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WO2007056905A1 - Hifu tumor ablating system - Google Patents

Hifu tumor ablating system Download PDF

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Publication number
WO2007056905A1
WO2007056905A1 PCT/CN2006/000322 CN2006000322W WO2007056905A1 WO 2007056905 A1 WO2007056905 A1 WO 2007056905A1 CN 2006000322 W CN2006000322 W CN 2006000322W WO 2007056905 A1 WO2007056905 A1 WO 2007056905A1
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WIPO (PCT)
Prior art keywords
hifu
treatment device
tumor ablation
hifu treatment
magnetic materials
Prior art date
Application number
PCT/CN2006/000322
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French (fr)
Chinese (zh)
Inventor
Jiwei Jiang
Jiaxian Dong
Haijin Ma
Yisheng Chen
Yong Zhou
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Shanghai A & S Science Technology Development Co., Ltd.
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Publication of WO2007056905A1 publication Critical patent/WO2007056905A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3806—Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/4814—MR combined with ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • A61B17/2258—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means integrated in a central portion of the shock wave apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI

Definitions

  • the invention relates to the field of tumor treatment, in particular to a HIFU tumor ablation system.
  • the MRI (Magnetic Resonance Imaging) system is an imaging technique that reconstructs an image by collecting signals generated by magnetic resonance phenomena.
  • the nucleus in the human tissue including the base proton or neutron, generally referred to as the proton of hydrogen
  • the RF pulse excites the hydrogen proton at a specific precession frequency, and the hydrogen proton that receives the excitation is in motion.
  • the energy released during the process of helium is the magnetic resonance signal.
  • the magnetic resonance signals are collected by a computer and converted into black and white gray scales according to the intensity of the signal.
  • the two-dimensional or three-dimensional form is formed by position, and the magnetic resonance image (MRI) is finally formed.
  • non-invasive real-time temperature measurement for patients can be achieved by using temperature-dependent parameter changes such as changes in hydrogen proton resonance frequency and spin lattice relaxation time in MRI.
  • the basic components of the MRI system are magnets, spectrometers, patient carriers, computer analysis software, and more.
  • the magnet has two basic structures, one is an open structure, and one magnetic material is placed on the upper and lower sides, and the main constant magnetic field generated is perpendicular to the ground, which is called an open MRI system;
  • the MRI system is a ring-shaped structure that produces a main constant magnetic field in a closed annulus, in which the patient is placed in the annulus.
  • HIFU High Intensity Focused Ultrasound
  • HIFU treatment devices also known as ultrasound transducers, transducer groups, wave sources, treatment heads, etc.
  • patient carriers for carrying patients computer control software, power generators, etc.
  • the basic treatment principle is that a single or multiple ultrasonic transducers emit an ultrasound beam, and the patient's external body is focused by the medium to the target region of the body, so that the ultrasonic intensity at the focus of the target region reaches several thousand or even tens of thousands of W/cm 2 .
  • the biological tissue at the focus of the target area produces intense mechanical vibration (relaxation) under the action of energy superposition, and continuously converts the ordered molecular vibration energy into disordered molecular thermal motion energy, that is, the mechanical energy is converted into thermal energy in the medium.
  • the temperature of the biological tissue at the focus of the target region rises to above 65 °C in an instant (0.1-ls), and the irreversible coagulative necrosis of the protein is rapidly caused.
  • HIFU tumor ablation therapy is a non-invasive, non-toxic and side-effect tumor treatment method.
  • HIFU treatment technology has been promoted by certain clinical applications. It has been confirmed that China is the earliest and largest number of clinically applied HIFU treatment technologies in the world, and is also the country with the largest number of products manufacturing systems.
  • the HIFU treatment system on the market adopts B-mode image guidance to implement positioning, and the system has fatal defects such as unclear imaging effect, inaccurate tumor positioning accuracy, and relatively poor safety and reliability.
  • the inability to perform non-invasive temperature measurement and real-time evaluation of imaging has become a problem for its clinical application.
  • the EXABLTE 2000 ultrasound treatment system produced by Israel INSIGHTEC company uses US 1.5 GE magnetic resonance imaging system to guide the positioning, and the imaging effect is clear and the tumor positioning is accurate.
