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WO2007112940A3 - Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same - Google Patents

Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same Download PDF

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Publication number
WO2007112940A3
WO2007112940A3 PCT/EP2007/002817 EP2007002817W WO2007112940A3 WO 2007112940 A3 WO2007112940 A3 WO 2007112940A3 EP 2007002817 W EP2007002817 W EP 2007002817W WO 2007112940 A3 WO2007112940 A3 WO 2007112940A3
Authority
WO
WIPO (PCT)
Prior art keywords
albumin
entities
life
amino acid
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/002817
Other languages
French (fr)
Other versions
WO2007112940A2 (en
Inventor
Hilde Adi Pierrette Revets
Hendricus Renerus J Hoogenboom
Els Beirnaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ablynx NV
Original Assignee
Ablynx NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx NV filed Critical Ablynx NV
Publication of WO2007112940A2 publication Critical patent/WO2007112940A2/en
Publication of WO2007112940A3 publication Critical patent/WO2007112940A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to albumin-derived amino acid sequences that can be used to increase the half-life of therapeutic proteins and of other therapeutic compounds and entities.
PCT/EP2007/002817 2006-03-31 2007-03-29 Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same Ceased WO2007112940A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78825606P 2006-03-31 2006-03-31
US60/788,256 2006-03-31

Publications (2)

Publication Number Publication Date
WO2007112940A2 WO2007112940A2 (en) 2007-10-11
WO2007112940A3 true WO2007112940A3 (en) 2008-01-03

Family

ID=38477256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/002817 Ceased WO2007112940A2 (en) 2006-03-31 2007-03-29 Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same

Country Status (1)

Country Link
WO (1) WO2007112940A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11447573B2 (en) 2016-07-20 2022-09-20 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009273251B2 (en) 2008-07-22 2014-12-18 Ablynx Nv Amino acid sequences directed against multitarget scavenger receptors and polypeptides
IT1392551B1 (en) * 2008-11-25 2012-03-09 Bioindustry Park Del Canavese S P A BIOMARCERS FOR DIAGNOSIS AND TO DETECT THE PROGRESSION OF NEURODEGENERATIVE DISEASES, IN PARTICULAR OF AMIOTROPHIC LATERAL SCLEROSIS
KR101722961B1 (en) 2009-02-11 2017-04-04 알부메딕스 에이/에스 Albumin variants and conjugates
AU2010234459A1 (en) * 2009-04-08 2011-11-03 The Regents Of The University Of California Human protein scaffold with controlled serum pharmacokinetics
ES2700230T3 (en) 2009-10-30 2019-02-14 Albumedix Ltd Albumin variants
EP2513145B1 (en) 2009-12-14 2018-01-24 Ablynx N.V. Single variable domain antibodies against ox40l, constructs and therapeutic use
WO2011083141A2 (en) 2010-01-08 2011-07-14 Ablynx Nv Method for generation of immunoglobulin sequences by using lipoprotein particles
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
US10233228B2 (en) 2010-04-09 2019-03-19 Albumedix Ltd Albumin derivatives and variants
KR20130080790A (en) 2010-05-20 2013-07-15 아블린쓰 엔.브이. Biological materials related to her3
EA202092589A3 (en) 2010-11-08 2021-06-30 Аблинкс Н.В. CXCR2-BINDING POLYPEPTIDES
JP6430828B2 (en) 2011-05-05 2018-11-28 アルブミディクス リミティド Albumin variant
UA117218C2 (en) 2011-05-05 2018-07-10 Мерк Патент Гмбх POLYPEPTIDE AGAINST IL-17A, IL-17F AND / OR IL17-A / F
SG195196A1 (en) 2011-05-27 2013-12-30 Dutalys Dual targeting
EP2726506A1 (en) 2011-05-27 2014-05-07 Dutalys Removal of monomeric targets
US20140315817A1 (en) 2011-11-18 2014-10-23 Eleven Biotherapeutics, Inc. Variant serum albumin with improved half-life and other properties
DK2825556T3 (en) 2012-03-16 2018-04-16 Albumedix As albumin Variants
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
RU2670063C2 (en) 2012-11-08 2018-10-17 Альбумедикс А/С Albumin variants
EP3337816B1 (en) 2015-08-20 2024-02-14 Albumedix Ltd Albumin variants and conjugates
WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
SG11202004158QA (en) 2017-12-28 2020-06-29 Nanjing Legend Biotech Co Ltd Single-domain antibodies and variants thereof against tigit
CA3084518A1 (en) 2018-01-15 2019-07-18 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against pd-1
KR102876940B1 (en) 2018-03-30 2025-10-24 난징 레전드 바이오테크 씨오., 엘티디. Single-domain antibodies to LAG-3 and uses thereof
CN110988361B (en) * 2019-12-13 2020-09-18 山东民康生物科技有限公司 Human serum albumin removing kit
EP4605077A1 (en) 2022-10-18 2025-08-27 Confo Therapeutics N.V. Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003060071A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2004041863A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003060071A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2004041863A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DOCKAL M ET AL: "The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 274, no. 41, 8 October 1999 (1999-10-08), pages 29303 - 29310, XP002990741, ISSN: 0021-9258 *
FASANO M ET AL: "The extraordinary ligand binding properties of human serum albumin", IUBMB LIFE, TAYLOR AND FRANCIS, LONDON,, GB, vol. 57, no. 12, December 2005 (2005-12-01), pages 787 - 796, XP009090343, ISSN: 1521-6543 *
GIBBS W W: "NANOBODIES", SCIENTIFIC AMERICAN, SCIENTIFIC AMERICAN INC., NEW YORK, NY, US, vol. 293, no. 2, August 2005 (2005-08-01), pages 67 - 71, XP001238880, ISSN: 0036-8733 *
KRAGH-HANSEN U: "Structure and ligand binding properties of human serum albumin", DANISH MEDICAL BULLETIN, DANISH MEDICAL ASSOCIATION, COPENHAGEN, DK, vol. 37, no. 1, 1990, pages 57 - 84, XP009090324, ISSN: 0007-8916 *
REVETS H ET AL: "NANOBODIES AS NOVEL AGENTS FOR CANCER THERAPY", EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 5, no. 1, 2005, pages 111 - 124, XP009076361, ISSN: 1471-2598 *
SMITH B J ET AL: "Prolonged in vivo residence times of antibody fragments associated with albumin", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 12, no. 5, September 2001 (2001-09-01), pages 750 - 756, XP002270731, ISSN: 1043-1802 *
WANG W ET AL: "AlbuBNP, a Recombinant B-Type Natriuretic Peptide and Human Serum Albumin Fusion Hormone, as a Long-Term Therapy of Congestive Heart Failure", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 21, no. 11, November 2004 (2004-11-01), pages 2105 - 2110, XP003014318, ISSN: 0724-8741 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11447573B2 (en) 2016-07-20 2022-09-20 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof

Also Published As

Publication number Publication date
WO2007112940A2 (en) 2007-10-11

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