Dietary fibers are non-fermentable fibers, (for example, lignins), which attract liquid into the intestinal lumen, and / or fermentable pectins, which have sorption and bifidogenic effects, are metabolized by intestinal bacteria to form short chain fatty carboxylic acids (acetic, propionic and butyric acid). Metabolized acids are a source of energy for the colon mucosa.
- Example 1 The formulation of the dry nutrient mixture (in 100 g of product): [g]
- the aromatic additive can be replaced with any other aromatic additive, for example, Exotic, Vanilla, Lemon, Apelsin, etc.
- Example 2 The recipe for a dry protein drink (in 100 g of product): [g]
- the aromatic additive can be replaced with any other aromatic additive, for example, Exotic, Vanilla, Banana, Orange, etc.
- This food composition is the most balanced source of essential and non-essential amino acids, and can be used for dietetic nutrition, including with a low-protein diet.
- these compositions are mixed in examples 1 and 2 in a certain ratio, a mixture is formed that is balanced by macro- and micronutrients of nutrition, which can be used as a full-fledged main nutrition.
- Example 3 A simple mixture of the components to prepare a mixture comprising 100 g of product: [g]
- soy protein isolate "SUPRO X-T 10" 19.0
- SUPRO X-T 10 soy protein isolates are high-quality proteins that are fully absorbed by the body (adjusted amino acid coefficient of protein digestibility
- the aromatic additive can be replaced with any other aromatic additive, for example Exotic,
- compositions A wide spectrum of action of the composition is achieved by the additional introduction of probiotics into the claimed composition - a live culture of lactobacilli and bifidobacteria, as well as herbal medicines, for example, diuretics, choleretic, other drugs and / or dry extracts or liquid extracts of medicinal plants microencapsulated in gelatin or chitosan.
- L-carnitine and / or its derivatives (for example, propionylcarnitine, acetylcarnitine, palmitoylcarnitine) play an important role in providing energy to the myocardium.
- the claimed composite mixture has a multidirectional effect and is a balanced source of interchangeable and irreplaceable amino acids.
- the stated advantages of the proposed nutritional nutrition based on the claimed mixture can improve the quality of prevention and correction of protein-energy imbalance with a decrease in the level of possible multivalent complications.
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Abstract
Description
СУХАЯ ПИТАТЕЛЬНАЯ СМЕСЬ ДЛЯ ДИЕТОЛОГИЧЕСКОГО ПИТАНИЯ DRY NUTRITION MIXTURE FOR DIETOLOGICAL FOOD
Область техники Изобретение относится к области специализированного диетологического питания, в частности к сухим питательным смесям, которые могут применяться при профилактическом, специализированном и спортивном питании, а также при различных состояниях, требующих коррекции метаболических нарушений. Предшествующий уровень техникиThe technical field The invention relates to the field of specialized dietetic nutrition, in particular to dry nutritional mixtures, which can be used in preventive, specialized and sports nutrition, as well as in various conditions requiring correction of metabolic disorders. State of the art
Разработки в области лечебно-профилактического питания из биологически активных веществ дали широкий толчок глубоким исследованиям самых различных макро- и микронутриентов. За последнее время список биологически активных компонентов лечебно- профилактического питания пополнился сотнями новых наименований, из которых создаются новые композиции для диетологического и терапевтического питания.Developments in the field of therapeutic and prophylactic nutrition from biologically active substances have given a wide impetus to in-depth studies of a wide variety of macro and micronutrients. Recently, the list of biologically active components of therapeutic and prophylactic nutrition has replenished with hundreds of new items, from which new compositions for dietetic and therapeutic nutrition are created.
В настоящее время известны пищевые ингредиенты для введения в рацион питания человека, в качестве которых используют комплекс витаминов. Недостатком данных ингредиентов является невозможность корректировки пластического обмена, возможное нарушение микробиоценоза, а также отсутствие эффекта энергообразования и энергоутилизации, что может привести к снижению активности обменных процессов и истощению организма. Кроме того, при использовании данных витаминных ингредиентов не происходит необходимой колонизационной резистентности кишечного барьера в экстремальных ситуациях, что повышает риск инфекционной патологии.Currently known food ingredients for introduction into the human diet, which use a complex of vitamins. The disadvantage of these ingredients is the inability to adjust plastic metabolism, a possible violation of microbiocenosis, as well as the lack of the effect of energy production and energy recovery, which can lead to a decrease in the activity of metabolic processes and depletion of the body. In addition, when using these vitamin ingredients, the necessary colonization resistance of the intestinal barrier does not occur in extreme situations, which increases the risk of infectious pathology.