  • the magnets are made of superconducting materials, and a circulating cooling device using liquid nitrogen is required, which makes the entire system too bulky, relatively cumbersome to operate, and expensive to manufacture.
  • the MRI system part of the HIFU system they use uses a traditional ring structure.
  • a HIFU tumor ablation system comprising at least one HIFU treatment device, further comprising an open MRI system, the magnetic material of the open MRI system being disposed perpendicular to the ground, the HIFU treatment device being disposed between the magnetic materials.
  • the direction of the main constant magnetic field of the MRI system is parallel to the ground.
  • the HIFU treatment device is an upper HIFU treatment device disposed between the magnetic materials of the open MRI system.
  • the HIFU treatment device can be an underlying HIFU treatment device disposed between the magnetic materials of the open M I system.
  • the HIFU tumor ablation system includes an upper HIFU treatment device disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device disposed between the magnetic materials of the open MRI system.
  • the upper HIFU treatment device is disposed on the upper portion between the magnetic materials by suspension or support.
  • the underlying HIFU treatment device is carried on the base of the HIFU tumor ablation system.
  • system further includes a patient carrying device coupled to the base by a lifting device, and The sealing device is connected to the underlying HIFU treatment device.
  • the patient carrying device is provided with an opening corresponding to the underlying HIFU treatment device.
  • the positive progress of the invention is as follows:
  • the invention combines the MRI technology and the HIFU technology into one body, and creatively changes the magnetic material of the MRI system from the traditional horizontal up and down to the vertical plane setting, so that the magnetic material is more convenient to install HIFU.
  • the treatment device solves the fundamental problems of precise positioning, non-invasive temperature measurement and therapeutic evaluation in the development and application of the B-type HIFU system by utilizing the MRI system precise positioning technology, real-time temperature change detection technology, and high-definition real-time image technology. It breaks through the development bottleneck of HIFU tumor ablation technology, makes HIFU treatment technology more secure, reliable, practical and credible, and it also has the advantages of low manufacturing cost and convenient use.
  • Figure 1 is a front elevational view showing a first embodiment of the present invention.
  • Fig. 2 is a side view showing the first embodiment of the present invention. detailed description
  • a HIFU tumor ablation system includes an open MRI system in which the magnetic materials 5, 6 are placed perpendicular to the ground, and the direction of the main constant magnetic field of the MRI system is parallel to the ground. Further comprising an upper HIFU treatment device 1 disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device 2 disposed between the magnetic materials of the open MRI system, further comprising a A patient carrying device 3 for carrying a patient.
  • the magnetic material 5, 6 is placed vertically on a horizontally placed base 4, and the MRI magnetic resonance imaging system has an open structure with an upward opening and a HIFU high intensity focused ultrasound system placed at the opening of the MRI magnetic resonance imaging system.
  • the upper HIFU treatment device 1 is suspended or supported in an upper portion between the magnetic materials 5, 6 above the patient carrying device 3, that is, above the patient.
  • the upper HIFU treatment device 1 is connected to the two magnetic materials 5, 6 via a bracket 8 and suspended above the patient carrying device 3.
  • the upper HIFU treatment device 1 is controlled to perform a positioning sway of ⁇ 90° along the axial and radial directions of the patient carrier 3.
  • the underlying HIFU treatment device 2 is located below the patient carrier device 3 and is disposed on the base 4 and connected to the patient carrier device 3 by a sealing material (not shown).
  • the patient carrier 3 is carried on a lifting device 9 connected to the base 4 of the HIFU tumor ablation system.
  • the lifting device 9 is disposed on the base 4, and the patient carrying device 3 is provided with an opening corresponding to the underlying HIFU treatment device 2 for use in the treatment of the lower HIFU treatment device 2.
  • the patient 7 is placed in the center of the magnetic field formed by the magnetic materials 5 and 6 of the MRI magnetic resonance imaging system to form an integrated MRI-guided HIFU tumor.
  • Ablation system to achieve the purpose of treating tumors.
  • Embodiment 2 differs from Embodiment 1 in that: the HIFU treatment device is an upper-mounted HIFU treatment device located above the patient carrier device, not shown, and the other structures of Embodiment 2 are the same as Embodiment 1, and Make a statement.
  • Embodiment 3 differs from Embodiment 1 in that: the HIFU treatment device is an underlying HIFU treatment device located below the patient carrier device, and is not shown.
