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WO2007076320A8 - Compounds - Google Patents

Compounds

Info

Publication number
WO2007076320A8
WO2007076320A8 PCT/US2006/062224 US2006062224W WO2007076320A8 WO 2007076320 A8 WO2007076320 A8 WO 2007076320A8 US 2006062224 W US2006062224 W US 2006062224W WO 2007076320 A8 WO2007076320 A8 WO 2007076320A8
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
arthritis
invented
inhibitors
cancer
Prior art date
Application number
PCT/US2006/062224
Other languages
French (fr)
Other versions
WO2007076320A2 (en
WO2007076320A3 (en
Inventor
Toshihiro Hamajima
Hiroko Nakamura
Jun Tang
Original Assignee
Smithkline Beecham Corp
Toshihiro Hamajima
Hiroko Nakamura
Jun Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Toshihiro Hamajima, Hiroko Nakamura, Jun Tang filed Critical Smithkline Beecham Corp
Priority to JP2008547704A priority Critical patent/JP2009521490A/en
Priority to EP06840303A priority patent/EP1962851A2/en
Publication of WO2007076320A2 publication Critical patent/WO2007076320A2/en
Publication of WO2007076320A3 publication Critical patent/WO2007076320A3/en
Publication of WO2007076320A8 publication Critical patent/WO2007076320A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Invented are novel azaindole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
PCT/US2006/062224 2005-12-22 2006-12-18 Compounds WO2007076320A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008547704A JP2009521490A (en) 2005-12-22 2006-12-18 Compound
EP06840303A EP1962851A2 (en) 2005-12-22 2006-12-18 Compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75321705P 2005-12-22 2005-12-22
US60/753,217 2005-12-22

Publications (3)

Publication Number Publication Date
WO2007076320A2 WO2007076320A2 (en) 2007-07-05
WO2007076320A3 WO2007076320A3 (en) 2007-11-29
WO2007076320A8 true WO2007076320A8 (en) 2008-07-10

Family

ID=38218788

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/062224 WO2007076320A2 (en) 2005-12-22 2006-12-18 Compounds

Country Status (3)

Country Link
EP (1) EP1962851A2 (en)
JP (1) JP2009521490A (en)
WO (1) WO2007076320A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200738709A (en) * 2006-01-19 2007-10-16 Osi Pharm Inc Fused heterobicyclic kinase inhibitors
GB0804592D0 (en) * 2008-03-12 2008-04-16 Glaxo Group Ltd Novel compounds
JP5632379B2 (en) 2008-10-09 2014-11-26 アメリカ合衆国 Human pyruvate kinase activator
DE102008052943A1 (en) 2008-10-23 2010-04-29 Merck Patent Gmbh azaindole derivatives
JP2012527631A (en) * 2009-05-22 2012-11-08 ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンティド・バイ・ザ・セクレタリー・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシズ AKT phosphorylation at SER473 as an indicator for taxane-type chemotherapeutic agents
WO2011137089A1 (en) 2010-04-29 2011-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
EP3866807A1 (en) 2018-10-16 2021-08-25 F. Hoffmann-La Roche AG Use of akt inhibitors in ophthalmology

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
CN102786482A (en) * 2003-11-21 2012-11-21 阿雷生物药品公司 Akt protein kinase inhibitors
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
WO2007076320A2 (en) 2007-07-05
WO2007076320A3 (en) 2007-11-29
JP2009521490A (en) 2009-06-04
EP1962851A2 (en) 2008-09-03

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