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WO2007015257A3 - A process for the preparation of gemcitabine using novel intermediates - Google Patents

A process for the preparation of gemcitabine using novel intermediates Download PDF

Info

Publication number
WO2007015257A3
WO2007015257A3 PCT/IN2005/000256 IN2005000256W WO2007015257A3 WO 2007015257 A3 WO2007015257 A3 WO 2007015257A3 IN 2005000256 W IN2005000256 W IN 2005000256W WO 2007015257 A3 WO2007015257 A3 WO 2007015257A3
Authority
WO
WIPO (PCT)
Prior art keywords
gemcitabine
novel intermediates
preparation
purity
pharmaceutically acceptable
Prior art date
Application number
PCT/IN2005/000256
Other languages
French (fr)
Other versions
WO2007015257A2 (en
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Rapolu Raji
Reddy Dasari Muralidhara
Reddy Itiyala Srinivas
Original Assignee
Hetero Drugs Ltd
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Rapolu Raji
Reddy Dasari Muralidhara
Reddy Itiyala Srinivas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Drugs Ltd, Reddy Bandi Parthasaradhi, Reddy Kura Rathnakar, Reddy Rapolu Raji, Reddy Dasari Muralidhara, Reddy Itiyala Srinivas filed Critical Hetero Drugs Ltd
Priority to PCT/IN2005/000256 priority Critical patent/WO2007015257A2/en
Priority to ARP050103954A priority patent/AR051374A1/en
Priority to PE2006000283A priority patent/PE20070315A1/en
Publication of WO2007015257A2 publication Critical patent/WO2007015257A2/en
Publication of WO2007015257A3 publication Critical patent/WO2007015257A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a commercially viable process for preparing gemcitabine and its pharmaceutically acceptable acid addition salts thereof in high yield and purity using novel intermediates.
PCT/IN2005/000256 2005-08-04 2005-08-04 A process for the preparation of gemcitabine using novel intermediates WO2007015257A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/IN2005/000256 WO2007015257A2 (en) 2005-08-04 2005-08-04 A process for the preparation of gemcitabine using novel intermediates
ARP050103954A AR051374A1 (en) 2005-08-04 2005-09-21 GEMCITABIN PREPARATION PROCESS AND RELATED COMPOUNDS
PE2006000283A PE20070315A1 (en) 2005-08-04 2006-03-14 PROCEDURE FOR THE PREPARATION OF GEMCITABIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000256 WO2007015257A2 (en) 2005-08-04 2005-08-04 A process for the preparation of gemcitabine using novel intermediates

Publications (2)

Publication Number Publication Date
WO2007015257A2 WO2007015257A2 (en) 2007-02-08
WO2007015257A3 true WO2007015257A3 (en) 2008-04-10

Family

ID=37600974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2005/000256 WO2007015257A2 (en) 2005-08-04 2005-08-04 A process for the preparation of gemcitabine using novel intermediates

Country Status (3)

Country Link
AR (1) AR051374A1 (en)
PE (1) PE20070315A1 (en)
WO (1) WO2007015257A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009531284A (en) * 2006-02-06 2009-09-03 ドクター レディズ ラボラトリーズ リミテッド Preparation of gemcitabine
CN102659884B (en) * 2012-04-23 2014-07-02 南京臣功制药股份有限公司 Gemcitabine hydrochloride purifying method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2136425A (en) * 1983-03-10 1984-09-19 Lilly Co Eli Nucleosides
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2136425A (en) * 1983-03-10 1984-09-19 Lilly Co Eli Nucleosides
WO2004041203A2 (en) * 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 7, 1995, pages 743 - 748 *
DATABASE CAPLUS [online] XIANG Y. ET AL.: "Synthesis and anti-HIV activities of 2'-deoxy-2',2"-difluoro-beta-L-ribofuranosyl-pyrimidine and -purine nucleosides", Database accession no. (1995:519328) *

Also Published As

Publication number Publication date
WO2007015257A2 (en) 2007-02-08
PE20070315A1 (en) 2007-06-06
AR051374A1 (en) 2007-01-10

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