  • the other structures of Embodiment 3 are the same as in Embodiment 1, and Make a statement.

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Theoretical Computer Science (AREA)
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Abstract

A HIFU tumor ablating system comprises at least a HIFU treatment means and an open-type MRI system. The magnetic material of the open-type MRI system is arranged vertical to the ground, and the HIFU treatment means is arranged between the magnetic materials. The MRI technology is combined with the HIFU technology; the common ground-parallel arrangement of the magnetic materials is changed to be a vertical arrangement.

Description

HIFU肿瘤消融系统 技术领域  HIFU tumor ablation system
本发明涉及一种肿瘤治疗领域， 特别涉及 HIFU肿瘤消融系统。 技术背景  The invention relates to the field of tumor treatment, in particular to a HIFU tumor ablation system. technical background
MRI (Magnetic Resonance Imaging磁共振成像） 系统是利用收集磁共振现象所产生 的信号而重建图像的成像技术。 人体组织中的原子核 （含基数质子或中子， 一般指氢质 子）， 在强磁场中磁化， 梯度场给予空间定位后， 射频脉冲激励特定进动频率的氢质子， 接受激励的氢质子在驰豫过程中释放出来的能量， 就是磁共振信号。 由计算机将磁共振 信号收集起来， 按信号强度的不同转换成黑白灰阶， 按位置组成二维或三维的形态， 最 终组成磁共振图像 （MRI)。 它具有无放射线损害、 无骨性伪影、 可以多方面、 多参数成 像、 髙度的软组织分辨能力的优点。 另外， 利用 MRI中的氢质子共振频率的改变和自旋 晶格驰豫时间等与温度有关的参数变化， 可实现对患者的无创实时测温。  The MRI (Magnetic Resonance Imaging) system is an imaging technique that reconstructs an image by collecting signals generated by magnetic resonance phenomena. The nucleus in the human tissue (including the base proton or neutron, generally referred to as the proton of hydrogen) is magnetized in a strong magnetic field. After the gradient field gives spatial localization, the RF pulse excites the hydrogen proton at a specific precession frequency, and the hydrogen proton that receives the excitation is in motion. The energy released during the process of helium is the magnetic resonance signal. The magnetic resonance signals are collected by a computer and converted into black and white gray scales according to the intensity of the signal. The two-dimensional or three-dimensional form is formed by position, and the magnetic resonance image (MRI) is finally formed. It has the advantages of no radiation damage, boneless artifacts, multi-faceted, multi-parametric imaging, and soft tissue resolution. In addition, non-invasive real-time temperature measurement for patients can be achieved by using temperature-dependent parameter changes such as changes in hydrogen proton resonance frequency and spin lattice relaxation time in MRI.
MRI系统的基本组成部件有磁体、 波谱仪、 患者承载装置、 计算机分析软件等。 目 前所使用的 MRI系统， 其磁体大体上有两种结构形式， 一种为开放式结构， 上下各设置 一个磁性材料， 所产生的主恒定磁场垂直于地面， 称为开放式 MRI系统； 另一种 MRI 系统为环形结构， 在一个封闭的环形空间产生主恒定磁场， 使用时， 需将患者置于该环 形空间内。  The basic components of the MRI system are magnets, spectrometers, patient carriers, computer analysis software, and more. In the MRI system currently used, the magnet has two basic structures, one is an open structure, and one magnetic material is placed on the upper and lower sides, and the main constant magnetic field generated is perpendicular to the ground, which is called an open MRI system; The MRI system is a ring-shaped structure that produces a main constant magnetic field in a closed annulus, in which the patient is placed in the annulus.
HIFU (High Intensity Focused Ultrasound高强度聚焦超声）肿瘤消融系统的基本组成 部分有： HIFU治疗装置 （又称超声换能器、 换能器组、 波源、 治疗头等)、 用于承载患 者的患者承载装置、 计算机控制软件、 功率发生器等。  The basic components of the HIFU (High Intensity Focused Ultrasound) tumor ablation system are: HIFU treatment devices (also known as ultrasound transducers, transducer groups, wave sources, treatment heads, etc.), patient carriers for carrying patients , computer control software, power generators, etc.