По технической сущности наиболее близкой к заявляемой сухой питательной смеси является пищевая смесь на основе водорастворимых комплексов соевого белка, включающая соевый белок и гидратированный гель фосфата щелочноземельного металла (ПатентAccording to the technical nature of the closest to the claimed dry nutrient mixture is a food mixture based on water-soluble soy protein complexes, including soy protein and a hydrated alkaline earth metal phosphate gel (Patent
РФ JNО 2032353, кл. A23JЗ/00 от 02.02.1987 г.)RF JNO 2032353, class A23JЗ / 00 02.02.1987)
Однако известная пищевая смесь не обеспечивает необходимое поступление макро- и микронутриентов, что не позволяет в должном объёме и качестве проводить коррекцию белково-энергетического дисбаланса.However, the known food mixture does not provide the necessary intake of macro- and micronutrients, which does not allow the correction of protein-energy imbalance in the proper volume and quality.
Раскрытие изобретенияDisclosure of invention
В основу изобретения поставлена задача улучшения качества коррекции и профилактики белково-энергетического дисбаланса со снижением уровня возможных поливалентных осложнений.The basis of the invention is the task of improving the quality of correction and prevention of protein-energy imbalance with a decrease in the level of possible multivalent complications.
Для решения этой технической задачи сухая питательная смесь для диетологического питания содержит как минимум: один растительный белок, один водорастворимый жир, один из углеводов, один эмульгатор, одну вкусовую добавку, а так же пищевые волокна, янтарную кислоту, L - карнитин и/или его производные, селен на органическом носителе (селенспирулина) и витаминеральный премикс при следующем соотношении компонентов в 100 г. продукта: [г.] растительный белок — 17,0-61,0 водорастворимый жир - 2,0-8,0 углевод - 20,0-40,0 эмульгатор — 0,1-0,5 вкусовая добавка - 0,1-0,8 пищевые волокна — 10,0-50,0 янтарная кислота - 0,1-1,0To solve this technical problem, a dry nutritional mixture for dietetic nutrition contains at least one vegetable protein, one water-soluble fat, one carbohydrate, one emulsifier, one flavoring additive, as well as dietary fiber, succinic acid, L - carnitine and / or its derivatives, selenium on an organic carrier (selenspirulina) and vitamin premix in the following ratio of components in 100 g of product: [g] vegetable protein - 17.0-61.0 water-soluble fat - 2.0-8.0 carbohydrate - 20, 0-40.0 emulsifier - 0.1-0.5 flavoring - 0.1-0.8 food fiber fibers - 10.0-50.0 succinic acid - 0.1-1.0
L - карнитин и/или его производные - 0,2-0,9 селен - 0,04-0,5 витаминеральный премикс - 0,2-1,0 , (витамины + микpoэлeмeнты),пpичeм в качестве растительного белка -растительный белок типа «Cynpo».L - carnitine and / or its derivatives - 0.2-0.9 selenium - 0.04-0.5 vitamin premix - 0.2-1.0, (vitamins + trace elements), moreover, as a vegetable protein, a vegetable protein of the Cynpo type.
Помимо этого, смесь дополнительно содержит молочный безлактозный белок, который в составе с растительным белком может составлять 17,0-61,0 г в 100 г продукта.In addition, the mixture additionally contains lactose-free milk protein, which in the composition with vegetable protein can be 17.0-61.0 g per 100 g of product.
Кроме того, смесь дополнительно может содержать ферменты для улучшения расщепления питательных веществ в желудочно- кишечном тракте, одно лекарственное средство для усиления перистальтики кишечника, а также дополнительно как минимум один пробиотик для стимуляции иммунной системы, и/или дополнительно содержит билогически-активные вещества, например, цветочную пыльцу, а в качестве лекарственного средства используются экстракты лекарственных растений в желатиновой или хитозановой микрокапсулах, причём смесь может быть выполнена в любой приемлемой для потребления форме в виде сухой порошковой смеси, гранулы, таблеток, батончика или капсулы, а также смесь может дополнительно содержать натриевую соль карбоксиметилцеллюлозы.In addition, the mixture may additionally contain enzymes to improve the breakdown of nutrients in the gastrointestinal tract, one drug to enhance intestinal motility, and also at least one probiotic to stimulate the immune system, and / or additionally contains biologically active substances, for example , pollen, and as a medicine, extracts of medicinal plants in gelatin or chitosan microcapsules are used, and the mixture can be made in any minutes acceptable for consumption in the form of a dry powder mixture, granules, tablets, capsules or the bar, and the mixture may further comprise sodium carboxymethylcellulose.
