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WO2007047242A3 - Ophthalmic surgical irrigating solutions containing hyaluronidase - Google Patents

Ophthalmic surgical irrigating solutions containing hyaluronidase Download PDF

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Publication number
WO2007047242A3
WO2007047242A3 PCT/US2006/039498 US2006039498W WO2007047242A3 WO 2007047242 A3 WO2007047242 A3 WO 2007047242A3 US 2006039498 W US2006039498 W US 2006039498W WO 2007047242 A3 WO2007047242 A3 WO 2007047242A3
Authority
WO
WIPO (PCT)
Prior art keywords
ophthalmic
surgery
hyaluronidase
eye
containing hyaluronidase
Prior art date
Application number
PCT/US2006/039498
Other languages
French (fr)
Other versions
WO2007047242A2 (en
Inventor
David B Soll
Original Assignee
David B Soll
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David B Soll filed Critical David B Soll
Publication of WO2007047242A2 publication Critical patent/WO2007047242A2/en
Publication of WO2007047242A3 publication Critical patent/WO2007047242A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

An ophthalmic irrigating solution containing hyaluronidase and an antioxidant is provided. The solution prevents a post-operative intraocular pressure rise when used during an ophthalmic surgical procedure, and also protects corneal endothelial cells. A method for preventing postoperative intraocular pressure increases in an eye during ophthalmic surgery involves irrigating an anterior chamber of the eye with an ophthalmic solution containing hyaluronidase and an antioxidant. Kits containing hyaluronidase and base medium solutions are also provided. The kits are designed such that the hyaluronidase and base medium solution are combined and administered together to an eye of a patient during or following an ophthalmic surgical procedure, such as cataract surgery, intraocular lens surgery, corneal transplant surgery, or glaucoma surgery. Administration of the components of the kit prevents an increase in post-operative intraocular pressure and also protects corneal endothelial cells.
PCT/US2006/039498 2005-10-14 2006-10-10 Ophthalmic surgical irrigating solutions containing hyaluronidase WO2007047242A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72657105P 2005-10-14 2005-10-14
US60/726,571 2005-10-14

Publications (2)

Publication Number Publication Date
WO2007047242A2 WO2007047242A2 (en) 2007-04-26
WO2007047242A3 true WO2007047242A3 (en) 2009-04-30

Family

ID=37963043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/039498 WO2007047242A2 (en) 2005-10-14 2006-10-10 Ophthalmic surgical irrigating solutions containing hyaluronidase

Country Status (2)

Country Link
US (2) US7976833B2 (en)
WO (1) WO2007047242A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG177008A1 (en) 2003-03-05 2012-01-30 Halozyme Inc Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof
US7976833B2 (en) * 2005-10-14 2011-07-12 Aspen Biomedical Research, Llc Ophthalmic surgical irrigating solutions containing hyaluronidase and method for preventing post-operative intraocular pressure increases
SG187427A1 (en) 2008-04-14 2013-02-28 Halozyme Inc Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
WO2010099310A1 (en) 2009-02-26 2010-09-02 Wake Forest University Health Sciences Endothelial scaffolds
NZ583602A (en) * 2010-02-26 2010-07-30 Bomac Research Ltd Improved Calcium Formulation
KR20140043438A (en) * 2011-06-17 2014-04-09 할로자임, 아이엔씨 Stable formulations of a hyaluronan-degrading enzyme
US9993529B2 (en) 2011-06-17 2018-06-12 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
FR2986419B1 (en) * 2012-02-08 2016-11-04 Van Tao Tran PSEUDOEXFOLIATION (PEX) WASHING DEVICE WITH BALANCED SALINE SOLUTION IRRIGATION CANNULA (BSS) COMBINED WITH CATARACT OPERATION TO REDUCE OCULAR VOLTAGE
CN105164204A (en) 2012-11-21 2015-12-16 路易斯维尔大学研究基金会 Compositions and methods for reducing oxidative damage
WO2015144995A1 (en) 2014-03-28 2015-10-01 Tran Van Tao Method and device for washing out pseudoexfoliation (pex) material using a balanced salt solution (bss) irrigation cannula in combination with cataract surgery for lowering intraocular pressure
US11406591B2 (en) 2015-02-09 2022-08-09 University Of Louisville Research Foundation, Inc. Ophthalmic compositions and methods for reducing oxidative damage to an eye lens
FR3101251B1 (en) * 2019-09-26 2022-06-24 Sandrine Sebban Formulation for topical application to the skin or mucous membranes
DE102023002156A1 (en) * 2023-05-26 2024-11-28 Carl Zeiss Meditec Ag Irrigation device with a first and a second ophthalmic irrigation solution and surgical device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792103A (en) * 1995-02-03 1998-08-11 Schwartz; Daniel M. Viscosurgical method and apparatus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1303503C (en) * 1987-11-10 1992-06-16 Marc Plamondon Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex
US5116868A (en) * 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
US4963563A (en) * 1989-10-13 1990-10-16 Abbott Laboratories 6-substituted-1,2,3,4-tetrahydroisoquinolines
CA2355814C (en) * 2000-09-14 2010-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition for ophthalmic use
US6745776B2 (en) 2001-04-10 2004-06-08 David B. Soll Methods for reducing postoperative intraocular pressure
ES2332049T5 (en) * 2003-08-07 2014-03-27 Allergan, Inc. Compositions of administration of therapeutic substances in the eyes
US7976833B2 (en) * 2005-10-14 2011-07-12 Aspen Biomedical Research, Llc Ophthalmic surgical irrigating solutions containing hyaluronidase and method for preventing post-operative intraocular pressure increases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792103A (en) * 1995-02-03 1998-08-11 Schwartz; Daniel M. Viscosurgical method and apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARAIE ET AL.: "Effect of oxidized glutathione on the barrier function of the corneal endothelium.", INVESTIGATIVE OPHTHALMOL. VISUAL SCI., vol. 29, December 1988 (1988-12-01), pages 1884 - 1887 *

Also Published As

Publication number Publication date
US7976833B2 (en) 2011-07-12
US20070137657A1 (en) 2007-06-21
WO2007047242A2 (en) 2007-04-26
US20110229452A1 (en) 2011-09-22

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