其基本治疗原理是由单个或者是多个超声换能器发出超声束， 由患者体外经媒介向 体内靶区进行聚焦， 使得靶区焦点处的超声声强达到几千甚至几万 W/cm2， 靶区焦点处 的生物组织在能量叠加的作用下产生剧烈的机械振动（驰豫）， 不断地把有序的分子震动 能量转化成无序的分子热运动能量， 即机械能转换为介质中的热能， 使靶区焦点处生物 组织的温度在瞬间 （0.1-ls)上升到 65°C以上， 迅速使蛋白质发生不可逆的凝固性坏死。 因为在如此短的时间内， 非靶区组织几乎不会受到 HIFU损伤， 所以能达到无创 "消融" (ablation) 肿瘤的目的。 HIFU肿瘤消融治疗技术是一种无创、 无毒副作用的肿瘤治疗 方法， 近年来已成为国际学术界的研究热点， 并且在医学界得到日趋广泛的应用。 HIFU治疗技术已经得到了一定的临床应用推广， 目前已证实中国是世界上临床应用 HIFU治疗技术最早、 数量最多的国家， 也是生产制造该系统产品企业最多的国家。 The basic treatment principle is that a single or multiple ultrasonic transducers emit an ultrasound beam, and the patient's external body is focused by the medium to the target region of the body, so that the ultrasonic intensity at the focus of the target region reaches several thousand or even tens of thousands of W/cm 2 . The biological tissue at the focus of the target area produces intense mechanical vibration (relaxation) under the action of energy superposition, and continuously converts the ordered molecular vibration energy into disordered molecular thermal motion energy, that is, the mechanical energy is converted into thermal energy in the medium. The temperature of the biological tissue at the focus of the target region rises to above 65 °C in an instant (0.1-ls), and the irreversible coagulative necrosis of the protein is rapidly caused. Because in such a short period of time, the non-target tissue is hardly damaged by HIFU, so the purpose of non-invasive "ablation" of the tumor can be achieved. HIFU tumor ablation therapy is a non-invasive, non-toxic and side-effect tumor treatment method. In recent years, it has become a research hotspot in the international academic community, and has been widely used in the medical field. HIFU treatment technology has been promoted by certain clinical applications. It has been confirmed that China is the earliest and largest number of clinically applied HIFU treatment technologies in the world, and is also the country with the largest number of products manufacturing systems.
目前市场上的 HIFU治疗系统均采用 B超图像引导实施定位， 系统存在着成像效果 不清晰、 肿瘤定位精度不准确、 安全可靠性相对较差等致命的缺陷。 另外， 无法进行无 创测温、 影像学实时疗效评估， 也已成为其临床应用的困扰。  At present, the HIFU treatment system on the market adopts B-mode image guidance to implement positioning, and the system has fatal defects such as unclear imaging effect, inaccurate tumor positioning accuracy, and relatively poor safety and reliability. In addition, the inability to perform non-invasive temperature measurement and real-time evaluation of imaging has become a problem for its clinical application.
以色列 INSIGHTEC公司生产的 EXABLTE 2000型超声治疗系统釆用美国 GE公司 的 1.5T磁共振成像系统引导定位， 成像效果清晰， 肿瘤定位准确。 但由于使用的是高场 MRI系统， 其磁体选用超导材料制成， 且须要使用液氮的循环冷却装置， 使得整个系统 过于膨大， 操作相对繁琐， 制造成本昂贵。 并且他们使用的 HIFU系统中 MRI系统部分 采用传统的环形结构。 发明内容  The EXABLTE 2000 ultrasound treatment system produced by Israel INSIGHTEC company uses US 1.5 GE magnetic resonance imaging system to guide the positioning, and the imaging effect is clear and the tumor positioning is accurate. However, due to the use of a high-field MRI system, the magnets are made of superconducting materials, and a circulating cooling device using liquid nitrogen is required, which makes the entire system too bulky, relatively cumbersome to operate, and expensive to manufacture. And the MRI system part of the HIFU system they use uses a traditional ring structure. Summary of the invention
本发明的目的在于克服上述现有技术的缺陷， 提供了一种全新的 HIFU肿瘤消融系 统。  It is an object of the present invention to overcome the above-discussed deficiencies of the prior art and to provide a novel HIFU tumor ablation system.