Сущность изобретения заключается в том, что наличие в составе смеси вышеописанных компонентов позволяет обеспечить качество коррекции белково-энергетического дисбаланса, так как используемые в смеси компоненты дополняют и усиливают действия друг друга.The essence of the invention lies in the fact that the presence in the mixture of the above components allows us to ensure the quality of correction of protein-energy imbalance, since the components used in the mixture complement and enhance the actions of each other.
При этом растительные белки типа «Cyпpo» являются сбалансированными источниками аминокислот с высокой степенью усвояемости, пищевые волокна, например, «Фибpим» нормализуют моторную активность желудочного тракта, поддерживают нормальную микрофлору кишечника и обладают выраженными сорбцианальми свойствами, а L - корнитин участвует в энергообеспечении мышечной ткани и нормализует жировой обмен. Углевод обеспечивает небелковую калорийность композиции.At the same time, plant proteins of the Cypo type are balanced sources of amino acids with a high degree of digestibility, dietary fibers, for example, Fiber, normalize the motor activity of the gastric tract, maintain normal intestinal microflora and have pronounced sorbicanal properties, and L - Cornitin is involved in the energy supply of muscle tissue and normalizes fat metabolism. Carbohydrate provides a non-protein calorie composition.
Водорастворимый жир является источником полиненасыщенных жирных кислот oмeгa-3, oмeгa-6 и среднецепочечных триглицеридов, легко гидролизуемые панкреатической липазой, а большая их часть не нуждается в гидролизе перед адсорбцией. Они всасываются непосредственно в кровеносные сосуды воротной вены, минуя лимфатическую систему; не нуждаются в эмульгации желчными кислотами; быстро оксигенируются в тканях. В результате триглицериды не поступают в жировую ткань, что оказывает лечебно- профилактическое действие и предупреждает ожирение. Водорастворимый жир служит доступным источником калорий у истощённых больных с нарушением всех стадий абсорбции жира.Water-soluble fat is a source of polyunsaturated fatty acids omega-3, omega-6 and medium chain triglycerides, easily hydrolyzed by pancreatic lipase, and most of them do not need hydrolysis before adsorption. They are absorbed directly into the blood vessels of the portal vein, bypassing the lymphatic system; do not need emulsification with bile acids; quickly oxygenated in tissues. As a result, triglycerides do not enter the adipose tissue, which has a therapeutic and prophylactic effect and prevents obesity. Water-soluble fat is an affordable source of calories in malnourished patients with impaired all stages of fat absorption.
Антиоксидант в виде селена играет существенную роль в ингибировании процессов образования свободных радикалов, которые являются самыми универсальными патологическими механизмами, лежащими в основе большинства заболеваний, таких, как сердечнососудистые. Активация перекисленного окисления липидов клеточных мембран сопровождается повышением проницаемости и текучести последних. В условиях повышенной проницаемости и нестабильности мембран кардиомиоцитов, эндотелиальных и гладкомышечных клеток сосудов происходит нарушение трансдермального обмена ионов, и в частности избыточное накопление возбудимости кардиомиоцитов и клеток сосудов и, соответственно, склонность к аритмиям, а также гипертензивным реакциям сосудистой системы.The antioxidant in the form of selenium plays a significant role in inhibiting the formation of free radicals, which are the most universal pathological mechanisms that underlie most diseases, such as cardiovascular. Activation of the lipid peroxidation of cell membranes is accompanied by an increase in the permeability and fluidity of the latter. Under conditions of increased permeability and instability of the membranes of cardiomyocytes, endothelial and smooth muscle cells of blood vessels, a transdermal exchange of ions occurs, and in particular, excessive accumulation of excitability of cardiomyocytes and vascular cells and, consequently, a tendency to arrhythmias, as well as hypertensive reactions of the vascular system.
