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WO2008009895A3 - Matriptase-2 - Google Patents

Matriptase-2 Download PDF

Info

Publication number
WO2008009895A3
WO2008009895A3 PCT/GB2007/002598 GB2007002598W WO2008009895A3 WO 2008009895 A3 WO2008009895 A3 WO 2008009895A3 GB 2007002598 W GB2007002598 W GB 2007002598W WO 2008009895 A3 WO2008009895 A3 WO 2008009895A3
Authority
WO
WIPO (PCT)
Prior art keywords
matriptase
role
relates
prostate cancer
treating prostate
Prior art date
Application number
PCT/GB2007/002598
Other languages
French (fr)
Other versions
WO2008009895A2 (en
Inventor
Wen Guo Jiang
Malcolm David Mason
Original Assignee
Univ Cardiff
Wen Guo Jiang
Malcolm David Mason
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff, Wen Guo Jiang, Malcolm David Mason filed Critical Univ Cardiff
Publication of WO2008009895A2 publication Critical patent/WO2008009895A2/en
Publication of WO2008009895A3 publication Critical patent/WO2008009895A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21109—Matriptase (3.4.21.109)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the role of matriptase-2 in treating prostate cancer.
PCT/GB2007/002598 2006-07-18 2007-07-12 Matriptase-2 WO2008009895A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0614201.2 2006-07-18
GB0614201A GB0614201D0 (en) 2006-07-18 2006-07-18 Matriptase-2

Publications (2)

Publication Number Publication Date
WO2008009895A2 WO2008009895A2 (en) 2008-01-24
WO2008009895A3 true WO2008009895A3 (en) 2008-04-10

Family

ID=36955810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002598 WO2008009895A2 (en) 2006-07-18 2007-07-12 Matriptase-2

Country Status (2)

Country Link
GB (1) GB0614201D0 (en)
WO (1) WO2008009895A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4065607A1 (en) * 2019-11-29 2022-10-05 Kymab Limited Treatment for physiological iron overload
JP2023520969A (en) * 2020-04-07 2023-05-23 マブウェル セラピューティクス インコーポレイテッド Anti-TMPRSS6 antibody and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057194A2 (en) * 2000-02-03 2001-08-09 Corvas International, Inc. Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057194A2 (en) * 2000-02-03 2001-08-09 Corvas International, Inc. Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HOOPER J D ET AL: "Type II transmembrane serine proteases", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 276, no. 2, 12 January 2001 (2001-01-12), pages 857 - 860, XP002192577, ISSN: 0021-9258 *
HOOPER JOHN D ET AL: "MOUSE MATRIPTASE-2: IDENTIFICATION, CHARACTERIZATION AND COMPARATIVE MRNA EXPRESSION ANALYSIS WITH MOUSE HEPSIN IN ADULT AND EMBRYONIC TISSUES", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 373, no. 3, 1 August 2003 (2003-08-01), pages 689 - 702, XP009078644, ISSN: 0264-6021 *
NETZEL-ARNETT S ET AL: "MEMBRANE ANCHORED SERINE PROTEASES: A RAPIDLY EXPANDING GROUP OF CELL SURFACE PROTEOLYTIC ENZYMES WITH POTENTIAL ROLES IN CANCER", CANCER AND METASTASIS REVIEWS, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NL, vol. 22, no. 2/3, 2003, pages 237 - 258, XP009036432, ISSN: 0167-7659 *
PARR CHRISTIAN ET AL: "Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 JUN 2007, vol. 13, no. 12, 15 June 2007 (2007-06-15), pages 3568 - 3576, XP002464747, ISSN: 1078-0432 *
SANDERS AJ: "Alterations in the expression levels of matriptase-1 & 2 affect the invasive potential of prostate cancer cells", 24 February 2006, 2006 PROSTATE CANCER MEETING, XP002465360 *
VELASCO GLORIA ET AL: "MATRIPTASE-2, A MEMBRANE-BOUND MOSAIC SERINE PROTEINASE PREDOMINANTLY EXPRESSED IN HUMAN LIVER AND SHOWING DEGRADING ACTIVITY AGAINST EXTRACELLULAR MATRIX PROTEINS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 277, no. 40, 4 October 2002 (2002-10-04), pages 37637 - 37646, XP009078645, ISSN: 0021-9258 *
WILSON SUSAN ET AL: "The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells", BIOCHEMICAL JOURNAL, vol. 388, no. Part 3, June 2005 (2005-06-01), pages 967 - 972, XP002464746, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
WO2008009895A2 (en) 2008-01-24
GB0614201D0 (en) 2006-08-23

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