本发明的目的是通过以下技术方案实现的：  The object of the invention is achieved by the following technical solutions:
一种 HIFU肿瘤消融系统，其包括至少一个 HIFU治疗装置，还包括一个开放式 MRI 系统， 该开放式 MRI系统的磁性材料垂直于地面设置， 该 HIFU治疗装置设置于该磁性 材料之间。  A HIFU tumor ablation system comprising at least one HIFU treatment device, further comprising an open MRI system, the magnetic material of the open MRI system being disposed perpendicular to the ground, the HIFU treatment device being disposed between the magnetic materials.
其中， 该 MRI系统的主恒定磁场的方向与地面平行。  Wherein, the direction of the main constant magnetic field of the MRI system is parallel to the ground.
其中， 该 HIFU治疗装置是一个设在该开放式 MRI系统的磁性材料之间上部的上置 式 HIFU治疗装置。  Wherein, the HIFU treatment device is an upper HIFU treatment device disposed between the magnetic materials of the open MRI system.
另外， 该 HIFU治疗装置还可以是一个设在该开放式 M I系统的磁性材料之间下部 的下置式 HIFU治疗装置。  Alternatively, the HIFU treatment device can be an underlying HIFU treatment device disposed between the magnetic materials of the open M I system.
或者， 该 HIFU肿瘤消融系统包括一个设在该开放式 MRI系统的磁性材料之间上部 的上置式 HIFU 治疗装置和一个设在该幵放式 MRI系统的磁性材料之间下部的下置式 HIFU治疗装置。  Alternatively, the HIFU tumor ablation system includes an upper HIFU treatment device disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device disposed between the magnetic materials of the open MRI system. .
其中， 该上置式 HIFU治疗装置釆用悬挂或支撑的方式设置在该磁性材料之间的上 部。  Wherein, the upper HIFU treatment device is disposed on the upper portion between the magnetic materials by suspension or support.
该下置式 HIFU治疗装置承载于该 HIFU肿瘤消融系统的底座上。  The underlying HIFU treatment device is carried on the base of the HIFU tumor ablation system.
另外， 该系统还包括一个患者承载装置， 其通过一个升降装置与该底座相连， 并且 通过密封材料与该下置式 HIFU治疗装置相连。 Additionally, the system further includes a patient carrying device coupled to the base by a lifting device, and The sealing device is connected to the underlying HIFU treatment device.
并且， 该患者承载装置上设有与该下置式 HIFU治疗装置相对应的开孔。  And, the patient carrying device is provided with an opening corresponding to the underlying HIFU treatment device.
本发明的积极进步效果在于： 本发明将 MRI技术和 HIFU技术融合为一体， 开创性 地将 MRI系统的磁性材料从传统的水平上下放置改为垂直于水平面设置， 使磁性材料间 更方便安装 HIFU治疗装置，通过利用 MRI系统精确定位技术、实时温度变化检测技术、 高清晰的实时影像技术等， 解决了困扰 B超式 HIFU系统发展应用中的精确定位、 无创 测温、疗效评估等根本性问题， 突破了 HIFU肿瘤消融技术的发展瓶颈， 使 HIFU治疗技 术更具安全性、 可靠性、 实用性和可信性， 并且其还具有制造成本低、 使用方便等优点。 附图说明  The positive progress of the invention is as follows: The invention combines the MRI technology and the HIFU technology into one body, and creatively changes the magnetic material of the MRI system from the traditional horizontal up and down to the vertical plane setting, so that the magnetic material is more convenient to install HIFU. The treatment device solves the fundamental problems of precise positioning, non-invasive temperature measurement and therapeutic evaluation in the development and application of the B-type HIFU system by utilizing the MRI system precise positioning technology, real-time temperature change detection technology, and high-definition real-time image technology. It breaks through the development bottleneck of HIFU tumor ablation technology, makes HIFU treatment technology more secure, reliable, practical and credible, and it also has the advantages of low manufacturing cost and convenient use. DRAWINGS
图 1为本发明实施例 1的正面示意图。  BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a front elevational view showing a first embodiment of the present invention.