Включение в состав питательной смеси органических соединений селена, например селеноцистеина или селенометионина обеспечивает: А) нормальный синтез селен-индуцированного фермента глутатионпероксидазы (GPX) — основного фермента антиоксидантной защиты клетки организма.The inclusion in the composition of the nutrient mixture of organic compounds of selenium, for example, selenocysteine or selenomethionine provides: A) the normal synthesis of the selenium-induced enzyme glutathione peroxidase (GPX) - the main enzyme of the antioxidant defense of the body cells.
Б) нормальный синтез селенпротеина P, биологической функцией которого, по современным представлениям , является защита от воздействия перекисей (оксидантного стресса), нейтрализация токсического действия тяжелых металлов.B) normal synthesis of selenoprotein P, the biological function of which, according to modern concepts, is to protect against the effects of peroxides (oxidative stress) and neutralize the toxic effects of heavy metals.
В качестве вкусовых добавок могут быть использованы известные пищевые добавки, улучшающие вкус, например, ароматическая добавка «Лимoн», «Aпeльcин», «Бaнaн», «Экзoтик» и т.п.As flavoring additives, known food additives that improve taste can be used, for example, the aromatic additive “Lemon”, “Apelsin”, “Banana”, “Exotic”, etc.
В качестве витаминной смеси композиция содержит, по крайней мере один, витамин A5 Д, E, Ki, С, группы В, Биотин PPi, фолиевую кислоту, холин и/или их смесь, а также микроэлементы такие как Na, Ca, P, К, Fe и другие.As a vitamin mixture, the composition contains at least one, vitamin A 5 D, E, Ki, C, group B, Biotin PPi, folic acid, choline and / or a mixture thereof, as well as trace elements such as Na, Ca, P, K, Fe and others.
Особенностями белков типа «Cyпpo» является содержание всех известных аминокислот в оптимальных соотношениях.Features of proteins of the type "Cypo" is the content of all known amino acids in optimal proportions.
Янтарная кислота является универсальным промежуточным метаболитом клеток, повышает резистентность организма к негативным воздействиям внешней и внутренней среды, уменьшает энергетический дефицит организма. Янтарная кислота является мощным источником восстановительных эквивалентов, протонов и электронов в митохондриях, способствует быстрому ресинтезу аденозинтрифосфорной кислоты (АТФ), активизируя реакции цикла трикарбоновых кислот. Кроме того, в организме янтарная кислота является и сигнальным веществом. Внемитохондриальная янтарная кислота обладает кардиотоническим действием, активируя нейрогуморальную систему, облегчает отдачу кислорода оксигемоглобином, обладает антиоксидантным и антикетогенным действием.Succinic acid is a universal intermediate metabolite of cells, increases the body's resistance to the negative effects of the external and internal environment, reduces the energy deficit of the body. Succinic acid is a powerful source of reducing equivalents, protons and electrons in mitochondria, promotes rapid resynthesis of adenosine triphosphoric acid (ATP), activating the reactions of the tricarboxylic acid cycle. In addition, succinic acid is also a signaling substance in the body. Vnemitochondrial succinic acid has a cardiotonic effect, activating the neurohumoral system, facilitates the release of oxygen oxyhemoglobin, has antioxidant and antiketogenic effects.
Соотношение компонентов заявленной пищевой смеси подбирается в зависимости от реализации назначения или состояния пациента. Так, при эффективном регулировании чрезмерного аппетита и тяги к пище, обеспечивают относительно высокую концентрацию нутриентов в сочетании со значительным содержанием пищевых волокон, объем которых вызывает раздражение механорецепторов желудка с чувством его расширения. При реализации терапевтического назначения данной смеси при каком-то конкретном состоянии подбирают соответствующие концентрации компонентов для регулирования той или иной биохимической реакции и физиологических функций.The ratio of the components of the claimed food mixture is selected depending on the implementation of the appointment or condition of the patient. So, with the effective regulation of excessive appetite and cravings for food, they provide a relatively high concentration of nutrients in combination with a significant content of dietary fiber, the volume of which irritates the mechanoreceptors of the stomach with a feeling of its expansion. When implementing the therapeutic purpose of this mixture in a particular state, appropriate concentrations of the components are selected to regulate a particular biochemical reaction and physiological functions.
