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WO2007128973A3 - Interleukin 1-receptor antagonist composition to treat restenosis - Google Patents

Interleukin 1-receptor antagonist composition to treat restenosis Download PDF

Info

Publication number
WO2007128973A3
WO2007128973A3 PCT/GB2007/001271 GB2007001271W WO2007128973A3 WO 2007128973 A3 WO2007128973 A3 WO 2007128973A3 GB 2007001271 W GB2007001271 W GB 2007001271W WO 2007128973 A3 WO2007128973 A3 WO 2007128973A3
Authority
WO
WIPO (PCT)
Prior art keywords
interleukin
receptor antagonist
treat restenosis
antagonist composition
restenosis
Prior art date
Application number
PCT/GB2007/001271
Other languages
French (fr)
Other versions
WO2007128973A2 (en
Inventor
Kadem Al-Lamee
Martyn Lott
Stuart Bayes
David Crossman
Allison Morton
Julian Gunn
Sheila Francis
Original Assignee
Polybiomed Ltd
Univ Sheffield
Kadem Al-Lamee
Martyn Lott
Stuart Bayes
David Crossman
Allison Morton
Julian Gunn
Sheila Francis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polybiomed Ltd, Univ Sheffield, Kadem Al-Lamee, Martyn Lott, Stuart Bayes, David Crossman, Allison Morton, Julian Gunn, Sheila Francis filed Critical Polybiomed Ltd
Publication of WO2007128973A2 publication Critical patent/WO2007128973A2/en
Publication of WO2007128973A3 publication Critical patent/WO2007128973A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A coating composition comprising a polymer and Interleukin I-Receptor Antagonst (IL- 1ra) which allows (IL- 1ra) to be eluted in vivo from a medical device whilst retaining its activity to treat restenosis.
PCT/GB2007/001271 2006-04-10 2007-04-05 Interleukin 1-receptor antagonist composition to treat restenosis WO2007128973A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0607189.8 2006-04-10
GB0607189A GB0607189D0 (en) 2006-04-10 2006-04-10 interleukin IL 1ra composition

Publications (2)

Publication Number Publication Date
WO2007128973A2 WO2007128973A2 (en) 2007-11-15
WO2007128973A3 true WO2007128973A3 (en) 2008-05-02

Family

ID=36539672

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/001271 WO2007128973A2 (en) 2006-04-10 2007-04-05 Interleukin 1-receptor antagonist composition to treat restenosis

Country Status (2)

Country Link
GB (1) GB0607189D0 (en)
WO (1) WO2007128973A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8753690B2 (en) 2008-02-27 2014-06-17 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
EP2620139B1 (en) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1 receptor antagonist rich solutions
AU2010292486B2 (en) * 2009-08-27 2014-08-07 Biomet Biologics, Llc Implantable device for production of interleukin-1 receptor antagonist
KR20140003398A (en) 2010-09-03 2014-01-09 바이오멧 바이오로직스, 엘엘씨 Methods and compositions for delivering interleukin-1 receptor antagonist
US9758806B2 (en) 2013-03-15 2017-09-12 Biomet Biologics, Llc Acellular compositions for treating inflammatory disorders
US9878011B2 (en) 2013-03-15 2018-01-30 Biomet Biologics, Llc Treatment of inflammatory respiratory disease using biological solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9833474B2 (en) 2013-11-26 2017-12-05 Biomet Biologies, LLC Methods of mediating macrophage phenotypes
US10441635B2 (en) 2014-11-10 2019-10-15 Biomet Biologics, Llc Methods of treating pain using protein solutions
US9763800B2 (en) 2015-03-18 2017-09-19 Biomet C. V. Implant configured for hammertoe and small bone fixation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024134A1 (en) * 1992-05-22 1993-12-09 Genta Incorporated Treatment of cellular hyperproliferation by inhibition of interleukin-1
EP0855404A1 (en) * 1997-01-28 1998-07-29 Smithkline Beecham Corporation Interleukin-1 receptor antagonist beta (il-1rabeta)
WO2004100987A2 (en) * 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat neointimal hyperplasia
WO2005018696A1 (en) * 2003-08-19 2005-03-03 Polybiomed Limited Polymeric drug release system for medical devices

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024134A1 (en) * 1992-05-22 1993-12-09 Genta Incorporated Treatment of cellular hyperproliferation by inhibition of interleukin-1
EP0855404A1 (en) * 1997-01-28 1998-07-29 Smithkline Beecham Corporation Interleukin-1 receptor antagonist beta (il-1rabeta)
WO2004100987A2 (en) * 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat neointimal hyperplasia
WO2005018696A1 (en) * 2003-08-19 2005-03-03 Polybiomed Limited Polymeric drug release system for medical devices

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALLISON C. MORTON, NADINE D. ARNOLD, JULIAN GUNN, RICHARD VARCOE, SHEILA E. FRANCIS, STEVEN K. DOWER, DAVID C. CROSSMAN: "Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model", CARDIOVASCULAR RESEARCH, vol. 68, 2005, pages 493 - 501, XP002470976 *

Also Published As

Publication number Publication date
GB0607189D0 (en) 2006-05-17
WO2007128973A2 (en) 2007-11-15

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