图 2为本发明实施例 1的侧面示意图。 具体实施方式  Fig. 2 is a side view showing the first embodiment of the present invention. detailed description
实施例 1  Example 1
如图 1-2所示，一种 HIFU肿瘤消融系统，包括一个开放式 MRI系统，该开放式 MRI 系统的磁性材料 5、 6垂直于地面设置， 该 MRI系统的主恒定磁场的方向与地面平行， 还包括一个设在该开放式 MRI系统的磁性材料之间上部的上置式 HIFU治疗装置 1和一 个设在该开放式 MRI系统的磁性材料之间下部的下置式 HIFU治疗装置 2， 还包括一个 用于承载患者的患者承载装置 3。  As shown in Figure 1-2, a HIFU tumor ablation system includes an open MRI system in which the magnetic materials 5, 6 are placed perpendicular to the ground, and the direction of the main constant magnetic field of the MRI system is parallel to the ground. Further comprising an upper HIFU treatment device 1 disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device 2 disposed between the magnetic materials of the open MRI system, further comprising a A patient carrying device 3 for carrying a patient.
磁性材料 5、 6垂直设置在一个水平置于地面的底座 4上， MRI磁共振成像系统采用 开放式结构， 其开口向上， HIFU高强度聚焦超声系统置于该 MRI磁共振成像系统的开 口处。  The magnetic material 5, 6 is placed vertically on a horizontally placed base 4, and the MRI magnetic resonance imaging system has an open structure with an upward opening and a HIFU high intensity focused ultrasound system placed at the opening of the MRI magnetic resonance imaging system.
其中， 该上置式 HIFU治疗装置 1采用悬挂或支撑的方式设置在该磁性材料 5、 6之 间的上部， 位于该患者承载装置 3的上方， 即位于患者的上方。  The upper HIFU treatment device 1 is suspended or supported in an upper portion between the magnetic materials 5, 6 above the patient carrying device 3, that is, above the patient.
本实施例中，该上置式 HIFU治疗装置 1通过一个支架 8与两个磁性材料 5、 6连接， 悬挂在该患者承载装置 3的上方。该上置式 HIFU治疗装置 1经控制可沿患者承载装置 3 的轴向和径向做<90°的定位摇摆。  In the present embodiment, the upper HIFU treatment device 1 is connected to the two magnetic materials 5, 6 via a bracket 8 and suspended above the patient carrying device 3. The upper HIFU treatment device 1 is controlled to perform a positioning sway of <90° along the axial and radial directions of the patient carrier 3.
该下置式 HIFU治疗装置 2位于患者承载装置 3的下方， 设在该底座 4上， 通过密 封材料 （图未示） 与患者承载装置 3相连。 患者承载装置 3承载于一个与 HIFU肿瘤消融系统的底座 4相连接的升降装置 9上。 该升降装置 9设在底座 4上， 该患者承载装置 3设有与下置式 HIFU治疗装置 2相对应 的开孔， 供下置式 HIFU治疗装置 2治疗时使用。 The underlying HIFU treatment device 2 is located below the patient carrier device 3 and is disposed on the base 4 and connected to the patient carrier device 3 by a sealing material (not shown). The patient carrier 3 is carried on a lifting device 9 connected to the base 4 of the HIFU tumor ablation system. The lifting device 9 is disposed on the base 4, and the patient carrying device 3 is provided with an opening corresponding to the underlying HIFU treatment device 2 for use in the treatment of the lower HIFU treatment device 2.
具体应用时， 通过控制患者承载装置 3的上下、 左右、 前后的运动， 使患者 7处于 MRI磁共振成像系统的磁性材料 5、6形成的磁场中央，构成一体化的 MRI导引下的 HIFU 肿瘤消融系统， 从而达到治疗肿瘤的目的。  In the specific application, by controlling the up, down, left and right, and front and rear movements of the patient carrying device 3, the patient 7 is placed in the center of the magnetic field formed by the magnetic materials 5 and 6 of the MRI magnetic resonance imaging system to form an integrated MRI-guided HIFU tumor. Ablation system to achieve the purpose of treating tumors.
实施例 2  Example 2
实施例 2与实施例 1不同之处在于: 该 HIFU治疗装置是一个位于患者承载装置上 方的上置式 HIFU治疗装置， 图未示， 实施例 2的其它结构均与实施例 1相同， 在此不 做赘述。  Embodiment 2 differs from Embodiment 1 in that: the HIFU treatment device is an upper-mounted HIFU treatment device located above the patient carrier device, not shown, and the other structures of Embodiment 2 are the same as Embodiment 1, and Make a statement.