Примером такой смеси служит пищевая композиция, включающая растительный белок, углевод, например, мальто декстрин, жир водорастворимый, вкусовую ароматическую добавку, кальций молочнокислый, витаминную смесь, оксид магния, янтарную кислоту, селен на оригинальном носителе, L - карнитин. Данная пищевая композиция может быть выполнена простым смешением компонентов в виде сухой порошковой смеси, гранул, таблеток, батончика или капсулы и т. п. Она легко растворима в воде и поэтому может быть использована при разведении её водой как белковый напиток. При этом смесь дополнительно может содержать следующие компоненты: молочный безлантозный белок, который в составе с растительным белком может составлять 17-61 г в 100 г продукта, ферменты - для улучшения расщепления питательных веществ в желудочно-кишечном тракте, как минимум одно лекарственное средство для усиления перистальтики кишечника, как минимум один пробиотик для стимуляции иммунной системы, билогически-активные вещества, например, цветочную пыльцу.An example of such a mixture is a food composition including vegetable protein, a carbohydrate, for example, malto dextrin, water-soluble fat, flavoring agent, calcium lactic acid, vitamin mixture, magnesium oxide, succinic acid, selenium on the original carrier, L - carnitine. This food composition can be performed by simply mixing the components in the form of a dry powder mixture, granules, tablets, bar or capsule, etc. It is readily soluble in water and therefore can be used when diluted with water as a protein drink. In this case, the mixture may additionally contain the following components: milk-free lactose-free protein, which together with vegetable protein can be 17-61 g per 100 g of product, enzymes - to improve the breakdown of nutrients in the gastrointestinal tract, at least one drug to enhance intestinal motility as at least one probiotic to stimulate the immune system, biologically active substances, for example, pollen.
Белки типа «Cyпpo» или молочного происхождения являются концентрированным источником полноценного белка, близким по составу к «идeaльнoмy» белку и удовлетворяющим требованиям ФАО/ВОЗ по заменимым и незаменимым аминокислотам (скорректированный аминокислотный коэффициент усвояемости белка - 1,0 т.е максимально возможный).Proteins of the Cypo type or of dairy origin are a concentrated source of complete protein, similar in composition to an "ideal" protein and meet the requirements of the FAO / WHO for replaceable and irreplaceable amino acids (adjusted amino acid coefficient of protein digestibility - 1.0 ie maximum possible).
Пищевые волокна представляют собой неферментируемые волокна, (например, лигнины), которые привлекают жидкость в просвет кишечника, и/или ферментируемые пектины, которые обладают сорбционным и бифидогенным действием, метаболизируются бактериями кишечника с образованием предельных карбоновых кислот жирного ряда с короткой цепью (уксусная, пропионовая и масляная кислоты). Метаболизированные кислоты являются источником энергии для слизистой оболочки толстой кишки.Dietary fibers are non-fermentable fibers, (for example, lignins), which attract liquid into the intestinal lumen, and / or fermentable pectins, which have sorption and bifidogenic effects, are metabolized by intestinal bacteria to form short chain fatty carboxylic acids (acetic, propionic and butyric acid). Metabolized acids are a source of energy for the colon mucosa.