实施例 3  Example 3
实施例 3与实施例 1不同之处在于： 该 HIFU治疗装置是一个位于患者承载装置下 方的下置式 HIFU治疗装置， 图未示， 实施例 3的其它结构均与实施例 1相同， 在此不 做赘述。  Embodiment 3 differs from Embodiment 1 in that: the HIFU treatment device is an underlying HIFU treatment device located below the patient carrier device, and is not shown. The other structures of Embodiment 3 are the same as in Embodiment 1, and Make a statement.

Claims

权利要求 Rights request
1、 一种 HIFU肿瘤消融系统， 其包括至少一个 HIFU治疗装置， 其特征在于： 其还 包括一个开放式 MRI系统，该幵放式 MRI系统的磁性材料垂直于地面设置，该 HIFU治 疗装置设置于该磁性材料之间。 What is claimed is: 1. A HIFU tumor ablation system comprising at least one HIFU treatment device, further comprising: an open MRI system, the magnetic material of the open MRI system being disposed perpendicular to the ground, the HIFU treatment device being disposed at Between the magnetic materials.
2、根据权利要求 1所述的 HIFU肿瘤消融系统，其特征在于：该 MRI系统的主恒定 磁场的方向与地面平行。  2. A HIFU tumor ablation system according to claim 1 wherein the direction of the main constant magnetic field of the MRI system is parallel to the ground.
3、 根据权利要求 1所述的 HIFU肿瘤消融系统， 其特征在于： 该 HIFU治疗装置是 一个设在该开放式 MRI系统的磁性材料之间上部的上置式 HIFU治疗装置。  3. The HIFU tumor ablation system according to claim 1, wherein: the HIFU treatment device is an upper HIFU treatment device disposed between the magnetic materials of the open MRI system.
4、 根据权利要求 1所述的 HIFU肿瘤消融系统， 其特征在于： 该 HIFU治疗装置是 一个设在该开放式 MRI系统的磁性材料之间下部的下置式 HIFU治疗装置。  4. The HIFU tumor ablation system according to claim 1, wherein: the HIFU treatment device is an underlying HIFU treatment device disposed between the magnetic materials of the open MRI system.
5、 根据权利要求 1所述的 HIFU肿瘤消融系统， 其特征在于： 其包括一个设在该开 放式 MRI系统的磁性材料之间上部的上置式 HIFU治疗装置和一个设在该开放式 MRI 系统的磁性材料之间下部的下置式 HIFU治疗装置。  5. The HIFU tumor ablation system according to claim 1, comprising: an upper HIFU treatment device disposed between the magnetic materials of the open MRI system; and an upper MRI system disposed in the open MRI system A lower-mounted HIFU treatment device between the magnetic materials.
6、 根据权利要求 3或 5所述的 HIFU肿瘤消融系统， 其特征在于： 该上置式 HIFU 治疗装置采用悬挂或支撑的方式设置在该磁性材料之间的上部。  6. The HIFU tumor ablation system according to claim 3 or 5, wherein the upper HIFU treatment device is suspended or supported in an upper portion between the magnetic materials.
7、 根据权利要求 4或 5所述的 HIFU肿瘤消融系统， 其特征在于： 该下置式 HIFU 治疗装置承载于该 HIFU肿瘤消融系统的底座上。  7. The HIFU tumor ablation system of claim 4 or 5, wherein: the underlying HIFU treatment device is carried on a base of the HIFU tumor ablation system.
8、 根据权利要求 7所述的 HIFU肿瘤消融系统， 其特征在于， 其还包括一个患者承 载装置， 其通过一个升降装置与该底座相连， 并且通过密封材料与该下置式 HIFU治疗 装置相连。  8. The HIFU tumor ablation system of claim 7, further comprising a patient carrying device coupled to the base by a lifting device and coupled to the underlying HIFU therapy device by a sealing material.
9、 根据权利要求 8所述的 HIFU肿瘤消融系统， 其特征在于， 该患者承载装置上设 有与该下置式 HIFU治疗装置相对应的开孔。  9. The HIFU tumor ablation system according to claim 8, wherein the patient carrying device is provided with an opening corresponding to the underlying HIFU treatment device.
PCT/CN2006/000322 2005-11-16 2006-03-03 Hifu tumor ablating system WO2007056905A1 (en)

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