Пример 1. Рецептура сухой питательной смеси (в 100 г продукта): [г.]Example 1. The formulation of the dry nutrient mixture (in 100 g of product): [g]
Простым смешением компонентов готовят смесь, содержащую: 1. белковый соевый изолят Супро Икс-Ти 10 58,5By simple mixing of the components, a mixture is prepared containing: 1. Protein soy isolate Supro X-Ti 10 58.5
2. жир водорастворимый 2,02. fat water-soluble 2.0
3. мальтодекстрин (углевод) 25,33. maltodextrin (carbohydrate) 25.3
4. пищевые соевые волокна Фибрим 2000 10,04. dietary soy fiber Fibrim 2000 10.0
5. молочный белок 2,3 6. витаминно-минеральный комплекс 0,65. milk protein 2.3 6. vitamin and mineral complex 0.6
7. ароматическая добавка «Бaнaн» 0,27. aromatic additive "Banana" 0.2
8. сукцинат натрия (янтарная кислота) 0,78. sodium succinate (succinic acid) 0.7
9. селенированная спирулина 0,19. selenized spirulina 0.1
10. эмульгатор 0,1 11. L-карнитин 0,210. emulsifier 0.1 11. L-carnitine 0.2
В данной рецептуре ароматическая добавка может быть заменена на любую другую ароматическую добавку, например, «Экзoтик», «Baниль», «Лимoн», «Aпeльcин» и т.д. Пример 2. Рецептура сухого белкового напитка (в 100 г продукта): [г.]In this recipe, the aromatic additive can be replaced with any other aromatic additive, for example, Exotic, Vanilla, Lemon, Apelsin, etc. Example 2. The recipe for a dry protein drink (in 100 g of product): [g]
Простым смешением компонентов готовят смесь, содержащую:By simple mixing of the components, a mixture is prepared containing:
1. растительный белок 17,01. vegetable protein 17.0
2. жир водорастворимый 8,0 3. мальтодекстрин (углевод) 25,52. water-soluble fat 8.0 3. maltodextrin (carbohydrate) 25.5
4. пищевые волокна Фибрим 2000 47,04. dietary fiber Fibrim 2000 47.0
5. витаминно-минеральный комплекс 0,35. vitamin and mineral complex 0.3
6. ароматическая добавка «Лимoн» 0,66. aromatic additive "Lemon" 0.6
7. сукцинат натрия (янтарная кислота) 0,5 8. селенированная спирулина 0,57. sodium succinate (succinic acid) 0.5 8. selenized spirulina 0.5
9. L - карнитин 0,59. L - carnitine 0.5
10.Эмульгатор 0, 110.Emulsifier 0, 1
В данной рецептуре ароматическая добавка может быть заменена на любую другую ароматическую добавку, например «Экзoтик», «Baниль», «Бaнaн», «aпeльcин» и т.д.In this recipe, the aromatic additive can be replaced with any other aromatic additive, for example, Exotic, Vanilla, Banana, Orange, etc.
Данная пищевая композиция является наиболее сбалансированным источником заменимых и незаменимых аминокислот, может применяться для диетологического питания, в том числе и при соблюдении малобелковой диеты. При смешении указанных композиций в примерах 1 и 2 в определенном соотношении образуется сбалансированная по макро- и микронутриентам питания смесь, которая может применяться в качестве полноценного основного питания. Пример 3. Простым смешением компонентов готовят смесь, включающую на 100 г продукта: [ г.]This food composition is the most balanced source of essential and non-essential amino acids, and can be used for dietetic nutrition, including with a low-protein diet. When these compositions are mixed in examples 1 and 2 in a certain ratio, a mixture is formed that is balanced by macro- and micronutrients of nutrition, which can be used as a full-fledged main nutrition. Example 3 A simple mixture of the components to prepare a mixture comprising 100 g of product: [g]
1. изолят белковый соевый «SUPRO X-T 10» 19,01. soy protein isolate "SUPRO X-T 10" 19.0
2. жир водорастворимый 8,0 3. мальтодекстрин (углевод) 34,02. water-soluble fat 8.0 3. maltodextrin (carbohydrate) 34.0
4. пищевые волокна «FIBRIM 2000» 37,54. dietary fiber "FIBRIM 2000" 37.5
5. витаминно-минеральный комплекс 0,25. vitamin and mineral complex 0.2
6. ароматическая добавка «Бaнaн» 0,16. aromatic additive "Banana" 0.1
7. янтарная кислота 0,5 8. селенированная спирулина 0,17. succinic acid 0.5 8. selenized spirulina 0.1
9. L - карнитин 0,59. L - carnitine 0.5
10. эмульгатор 0,110. emulsifier 0.1
Данная питательная смесь на основе изолята соевого белка «SUPRO X-T 10» с низким содержанием фосфатов, натрия, калия, обогащена витаминно-минеральным комплексом, пищевым волокнами и сукцинатом натрия. Изоляты соевого белка «SUPRO X-T 10» являются белками высокого качества, полностью усваиваются организмом (скорректированный аминокислотный коэффициент усвояемости белкаThis nutrient mixture based on SUPRO X-T 10 soy protein isolate with a low content of phosphates, sodium, potassium, is enriched with a vitamin-mineral complex, dietary fiber and sodium succinate. “SUPRO X-T 10” soy protein isolates are high-quality proteins that are fully absorbed by the body (adjusted amino acid coefficient of protein digestibility
- 1,0). В данной рецептуре ароматическая добавка может быть заменена на любую другую ароматическую добавку, например «Экзoтик»,- 1.0). In this recipe, the aromatic additive can be replaced with any other aromatic additive, for example Exotic,
«Baниль», «Лимoн», «Aпeльcин» и т.д.“Vanil”, “Lemon”, “Orange”, etc.
Широкий спектр действия композиции достигается дополнительным введением в заявленную композицию пробиотиков - живой культуры лактобацилл и бифидобактерий, а также растительных лекарственных средств, например, мочегонных, желчегонных, других препаратов и/или сухие экстракты или жидкие экстракты лекарственных растений микрокапсулированные в желатине или хитозане. L-карнитин и/или его производные (например, пропионилкарнитин, ацетилкарнитин, пальмитоилкарнитин) играют важную роль в обеспечении миокарда энергией. Они являются незаменимым фактором метаболизма жирных кислот, связываясь со свободными жирными кислотами, обеспечивают их перенос через мембрану митохондрий, внутри которых происходит бета-окисление жирных кислот с образованием субстратов цикла Кребса, являющегося основным источником энергии для миокарда, а также препятствуют избыточному накоплению свободных и этерифицированных жирных кислот в цитоплазме клетки. Достоверно установлено, что карнитин защищает миокард от ищемии, поддерживает достаточный уровень АТФ в сердечной мышце и увеличивают её сократительную способность, а также является важным фактором снижения риска развития атеросклероза и других сердечно-сосудистых заболеваний. Таким образом, заявленная композиционная смесь обладает разнонаправленным действием и является сбалансированным источником заменимых и незаменимых аминокислот. Клинические испытания показали, что регулярное питание смесями, созданными на основе данной композиции, снижает риск развития белково- энергетической недостаточности, поддерживает трофический гомеостаз, увеличивает элиминицию воды через кишечник, оказывает бифидогенное и гипохолестеринемическое действие, уменьшает фильтрационную нагрузку на почки в сравнении с продуктами животного происхождения. Промышленная применимостьA wide spectrum of action of the composition is achieved by the additional introduction of probiotics into the claimed composition - a live culture of lactobacilli and bifidobacteria, as well as herbal medicines, for example, diuretics, choleretic, other drugs and / or dry extracts or liquid extracts of medicinal plants microencapsulated in gelatin or chitosan. L-carnitine and / or its derivatives (for example, propionylcarnitine, acetylcarnitine, palmitoylcarnitine) play an important role in providing energy to the myocardium. They are an indispensable factor in the metabolism of fatty acids, binding to free fatty acids, ensure their transfer through the mitochondrial membrane, within which beta-oxidation of fatty acids occurs with the formation of substrates of the Krebs cycle, which is the main source of energy for the myocardium, and also prevent excessive accumulation of free and esterified fatty acids in the cytoplasm of a cell. It has been reliably established that carnitine protects the myocardium from ischemia, maintains a sufficient level of ATP in the heart muscle and increases its contractility, and is also an important factor in reducing the risk of developing atherosclerosis and other cardiovascular diseases. Thus, the claimed composite mixture has a multidirectional effect and is a balanced source of interchangeable and irreplaceable amino acids. Clinical trials have shown that regular nutrition with mixtures created on the basis of this composition reduces the risk of protein-energy deficiency, supports trophic homeostasis, increases elimination of water through the intestines, has a bifidogenic and hypocholesterolemic effect, and reduces the filtering load on the kidneys in comparison with animal products . Industrial applicability
Изложенные преимущества предлагаемого диетологического питания на основе заявленной смеси позволяют улучшить качество профилактики и коррекции белково-энергетического дисбаланса со снижением уровня возможных поливалентных осложнений. The stated advantages of the proposed nutritional nutrition based on the claimed mixture can improve the quality of prevention and correction of protein-energy imbalance with a decrease in the level of possible multivalent complications.
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| RU2438343C1 (en) * | 2010-10-18 | 2012-01-10 | Закрытое Акционерное Общество "Валетек Продимпэкс" | Dry protein mixture for preparation of cocktails for pregnant and nursing women |
| RU2612776C1 (en) * | 2015-12-04 | 2017-03-13 | Общество с ограниченной ответственностью "РЕБОРН" | Concentrate for vegetarian and dietary feeding |
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